2KVKA

Solution structure of adf/cofilin (ldcof) from leishmania donovani
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
144
structure length
144
Chain Sequence
MAISGVTLEESVRGAIDDLRMKKSRYVMMCIGADGKKIEVTEVGERSVNYTDLKEKFSTEKPCYVAFDFEYNDAGSKREKLILIQWIPDTARPREKMMYSASRDALSSVSEGYLPIQANDESGLDAEEIIRKVRLHRSVAAALE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure and dynamics of ADF/cofilin from Leishmania donovani
pubmed doi rcsb
molecule tags Hormone
source organism Leishmania donovani
molecule keywords Actin severing and dynamics regulatory protein
total genus 46
structure length 144
sequence length 144
ec nomenclature
pdb deposition date 2010-03-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2kvkA00
1DEJS 2VILA 3EGDB 2MV2A 1CFYA 1NM1G 1D0NA 4BEX1 3FFKA 1D4XG 4JD2H 2FH3A 1NLVG 5KYUA 1T2LA 2MP4A 5KYXB 1T3YA 2FH2A 2XFAA 3EFOA 3L50A 3EGXA 2L72A 1Q8XA 2LXXA 1NMDG 3EG9B 3CI5G 5HVKD 4CBWG 1P8XA 1M2VA 3EH1A 2D8BA 4KEDA 5DD2A 1SVRA 1JHWA 1C0FS 4KEFA 5KYWA 3A5MS 1ESVS 2QTVA 4PKHB 5KYYA 1Q8GA 3TU5B 4Z94G 3EH2A 2KVKA 2FH4A 1SVQA 1T44G 5FAFA 4CBXG 1PD1A 4CBUG 1P8ZG 5KYUB 2I2QA 1QPVA 3CIPG 2VACA 3FG7A 1PD0A 1EQYS 1TVJA 3EFOB 4KEEA 1M2OA 3FG6A 2FGHA 1C0GS 1HQZ1 3A5LS 1VFQA 2FH1A 3A5OS 4PKIG 3EGXB 2NUPA 1WFSA 1NPHA 1RGIG 1YAGG 1AK6A 3Q2BA 2W0IA 5HVKB 1M4JA 2NUTA 3EGDA 1SVYA 4PKGG 1J72A 1F7SA 3A5NS 5L6WC 1T3XA 5KYNA 1AK7A 1M2VB 4S10C 2VIKA 2FF3A 5KYXA 1UDMA 3FFNA 5KYWB 1H1VG 1PCXA 1COFA 2NUTB 5KYYB 1MDUA 1AHQA 1KCQA 2MOTA 5IVUA 1TMWA 1WNJA 1X67A 3EG9A 1VKKA 2HD7A 2LJ8A 1YVNG 3DAWB 1V6FA 3CJBG 2FF6G 1CNUA 2LLFA 2NUPB 3CJCG 2XF1A 4LIZA 5FAEA 5A1MA 1WM4A
chains in the Genus database with same CATH superfamily
1DEJS 2VILA 3EGDB 2MV2A 1CFYA 1NM1G 1D0NA 4BEX1 3FFKA 1D4XG 4JD2H 2FH3A 1NLVG 5KYUA 1T2LA 2MP4A 5KYXB 1T3YA 2FH2A 2XFAA 3EFOA 3L50A 3EGXA 2L72A 1Q8XA 2LXXA 1NMDG 3EG9B 3CI5G 5HVKD 4CBWG 1P8XA 1M2VA 3EH1A 2D8BA 4KEDA 5DD2A 1SVRA 1JHWA 1C0FS 4KEFA 5KYWA 3A5MS 1ESVS 2QTVA 4PKHB 5KYYA 1Q8GA 3TU5B 4Z94G 3EH2A 2KVKA 2FH4A 1SVQA 1T44G 5FAFA 4CBXG 1PD1A 4CBUG 1P8ZG 5KYUB 2I2QA 1QPVA 3CIPG 2VACA 3FG7A 1PD0A 1EQYS 1TVJA 3EFOB 4KEEA 1M2OA 3FG6A 2FGHA 1C0GS 1HQZ1 3A5LS 1VFQA 2FH1A 3A5OS 4PKIG 3EGXB 2NUPA 1WFSA 1NPHA 1RGIG 1YAGG 1AK6A 3Q2BA 2W0IA 5HVKB 1M4JA 2NUTA 3EGDA 1SVYA 4PKGG 1J72A 1F7SA 3A5NS 5L6WC 1T3XA 5KYNA 1AK7A 1M2VB 3DA7A 4S10C 2VIKA 2FF3A 5KYXA 1UDMA 3FFNA 5KYWB 1H1VG 1PCXA 1COFA 2NUTB 5KYYB 1MDUA 1AHQA 1KCQA 2MOTA 5IVUA 1TMWA 1WNJA 1X67A 3EG9A 1VKKA 2HD7A 2LJ8A 1YVNG 3DAWB 1V6FA 3CJBG 2FF6G 1CNUA 2LLFA 2NUPB 3CJCG 2XF1A 4LIZA 5FAEA 5A1MA 1WM4A
chains in the Genus database with same CATH topology
1DEJS 2VILA 3EGDB 2MV2A 1CFYA 1NM1G 1D0NA 4BEX1 3FFKA 1D4XG 4JD2H 2FH3A 1NLVG 5KYUA 1T2LA 2MP4A 5KYXB 1T3YA 2FH2A 2XFAA 3EFOA 3L50A 3EGXA 2L72A 1Q8XA 2LXXA 1NMDG 3EG9B 3CI5G 5HVKD 4CBWG 1P8XA 1M2VA 3EH1A 2D8BA 4KEDA 5DD2A 1SVRA 1JHWA 1C0FS 4KEFA 5KYWA 3A5MS 1ESVS 2QTVA 4PKHB 5KYYA 1Q8GA 3TU5B 4Z94G 3EH2A 2KVKA 2FH4A 1SVQA 1T44G 5FAFA 4CBXG 1PD1A 4CBUG 1P8ZG 5KYUB 2I2QA 1QPVA 3CIPG 2VACA 3FG7A 1PD0A 1EQYS 1TVJA 3EFOB 4KEEA 1M2OA 3FG6A 2FGHA 1C0GS 1HQZ1 3A5LS 1VFQA 2FH1A 3A5OS 4PKIG 3EGXB 2NUPA 1WFSA 1NPHA 1RGIG 1YAGG 1AK6A 3Q2BA 2W0IA 5HVKB 1M4JA 2NUTA 3EGDA 1SVYA 4PKGG 1J72A 1F7SA 3A5NS 5L6WC 1T3XA 5KYNA 1AK7A 1M2VB 3DA7A 4S10C 2VIKA 2FF3A 5KYXA 1UDMA 3FFNA 5KYWB 1H1VG 1PCXA 1COFA 2NUTB 5KYYB 1MDUA 1AHQA 1KCQA 2MOTA 5IVUA 1TMWA 1WNJA 1X67A 3EG9A 1VKKA 2HD7A 2LJ8A 1YVNG 3DAWB 1V6FA 3CJBG 2FF6G 1CNUA 2LLFA 2NUPB 3CJCG 2XF1A 4LIZA 5FAEA 5A1MA 1WM4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DEJ S;  2VIL A;  3EGD B;  2MV2 A;  1CFY A;  1NM1 G;  1D0N A;  4BEX 1;  3FFK A;  1D4X G;  4JD2 H;  2FH3 A;  1NLV G;  5KYU A;  1T2L A;  2MP4 A;  5KYX B;  1T3Y A;  2FH2 A;  2XFA A;  3EFO A;  3L50 A;  3EGX A;  2L72 A;  1Q8X A;  2LXX A;  1NMD G;  3EG9 B;  3CI5 G;  5HVK D;  4CBW G;  1P8X A;  1M2V A;  3EH1 A;  2D8B A;  4KED A;  5DD2 A;  1SVR A;  1JHW A;  1C0F S;  4KEF A;  5KYW A;  3A5M S;  1ESV S;  2QTV A;  4PKH B;  5KYY A;  1Q8G A;  3TU5 B;  4Z94 G;  3EH2 A;  2KVK A;  2FH4 A;  1SVQ A;  1T44 G;  5FAF A;  4CBX G;  1PD1 A;  4CBU G;  1P8Z G;  5KYU B;  2I2Q A;  1QPV A;  3CIP G;  2VAC A;  3FG7 A;  1PD0 A;  1EQY S;  1TVJ A;  3EFO B;  4KEE A;  1M2O A;  3FG6 A;  2FGH A;  1C0G S;  1HQZ 1;  3A5L S;  1VFQ A;  2FH1 A;  3A5O S;  4PKI G;  3EGX B;  2NUP A;  1WFS A;  1NPH A;  1RGI G;  1YAG G;  1AK6 A;  3Q2B A;  2W0I A;  5HVK B;  1M4J A;  2NUT A;  3EGD A;  1SVY A;  4PKG G;  1J72 A;  1F7S A;  3A5N S;  5L6W C;  1T3X A;  5KYN A;  1AK7 A;  1M2V B;  4S10 C;  2VIK A;  2FF3 A;  5KYX A;  1UDM A;  3FFN A;  5KYW B;  1H1V G;  1PCX A;  1COF A;  2NUT B;  5KYY B;  1MDU A;  1AHQ A;  1KCQ A;  2MOT A;  5IVU A;  1TMW A;  1WNJ A;  1X67 A;  3EG9 A;  1VKK A;  2HD7 A;  2LJ8 A;  1YVN G;  3DAW B;  1V6F A;  3CJB G;  2FF6 G;  1CNU A;  2LLF A;  2NUP B;  3CJC G;  2XF1 A;  4LIZ A;  5FAE A;  5A1M A;  1WM4 A; 
#chains in the Genus database with same CATH topology
 1DEJ S;  2VIL A;  3EGD B;  2MV2 A;  1CFY A;  1NM1 G;  1D0N A;  4BEX 1;  3FFK A;  1D4X G;  4JD2 H;  2FH3 A;  1NLV G;  5KYU A;  1T2L A;  2MP4 A;  5KYX B;  1T3Y A;  2FH2 A;  2XFA A;  3EFO A;  3L50 A;  3EGX A;  2L72 A;  1Q8X A;  2LXX A;  1NMD G;  3EG9 B;  3CI5 G;  5HVK D;  4CBW G;  1P8X A;  1M2V A;  3EH1 A;  2D8B A;  4KED A;  5DD2 A;  1SVR A;  1JHW A;  1C0F S;  4KEF A;  5KYW A;  3A5M S;  1ESV S;  2QTV A;  4PKH B;  5KYY A;  1Q8G A;  3TU5 B;  4Z94 G;  3EH2 A;  2KVK A;  2FH4 A;  1SVQ A;  1T44 G;  5FAF A;  4CBX G;  1PD1 A;  4CBU G;  1P8Z G;  5KYU B;  2I2Q A;  1QPV A;  3CIP G;  2VAC A;  3FG7 A;  1PD0 A;  1EQY S;  1TVJ A;  3EFO B;  4KEE A;  1M2O A;  3FG6 A;  2FGH A;  1C0G S;  1HQZ 1;  3A5L S;  1VFQ A;  2FH1 A;  3A5O S;  4PKI G;  3EGX B;  2NUP A;  1WFS A;  1NPH A;  1RGI G;  1YAG G;  1AK6 A;  3Q2B A;  2W0I A;  5HVK B;  1M4J A;  2NUT A;  3EGD A;  1SVY A;  4PKG G;  1J72 A;  1F7S A;  3A5N S;  5L6W C;  1T3X A;  5KYN A;  1AK7 A;  1M2V B;  3DA7 A;  4S10 C;  2VIK A;  2FF3 A;  5KYX A;  1UDM A;  3FFN A;  5KYW B;  1H1V G;  1PCX A;  1COF A;  2NUT B;  5KYY B;  1MDU A;  1AHQ A;  1KCQ A;  2MOT A;  5IVU A;  1TMW A;  1WNJ A;  1X67 A;  3EG9 A;  1VKK A;  2HD7 A;  2LJ8 A;  1YVN G;  3DAW B;  1V6F A;  3CJB G;  2FF6 G;  1CNU A;  2LLF A;  2NUP B;  3CJC G;  2XF1 A;  4LIZ A;  5FAE A;  5A1M A;  1WM4 A; 
#chains in the Genus database with same CATH homology
 1DEJ S;  2VIL A;  3EGD B;  2MV2 A;  1CFY A;  1NM1 G;  1D0N A;  4BEX 1;  3FFK A;  1D4X G;  4JD2 H;  2FH3 A;  1NLV G;  5KYU A;  1T2L A;  2MP4 A;  5KYX B;  1T3Y A;  2FH2 A;  2XFA A;  3EFO A;  3L50 A;  3EGX A;  2L72 A;  1Q8X A;  2LXX A;  1NMD G;  3EG9 B;  3CI5 G;  5HVK D;  4CBW G;  1P8X A;  1M2V A;  3EH1 A;  2D8B A;  4KED A;  5DD2 A;  1SVR A;  1JHW A;  1C0F S;  4KEF A;  5KYW A;  3A5M S;  1ESV S;  2QTV A;  4PKH B;  5KYY A;  1Q8G A;  3TU5 B;  4Z94 G;  3EH2 A;  2KVK A;  2FH4 A;  1SVQ A;  1T44 G;  5FAF A;  4CBX G;  1PD1 A;  4CBU G;  1P8Z G;  5KYU B;  2I2Q A;  1QPV A;  3CIP G;  2VAC A;  3FG7 A;  1PD0 A;  1EQY S;  1TVJ A;  3EFO B;  4KEE A;  1M2O A;  3FG6 A;  2FGH A;  1C0G S;  1HQZ 1;  3A5L S;  1VFQ A;  2FH1 A;  3A5O S;  4PKI G;  3EGX B;  2NUP A;  1WFS A;  1NPH A;  1RGI G;  1YAG G;  1AK6 A;  3Q2B A;  2W0I A;  5HVK B;  1M4J A;  2NUT A;  3EGD A;  1SVY A;  4PKG G;  1J72 A;  1F7S A;  3A5N S;  5L6W C;  1T3X A;  5KYN A;  1AK7 A;  1M2V B;  3DA7 A;  4S10 C;  2VIK A;  2FF3 A;  5KYX A;  1UDM A;  3FFN A;  5KYW B;  1H1V G;  1PCX A;  1COF A;  2NUT B;  5KYY B;  1MDU A;  1AHQ A;  1KCQ A;  2MOT A;  5IVU A;  1TMW A;  1WNJ A;  1X67 A;  3EG9 A;  1VKK A;  2HD7 A;  2LJ8 A;  1YVN G;  3DAW B;  1V6F A;  3CJB G;  2FF6 G;  1CNU A;  2LLF A;  2NUP B;  3CJC G;  2XF1 A;  4LIZ A;  5FAE A;  5A1M A;  1WM4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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