2W0IA

Structure of c-terminal actin depolymerizing factor homology (adf-h) domain of human twinfilin-2
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
135
structure length
135
Chain Sequence
SMPLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDAARYHFFLYKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAKKIEIGDGAELTAEFLDDEVH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of C-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain of Human Twinfilin- 2
rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords TWINFILIN-2
total genus 41
structure length 135
sequence length 135
ec nomenclature
pdb deposition date 2008-08-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2w0iA00
1MDUA 4KEFA 5IVUA 2NUTB 1CFYA 5KYWA 4Z94G 1RGIG 4CBXG 4KEDA 2D8BA 3A5LS 2HD7A 1UDMA 3EG9B 3L50A 5KYXA 1TVJA 1AHQA 2QTVA 2FF3A 2I2QA 3EFOB 1J72A 2L72A 5A1MA 1VKKA 1KCQA 1WFSA 4BEX1 3EGXB 4CBWG 5KYUB 1YAGG 1CNUA 1AK7A 4CBUG 1D4XG 5KYYB 3FG6A 2FH1A 1SVYA 1M2VB 1ESVS 2LJ8A 3TU5B 5HVKB 2VACA 4LIZA 1C0GS 1PD1A 1JHWA 3FFNA 5FAEA 1VFQA 3FG7A 1QPVA 1COFA 3EH2A 1DEJS 1PCXA 3CJCG 2LLFA 3EGDB 1X67A 5DD2A 1NMDG 3A5NS 1Q8GA 2NUPB 3FFKA 2NUTA 5HVKD 3A5OS 3A5MS 4PKIG 3EG9A 5KYWB 4KEEA 2FH3A 1HQZ1 3EFOA 5KYNA 1WM4A 3Q2BA 1TMWA 1M2OA 2XF1A 5KYXB 1WNJA 1T44G 3EGXA 2FH2A 5KYUA 3CJBG 3CIPG 1EQYS 1SVQA 1D0NA 1F7SA 2FF6G 1NM1G 3CI5G 1T3XA 1YVNG 4PKHB 2MP4A 2XFAA 4PKGG 1M2VA 3EH1A 1T2LA 1V6FA 1AK6A 1NLVG 2FH4A 3DAWB 1P8XA 1PD0A 2LXXA 2VIKA 1H1VG 3EGDA 1C0FS 1T3YA 2MOTA 2VILA 5L6WC 1NPHA 2W0IA 1SVRA 1P8ZG 5FAFA 2NUPA 2KVKA 5KYYA 2FGHA 1M4JA 1Q8XA 2MV2A 4JD2H 4S10C
chains in the Genus database with same CATH superfamily
1MDUA 4KEFA 5IVUA 2NUTB 1CFYA 5KYWA 4Z94G 1RGIG 4CBXG 4KEDA 2D8BA 3A5LS 2HD7A 1UDMA 3EG9B 3L50A 5KYXA 1TVJA 1AHQA 2QTVA 2FF3A 2I2QA 3EFOB 1J72A 2L72A 5A1MA 1VKKA 1KCQA 1WFSA 4BEX1 3EGXB 4CBWG 5KYUB 1YAGG 1CNUA 1AK7A 4CBUG 1D4XG 5KYYB 3FG6A 2FH1A 1SVYA 1M2VB 1ESVS 2LJ8A 3TU5B 5HVKB 2VACA 4LIZA 1C0GS 1PD1A 1JHWA 3FFNA 5FAEA 1VFQA 3FG7A 1QPVA 1COFA 3EH2A 1DEJS 1PCXA 3CJCG 2LLFA 3EGDB 1X67A 5DD2A 1NMDG 3A5NS 1Q8GA 2NUPB 3FFKA 2NUTA 5HVKD 3A5OS 3A5MS 4PKIG 3EG9A 5KYWB 4KEEA 2FH3A 1HQZ1 3EFOA 5KYNA 1WM4A 3Q2BA 1TMWA 1M2OA 2XF1A 5KYXB 1WNJA 1T44G 3EGXA 2FH2A 5KYUA 3CJBG 3CIPG 1EQYS 1SVQA 1D0NA 1F7SA 2FF6G 1NM1G 3CI5G 1T3XA 1YVNG 4PKHB 2MP4A 2XFAA 4PKGG 1M2VA 3EH1A 1T2LA 1V6FA 1AK6A 3DA7A 1NLVG 2FH4A 3DAWB 1P8XA 1PD0A 2LXXA 2VIKA 1H1VG 3EGDA 1C0FS 1T3YA 2MOTA 2VILA 5L6WC 1NPHA 2W0IA 1SVRA 1P8ZG 5FAFA 2NUPA 2KVKA 5KYYA 2FGHA 1M4JA 1Q8XA 2MV2A 4JD2H 4S10C
chains in the Genus database with same CATH topology
1MDUA 4KEFA 5IVUA 2NUTB 1CFYA 5KYWA 4Z94G 1RGIG 4CBXG 4KEDA 2D8BA 3A5LS 2HD7A 1UDMA 3EG9B 3L50A 5KYXA 1TVJA 1AHQA 2QTVA 2FF3A 2I2QA 3EFOB 1J72A 2L72A 5A1MA 1VKKA 1KCQA 1WFSA 4BEX1 3EGXB 4CBWG 5KYUB 1YAGG 1CNUA 1AK7A 4CBUG 1D4XG 5KYYB 3FG6A 2FH1A 1SVYA 1M2VB 1ESVS 2LJ8A 3TU5B 5HVKB 2VACA 4LIZA 1C0GS 1PD1A 1JHWA 3FFNA 5FAEA 1VFQA 3FG7A 1QPVA 1COFA 3EH2A 1DEJS 1PCXA 3CJCG 2LLFA 3EGDB 1X67A 5DD2A 1NMDG 3A5NS 1Q8GA 2NUPB 3FFKA 2NUTA 5HVKD 3A5OS 3A5MS 4PKIG 3EG9A 5KYWB 4KEEA 2FH3A 1HQZ1 3EFOA 5KYNA 1WM4A 3Q2BA 1TMWA 1M2OA 2XF1A 5KYXB 1WNJA 1T44G 3EGXA 2FH2A 5KYUA 3CJBG 3CIPG 1EQYS 1SVQA 1D0NA 1F7SA 2FF6G 1NM1G 3CI5G 1T3XA 1YVNG 4PKHB 2MP4A 2XFAA 4PKGG 1M2VA 3EH1A 1T2LA 1V6FA 1AK6A 3DA7A 1NLVG 2FH4A 3DAWB 1P8XA 1PD0A 2LXXA 2VIKA 1H1VG 3EGDA 1C0FS 1T3YA 2MOTA 2VILA 5L6WC 1NPHA 2W0IA 1SVRA 1P8ZG 5FAFA 2NUPA 2KVKA 5KYYA 2FGHA 1M4JA 1Q8XA 2MV2A 4JD2H 4S10C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MDU A;  4KEF A;  5IVU A;  2NUT B;  1CFY A;  5KYW A;  4Z94 G;  1RGI G;  4CBX G;  4KED A;  2D8B A;  3A5L S;  2HD7 A;  1UDM A;  3EG9 B;  3L50 A;  5KYX A;  1TVJ A;  1AHQ A;  2QTV A;  2FF3 A;  2I2Q A;  3EFO B;  1J72 A;  2L72 A;  5A1M A;  1VKK A;  1KCQ A;  1WFS A;  4BEX 1;  3EGX B;  4CBW G;  5KYU B;  1YAG G;  1CNU A;  1AK7 A;  4CBU G;  1D4X G;  5KYY B;  3FG6 A;  2FH1 A;  1SVY A;  1M2V B;  1ESV S;  2LJ8 A;  3TU5 B;  5HVK B;  2VAC A;  4LIZ A;  1C0G S;  1PD1 A;  1JHW A;  3FFN A;  5FAE A;  1VFQ A;  3FG7 A;  1QPV A;  1COF A;  3EH2 A;  1DEJ S;  1PCX A;  3CJC G;  2LLF A;  3EGD B;  1X67 A;  5DD2 A;  1NMD G;  3A5N S;  1Q8G A;  2NUP B;  3FFK A;  2NUT A;  5HVK D;  3A5O S;  3A5M S;  4PKI G;  3EG9 A;  5KYW B;  4KEE A;  2FH3 A;  1HQZ 1;  3EFO A;  5KYN A;  1WM4 A;  3Q2B A;  1TMW A;  1M2O A;  2XF1 A;  5KYX B;  1WNJ A;  1T44 G;  3EGX A;  2FH2 A;  5KYU A;  3CJB G;  3CIP G;  1EQY S;  1SVQ A;  1D0N A;  1F7S A;  2FF6 G;  1NM1 G;  3CI5 G;  1T3X A;  1YVN G;  4PKH B;  2MP4 A;  2XFA A;  4PKG G;  1M2V A;  3EH1 A;  1T2L A;  1V6F A;  1AK6 A;  1NLV G;  2FH4 A;  3DAW B;  1P8X A;  1PD0 A;  2LXX A;  2VIK A;  1H1V G;  3EGD A;  1C0F S;  1T3Y A;  2MOT A;  2VIL A;  5L6W C;  1NPH A;  2W0I A;  1SVR A;  1P8Z G;  5FAF A;  2NUP A;  2KVK A;  5KYY A;  2FGH A;  1M4J A;  1Q8X A;  2MV2 A;  4JD2 H;  4S10 C; 
#chains in the Genus database with same CATH topology
 1MDU A;  4KEF A;  5IVU A;  2NUT B;  1CFY A;  5KYW A;  4Z94 G;  1RGI G;  4CBX G;  4KED A;  2D8B A;  3A5L S;  2HD7 A;  1UDM A;  3EG9 B;  3L50 A;  5KYX A;  1TVJ A;  1AHQ A;  2QTV A;  2FF3 A;  2I2Q A;  3EFO B;  1J72 A;  2L72 A;  5A1M A;  1VKK A;  1KCQ A;  1WFS A;  4BEX 1;  3EGX B;  4CBW G;  5KYU B;  1YAG G;  1CNU A;  1AK7 A;  4CBU G;  1D4X G;  5KYY B;  3FG6 A;  2FH1 A;  1SVY A;  1M2V B;  1ESV S;  2LJ8 A;  3TU5 B;  5HVK B;  2VAC A;  4LIZ A;  1C0G S;  1PD1 A;  1JHW A;  3FFN A;  5FAE A;  1VFQ A;  3FG7 A;  1QPV A;  1COF A;  3EH2 A;  1DEJ S;  1PCX A;  3CJC G;  2LLF A;  3EGD B;  1X67 A;  5DD2 A;  1NMD G;  3A5N S;  1Q8G A;  2NUP B;  3FFK A;  2NUT A;  5HVK D;  3A5O S;  3A5M S;  4PKI G;  3EG9 A;  5KYW B;  4KEE A;  2FH3 A;  1HQZ 1;  3EFO A;  5KYN A;  1WM4 A;  3Q2B A;  1TMW A;  1M2O A;  2XF1 A;  5KYX B;  1WNJ A;  1T44 G;  3EGX A;  2FH2 A;  5KYU A;  3CJB G;  3CIP G;  1EQY S;  1SVQ A;  1D0N A;  1F7S A;  2FF6 G;  1NM1 G;  3CI5 G;  1T3X A;  1YVN G;  4PKH B;  2MP4 A;  2XFA A;  4PKG G;  1M2V A;  3EH1 A;  1T2L A;  1V6F A;  1AK6 A;  3DA7 A;  1NLV G;  2FH4 A;  3DAW B;  1P8X A;  1PD0 A;  2LXX A;  2VIK A;  1H1V G;  3EGD A;  1C0F S;  1T3Y A;  2MOT A;  2VIL A;  5L6W C;  1NPH A;  2W0I A;  1SVR A;  1P8Z G;  5FAF A;  2NUP A;  2KVK A;  5KYY A;  2FGH A;  1M4J A;  1Q8X A;  2MV2 A;  4JD2 H;  4S10 C; 
#chains in the Genus database with same CATH homology
 1MDU A;  4KEF A;  5IVU A;  2NUT B;  1CFY A;  5KYW A;  4Z94 G;  1RGI G;  4CBX G;  4KED A;  2D8B A;  3A5L S;  2HD7 A;  1UDM A;  3EG9 B;  3L50 A;  5KYX A;  1TVJ A;  1AHQ A;  2QTV A;  2FF3 A;  2I2Q A;  3EFO B;  1J72 A;  2L72 A;  5A1M A;  1VKK A;  1KCQ A;  1WFS A;  4BEX 1;  3EGX B;  4CBW G;  5KYU B;  1YAG G;  1CNU A;  1AK7 A;  4CBU G;  1D4X G;  5KYY B;  3FG6 A;  2FH1 A;  1SVY A;  1M2V B;  1ESV S;  2LJ8 A;  3TU5 B;  5HVK B;  2VAC A;  4LIZ A;  1C0G S;  1PD1 A;  1JHW A;  3FFN A;  5FAE A;  1VFQ A;  3FG7 A;  1QPV A;  1COF A;  3EH2 A;  1DEJ S;  1PCX A;  3CJC G;  2LLF A;  3EGD B;  1X67 A;  5DD2 A;  1NMD G;  3A5N S;  1Q8G A;  2NUP B;  3FFK A;  2NUT A;  5HVK D;  3A5O S;  3A5M S;  4PKI G;  3EG9 A;  5KYW B;  4KEE A;  2FH3 A;  1HQZ 1;  3EFO A;  5KYN A;  1WM4 A;  3Q2B A;  1TMW A;  1M2O A;  2XF1 A;  5KYX B;  1WNJ A;  1T44 G;  3EGX A;  2FH2 A;  5KYU A;  3CJB G;  3CIP G;  1EQY S;  1SVQ A;  1D0N A;  1F7S A;  2FF6 G;  1NM1 G;  3CI5 G;  1T3X A;  1YVN G;  4PKH B;  2MP4 A;  2XFA A;  4PKG G;  1M2V A;  3EH1 A;  1T2L A;  1V6F A;  1AK6 A;  3DA7 A;  1NLV G;  2FH4 A;  3DAW B;  1P8X A;  1PD0 A;  2LXX A;  2VIK A;  1H1V G;  3EGD A;  1C0F S;  1T3Y A;  2MOT A;  2VIL A;  5L6W C;  1NPH A;  2W0I A;  1SVR A;  1P8Z G;  5FAF A;  2NUP A;  2KVK A;  5KYY A;  2FGH A;  1M4J A;  1Q8X A;  2MV2 A;  4JD2 H;  4S10 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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