2I2QA

Fission yeast cofilin
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
122
structure length
122
Chain Sequence
SFSGVKVSPECLEAFQELKLGKSLRYVVFKMNDTKTEIVVEKKSTDKDFDTFLGDLPEKDCRYAIYDFEFNLGEGVRNKIIFISWSPDVAPIKSKMVYSSSKDTLRRAFTGIGTDIQATDFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanism of Actin Filament Turnover by Severing and Nucleation at Different Concentrations of ADF/Cofilin.
pubmed doi rcsb
molecule tags Actin-binding protein
source organism Schizosaccharomyces pombe
molecule keywords Cofilin
total genus 35
structure length 122
sequence length 122
ec nomenclature
pdb deposition date 2006-08-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2i2qA00
1C0FS 2FH1A 5IVUA 1YVNG 5KYYB 1UDMA 1PCXA 2FH2A 1WFSA 1TMWA 5KYWB 1PD0A 1WNJA 3EGXA 1KCQA 1T3XA 5HVKD 2NUTB 2LLFA 1C0GS 1T3YA 1M4JA 1QPVA 3A5OS 3FG7A 1M2OA 1P8XA 1AK7A 1H1VG 1D0NA 5A1MA 4CBWG 3EH1A 3A5LS 2KVKA 1AHQA 2FGHA 1NMDG 3FG6A 1PD1A 3CJBG 4KEFA 1COFA 1RGIG 4Z94G 1NPHA 1NM1G 1M2VB 1T2LA 4PKHB 5DD2A 2QTVA 3EGDB 2MOTA 3EFOB 3Q2BA 1X67A 3EG9A 1V6FA 5FAEA 4BEX1 1D4XG 3CIPG 4JD2H 2FH3A 1P8ZG 2HD7A 2NUPA 5KYXB 3FFKA 3CJCG 3TU5B 5KYUB 3EH2A 2MV2A 2D8BA 1SVQA 1T44G 4KEDA 2FF6G 5KYWA 1F7SA 2VILA 3A5MS 2I2QA 3FFNA 1EQYS 3A5NS 2NUTA 2W0IA 1VKKA 1SVRA 2FH4A 2L72A 3EGXB 2XF1A 5HVKB 1NLVG 1SVYA 4S10C 1Q8XA 4KEEA 1HQZ1 3EFOA 1Q8GA 2NUPB 1JHWA 3CI5G 5KYYA 1AK6A 2VIKA 4PKGG 1CFYA 1ESVS 4PKIG 1MDUA 4CBXG 4LIZA 2LXXA 3L50A 1M2VA 5KYNA 1J72A 1DEJS 1WM4A 4CBUG 3EGDA 1TVJA 1YAGG 5FAFA 1VFQA 2LJ8A 5L6WC 5KYXA 2VACA 3DAWB 1CNUA 2MP4A 3EG9B 5KYUA 2XFAA 2FF3A
chains in the Genus database with same CATH superfamily
1C0FS 2FH1A 5IVUA 1YVNG 5KYYB 1UDMA 1PCXA 2FH2A 1WFSA 1TMWA 5KYWB 1PD0A 3DA7A 1WNJA 3EGXA 1KCQA 1T3XA 5HVKD 2NUTB 2LLFA 1C0GS 1T3YA 1M4JA 1QPVA 3A5OS 3FG7A 1M2OA 1P8XA 1AK7A 1H1VG 1D0NA 5A1MA 4CBWG 3EH1A 3A5LS 2KVKA 1AHQA 2FGHA 1NMDG 3FG6A 1PD1A 3CJBG 4KEFA 1COFA 1RGIG 4Z94G 1NPHA 1NM1G 1M2VB 1T2LA 4PKHB 5DD2A 2QTVA 3EGDB 2MOTA 3EFOB 3Q2BA 1X67A 3EG9A 1V6FA 5FAEA 4BEX1 1D4XG 3CIPG 4JD2H 2FH3A 1P8ZG 2HD7A 2NUPA 5KYXB 3FFKA 3CJCG 3TU5B 5KYUB 3EH2A 2MV2A 2D8BA 1SVQA 1T44G 4KEDA 2FF6G 5KYWA 1F7SA 2VILA 3A5MS 2I2QA 3FFNA 1EQYS 3A5NS 2NUTA 2W0IA 1VKKA 1SVRA 2FH4A 2L72A 3EGXB 2XF1A 5HVKB 1NLVG 1SVYA 4S10C 1Q8XA 4KEEA 1HQZ1 3EFOA 1Q8GA 2NUPB 1JHWA 3CI5G 5KYYA 1AK6A 2VIKA 4PKGG 1CFYA 1ESVS 4PKIG 1MDUA 4CBXG 4LIZA 2LXXA 3L50A 1M2VA 5KYNA 1J72A 1DEJS 1WM4A 4CBUG 3EGDA 1TVJA 1YAGG 5FAFA 1VFQA 2LJ8A 5L6WC 5KYXA 2VACA 3DAWB 1CNUA 2MP4A 3EG9B 5KYUA 2XFAA 2FF3A
chains in the Genus database with same CATH topology
1C0FS 2FH1A 5IVUA 1YVNG 5KYYB 1UDMA 1PCXA 2FH2A 1WFSA 1TMWA 5KYWB 1PD0A 3DA7A 1WNJA 3EGXA 1KCQA 1T3XA 5HVKD 2NUTB 2LLFA 1C0GS 1T3YA 1M4JA 1QPVA 3A5OS 3FG7A 1M2OA 1P8XA 1AK7A 1H1VG 1D0NA 5A1MA 4CBWG 3EH1A 3A5LS 2KVKA 1AHQA 2FGHA 1NMDG 3FG6A 1PD1A 3CJBG 4KEFA 1COFA 1RGIG 4Z94G 1NPHA 1NM1G 1M2VB 1T2LA 4PKHB 5DD2A 2QTVA 3EGDB 2MOTA 3EFOB 3Q2BA 1X67A 3EG9A 1V6FA 5FAEA 4BEX1 1D4XG 3CIPG 4JD2H 2FH3A 1P8ZG 2HD7A 2NUPA 5KYXB 3FFKA 3CJCG 3TU5B 5KYUB 3EH2A 2MV2A 2D8BA 1SVQA 1T44G 4KEDA 2FF6G 5KYWA 1F7SA 2VILA 3A5MS 2I2QA 3FFNA 1EQYS 3A5NS 2NUTA 2W0IA 1VKKA 1SVRA 2FH4A 2L72A 3EGXB 2XF1A 5HVKB 1NLVG 1SVYA 4S10C 1Q8XA 4KEEA 1HQZ1 3EFOA 1Q8GA 2NUPB 1JHWA 3CI5G 5KYYA 1AK6A 2VIKA 4PKGG 1CFYA 1ESVS 4PKIG 1MDUA 4CBXG 4LIZA 2LXXA 3L50A 1M2VA 5KYNA 1J72A 1DEJS 1WM4A 4CBUG 3EGDA 1TVJA 1YAGG 5FAFA 1VFQA 2LJ8A 5L6WC 5KYXA 2VACA 3DAWB 1CNUA 2MP4A 3EG9B 5KYUA 2XFAA 2FF3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C0F S;  2FH1 A;  5IVU A;  1YVN G;  5KYY B;  1UDM A;  1PCX A;  2FH2 A;  1WFS A;  1TMW A;  5KYW B;  1PD0 A;  1WNJ A;  3EGX A;  1KCQ A;  1T3X A;  5HVK D;  2NUT B;  2LLF A;  1C0G S;  1T3Y A;  1M4J A;  1QPV A;  3A5O S;  3FG7 A;  1M2O A;  1P8X A;  1AK7 A;  1H1V G;  1D0N A;  5A1M A;  4CBW G;  3EH1 A;  3A5L S;  2KVK A;  1AHQ A;  2FGH A;  1NMD G;  3FG6 A;  1PD1 A;  3CJB G;  4KEF A;  1COF A;  1RGI G;  4Z94 G;  1NPH A;  1NM1 G;  1M2V B;  1T2L A;  4PKH B;  5DD2 A;  2QTV A;  3EGD B;  2MOT A;  3EFO B;  3Q2B A;  1X67 A;  3EG9 A;  1V6F A;  5FAE A;  4BEX 1;  1D4X G;  3CIP G;  4JD2 H;  2FH3 A;  1P8Z G;  2HD7 A;  2NUP A;  5KYX B;  3FFK A;  3CJC G;  3TU5 B;  5KYU B;  3EH2 A;  2MV2 A;  2D8B A;  1SVQ A;  1T44 G;  4KED A;  2FF6 G;  5KYW A;  1F7S A;  2VIL A;  3A5M S;  2I2Q A;  3FFN A;  1EQY S;  3A5N S;  2NUT A;  2W0I A;  1VKK A;  1SVR A;  2FH4 A;  2L72 A;  3EGX B;  2XF1 A;  5HVK B;  1NLV G;  1SVY A;  4S10 C;  1Q8X A;  4KEE A;  1HQZ 1;  3EFO A;  1Q8G A;  2NUP B;  1JHW A;  3CI5 G;  5KYY A;  1AK6 A;  2VIK A;  4PKG G;  1CFY A;  1ESV S;  4PKI G;  1MDU A;  4CBX G;  4LIZ A;  2LXX A;  3L50 A;  1M2V A;  5KYN A;  1J72 A;  1DEJ S;  1WM4 A;  4CBU G;  3EGD A;  1TVJ A;  1YAG G;  5FAF A;  1VFQ A;  2LJ8 A;  5L6W C;  5KYX A;  2VAC A;  3DAW B;  1CNU A;  2MP4 A;  3EG9 B;  5KYU A;  2XFA A;  2FF3 A; 
#chains in the Genus database with same CATH topology
 1C0F S;  2FH1 A;  5IVU A;  1YVN G;  5KYY B;  1UDM A;  1PCX A;  2FH2 A;  1WFS A;  1TMW A;  5KYW B;  1PD0 A;  3DA7 A;  1WNJ A;  3EGX A;  1KCQ A;  1T3X A;  5HVK D;  2NUT B;  2LLF A;  1C0G S;  1T3Y A;  1M4J A;  1QPV A;  3A5O S;  3FG7 A;  1M2O A;  1P8X A;  1AK7 A;  1H1V G;  1D0N A;  5A1M A;  4CBW G;  3EH1 A;  3A5L S;  2KVK A;  1AHQ A;  2FGH A;  1NMD G;  3FG6 A;  1PD1 A;  3CJB G;  4KEF A;  1COF A;  1RGI G;  4Z94 G;  1NPH A;  1NM1 G;  1M2V B;  1T2L A;  4PKH B;  5DD2 A;  2QTV A;  3EGD B;  2MOT A;  3EFO B;  3Q2B A;  1X67 A;  3EG9 A;  1V6F A;  5FAE A;  4BEX 1;  1D4X G;  3CIP G;  4JD2 H;  2FH3 A;  1P8Z G;  2HD7 A;  2NUP A;  5KYX B;  3FFK A;  3CJC G;  3TU5 B;  5KYU B;  3EH2 A;  2MV2 A;  2D8B A;  1SVQ A;  1T44 G;  4KED A;  2FF6 G;  5KYW A;  1F7S A;  2VIL A;  3A5M S;  2I2Q A;  3FFN A;  1EQY S;  3A5N S;  2NUT A;  2W0I A;  1VKK A;  1SVR A;  2FH4 A;  2L72 A;  3EGX B;  2XF1 A;  5HVK B;  1NLV G;  1SVY A;  4S10 C;  1Q8X A;  4KEE A;  1HQZ 1;  3EFO A;  1Q8G A;  2NUP B;  1JHW A;  3CI5 G;  5KYY A;  1AK6 A;  2VIK A;  4PKG G;  1CFY A;  1ESV S;  4PKI G;  1MDU A;  4CBX G;  4LIZ A;  2LXX A;  3L50 A;  1M2V A;  5KYN A;  1J72 A;  1DEJ S;  1WM4 A;  4CBU G;  3EGD A;  1TVJ A;  1YAG G;  5FAF A;  1VFQ A;  2LJ8 A;  5L6W C;  5KYX A;  2VAC A;  3DAW B;  1CNU A;  2MP4 A;  3EG9 B;  5KYU A;  2XFA A;  2FF3 A; 
#chains in the Genus database with same CATH homology
 1C0F S;  2FH1 A;  5IVU A;  1YVN G;  5KYY B;  1UDM A;  1PCX A;  2FH2 A;  1WFS A;  1TMW A;  5KYW B;  1PD0 A;  3DA7 A;  1WNJ A;  3EGX A;  1KCQ A;  1T3X A;  5HVK D;  2NUT B;  2LLF A;  1C0G S;  1T3Y A;  1M4J A;  1QPV A;  3A5O S;  3FG7 A;  1M2O A;  1P8X A;  1AK7 A;  1H1V G;  1D0N A;  5A1M A;  4CBW G;  3EH1 A;  3A5L S;  2KVK A;  1AHQ A;  2FGH A;  1NMD G;  3FG6 A;  1PD1 A;  3CJB G;  4KEF A;  1COF A;  1RGI G;  4Z94 G;  1NPH A;  1NM1 G;  1M2V B;  1T2L A;  4PKH B;  5DD2 A;  2QTV A;  3EGD B;  2MOT A;  3EFO B;  3Q2B A;  1X67 A;  3EG9 A;  1V6F A;  5FAE A;  4BEX 1;  1D4X G;  3CIP G;  4JD2 H;  2FH3 A;  1P8Z G;  2HD7 A;  2NUP A;  5KYX B;  3FFK A;  3CJC G;  3TU5 B;  5KYU B;  3EH2 A;  2MV2 A;  2D8B A;  1SVQ A;  1T44 G;  4KED A;  2FF6 G;  5KYW A;  1F7S A;  2VIL A;  3A5M S;  2I2Q A;  3FFN A;  1EQY S;  3A5N S;  2NUT A;  2W0I A;  1VKK A;  1SVR A;  2FH4 A;  2L72 A;  3EGX B;  2XF1 A;  5HVK B;  1NLV G;  1SVY A;  4S10 C;  1Q8X A;  4KEE A;  1HQZ 1;  3EFO A;  1Q8G A;  2NUP B;  1JHW A;  3CI5 G;  5KYY A;  1AK6 A;  2VIK A;  4PKG G;  1CFY A;  1ESV S;  4PKI G;  1MDU A;  4CBX G;  4LIZ A;  2LXX A;  3L50 A;  1M2V A;  5KYN A;  1J72 A;  1DEJ S;  1WM4 A;  4CBU G;  3EGD A;  1TVJ A;  1YAG G;  5FAF A;  1VFQ A;  2LJ8 A;  5L6W C;  5KYX A;  2VAC A;  3DAW B;  1CNU A;  2MP4 A;  3EG9 B;  5KYU A;  2XFA A;  2FF3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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