2VACA

Structure of n-terminal actin depolymerizing factor homology (adf-h) domain of human twinfilin-2
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
134
structure length
134
Chain Sequence
SMGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSFAGYQKH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of N-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain of Human Twinfilin-2
rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords TWINFILIN-2
total genus 39
structure length 134
sequence length 134
ec nomenclature
pdb deposition date 2007-08-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2vacA00
1CFYA 1COFA 1PD0A 2KVKA 3EH2A 2HD7A 5L6WC 1D4XG 1WFSA 2MV2A 3A5LS 2L72A 5FAFA 5KYXA 1T3XA 4CBWG 2NUPB 3EFOA 1AK6A 4KEFA 5A1MA 4S10C 1T3YA 2VACA 1Q8GA 1YAGG 1ESVS 1H1VG 1NLVG 5KYWB 1M2VA 1T2LA 1NMDG 5KYWA 4PKGG 1T44G 3EGXA 3CJCG 1M4JA 1TVJA 2FF3A 2FGHA 1YVNG 1Q8XA 4Z94G 3EG9B 1AK7A 3Q2BA 5KYXB 3EG9A 3EFOB 1QPVA 1VKKA 1X67A 3CJBG 4CBUG 4JD2H 1EQYS 4KEEA 2FH4A 2XFAA 2FH1A 5KYNA 2MP4A 1PD1A 3A5NS 1V6FA 4KEDA 1M2VB 1RGIG 3FFNA 4PKHB 1HQZ1 3CIPG 3EGXB 4LIZA 2VILA 1C0GS 1J72A 1NPHA 2NUTB 2VIKA 5IVUA 1KCQA 2NUTA 2XF1A 1D0NA 2LLFA 1AHQA 1DEJS 3A5OS 1P8XA 5HVKD 3FFKA 5KYUB 2MOTA 2FF6G 1NM1G 1C0FS 5KYUA 3EH1A 4PKIG 1VFQA 1SVQA 2FH3A 2I2QA 1M2OA 2FH2A 4CBXG 1WM4A 3EGDB 4BEX1 3EGDA 1P8ZG 2W0IA 3FG6A 5KYYB 1SVRA 5KYYA 3FG7A 3DAWB 1SVYA 3TU5B 3CI5G 2NUPA 3L50A 5FAEA 1WNJA 2D8BA 2LXXA 1PCXA 5HVKB 3A5MS 1F7SA 2QTVA 1UDMA 1MDUA 1TMWA 1JHWA 1CNUA 2LJ8A 5DD2A
chains in the Genus database with same CATH superfamily
1CFYA 1COFA 1PD0A 2KVKA 3EH2A 2HD7A 5L6WC 1D4XG 1WFSA 2MV2A 3A5LS 2L72A 5FAFA 5KYXA 1T3XA 4CBWG 2NUPB 3EFOA 1AK6A 4KEFA 5A1MA 4S10C 1T3YA 2VACA 1Q8GA 1YAGG 1ESVS 1H1VG 1NLVG 5KYWB 1M2VA 1T2LA 1NMDG 5KYWA 4PKGG 1T44G 3EGXA 3CJCG 1M4JA 1TVJA 2FF3A 2FGHA 1YVNG 1Q8XA 4Z94G 3EG9B 1AK7A 3Q2BA 5KYXB 3EG9A 3EFOB 1QPVA 1VKKA 1X67A 3CJBG 4CBUG 4JD2H 1EQYS 4KEEA 2FH4A 2XFAA 2FH1A 5KYNA 2MP4A 1PD1A 3A5NS 1V6FA 4KEDA 1M2VB 1RGIG 3FFNA 4PKHB 1HQZ1 3CIPG 3EGXB 4LIZA 2VILA 1C0GS 1J72A 1NPHA 2NUTB 2VIKA 5IVUA 1KCQA 2NUTA 2XF1A 1D0NA 2LLFA 1AHQA 1DEJS 3A5OS 1P8XA 5HVKD 3FFKA 5KYUB 2MOTA 2FF6G 1NM1G 1C0FS 5KYUA 3EH1A 4PKIG 1VFQA 1SVQA 2FH3A 2I2QA 1M2OA 2FH2A 4CBXG 1WM4A 3EGDB 4BEX1 3EGDA 1P8ZG 2W0IA 3FG6A 5KYYB 1SVRA 5KYYA 3FG7A 3DAWB 1SVYA 3TU5B 3CI5G 2NUPA 3L50A 5FAEA 1WNJA 2D8BA 2LXXA 1PCXA 5HVKB 3A5MS 1F7SA 2QTVA 1UDMA 1MDUA 1TMWA 1JHWA 1CNUA 3DA7A 2LJ8A 5DD2A
chains in the Genus database with same CATH topology
1CFYA 1COFA 1PD0A 2KVKA 3EH2A 2HD7A 5L6WC 1D4XG 1WFSA 2MV2A 3A5LS 2L72A 5FAFA 5KYXA 1T3XA 4CBWG 2NUPB 3EFOA 1AK6A 4KEFA 5A1MA 4S10C 1T3YA 2VACA 1Q8GA 1YAGG 1ESVS 1H1VG 1NLVG 5KYWB 1M2VA 1T2LA 1NMDG 5KYWA 4PKGG 1T44G 3EGXA 3CJCG 1M4JA 1TVJA 2FF3A 2FGHA 1YVNG 1Q8XA 4Z94G 3EG9B 1AK7A 3Q2BA 5KYXB 3EG9A 3EFOB 1QPVA 1VKKA 1X67A 3CJBG 4CBUG 4JD2H 1EQYS 4KEEA 2FH4A 2XFAA 2FH1A 5KYNA 2MP4A 1PD1A 3A5NS 1V6FA 4KEDA 1M2VB 1RGIG 3FFNA 4PKHB 1HQZ1 3CIPG 3EGXB 4LIZA 2VILA 1C0GS 1J72A 1NPHA 2NUTB 2VIKA 5IVUA 1KCQA 2NUTA 2XF1A 1D0NA 2LLFA 1AHQA 1DEJS 3A5OS 1P8XA 5HVKD 3FFKA 5KYUB 2MOTA 2FF6G 1NM1G 1C0FS 5KYUA 3EH1A 4PKIG 1VFQA 1SVQA 2FH3A 2I2QA 1M2OA 2FH2A 4CBXG 1WM4A 3EGDB 4BEX1 3EGDA 1P8ZG 2W0IA 3FG6A 5KYYB 1SVRA 5KYYA 3FG7A 3DAWB 1SVYA 3TU5B 3CI5G 2NUPA 3L50A 5FAEA 1WNJA 2D8BA 2LXXA 1PCXA 5HVKB 3A5MS 1F7SA 2QTVA 1UDMA 1MDUA 1TMWA 1JHWA 1CNUA 3DA7A 2LJ8A 5DD2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1CFY A;  1COF A;  1PD0 A;  2KVK A;  3EH2 A;  2HD7 A;  5L6W C;  1D4X G;  1WFS A;  2MV2 A;  3A5L S;  2L72 A;  5FAF A;  5KYX A;  1T3X A;  4CBW G;  2NUP B;  3EFO A;  1AK6 A;  4KEF A;  5A1M A;  4S10 C;  1T3Y A;  2VAC A;  1Q8G A;  1YAG G;  1ESV S;  1H1V G;  1NLV G;  5KYW B;  1M2V A;  1T2L A;  1NMD G;  5KYW A;  4PKG G;  1T44 G;  3EGX A;  3CJC G;  1M4J A;  1TVJ A;  2FF3 A;  2FGH A;  1YVN G;  1Q8X A;  4Z94 G;  3EG9 B;  1AK7 A;  3Q2B A;  5KYX B;  3EG9 A;  3EFO B;  1QPV A;  1VKK A;  1X67 A;  3CJB G;  4CBU G;  4JD2 H;  1EQY S;  4KEE A;  2FH4 A;  2XFA A;  2FH1 A;  5KYN A;  2MP4 A;  1PD1 A;  3A5N S;  1V6F A;  4KED A;  1M2V B;  1RGI G;  3FFN A;  4PKH B;  1HQZ 1;  3CIP G;  3EGX B;  4LIZ A;  2VIL A;  1C0G S;  1J72 A;  1NPH A;  2NUT B;  2VIK A;  5IVU A;  1KCQ A;  2NUT A;  2XF1 A;  1D0N A;  2LLF A;  1AHQ A;  1DEJ S;  3A5O S;  1P8X A;  5HVK D;  3FFK A;  5KYU B;  2MOT A;  2FF6 G;  1NM1 G;  1C0F S;  5KYU A;  3EH1 A;  4PKI G;  1VFQ A;  1SVQ A;  2FH3 A;  2I2Q A;  1M2O A;  2FH2 A;  4CBX G;  1WM4 A;  3EGD B;  4BEX 1;  3EGD A;  1P8Z G;  2W0I A;  3FG6 A;  5KYY B;  1SVR A;  5KYY A;  3FG7 A;  3DAW B;  1SVY A;  3TU5 B;  3CI5 G;  2NUP A;  3L50 A;  5FAE A;  1WNJ A;  2D8B A;  2LXX A;  1PCX A;  5HVK B;  3A5M S;  1F7S A;  2QTV A;  1UDM A;  1MDU A;  1TMW A;  1JHW A;  1CNU A;  2LJ8 A;  5DD2 A; 
#chains in the Genus database with same CATH topology
 1CFY A;  1COF A;  1PD0 A;  2KVK A;  3EH2 A;  2HD7 A;  5L6W C;  1D4X G;  1WFS A;  2MV2 A;  3A5L S;  2L72 A;  5FAF A;  5KYX A;  1T3X A;  4CBW G;  2NUP B;  3EFO A;  1AK6 A;  4KEF A;  5A1M A;  4S10 C;  1T3Y A;  2VAC A;  1Q8G A;  1YAG G;  1ESV S;  1H1V G;  1NLV G;  5KYW B;  1M2V A;  1T2L A;  1NMD G;  5KYW A;  4PKG G;  1T44 G;  3EGX A;  3CJC G;  1M4J A;  1TVJ A;  2FF3 A;  2FGH A;  1YVN G;  1Q8X A;  4Z94 G;  3EG9 B;  1AK7 A;  3Q2B A;  5KYX B;  3EG9 A;  3EFO B;  1QPV A;  1VKK A;  1X67 A;  3CJB G;  4CBU G;  4JD2 H;  1EQY S;  4KEE A;  2FH4 A;  2XFA A;  2FH1 A;  5KYN A;  2MP4 A;  1PD1 A;  3A5N S;  1V6F A;  4KED A;  1M2V B;  1RGI G;  3FFN A;  4PKH B;  1HQZ 1;  3CIP G;  3EGX B;  4LIZ A;  2VIL A;  1C0G S;  1J72 A;  1NPH A;  2NUT B;  2VIK A;  5IVU A;  1KCQ A;  2NUT A;  2XF1 A;  1D0N A;  2LLF A;  1AHQ A;  1DEJ S;  3A5O S;  1P8X A;  5HVK D;  3FFK A;  5KYU B;  2MOT A;  2FF6 G;  1NM1 G;  1C0F S;  5KYU A;  3EH1 A;  4PKI G;  1VFQ A;  1SVQ A;  2FH3 A;  2I2Q A;  1M2O A;  2FH2 A;  4CBX G;  1WM4 A;  3EGD B;  4BEX 1;  3EGD A;  1P8Z G;  2W0I A;  3FG6 A;  5KYY B;  1SVR A;  5KYY A;  3FG7 A;  3DAW B;  1SVY A;  3TU5 B;  3CI5 G;  2NUP A;  3L50 A;  5FAE A;  1WNJ A;  2D8B A;  2LXX A;  1PCX A;  5HVK B;  3A5M S;  1F7S A;  2QTV A;  1UDM A;  1MDU A;  1TMW A;  1JHW A;  1CNU A;  3DA7 A;  2LJ8 A;  5DD2 A; 
#chains in the Genus database with same CATH homology
 1CFY A;  1COF A;  1PD0 A;  2KVK A;  3EH2 A;  2HD7 A;  5L6W C;  1D4X G;  1WFS A;  2MV2 A;  3A5L S;  2L72 A;  5FAF A;  5KYX A;  1T3X A;  4CBW G;  2NUP B;  3EFO A;  1AK6 A;  4KEF A;  5A1M A;  4S10 C;  1T3Y A;  2VAC A;  1Q8G A;  1YAG G;  1ESV S;  1H1V G;  1NLV G;  5KYW B;  1M2V A;  1T2L A;  1NMD G;  5KYW A;  4PKG G;  1T44 G;  3EGX A;  3CJC G;  1M4J A;  1TVJ A;  2FF3 A;  2FGH A;  1YVN G;  1Q8X A;  4Z94 G;  3EG9 B;  1AK7 A;  3Q2B A;  5KYX B;  3EG9 A;  3EFO B;  1QPV A;  1VKK A;  1X67 A;  3CJB G;  4CBU G;  4JD2 H;  1EQY S;  4KEE A;  2FH4 A;  2XFA A;  2FH1 A;  5KYN A;  2MP4 A;  1PD1 A;  3A5N S;  1V6F A;  4KED A;  1M2V B;  1RGI G;  3FFN A;  4PKH B;  1HQZ 1;  3CIP G;  3EGX B;  4LIZ A;  2VIL A;  1C0G S;  1J72 A;  1NPH A;  2NUT B;  2VIK A;  5IVU A;  1KCQ A;  2NUT A;  2XF1 A;  1D0N A;  2LLF A;  1AHQ A;  1DEJ S;  3A5O S;  1P8X A;  5HVK D;  3FFK A;  5KYU B;  2MOT A;  2FF6 G;  1NM1 G;  1C0F S;  5KYU A;  3EH1 A;  4PKI G;  1VFQ A;  1SVQ A;  2FH3 A;  2I2Q A;  1M2O A;  2FH2 A;  4CBX G;  1WM4 A;  3EGD B;  4BEX 1;  3EGD A;  1P8Z G;  2W0I A;  3FG6 A;  5KYY B;  1SVR A;  5KYY A;  3FG7 A;  3DAW B;  1SVY A;  3TU5 B;  3CI5 G;  2NUP A;  3L50 A;  5FAE A;  1WNJ A;  2D8B A;  2LXX A;  1PCX A;  5HVK B;  3A5M S;  1F7S A;  2QTV A;  1UDM A;  1MDU A;  1TMW A;  1JHW A;  1CNU A;  3DA7 A;  2LJ8 A;  5DD2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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