2VIKA

Refined structure of the actin-severing domain villin 14t, determined by solution nmr, minimized average structure
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
126
structure length
126
Chain Sequence
VELSKKVTGKLDKTTPGIQIWRIENMEMVPVPTKSYGNFYEGDCYVLLSTRKTGSGFSYNIHYWLGKNSSQDEQGAAAIYTTQMDEYLGSVAVQHREVQGHESETFRAYFKQGLIYKQGGVASGMK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Refined structure of villin 14T and a detailed comparison with other actin-severing domains.
pubmed rcsb
molecule tags Actin-binding protein
source organism Gallus gallus
molecule keywords VILLIN 14T
total genus 18
structure length 126
sequence length 126
ec nomenclature
pdb deposition date 1997-01-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2vikA00
5KYYB 1NMDG 1AK6A 1M2VB 5IVUA 5KYNA 4KEFA 1WFSA 3EGDB 1AHQA 3EGXA 5KYWA 4Z94G 3A5MS 3FG7A 1Q8GA 1C0FS 1UDMA 4CBWG 1T3XA 2VILA 1YAGG 1H1VG 1COFA 1T2LA 5KYXB 1PCXA 2FF3A 5HVKD 1QPVA 4KEEA 2FH4A 2XFAA 4CBUG 1WNJA 3EG9B 1M2OA 2W0IA 1M2VA 3CJCG 1RGIG 3EFOA 3EGDA 2HD7A 3A5LS 5A1MA 2MV2A 1KCQA 2XF1A 2FH1A 2NUTB 4KEDA 4LIZA 3CJBG 1NLVG 1T3YA 1J72A 1NM1G 1EQYS 4BEX1 5KYXA 4S10C 2VIKA 1DEJS 5FAFA 2LLFA 4JD2H 3EG9A 5KYYA 3A5NS 3Q2BA 2LJ8A 5KYUB 4PKHB 1ESVS 1Q8XA 3FFKA 3DAWB 2NUPB 1VKKA 2NUTA 5KYWB 1TMWA 2KVKA 2LXXA 1P8XA 1TVJA 2D8BA 1SVYA 4PKIG 1SVRA 1CNUA 5L6WC 3EH1A 1MDUA 1M4JA 2MOTA 1VFQA 3FFNA 2FF6G 1PD0A 3EH2A 5KYUA 1NPHA 1D0NA 5DD2A 2MP4A 1CFYA 3L50A 4PKGG 1D4XG 2NUPA 3A5OS 1PD1A 3EFOB 3TU5B 1AK7A 3EGXB 2FGHA 1SVQA 2QTVA 1JHWA 4CBXG 1P8ZG 3CI5G 2FH3A 3CIPG 1WM4A 2I2QA 3FG6A 5FAEA 1V6FA 1T44G 2FH2A 1C0GS 1F7SA 1HQZ1 5HVKB 1YVNG 1X67A 2VACA 2L72A
chains in the Genus database with same CATH superfamily
5KYYB 1NMDG 1AK6A 1M2VB 5IVUA 5KYNA 4KEFA 1WFSA 3EGDB 1AHQA 3EGXA 5KYWA 4Z94G 3A5MS 3FG7A 1Q8GA 1C0FS 1UDMA 4CBWG 1T3XA 2VILA 1YAGG 1H1VG 1COFA 1T2LA 5KYXB 1PCXA 2FF3A 5HVKD 1QPVA 4KEEA 2FH4A 2XFAA 4CBUG 1WNJA 3EG9B 1M2OA 2W0IA 1M2VA 3CJCG 1RGIG 3EFOA 3EGDA 2HD7A 3A5LS 5A1MA 2MV2A 1KCQA 2XF1A 2FH1A 2NUTB 4KEDA 4LIZA 3CJBG 1NLVG 1T3YA 1J72A 1NM1G 1EQYS 4BEX1 3DA7A 5KYXA 4S10C 2VIKA 1DEJS 5FAFA 2LLFA 4JD2H 3EG9A 5KYYA 3A5NS 3Q2BA 2LJ8A 5KYUB 4PKHB 1ESVS 1Q8XA 3FFKA 3DAWB 2NUPB 1VKKA 2NUTA 5KYWB 1TMWA 2KVKA 2LXXA 1P8XA 1TVJA 2D8BA 1SVYA 4PKIG 1SVRA 1CNUA 5L6WC 3EH1A 1MDUA 1M4JA 2MOTA 1VFQA 3FFNA 2FF6G 1PD0A 3EH2A 5KYUA 1NPHA 1D0NA 5DD2A 2MP4A 1CFYA 3L50A 4PKGG 1D4XG 2NUPA 3A5OS 1PD1A 3EFOB 3TU5B 1AK7A 3EGXB 2FGHA 1SVQA 2QTVA 1JHWA 4CBXG 1P8ZG 3CI5G 2FH3A 3CIPG 1WM4A 2I2QA 3FG6A 5FAEA 1V6FA 1T44G 2FH2A 1C0GS 1F7SA 1HQZ1 5HVKB 1YVNG 1X67A 2VACA 2L72A
chains in the Genus database with same CATH topology
5KYYB 1NMDG 1AK6A 1M2VB 5IVUA 5KYNA 4KEFA 1WFSA 3EGDB 1AHQA 3EGXA 5KYWA 4Z94G 3A5MS 3FG7A 1Q8GA 1C0FS 1UDMA 4CBWG 1T3XA 2VILA 1YAGG 1H1VG 1COFA 1T2LA 5KYXB 1PCXA 2FF3A 5HVKD 1QPVA 4KEEA 2FH4A 2XFAA 4CBUG 1WNJA 3EG9B 1M2OA 2W0IA 1M2VA 3CJCG 1RGIG 3EFOA 3EGDA 2HD7A 3A5LS 5A1MA 2MV2A 1KCQA 2XF1A 2FH1A 2NUTB 4KEDA 4LIZA 3CJBG 1NLVG 1T3YA 1J72A 1NM1G 1EQYS 4BEX1 3DA7A 5KYXA 4S10C 2VIKA 1DEJS 5FAFA 2LLFA 4JD2H 3EG9A 5KYYA 3A5NS 3Q2BA 2LJ8A 5KYUB 4PKHB 1ESVS 1Q8XA 3FFKA 3DAWB 2NUPB 1VKKA 2NUTA 5KYWB 1TMWA 2KVKA 2LXXA 1P8XA 1TVJA 2D8BA 1SVYA 4PKIG 1SVRA 1CNUA 5L6WC 3EH1A 1MDUA 1M4JA 2MOTA 1VFQA 3FFNA 2FF6G 1PD0A 3EH2A 5KYUA 1NPHA 1D0NA 5DD2A 2MP4A 1CFYA 3L50A 4PKGG 1D4XG 2NUPA 3A5OS 1PD1A 3EFOB 3TU5B 1AK7A 3EGXB 2FGHA 1SVQA 2QTVA 1JHWA 4CBXG 1P8ZG 3CI5G 2FH3A 3CIPG 1WM4A 2I2QA 3FG6A 5FAEA 1V6FA 1T44G 2FH2A 1C0GS 1F7SA 1HQZ1 5HVKB 1YVNG 1X67A 2VACA 2L72A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5KYY B;  1NMD G;  1AK6 A;  1M2V B;  5IVU A;  5KYN A;  4KEF A;  1WFS A;  3EGD B;  1AHQ A;  3EGX A;  5KYW A;  4Z94 G;  3A5M S;  3FG7 A;  1Q8G A;  1C0F S;  1UDM A;  4CBW G;  1T3X A;  2VIL A;  1YAG G;  1H1V G;  1COF A;  1T2L A;  5KYX B;  1PCX A;  2FF3 A;  5HVK D;  1QPV A;  4KEE A;  2FH4 A;  2XFA A;  4CBU G;  1WNJ A;  3EG9 B;  1M2O A;  2W0I A;  1M2V A;  3CJC G;  1RGI G;  3EFO A;  3EGD A;  2HD7 A;  3A5L S;  5A1M A;  2MV2 A;  1KCQ A;  2XF1 A;  2FH1 A;  2NUT B;  4KED A;  4LIZ A;  3CJB G;  1NLV G;  1T3Y A;  1J72 A;  1NM1 G;  1EQY S;  4BEX 1;  5KYX A;  4S10 C;  2VIK A;  1DEJ S;  5FAF A;  2LLF A;  4JD2 H;  3EG9 A;  5KYY A;  3A5N S;  3Q2B A;  2LJ8 A;  5KYU B;  4PKH B;  1ESV S;  1Q8X A;  3FFK A;  3DAW B;  2NUP B;  1VKK A;  2NUT A;  5KYW B;  1TMW A;  2KVK A;  2LXX A;  1P8X A;  1TVJ A;  2D8B A;  1SVY A;  4PKI G;  1SVR A;  1CNU A;  5L6W C;  3EH1 A;  1MDU A;  1M4J A;  2MOT A;  1VFQ A;  3FFN A;  2FF6 G;  1PD0 A;  3EH2 A;  5KYU A;  1NPH A;  1D0N A;  5DD2 A;  2MP4 A;  1CFY A;  3L50 A;  4PKG G;  1D4X G;  2NUP A;  3A5O S;  1PD1 A;  3EFO B;  3TU5 B;  1AK7 A;  3EGX B;  2FGH A;  1SVQ A;  2QTV A;  1JHW A;  4CBX G;  1P8Z G;  3CI5 G;  2FH3 A;  3CIP G;  1WM4 A;  2I2Q A;  3FG6 A;  5FAE A;  1V6F A;  1T44 G;  2FH2 A;  1C0G S;  1F7S A;  1HQZ 1;  5HVK B;  1YVN G;  1X67 A;  2VAC A;  2L72 A; 
#chains in the Genus database with same CATH topology
 5KYY B;  1NMD G;  1AK6 A;  1M2V B;  5IVU A;  5KYN A;  4KEF A;  1WFS A;  3EGD B;  1AHQ A;  3EGX A;  5KYW A;  4Z94 G;  3A5M S;  3FG7 A;  1Q8G A;  1C0F S;  1UDM A;  4CBW G;  1T3X A;  2VIL A;  1YAG G;  1H1V G;  1COF A;  1T2L A;  5KYX B;  1PCX A;  2FF3 A;  5HVK D;  1QPV A;  4KEE A;  2FH4 A;  2XFA A;  4CBU G;  1WNJ A;  3EG9 B;  1M2O A;  2W0I A;  1M2V A;  3CJC G;  1RGI G;  3EFO A;  3EGD A;  2HD7 A;  3A5L S;  5A1M A;  2MV2 A;  1KCQ A;  2XF1 A;  2FH1 A;  2NUT B;  4KED A;  4LIZ A;  3CJB G;  1NLV G;  1T3Y A;  1J72 A;  1NM1 G;  1EQY S;  4BEX 1;  3DA7 A;  5KYX A;  4S10 C;  2VIK A;  1DEJ S;  5FAF A;  2LLF A;  4JD2 H;  3EG9 A;  5KYY A;  3A5N S;  3Q2B A;  2LJ8 A;  5KYU B;  4PKH B;  1ESV S;  1Q8X A;  3FFK A;  3DAW B;  2NUP B;  1VKK A;  2NUT A;  5KYW B;  1TMW A;  2KVK A;  2LXX A;  1P8X A;  1TVJ A;  2D8B A;  1SVY A;  4PKI G;  1SVR A;  1CNU A;  5L6W C;  3EH1 A;  1MDU A;  1M4J A;  2MOT A;  1VFQ A;  3FFN A;  2FF6 G;  1PD0 A;  3EH2 A;  5KYU A;  1NPH A;  1D0N A;  5DD2 A;  2MP4 A;  1CFY A;  3L50 A;  4PKG G;  1D4X G;  2NUP A;  3A5O S;  1PD1 A;  3EFO B;  3TU5 B;  1AK7 A;  3EGX B;  2FGH A;  1SVQ A;  2QTV A;  1JHW A;  4CBX G;  1P8Z G;  3CI5 G;  2FH3 A;  3CIP G;  1WM4 A;  2I2Q A;  3FG6 A;  5FAE A;  1V6F A;  1T44 G;  2FH2 A;  1C0G S;  1F7S A;  1HQZ 1;  5HVK B;  1YVN G;  1X67 A;  2VAC A;  2L72 A; 
#chains in the Genus database with same CATH homology
 5KYY B;  1NMD G;  1AK6 A;  1M2V B;  5IVU A;  5KYN A;  4KEF A;  1WFS A;  3EGD B;  1AHQ A;  3EGX A;  5KYW A;  4Z94 G;  3A5M S;  3FG7 A;  1Q8G A;  1C0F S;  1UDM A;  4CBW G;  1T3X A;  2VIL A;  1YAG G;  1H1V G;  1COF A;  1T2L A;  5KYX B;  1PCX A;  2FF3 A;  5HVK D;  1QPV A;  4KEE A;  2FH4 A;  2XFA A;  4CBU G;  1WNJ A;  3EG9 B;  1M2O A;  2W0I A;  1M2V A;  3CJC G;  1RGI G;  3EFO A;  3EGD A;  2HD7 A;  3A5L S;  5A1M A;  2MV2 A;  1KCQ A;  2XF1 A;  2FH1 A;  2NUT B;  4KED A;  4LIZ A;  3CJB G;  1NLV G;  1T3Y A;  1J72 A;  1NM1 G;  1EQY S;  4BEX 1;  3DA7 A;  5KYX A;  4S10 C;  2VIK A;  1DEJ S;  5FAF A;  2LLF A;  4JD2 H;  3EG9 A;  5KYY A;  3A5N S;  3Q2B A;  2LJ8 A;  5KYU B;  4PKH B;  1ESV S;  1Q8X A;  3FFK A;  3DAW B;  2NUP B;  1VKK A;  2NUT A;  5KYW B;  1TMW A;  2KVK A;  2LXX A;  1P8X A;  1TVJ A;  2D8B A;  1SVY A;  4PKI G;  1SVR A;  1CNU A;  5L6W C;  3EH1 A;  1MDU A;  1M4J A;  2MOT A;  1VFQ A;  3FFN A;  2FF6 G;  1PD0 A;  3EH2 A;  5KYU A;  1NPH A;  1D0N A;  5DD2 A;  2MP4 A;  1CFY A;  3L50 A;  4PKG G;  1D4X G;  2NUP A;  3A5O S;  1PD1 A;  3EFO B;  3TU5 B;  1AK7 A;  3EGX B;  2FGH A;  1SVQ A;  2QTV A;  1JHW A;  4CBX G;  1P8Z G;  3CI5 G;  2FH3 A;  3CIP G;  1WM4 A;  2I2Q A;  3FG6 A;  5FAE A;  1V6F A;  1T44 G;  2FH2 A;  1C0G S;  1F7S A;  1HQZ 1;  5HVK B;  1YVN G;  1X67 A;  2VAC A;  2L72 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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