2I2QA

Fission yeast cofilin
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
122
structure length
122
Chain Sequence
SFSGVKVSPECLEAFQELKLGKSLRYVVFKMNDTKTEIVVEKKSTDKDFDTFLGDLPEKDCRYAIYDFEFNLGEGVRNKIIFISWSPDVAPIKSKMVYSSSKDTLRRAFTGIGTDIQATDFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanism of Actin Filament Turnover by Severing and Nucleation at Different Concentrations of ADF/Cofilin.
pubmed doi rcsb
molecule tags Actin-binding protein
source organism Schizosaccharomyces pombe
molecule keywords Cofilin
total genus 35
structure length 122
sequence length 122
ec nomenclature
pdb deposition date 2006-08-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2i2qA00
4PKHB 1MDUA 1EQYS 2MOTA 4KEEA 3EH1A 3L50A 1V6FA 1D4XG 1COFA 3CJCG 4CBWG 3CI5G 1C0GS 1VKKA 2W0IA 3CIPG 1TVJA 3EGDA 5HVKB 2QTVA 3A5OS 3A5NS 1RGIG 2XFAA 3EG9B 4KEFA 1PCXA 2FF6G 1H1VG 3FG7A 3FG6A 1VFQA 1C0FS 1Q8GA 1NMDG 5KYUA 5KYYB 3EFOA 1WM4A 2D8BA 3EH2A 3FFNA 2MP4A 1D0NA 2LLFA 2FH3A 1NM1G 1AK6A 1NLVG 3A5MS 1AK7A 4PKIG 1P8ZG 2NUTA 2L72A 1WFSA 2NUPA 1M2VA 2LXXA 3EGXB 1CFYA 2VACA 1JHWA 3EGDB 3Q2BA 1J72A 1Q8XA 4CBUG 1NPHA 5L6WC 2FF3A 5IVUA 1F7SA 1SVQA 5KYWA 5FAEA 5KYUB 1T3YA 1AHQA 2HD7A 3EFOB 5KYXA 1T44G 5KYNA 1TMWA 3EG9A 1M4JA 2XF1A 4CBXG 1QPVA 4S10C 2VILA 1YAGG 1T2LA 2VIKA 1ESVS 5FAFA 2NUTB 4BEX1 1T3XA 2NUPB 5DD2A 1M2VB 2FGHA 1HQZ1 1UDMA 1P8XA 2MV2A 4LIZA 1WNJA 4PKGG 3DAWB 3EGXA 3FFKA 5A1MA 1PD1A 1PD0A 1CNUA 2FH1A 1YVNG 5KYWB 2KVKA 5KYXB 3TU5B 5HVKD 2LJ8A 2FH2A 1SVRA 3CJBG 4KEDA 4Z94G 5KYYA 2FH4A 3A5LS 1DEJS 1M2OA 4JD2H 1KCQA 1X67A 2I2QA 1SVYA
chains in the Genus database with same CATH superfamily
4PKHB 1MDUA 1EQYS 2MOTA 4KEEA 3EH1A 3L50A 1V6FA 1D4XG 1COFA 3CJCG 4CBWG 3CI5G 1C0GS 1VKKA 2W0IA 3CIPG 1TVJA 3EGDA 5HVKB 2QTVA 3A5OS 3A5NS 1RGIG 2XFAA 3EG9B 4KEFA 1PCXA 2FF6G 1H1VG 3FG7A 3FG6A 1VFQA 1C0FS 1Q8GA 1NMDG 5KYUA 5KYYB 3EFOA 1WM4A 2D8BA 3EH2A 3FFNA 2MP4A 1D0NA 2LLFA 2FH3A 1NM1G 1AK6A 1NLVG 3A5MS 1AK7A 4PKIG 1P8ZG 2NUTA 2L72A 1WFSA 2NUPA 1M2VA 2LXXA 3EGXB 1CFYA 2VACA 1JHWA 3EGDB 3Q2BA 1J72A 1Q8XA 4CBUG 1NPHA 5L6WC 2FF3A 5IVUA 1F7SA 1SVQA 5KYWA 5FAEA 5KYUB 1T3YA 1AHQA 2HD7A 3EFOB 5KYXA 1T44G 5KYNA 1TMWA 3EG9A 1M4JA 2XF1A 4CBXG 1QPVA 4S10C 2VILA 1YAGG 1T2LA 2VIKA 1ESVS 5FAFA 2NUTB 4BEX1 1T3XA 2NUPB 5DD2A 1M2VB 2FGHA 1HQZ1 1UDMA 1P8XA 2MV2A 4LIZA 3DA7A 1WNJA 4PKGG 3DAWB 3EGXA 3FFKA 5A1MA 1PD1A 1PD0A 1CNUA 2FH1A 1YVNG 5KYWB 2KVKA 5KYXB 3TU5B 5HVKD 2LJ8A 2FH2A 1SVRA 3CJBG 4KEDA 4Z94G 5KYYA 2FH4A 3A5LS 1DEJS 1M2OA 4JD2H 1KCQA 1X67A 2I2QA 1SVYA
chains in the Genus database with same CATH topology
4PKHB 1MDUA 1EQYS 2MOTA 4KEEA 3EH1A 3L50A 1V6FA 1D4XG 1COFA 3CJCG 4CBWG 3CI5G 1C0GS 1VKKA 2W0IA 3CIPG 1TVJA 3EGDA 5HVKB 2QTVA 3A5OS 3A5NS 1RGIG 2XFAA 3EG9B 4KEFA 1PCXA 2FF6G 1H1VG 3FG7A 3FG6A 1VFQA 1C0FS 1Q8GA 1NMDG 5KYUA 5KYYB 3EFOA 1WM4A 2D8BA 3EH2A 3FFNA 2MP4A 1D0NA 2LLFA 2FH3A 1NM1G 1AK6A 1NLVG 3A5MS 1AK7A 4PKIG 1P8ZG 2NUTA 2L72A 1WFSA 2NUPA 1M2VA 2LXXA 3EGXB 1CFYA 2VACA 1JHWA 3EGDB 3Q2BA 1J72A 1Q8XA 4CBUG 1NPHA 5L6WC 2FF3A 5IVUA 1F7SA 1SVQA 5KYWA 5FAEA 5KYUB 1T3YA 1AHQA 2HD7A 3EFOB 5KYXA 1T44G 5KYNA 1TMWA 3EG9A 1M4JA 2XF1A 4CBXG 1QPVA 4S10C 2VILA 1YAGG 1T2LA 2VIKA 1ESVS 5FAFA 2NUTB 4BEX1 1T3XA 2NUPB 5DD2A 1M2VB 2FGHA 1HQZ1 1UDMA 1P8XA 2MV2A 4LIZA 3DA7A 1WNJA 4PKGG 3DAWB 3EGXA 3FFKA 5A1MA 1PD1A 1PD0A 1CNUA 2FH1A 1YVNG 5KYWB 2KVKA 5KYXB 3TU5B 5HVKD 2LJ8A 2FH2A 1SVRA 3CJBG 4KEDA 4Z94G 5KYYA 2FH4A 3A5LS 1DEJS 1M2OA 4JD2H 1KCQA 1X67A 2I2QA 1SVYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PKH B;  1MDU A;  1EQY S;  2MOT A;  4KEE A;  3EH1 A;  3L50 A;  1V6F A;  1D4X G;  1COF A;  3CJC G;  4CBW G;  3CI5 G;  1C0G S;  1VKK A;  2W0I A;  3CIP G;  1TVJ A;  3EGD A;  5HVK B;  2QTV A;  3A5O S;  3A5N S;  1RGI G;  2XFA A;  3EG9 B;  4KEF A;  1PCX A;  2FF6 G;  1H1V G;  3FG7 A;  3FG6 A;  1VFQ A;  1C0F S;  1Q8G A;  1NMD G;  5KYU A;  5KYY B;  3EFO A;  1WM4 A;  2D8B A;  3EH2 A;  3FFN A;  2MP4 A;  1D0N A;  2LLF A;  2FH3 A;  1NM1 G;  1AK6 A;  1NLV G;  3A5M S;  1AK7 A;  4PKI G;  1P8Z G;  2NUT A;  2L72 A;  1WFS A;  2NUP A;  1M2V A;  2LXX A;  3EGX B;  1CFY A;  2VAC A;  1JHW A;  3EGD B;  3Q2B A;  1J72 A;  1Q8X A;  4CBU G;  1NPH A;  5L6W C;  2FF3 A;  5IVU A;  1F7S A;  1SVQ A;  5KYW A;  5FAE A;  5KYU B;  1T3Y A;  1AHQ A;  2HD7 A;  3EFO B;  5KYX A;  1T44 G;  5KYN A;  1TMW A;  3EG9 A;  1M4J A;  2XF1 A;  4CBX G;  1QPV A;  4S10 C;  2VIL A;  1YAG G;  1T2L A;  2VIK A;  1ESV S;  5FAF A;  2NUT B;  4BEX 1;  1T3X A;  2NUP B;  5DD2 A;  1M2V B;  2FGH A;  1HQZ 1;  1UDM A;  1P8X A;  2MV2 A;  4LIZ A;  1WNJ A;  4PKG G;  3DAW B;  3EGX A;  3FFK A;  5A1M A;  1PD1 A;  1PD0 A;  1CNU A;  2FH1 A;  1YVN G;  5KYW B;  2KVK A;  5KYX B;  3TU5 B;  5HVK D;  2LJ8 A;  2FH2 A;  1SVR A;  3CJB G;  4KED A;  4Z94 G;  5KYY A;  2FH4 A;  3A5L S;  1DEJ S;  1M2O A;  4JD2 H;  1KCQ A;  1X67 A;  2I2Q A;  1SVY A; 
#chains in the Genus database with same CATH topology
 4PKH B;  1MDU A;  1EQY S;  2MOT A;  4KEE A;  3EH1 A;  3L50 A;  1V6F A;  1D4X G;  1COF A;  3CJC G;  4CBW G;  3CI5 G;  1C0G S;  1VKK A;  2W0I A;  3CIP G;  1TVJ A;  3EGD A;  5HVK B;  2QTV A;  3A5O S;  3A5N S;  1RGI G;  2XFA A;  3EG9 B;  4KEF A;  1PCX A;  2FF6 G;  1H1V G;  3FG7 A;  3FG6 A;  1VFQ A;  1C0F S;  1Q8G A;  1NMD G;  5KYU A;  5KYY B;  3EFO A;  1WM4 A;  2D8B A;  3EH2 A;  3FFN A;  2MP4 A;  1D0N A;  2LLF A;  2FH3 A;  1NM1 G;  1AK6 A;  1NLV G;  3A5M S;  1AK7 A;  4PKI G;  1P8Z G;  2NUT A;  2L72 A;  1WFS A;  2NUP A;  1M2V A;  2LXX A;  3EGX B;  1CFY A;  2VAC A;  1JHW A;  3EGD B;  3Q2B A;  1J72 A;  1Q8X A;  4CBU G;  1NPH A;  5L6W C;  2FF3 A;  5IVU A;  1F7S A;  1SVQ A;  5KYW A;  5FAE A;  5KYU B;  1T3Y A;  1AHQ A;  2HD7 A;  3EFO B;  5KYX A;  1T44 G;  5KYN A;  1TMW A;  3EG9 A;  1M4J A;  2XF1 A;  4CBX G;  1QPV A;  4S10 C;  2VIL A;  1YAG G;  1T2L A;  2VIK A;  1ESV S;  5FAF A;  2NUT B;  4BEX 1;  1T3X A;  2NUP B;  5DD2 A;  1M2V B;  2FGH A;  1HQZ 1;  1UDM A;  1P8X A;  2MV2 A;  4LIZ A;  3DA7 A;  1WNJ A;  4PKG G;  3DAW B;  3EGX A;  3FFK A;  5A1M A;  1PD1 A;  1PD0 A;  1CNU A;  2FH1 A;  1YVN G;  5KYW B;  2KVK A;  5KYX B;  3TU5 B;  5HVK D;  2LJ8 A;  2FH2 A;  1SVR A;  3CJB G;  4KED A;  4Z94 G;  5KYY A;  2FH4 A;  3A5L S;  1DEJ S;  1M2O A;  4JD2 H;  1KCQ A;  1X67 A;  2I2Q A;  1SVY A; 
#chains in the Genus database with same CATH homology
 4PKH B;  1MDU A;  1EQY S;  2MOT A;  4KEE A;  3EH1 A;  3L50 A;  1V6F A;  1D4X G;  1COF A;  3CJC G;  4CBW G;  3CI5 G;  1C0G S;  1VKK A;  2W0I A;  3CIP G;  1TVJ A;  3EGD A;  5HVK B;  2QTV A;  3A5O S;  3A5N S;  1RGI G;  2XFA A;  3EG9 B;  4KEF A;  1PCX A;  2FF6 G;  1H1V G;  3FG7 A;  3FG6 A;  1VFQ A;  1C0F S;  1Q8G A;  1NMD G;  5KYU A;  5KYY B;  3EFO A;  1WM4 A;  2D8B A;  3EH2 A;  3FFN A;  2MP4 A;  1D0N A;  2LLF A;  2FH3 A;  1NM1 G;  1AK6 A;  1NLV G;  3A5M S;  1AK7 A;  4PKI G;  1P8Z G;  2NUT A;  2L72 A;  1WFS A;  2NUP A;  1M2V A;  2LXX A;  3EGX B;  1CFY A;  2VAC A;  1JHW A;  3EGD B;  3Q2B A;  1J72 A;  1Q8X A;  4CBU G;  1NPH A;  5L6W C;  2FF3 A;  5IVU A;  1F7S A;  1SVQ A;  5KYW A;  5FAE A;  5KYU B;  1T3Y A;  1AHQ A;  2HD7 A;  3EFO B;  5KYX A;  1T44 G;  5KYN A;  1TMW A;  3EG9 A;  1M4J A;  2XF1 A;  4CBX G;  1QPV A;  4S10 C;  2VIL A;  1YAG G;  1T2L A;  2VIK A;  1ESV S;  5FAF A;  2NUT B;  4BEX 1;  1T3X A;  2NUP B;  5DD2 A;  1M2V B;  2FGH A;  1HQZ 1;  1UDM A;  1P8X A;  2MV2 A;  4LIZ A;  3DA7 A;  1WNJ A;  4PKG G;  3DAW B;  3EGX A;  3FFK A;  5A1M A;  1PD1 A;  1PD0 A;  1CNU A;  2FH1 A;  1YVN G;  5KYW B;  2KVK A;  5KYX B;  3TU5 B;  5HVK D;  2LJ8 A;  2FH2 A;  1SVR A;  3CJB G;  4KED A;  4Z94 G;  5KYY A;  2FH4 A;  3A5L S;  1DEJ S;  1M2O A;  4JD2 H;  1KCQ A;  1X67 A;  2I2Q A;  1SVY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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