2VILA

Refined structure of the actin-severing domain villin 14t, determined by solution nmr, 11 structures
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
126
structure length
126
Chain Sequence
VELSKKVTGKLDKTTPGIQIWRIENMEMVPVPTKSYGNFYEGDCYVLLSTRKTGSGFSYNIHYWLGKNSSQDEQGAAAIYTTQMDEYLGSVAVQHREVQGHESETFRAYFKQGLIYKQGGVASGMK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Refined structure of villin 14T and a detailed comparison with other actin-severing domains.
pubmed rcsb
molecule tags Actin-binding protein
source organism Gallus gallus
molecule keywords VILLIN 14T
total genus 19
structure length 126
sequence length 126
ec nomenclature
pdb deposition date 1997-01-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2vilA00
3EG9B 5KYYA 1QPVA 1EQYS 1PCXA 1YVNG 5KYXA 3A5LS 3TU5B 1J72A 2MOTA 2QTVA 1M2VB 3EGDA 1X67A 4PKIG 1T3XA 4KEFA 1AK7A 1YAGG 2KVKA 2LLFA 1MDUA 2NUPA 1WFSA 1D4XG 2FH3A 4CBWG 1T3YA 3FG7A 5L6WC 1Q8GA 1M2OA 3A5MS 1V6FA 3L50A 5HVKB 1KCQA 1SVQA 3Q2BA 2I2QA 2FGHA 1NPHA 3FG6A 2NUTB 2FH1A 1M2VA 5KYNA 5FAFA 1NMDG 1JHWA 5DD2A 3EH1A 4PKHB 5KYWB 3EGXB 1NLVG 4Z94G 2L72A 1VFQA 5FAEA 3A5NS 2NUTA 2XFAA 3EG9A 4LIZA 1COFA 1T2LA 3EFOB 2VACA 1M4JA 1CFYA 3EGDB 4KEDA 1AK6A 2D8BA 1PD0A 2MV2A 1C0FS 3FFNA 2FH4A 1VKKA 2W0IA 3EH2A 4BEX1 2HD7A 1SVYA 1AHQA 4PKGG 4KEEA 4JD2H 5KYUB 3CJBG 1D0NA 1HQZ1 1ESVS 2FH2A 2XF1A 3CIPG 4CBXG 1CNUA 1DEJS 1F7SA 1TMWA 2LXXA 1C0GS 4CBUG 5KYYB 5KYXB 1WNJA 2FF3A 1PD1A 3A5OS 2MP4A 1TVJA 1RGIG 5KYWA 3EGXA 2VILA 3CI5G 1NM1G 2VIKA 1Q8XA 5A1MA 2NUPB 1WM4A 3CJCG 1T44G 1P8XA 4S10C 5KYUA 2LJ8A 5HVKD 1P8ZG 3FFKA 5IVUA 3DAWB 1UDMA 3EFOA 2FF6G 1H1VG 1SVRA
chains in the Genus database with same CATH superfamily
3EG9B 5KYYA 1QPVA 1EQYS 1PCXA 1YVNG 5KYXA 3A5LS 3TU5B 1J72A 2MOTA 2QTVA 1M2VB 3EGDA 1X67A 4PKIG 1T3XA 4KEFA 1AK7A 1YAGG 2KVKA 2LLFA 1MDUA 2NUPA 1WFSA 1D4XG 2FH3A 4CBWG 1T3YA 3FG7A 5L6WC 1Q8GA 1M2OA 3A5MS 1V6FA 3L50A 5HVKB 1KCQA 1SVQA 3Q2BA 2I2QA 2FGHA 1NPHA 3FG6A 2NUTB 2FH1A 1M2VA 5KYNA 5FAFA 1NMDG 1JHWA 5DD2A 3EH1A 4PKHB 5KYWB 3EGXB 1NLVG 4Z94G 2L72A 3DA7A 1VFQA 5FAEA 3A5NS 2NUTA 2XFAA 3EG9A 4LIZA 1COFA 1T2LA 3EFOB 2VACA 1M4JA 1CFYA 3EGDB 4KEDA 1AK6A 2D8BA 1PD0A 2MV2A 1C0FS 3FFNA 2FH4A 1VKKA 2W0IA 3EH2A 4BEX1 2HD7A 1SVYA 1AHQA 4PKGG 4KEEA 4JD2H 5KYUB 3CJBG 1D0NA 1HQZ1 1ESVS 2FH2A 2XF1A 3CIPG 4CBXG 1CNUA 1DEJS 1F7SA 1TMWA 2LXXA 1C0GS 4CBUG 5KYYB 5KYXB 1WNJA 2FF3A 1PD1A 3A5OS 2MP4A 1TVJA 1RGIG 5KYWA 3EGXA 2VILA 3CI5G 1NM1G 2VIKA 1Q8XA 5A1MA 2NUPB 1WM4A 3CJCG 1T44G 1P8XA 4S10C 5KYUA 2LJ8A 5HVKD 1P8ZG 3FFKA 5IVUA 3DAWB 1UDMA 3EFOA 2FF6G 1H1VG 1SVRA
chains in the Genus database with same CATH topology
3EG9B 5KYYA 1QPVA 1EQYS 1PCXA 1YVNG 5KYXA 3A5LS 3TU5B 1J72A 2MOTA 2QTVA 1M2VB 3EGDA 1X67A 4PKIG 1T3XA 4KEFA 1AK7A 1YAGG 2KVKA 2LLFA 1MDUA 2NUPA 1WFSA 1D4XG 2FH3A 4CBWG 1T3YA 3FG7A 5L6WC 1Q8GA 1M2OA 3A5MS 1V6FA 3L50A 5HVKB 1KCQA 1SVQA 3Q2BA 2I2QA 2FGHA 1NPHA 3FG6A 2NUTB 2FH1A 1M2VA 5KYNA 5FAFA 1NMDG 1JHWA 5DD2A 3EH1A 4PKHB 5KYWB 3EGXB 1NLVG 4Z94G 2L72A 3DA7A 1VFQA 5FAEA 3A5NS 2NUTA 2XFAA 3EG9A 4LIZA 1COFA 1T2LA 3EFOB 2VACA 1M4JA 1CFYA 3EGDB 4KEDA 1AK6A 2D8BA 1PD0A 2MV2A 1C0FS 3FFNA 2FH4A 1VKKA 2W0IA 3EH2A 4BEX1 2HD7A 1SVYA 1AHQA 4PKGG 4KEEA 4JD2H 5KYUB 3CJBG 1D0NA 1HQZ1 1ESVS 2FH2A 2XF1A 3CIPG 4CBXG 1CNUA 1DEJS 1F7SA 1TMWA 2LXXA 1C0GS 4CBUG 5KYYB 5KYXB 1WNJA 2FF3A 1PD1A 3A5OS 2MP4A 1TVJA 1RGIG 5KYWA 3EGXA 2VILA 3CI5G 1NM1G 2VIKA 1Q8XA 5A1MA 2NUPB 1WM4A 3CJCG 1T44G 1P8XA 4S10C 5KYUA 2LJ8A 5HVKD 1P8ZG 3FFKA 5IVUA 3DAWB 1UDMA 3EFOA 2FF6G 1H1VG 1SVRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EG9 B;  5KYY A;  1QPV A;  1EQY S;  1PCX A;  1YVN G;  5KYX A;  3A5L S;  3TU5 B;  1J72 A;  2MOT A;  2QTV A;  1M2V B;  3EGD A;  1X67 A;  4PKI G;  1T3X A;  4KEF A;  1AK7 A;  1YAG G;  2KVK A;  2LLF A;  1MDU A;  2NUP A;  1WFS A;  1D4X G;  2FH3 A;  4CBW G;  1T3Y A;  3FG7 A;  5L6W C;  1Q8G A;  1M2O A;  3A5M S;  1V6F A;  3L50 A;  5HVK B;  1KCQ A;  1SVQ A;  3Q2B A;  2I2Q A;  2FGH A;  1NPH A;  3FG6 A;  2NUT B;  2FH1 A;  1M2V A;  5KYN A;  5FAF A;  1NMD G;  1JHW A;  5DD2 A;  3EH1 A;  4PKH B;  5KYW B;  3EGX B;  1NLV G;  4Z94 G;  2L72 A;  1VFQ A;  5FAE A;  3A5N S;  2NUT A;  2XFA A;  3EG9 A;  4LIZ A;  1COF A;  1T2L A;  3EFO B;  2VAC A;  1M4J A;  1CFY A;  3EGD B;  4KED A;  1AK6 A;  2D8B A;  1PD0 A;  2MV2 A;  1C0F S;  3FFN A;  2FH4 A;  1VKK A;  2W0I A;  3EH2 A;  4BEX 1;  2HD7 A;  1SVY A;  1AHQ A;  4PKG G;  4KEE A;  4JD2 H;  5KYU B;  3CJB G;  1D0N A;  1HQZ 1;  1ESV S;  2FH2 A;  2XF1 A;  3CIP G;  4CBX G;  1CNU A;  1DEJ S;  1F7S A;  1TMW A;  2LXX A;  1C0G S;  4CBU G;  5KYY B;  5KYX B;  1WNJ A;  2FF3 A;  1PD1 A;  3A5O S;  2MP4 A;  1TVJ A;  1RGI G;  5KYW A;  3EGX A;  2VIL A;  3CI5 G;  1NM1 G;  2VIK A;  1Q8X A;  5A1M A;  2NUP B;  1WM4 A;  3CJC G;  1T44 G;  1P8X A;  4S10 C;  5KYU A;  2LJ8 A;  5HVK D;  1P8Z G;  3FFK A;  5IVU A;  3DAW B;  1UDM A;  3EFO A;  2FF6 G;  1H1V G;  1SVR A; 
#chains in the Genus database with same CATH topology
 3EG9 B;  5KYY A;  1QPV A;  1EQY S;  1PCX A;  1YVN G;  5KYX A;  3A5L S;  3TU5 B;  1J72 A;  2MOT A;  2QTV A;  1M2V B;  3EGD A;  1X67 A;  4PKI G;  1T3X A;  4KEF A;  1AK7 A;  1YAG G;  2KVK A;  2LLF A;  1MDU A;  2NUP A;  1WFS A;  1D4X G;  2FH3 A;  4CBW G;  1T3Y A;  3FG7 A;  5L6W C;  1Q8G A;  1M2O A;  3A5M S;  1V6F A;  3L50 A;  5HVK B;  1KCQ A;  1SVQ A;  3Q2B A;  2I2Q A;  2FGH A;  1NPH A;  3FG6 A;  2NUT B;  2FH1 A;  1M2V A;  5KYN A;  5FAF A;  1NMD G;  1JHW A;  5DD2 A;  3EH1 A;  4PKH B;  5KYW B;  3EGX B;  1NLV G;  4Z94 G;  2L72 A;  3DA7 A;  1VFQ A;  5FAE A;  3A5N S;  2NUT A;  2XFA A;  3EG9 A;  4LIZ A;  1COF A;  1T2L A;  3EFO B;  2VAC A;  1M4J A;  1CFY A;  3EGD B;  4KED A;  1AK6 A;  2D8B A;  1PD0 A;  2MV2 A;  1C0F S;  3FFN A;  2FH4 A;  1VKK A;  2W0I A;  3EH2 A;  4BEX 1;  2HD7 A;  1SVY A;  1AHQ A;  4PKG G;  4KEE A;  4JD2 H;  5KYU B;  3CJB G;  1D0N A;  1HQZ 1;  1ESV S;  2FH2 A;  2XF1 A;  3CIP G;  4CBX G;  1CNU A;  1DEJ S;  1F7S A;  1TMW A;  2LXX A;  1C0G S;  4CBU G;  5KYY B;  5KYX B;  1WNJ A;  2FF3 A;  1PD1 A;  3A5O S;  2MP4 A;  1TVJ A;  1RGI G;  5KYW A;  3EGX A;  2VIL A;  3CI5 G;  1NM1 G;  2VIK A;  1Q8X A;  5A1M A;  2NUP B;  1WM4 A;  3CJC G;  1T44 G;  1P8X A;  4S10 C;  5KYU A;  2LJ8 A;  5HVK D;  1P8Z G;  3FFK A;  5IVU A;  3DAW B;  1UDM A;  3EFO A;  2FF6 G;  1H1V G;  1SVR A; 
#chains in the Genus database with same CATH homology
 3EG9 B;  5KYY A;  1QPV A;  1EQY S;  1PCX A;  1YVN G;  5KYX A;  3A5L S;  3TU5 B;  1J72 A;  2MOT A;  2QTV A;  1M2V B;  3EGD A;  1X67 A;  4PKI G;  1T3X A;  4KEF A;  1AK7 A;  1YAG G;  2KVK A;  2LLF A;  1MDU A;  2NUP A;  1WFS A;  1D4X G;  2FH3 A;  4CBW G;  1T3Y A;  3FG7 A;  5L6W C;  1Q8G A;  1M2O A;  3A5M S;  1V6F A;  3L50 A;  5HVK B;  1KCQ A;  1SVQ A;  3Q2B A;  2I2Q A;  2FGH A;  1NPH A;  3FG6 A;  2NUT B;  2FH1 A;  1M2V A;  5KYN A;  5FAF A;  1NMD G;  1JHW A;  5DD2 A;  3EH1 A;  4PKH B;  5KYW B;  3EGX B;  1NLV G;  4Z94 G;  2L72 A;  3DA7 A;  1VFQ A;  5FAE A;  3A5N S;  2NUT A;  2XFA A;  3EG9 A;  4LIZ A;  1COF A;  1T2L A;  3EFO B;  2VAC A;  1M4J A;  1CFY A;  3EGD B;  4KED A;  1AK6 A;  2D8B A;  1PD0 A;  2MV2 A;  1C0F S;  3FFN A;  2FH4 A;  1VKK A;  2W0I A;  3EH2 A;  4BEX 1;  2HD7 A;  1SVY A;  1AHQ A;  4PKG G;  4KEE A;  4JD2 H;  5KYU B;  3CJB G;  1D0N A;  1HQZ 1;  1ESV S;  2FH2 A;  2XF1 A;  3CIP G;  4CBX G;  1CNU A;  1DEJ S;  1F7S A;  1TMW A;  2LXX A;  1C0G S;  4CBU G;  5KYY B;  5KYX B;  1WNJ A;  2FF3 A;  1PD1 A;  3A5O S;  2MP4 A;  1TVJ A;  1RGI G;  5KYW A;  3EGX A;  2VIL A;  3CI5 G;  1NM1 G;  2VIK A;  1Q8X A;  5A1M A;  2NUP B;  1WM4 A;  3CJC G;  1T44 G;  1P8X A;  4S10 C;  5KYU A;  2LJ8 A;  5HVK D;  1P8Z G;  3FFK A;  5IVU A;  3DAW B;  1UDM A;  3EFO A;  2FF6 G;  1H1V G;  1SVR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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