2KVKA

Solution structure of adf/cofilin (ldcof) from leishmania donovani
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
144
structure length
144
Chain Sequence
MAISGVTLEESVRGAIDDLRMKKSRYVMMCIGADGKKIEVTEVGERSVNYTDLKEKFSTEKPCYVAFDFEYNDAGSKREKLILIQWIPDTARPREKMMYSASRDALSSVSEGYLPIQANDESGLDAEEIIRKVRLHRSVAAALE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure and dynamics of ADF/cofilin from Leishmania donovani
pubmed doi rcsb
molecule tags Hormone
source organism Leishmania donovani
molecule keywords Actin severing and dynamics regulatory protein
total genus 46
structure length 144
sequence length 144
ec nomenclature
pdb deposition date 2010-03-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2kvkA00
1Q8XA 5KYXB 2FH1A 5A1MA 1CFYA 1V6FA 1M2VB 3A5LS 3DAWB 1QPVA 2QTVA 4LIZA 1WM4A 2NUPA 5IVUA 1Q8GA 2XFAA 3TU5B 1SVYA 3EGDA 1M4JA 3EG9A 5FAFA 5L6WC 1TVJA 1D0NA 2FGHA 1T3YA 1TMWA 3EGDB 1AK6A 2FH4A 4S10C 2LJ8A 3EG9B 4PKIG 5DD2A 1M2OA 1YAGG 2XF1A 3EGXA 3EH2A 2MP4A 1DEJS 2LXXA 1YVNG 2VACA 1C0GS 5HVKB 1COFA 3EGXB 3A5NS 1WFSA 4CBWG 2VIKA 1UDMA 1PD1A 4CBXG 1HQZ1 1P8XA 4CBUG 2L72A 5KYWA 2FF3A 1F7SA 1MDUA 3A5MS 1NMDG 2LLFA 1CNUA 1VKKA 5HVKD 1WNJA 3CJBG 3L50A 1J72A 4KEEA 4Z94G 1P8ZG 5KYWB 1JHWA 3EH1A 2HD7A 1NPHA 1SVRA 4PKGG 2VILA 1VFQA 2MOTA 2W0IA 2NUTB 1NLVG 3FFNA 1KCQA 3FG7A 1PCXA 1X67A 2FH2A 2MV2A 2FH3A 1AK7A 1ESVS 1AHQA 1SVQA 4KEFA 5KYNA 1EQYS 2I2QA 2FF6G 4BEX1 3EFOB 1T2LA 5KYYA 3CIPG 1RGIG 2D8BA 3FG6A 3CJCG 3CI5G 5FAEA 5KYUA 1NM1G 2NUTA 4PKHB 1D4XG 4KEDA 3A5OS 5KYXA 2KVKA 1T3XA 5KYYB 3FFKA 3Q2BA 2NUPB 1C0FS 1T44G 1PD0A 1M2VA 4JD2H 5KYUB 3EFOA 1H1VG
chains in the Genus database with same CATH superfamily
1Q8XA 5KYXB 2FH1A 5A1MA 1CFYA 1V6FA 1M2VB 3A5LS 3DAWB 1QPVA 2QTVA 4LIZA 1WM4A 2NUPA 5IVUA 1Q8GA 2XFAA 3TU5B 1SVYA 3EGDA 3DA7A 1M4JA 3EG9A 5FAFA 5L6WC 1TVJA 1D0NA 2FGHA 1T3YA 1TMWA 3EGDB 1AK6A 2FH4A 4S10C 2LJ8A 3EG9B 4PKIG 5DD2A 1M2OA 1YAGG 2XF1A 3EGXA 3EH2A 2MP4A 1DEJS 2LXXA 1YVNG 2VACA 1C0GS 5HVKB 1COFA 3EGXB 3A5NS 1WFSA 4CBWG 2VIKA 1UDMA 1PD1A 4CBXG 1HQZ1 1P8XA 4CBUG 2L72A 5KYWA 2FF3A 1F7SA 1MDUA 3A5MS 1NMDG 2LLFA 1CNUA 1VKKA 5HVKD 1WNJA 3CJBG 3L50A 1J72A 4KEEA 4Z94G 1P8ZG 5KYWB 1JHWA 3EH1A 2HD7A 1NPHA 1SVRA 4PKGG 2VILA 1VFQA 2MOTA 2W0IA 2NUTB 1NLVG 3FFNA 1KCQA 3FG7A 1PCXA 1X67A 2FH2A 2MV2A 2FH3A 1AK7A 1ESVS 1AHQA 1SVQA 4KEFA 5KYNA 1EQYS 2I2QA 2FF6G 4BEX1 3EFOB 1T2LA 5KYYA 3CIPG 1RGIG 2D8BA 3FG6A 3CJCG 3CI5G 5FAEA 5KYUA 1NM1G 2NUTA 4PKHB 1D4XG 4KEDA 3A5OS 5KYXA 2KVKA 1T3XA 5KYYB 3FFKA 3Q2BA 2NUPB 1C0FS 1T44G 1PD0A 1M2VA 4JD2H 5KYUB 3EFOA 1H1VG
chains in the Genus database with same CATH topology
1Q8XA 5KYXB 2FH1A 5A1MA 1CFYA 1V6FA 1M2VB 3A5LS 3DAWB 1QPVA 2QTVA 4LIZA 1WM4A 2NUPA 5IVUA 1Q8GA 2XFAA 3TU5B 1SVYA 3EGDA 3DA7A 1M4JA 3EG9A 5FAFA 5L6WC 1TVJA 1D0NA 2FGHA 1T3YA 1TMWA 3EGDB 1AK6A 2FH4A 4S10C 2LJ8A 3EG9B 4PKIG 5DD2A 1M2OA 1YAGG 2XF1A 3EGXA 3EH2A 2MP4A 1DEJS 2LXXA 1YVNG 2VACA 1C0GS 5HVKB 1COFA 3EGXB 3A5NS 1WFSA 4CBWG 2VIKA 1UDMA 1PD1A 4CBXG 1HQZ1 1P8XA 4CBUG 2L72A 5KYWA 2FF3A 1F7SA 1MDUA 3A5MS 1NMDG 2LLFA 1CNUA 1VKKA 5HVKD 1WNJA 3CJBG 3L50A 1J72A 4KEEA 4Z94G 1P8ZG 5KYWB 1JHWA 3EH1A 2HD7A 1NPHA 1SVRA 4PKGG 2VILA 1VFQA 2MOTA 2W0IA 2NUTB 1NLVG 3FFNA 1KCQA 3FG7A 1PCXA 1X67A 2FH2A 2MV2A 2FH3A 1AK7A 1ESVS 1AHQA 1SVQA 4KEFA 5KYNA 1EQYS 2I2QA 2FF6G 4BEX1 3EFOB 1T2LA 5KYYA 3CIPG 1RGIG 2D8BA 3FG6A 3CJCG 3CI5G 5FAEA 5KYUA 1NM1G 2NUTA 4PKHB 1D4XG 4KEDA 3A5OS 5KYXA 2KVKA 1T3XA 5KYYB 3FFKA 3Q2BA 2NUPB 1C0FS 1T44G 1PD0A 1M2VA 4JD2H 5KYUB 3EFOA 1H1VG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q8X A;  5KYX B;  2FH1 A;  5A1M A;  1CFY A;  1V6F A;  1M2V B;  3A5L S;  3DAW B;  1QPV A;  2QTV A;  4LIZ A;  1WM4 A;  2NUP A;  5IVU A;  1Q8G A;  2XFA A;  3TU5 B;  1SVY A;  3EGD A;  1M4J A;  3EG9 A;  5FAF A;  5L6W C;  1TVJ A;  1D0N A;  2FGH A;  1T3Y A;  1TMW A;  3EGD B;  1AK6 A;  2FH4 A;  4S10 C;  2LJ8 A;  3EG9 B;  4PKI G;  5DD2 A;  1M2O A;  1YAG G;  2XF1 A;  3EGX A;  3EH2 A;  2MP4 A;  1DEJ S;  2LXX A;  1YVN G;  2VAC A;  1C0G S;  5HVK B;  1COF A;  3EGX B;  3A5N S;  1WFS A;  4CBW G;  2VIK A;  1UDM A;  1PD1 A;  4CBX G;  1HQZ 1;  1P8X A;  4CBU G;  2L72 A;  5KYW A;  2FF3 A;  1F7S A;  1MDU A;  3A5M S;  1NMD G;  2LLF A;  1CNU A;  1VKK A;  5HVK D;  1WNJ A;  3CJB G;  3L50 A;  1J72 A;  4KEE A;  4Z94 G;  1P8Z G;  5KYW B;  1JHW A;  3EH1 A;  2HD7 A;  1NPH A;  1SVR A;  4PKG G;  2VIL A;  1VFQ A;  2MOT A;  2W0I A;  2NUT B;  1NLV G;  3FFN A;  1KCQ A;  3FG7 A;  1PCX A;  1X67 A;  2FH2 A;  2MV2 A;  2FH3 A;  1AK7 A;  1ESV S;  1AHQ A;  1SVQ A;  4KEF A;  5KYN A;  1EQY S;  2I2Q A;  2FF6 G;  4BEX 1;  3EFO B;  1T2L A;  5KYY A;  3CIP G;  1RGI G;  2D8B A;  3FG6 A;  3CJC G;  3CI5 G;  5FAE A;  5KYU A;  1NM1 G;  2NUT A;  4PKH B;  1D4X G;  4KED A;  3A5O S;  5KYX A;  2KVK A;  1T3X A;  5KYY B;  3FFK A;  3Q2B A;  2NUP B;  1C0F S;  1T44 G;  1PD0 A;  1M2V A;  4JD2 H;  5KYU B;  3EFO A;  1H1V G; 
#chains in the Genus database with same CATH topology
 1Q8X A;  5KYX B;  2FH1 A;  5A1M A;  1CFY A;  1V6F A;  1M2V B;  3A5L S;  3DAW B;  1QPV A;  2QTV A;  4LIZ A;  1WM4 A;  2NUP A;  5IVU A;  1Q8G A;  2XFA A;  3TU5 B;  1SVY A;  3EGD A;  3DA7 A;  1M4J A;  3EG9 A;  5FAF A;  5L6W C;  1TVJ A;  1D0N A;  2FGH A;  1T3Y A;  1TMW A;  3EGD B;  1AK6 A;  2FH4 A;  4S10 C;  2LJ8 A;  3EG9 B;  4PKI G;  5DD2 A;  1M2O A;  1YAG G;  2XF1 A;  3EGX A;  3EH2 A;  2MP4 A;  1DEJ S;  2LXX A;  1YVN G;  2VAC A;  1C0G S;  5HVK B;  1COF A;  3EGX B;  3A5N S;  1WFS A;  4CBW G;  2VIK A;  1UDM A;  1PD1 A;  4CBX G;  1HQZ 1;  1P8X A;  4CBU G;  2L72 A;  5KYW A;  2FF3 A;  1F7S A;  1MDU A;  3A5M S;  1NMD G;  2LLF A;  1CNU A;  1VKK A;  5HVK D;  1WNJ A;  3CJB G;  3L50 A;  1J72 A;  4KEE A;  4Z94 G;  1P8Z G;  5KYW B;  1JHW A;  3EH1 A;  2HD7 A;  1NPH A;  1SVR A;  4PKG G;  2VIL A;  1VFQ A;  2MOT A;  2W0I A;  2NUT B;  1NLV G;  3FFN A;  1KCQ A;  3FG7 A;  1PCX A;  1X67 A;  2FH2 A;  2MV2 A;  2FH3 A;  1AK7 A;  1ESV S;  1AHQ A;  1SVQ A;  4KEF A;  5KYN A;  1EQY S;  2I2Q A;  2FF6 G;  4BEX 1;  3EFO B;  1T2L A;  5KYY A;  3CIP G;  1RGI G;  2D8B A;  3FG6 A;  3CJC G;  3CI5 G;  5FAE A;  5KYU A;  1NM1 G;  2NUT A;  4PKH B;  1D4X G;  4KED A;  3A5O S;  5KYX A;  2KVK A;  1T3X A;  5KYY B;  3FFK A;  3Q2B A;  2NUP B;  1C0F S;  1T44 G;  1PD0 A;  1M2V A;  4JD2 H;  5KYU B;  3EFO A;  1H1V G; 
#chains in the Genus database with same CATH homology
 1Q8X A;  5KYX B;  2FH1 A;  5A1M A;  1CFY A;  1V6F A;  1M2V B;  3A5L S;  3DAW B;  1QPV A;  2QTV A;  4LIZ A;  1WM4 A;  2NUP A;  5IVU A;  1Q8G A;  2XFA A;  3TU5 B;  1SVY A;  3EGD A;  3DA7 A;  1M4J A;  3EG9 A;  5FAF A;  5L6W C;  1TVJ A;  1D0N A;  2FGH A;  1T3Y A;  1TMW A;  3EGD B;  1AK6 A;  2FH4 A;  4S10 C;  2LJ8 A;  3EG9 B;  4PKI G;  5DD2 A;  1M2O A;  1YAG G;  2XF1 A;  3EGX A;  3EH2 A;  2MP4 A;  1DEJ S;  2LXX A;  1YVN G;  2VAC A;  1C0G S;  5HVK B;  1COF A;  3EGX B;  3A5N S;  1WFS A;  4CBW G;  2VIK A;  1UDM A;  1PD1 A;  4CBX G;  1HQZ 1;  1P8X A;  4CBU G;  2L72 A;  5KYW A;  2FF3 A;  1F7S A;  1MDU A;  3A5M S;  1NMD G;  2LLF A;  1CNU A;  1VKK A;  5HVK D;  1WNJ A;  3CJB G;  3L50 A;  1J72 A;  4KEE A;  4Z94 G;  1P8Z G;  5KYW B;  1JHW A;  3EH1 A;  2HD7 A;  1NPH A;  1SVR A;  4PKG G;  2VIL A;  1VFQ A;  2MOT A;  2W0I A;  2NUT B;  1NLV G;  3FFN A;  1KCQ A;  3FG7 A;  1PCX A;  1X67 A;  2FH2 A;  2MV2 A;  2FH3 A;  1AK7 A;  1ESV S;  1AHQ A;  1SVQ A;  4KEF A;  5KYN A;  1EQY S;  2I2Q A;  2FF6 G;  4BEX 1;  3EFO B;  1T2L A;  5KYY A;  3CIP G;  1RGI G;  2D8B A;  3FG6 A;  3CJC G;  3CI5 G;  5FAE A;  5KYU A;  1NM1 G;  2NUT A;  4PKH B;  1D4X G;  4KED A;  3A5O S;  5KYX A;  2KVK A;  1T3X A;  5KYY B;  3FFK A;  3Q2B A;  2NUP B;  1C0F S;  1T44 G;  1PD0 A;  1M2V A;  4JD2 H;  5KYU B;  3EFO A;  1H1V G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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