2VILA

Refined structure of the actin-severing domain villin 14t, determined by solution nmr, 11 structures
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
126
structure length
126
Chain Sequence
VELSKKVTGKLDKTTPGIQIWRIENMEMVPVPTKSYGNFYEGDCYVLLSTRKTGSGFSYNIHYWLGKNSSQDEQGAAAIYTTQMDEYLGSVAVQHREVQGHESETFRAYFKQGLIYKQGGVASGMK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Refined structure of villin 14T and a detailed comparison with other actin-severing domains.
pubmed rcsb
molecule tags Actin-binding protein
source organism Gallus gallus
molecule keywords VILLIN 14T
total genus 19
structure length 126
sequence length 126
ec nomenclature
pdb deposition date 1997-01-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2vilA00
2MP4A 1D4XG 1PD0A 3EFOB 2MOTA 1MDUA 1KCQA 2XFAA 1P8ZG 5KYYB 1WFSA 1D0NA 1X67A 2D8BA 2HD7A 4Z94G 4CBUG 3EGDA 5A1MA 1T3YA 2LLFA 3FG7A 4S10C 2FH1A 1J72A 1VKKA 5DD2A 2FGHA 1AK7A 1M2VB 1JHWA 1TVJA 4LIZA 5KYUA 3A5OS 3TU5B 4KEFA 1H1VG 1NPHA 2XF1A 2FF6G 5KYXA 2NUTA 5HVKB 5FAEA 2LXXA 1AK6A 4PKHB 1PCXA 3EGDB 1RGIG 2FH2A 1AHQA 1C0GS 1SVYA 1WM4A 1SVRA 1TMWA 3Q2BA 5KYUB 5FAFA 3EGXB 3A5MS 1NLVG 1QPVA 2LJ8A 3FG6A 4BEX1 1NM1G 5KYXB 2VIKA 2NUTB 2NUPA 5L6WC 3CI5G 3A5NS 3DAWB 3L50A 1PD1A 4KEDA 1T3XA 3EH2A 2QTVA 1CNUA 1C0FS 2MV2A 2FH3A 3FFKA 5HVKD 5KYYA 3A5LS 2VILA 3CJBG 4PKGG 5KYNA 2L72A 1VFQA 1UDMA 1T2LA 1P8XA 1WNJA 2NUPB 1M2OA 2FF3A 2W0IA 2VACA 1CFYA 3EG9A 5KYWA 4KEEA 3FFNA 4CBWG 1YVNG 2I2QA 3CJCG 1Q8XA 2FH4A 1YAGG 1HQZ1 3EFOA 1T44G 4CBXG 1NMDG 5IVUA 1COFA 1SVQA 3CIPG 1Q8GA 2KVKA 1ESVS 1EQYS 3EG9B 5KYWB 1F7SA 3EGXA 4PKIG 1DEJS 1M4JA 4JD2H 1M2VA 1V6FA 3EH1A
chains in the Genus database with same CATH superfamily
2MP4A 1D4XG 1PD0A 3EFOB 2MOTA 1MDUA 1KCQA 2XFAA 1P8ZG 5KYYB 1WFSA 1D0NA 1X67A 2D8BA 2HD7A 4Z94G 4CBUG 3EGDA 5A1MA 1T3YA 2LLFA 3FG7A 4S10C 2FH1A 1J72A 1VKKA 5DD2A 2FGHA 1AK7A 1M2VB 1JHWA 1TVJA 4LIZA 5KYUA 3A5OS 3TU5B 4KEFA 1H1VG 1NPHA 2XF1A 2FF6G 5KYXA 2NUTA 5HVKB 5FAEA 2LXXA 1AK6A 4PKHB 1PCXA 3EGDB 1RGIG 2FH2A 1AHQA 1C0GS 1SVYA 1WM4A 1SVRA 1TMWA 3DA7A 3Q2BA 5KYUB 5FAFA 3EGXB 3A5MS 1NLVG 1QPVA 2LJ8A 3FG6A 4BEX1 1NM1G 5KYXB 2VIKA 2NUTB 2NUPA 5L6WC 3CI5G 3A5NS 3DAWB 3L50A 1PD1A 4KEDA 1T3XA 3EH2A 2QTVA 1CNUA 1C0FS 2MV2A 2FH3A 3FFKA 5HVKD 5KYYA 3A5LS 2VILA 3CJBG 4PKGG 5KYNA 2L72A 1VFQA 1UDMA 1T2LA 1P8XA 1WNJA 2NUPB 1M2OA 2FF3A 2W0IA 2VACA 1CFYA 3EG9A 5KYWA 4KEEA 3FFNA 4CBWG 1YVNG 2I2QA 3CJCG 1Q8XA 2FH4A 1YAGG 1HQZ1 3EFOA 1T44G 4CBXG 1NMDG 5IVUA 1COFA 1SVQA 3CIPG 1Q8GA 2KVKA 1ESVS 1EQYS 3EG9B 5KYWB 1F7SA 3EGXA 4PKIG 1DEJS 1M4JA 4JD2H 1M2VA 1V6FA 3EH1A
chains in the Genus database with same CATH topology
2MP4A 1D4XG 1PD0A 3EFOB 2MOTA 1MDUA 1KCQA 2XFAA 1P8ZG 5KYYB 1WFSA 1D0NA 1X67A 2D8BA 2HD7A 4Z94G 4CBUG 3EGDA 5A1MA 1T3YA 2LLFA 3FG7A 4S10C 2FH1A 1J72A 1VKKA 5DD2A 2FGHA 1AK7A 1M2VB 1JHWA 1TVJA 4LIZA 5KYUA 3A5OS 3TU5B 4KEFA 1H1VG 1NPHA 2XF1A 2FF6G 5KYXA 2NUTA 5HVKB 5FAEA 2LXXA 1AK6A 4PKHB 1PCXA 3EGDB 1RGIG 2FH2A 1AHQA 1C0GS 1SVYA 1WM4A 1SVRA 1TMWA 3DA7A 3Q2BA 5KYUB 5FAFA 3EGXB 3A5MS 1NLVG 1QPVA 2LJ8A 3FG6A 4BEX1 1NM1G 5KYXB 2VIKA 2NUTB 2NUPA 5L6WC 3CI5G 3A5NS 3DAWB 3L50A 1PD1A 4KEDA 1T3XA 3EH2A 2QTVA 1CNUA 1C0FS 2MV2A 2FH3A 3FFKA 5HVKD 5KYYA 3A5LS 2VILA 3CJBG 4PKGG 5KYNA 2L72A 1VFQA 1UDMA 1T2LA 1P8XA 1WNJA 2NUPB 1M2OA 2FF3A 2W0IA 2VACA 1CFYA 3EG9A 5KYWA 4KEEA 3FFNA 4CBWG 1YVNG 2I2QA 3CJCG 1Q8XA 2FH4A 1YAGG 1HQZ1 3EFOA 1T44G 4CBXG 1NMDG 5IVUA 1COFA 1SVQA 3CIPG 1Q8GA 2KVKA 1ESVS 1EQYS 3EG9B 5KYWB 1F7SA 3EGXA 4PKIG 1DEJS 1M4JA 4JD2H 1M2VA 1V6FA 3EH1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2MP4 A;  1D4X G;  1PD0 A;  3EFO B;  2MOT A;  1MDU A;  1KCQ A;  2XFA A;  1P8Z G;  5KYY B;  1WFS A;  1D0N A;  1X67 A;  2D8B A;  2HD7 A;  4Z94 G;  4CBU G;  3EGD A;  5A1M A;  1T3Y A;  2LLF A;  3FG7 A;  4S10 C;  2FH1 A;  1J72 A;  1VKK A;  5DD2 A;  2FGH A;  1AK7 A;  1M2V B;  1JHW A;  1TVJ A;  4LIZ A;  5KYU A;  3A5O S;  3TU5 B;  4KEF A;  1H1V G;  1NPH A;  2XF1 A;  2FF6 G;  5KYX A;  2NUT A;  5HVK B;  5FAE A;  2LXX A;  1AK6 A;  4PKH B;  1PCX A;  3EGD B;  1RGI G;  2FH2 A;  1AHQ A;  1C0G S;  1SVY A;  1WM4 A;  1SVR A;  1TMW A;  3Q2B A;  5KYU B;  5FAF A;  3EGX B;  3A5M S;  1NLV G;  1QPV A;  2LJ8 A;  3FG6 A;  4BEX 1;  1NM1 G;  5KYX B;  2VIK A;  2NUT B;  2NUP A;  5L6W C;  3CI5 G;  3A5N S;  3DAW B;  3L50 A;  1PD1 A;  4KED A;  1T3X A;  3EH2 A;  2QTV A;  1CNU A;  1C0F S;  2MV2 A;  2FH3 A;  3FFK A;  5HVK D;  5KYY A;  3A5L S;  2VIL A;  3CJB G;  4PKG G;  5KYN A;  2L72 A;  1VFQ A;  1UDM A;  1T2L A;  1P8X A;  1WNJ A;  2NUP B;  1M2O A;  2FF3 A;  2W0I A;  2VAC A;  1CFY A;  3EG9 A;  5KYW A;  4KEE A;  3FFN A;  4CBW G;  1YVN G;  2I2Q A;  3CJC G;  1Q8X A;  2FH4 A;  1YAG G;  1HQZ 1;  3EFO A;  1T44 G;  4CBX G;  1NMD G;  5IVU A;  1COF A;  1SVQ A;  3CIP G;  1Q8G A;  2KVK A;  1ESV S;  1EQY S;  3EG9 B;  5KYW B;  1F7S A;  3EGX A;  4PKI G;  1DEJ S;  1M4J A;  4JD2 H;  1M2V A;  1V6F A;  3EH1 A; 
#chains in the Genus database with same CATH topology
 2MP4 A;  1D4X G;  1PD0 A;  3EFO B;  2MOT A;  1MDU A;  1KCQ A;  2XFA A;  1P8Z G;  5KYY B;  1WFS A;  1D0N A;  1X67 A;  2D8B A;  2HD7 A;  4Z94 G;  4CBU G;  3EGD A;  5A1M A;  1T3Y A;  2LLF A;  3FG7 A;  4S10 C;  2FH1 A;  1J72 A;  1VKK A;  5DD2 A;  2FGH A;  1AK7 A;  1M2V B;  1JHW A;  1TVJ A;  4LIZ A;  5KYU A;  3A5O S;  3TU5 B;  4KEF A;  1H1V G;  1NPH A;  2XF1 A;  2FF6 G;  5KYX A;  2NUT A;  5HVK B;  5FAE A;  2LXX A;  1AK6 A;  4PKH B;  1PCX A;  3EGD B;  1RGI G;  2FH2 A;  1AHQ A;  1C0G S;  1SVY A;  1WM4 A;  1SVR A;  1TMW A;  3DA7 A;  3Q2B A;  5KYU B;  5FAF A;  3EGX B;  3A5M S;  1NLV G;  1QPV A;  2LJ8 A;  3FG6 A;  4BEX 1;  1NM1 G;  5KYX B;  2VIK A;  2NUT B;  2NUP A;  5L6W C;  3CI5 G;  3A5N S;  3DAW B;  3L50 A;  1PD1 A;  4KED A;  1T3X A;  3EH2 A;  2QTV A;  1CNU A;  1C0F S;  2MV2 A;  2FH3 A;  3FFK A;  5HVK D;  5KYY A;  3A5L S;  2VIL A;  3CJB G;  4PKG G;  5KYN A;  2L72 A;  1VFQ A;  1UDM A;  1T2L A;  1P8X A;  1WNJ A;  2NUP B;  1M2O A;  2FF3 A;  2W0I A;  2VAC A;  1CFY A;  3EG9 A;  5KYW A;  4KEE A;  3FFN A;  4CBW G;  1YVN G;  2I2Q A;  3CJC G;  1Q8X A;  2FH4 A;  1YAG G;  1HQZ 1;  3EFO A;  1T44 G;  4CBX G;  1NMD G;  5IVU A;  1COF A;  1SVQ A;  3CIP G;  1Q8G A;  2KVK A;  1ESV S;  1EQY S;  3EG9 B;  5KYW B;  1F7S A;  3EGX A;  4PKI G;  1DEJ S;  1M4J A;  4JD2 H;  1M2V A;  1V6F A;  3EH1 A; 
#chains in the Genus database with same CATH homology
 2MP4 A;  1D4X G;  1PD0 A;  3EFO B;  2MOT A;  1MDU A;  1KCQ A;  2XFA A;  1P8Z G;  5KYY B;  1WFS A;  1D0N A;  1X67 A;  2D8B A;  2HD7 A;  4Z94 G;  4CBU G;  3EGD A;  5A1M A;  1T3Y A;  2LLF A;  3FG7 A;  4S10 C;  2FH1 A;  1J72 A;  1VKK A;  5DD2 A;  2FGH A;  1AK7 A;  1M2V B;  1JHW A;  1TVJ A;  4LIZ A;  5KYU A;  3A5O S;  3TU5 B;  4KEF A;  1H1V G;  1NPH A;  2XF1 A;  2FF6 G;  5KYX A;  2NUT A;  5HVK B;  5FAE A;  2LXX A;  1AK6 A;  4PKH B;  1PCX A;  3EGD B;  1RGI G;  2FH2 A;  1AHQ A;  1C0G S;  1SVY A;  1WM4 A;  1SVR A;  1TMW A;  3DA7 A;  3Q2B A;  5KYU B;  5FAF A;  3EGX B;  3A5M S;  1NLV G;  1QPV A;  2LJ8 A;  3FG6 A;  4BEX 1;  1NM1 G;  5KYX B;  2VIK A;  2NUT B;  2NUP A;  5L6W C;  3CI5 G;  3A5N S;  3DAW B;  3L50 A;  1PD1 A;  4KED A;  1T3X A;  3EH2 A;  2QTV A;  1CNU A;  1C0F S;  2MV2 A;  2FH3 A;  3FFK A;  5HVK D;  5KYY A;  3A5L S;  2VIL A;  3CJB G;  4PKG G;  5KYN A;  2L72 A;  1VFQ A;  1UDM A;  1T2L A;  1P8X A;  1WNJ A;  2NUP B;  1M2O A;  2FF3 A;  2W0I A;  2VAC A;  1CFY A;  3EG9 A;  5KYW A;  4KEE A;  3FFN A;  4CBW G;  1YVN G;  2I2Q A;  3CJC G;  1Q8X A;  2FH4 A;  1YAG G;  1HQZ 1;  3EFO A;  1T44 G;  4CBX G;  1NMD G;  5IVU A;  1COF A;  1SVQ A;  3CIP G;  1Q8G A;  2KVK A;  1ESV S;  1EQY S;  3EG9 B;  5KYW B;  1F7S A;  3EGX A;  4PKI G;  1DEJ S;  1M4J A;  4JD2 H;  1M2V A;  1V6F A;  3EH1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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