2W0I | Genus

Total Genus 41

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	41
sequence length	135
structure length	135
Chain Sequence	SMPLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDAARYHFFLYKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAKKIEIGDGAELTAEFLDDEVH

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

publication title	Structure of C-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain of Human Twinfilin- 2 rcsb
molecule keywords	TWINFILIN-2
molecule tags	Transferase
source organism	Homo sapiens
total genus	41
structure length	135
sequence length	135
ec nomenclature
pdb deposition date	2008-08-18

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00241	Cofilin_ADF	Cofilin/tropomyosin-type actin-binding protein

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	2w0iA00

2LLFA 2MOTA 3DAWB 2D8BA 3EGXB 5L6WC 2QTVA 3A5NS 2FH3A 3EFOB 1T3YA 1P8XA 4KEDA 3L50A 1WFSA 5KYWB 1WM4A 3FFNA 3EGXA 3EFOA 2XFAA 1NPHA 4S10C 1T3XA 1D0NA 1TMWA 5KYWA 1X67A 2NUPB 5KYNA 5KYYB 3TU5B 5KYUB 1EQYS 1SVQA 2KVKA 2LXXA 1P8ZG 2NUPA 5DD2A 5KYYA 2VIKA 5KYUA 4CBXG 1AHQA 4LIZA 1PCXA 1TVJA 3EH2A 3EGDB 3CI5G 3EH1A 1PD0A 2LJ8A 1Q8GA 1F7SA 2MV2A 1VKKA 1YAGG 2I2QA 3A5MS 5A1MA 1WNJA 3EGDA 1M2OA 3A5OS 1JHWA 5KYXB 2FH2A 1KCQA 3CIPG 3FG7A 1Q8XA 4BEX1 5KYXA 3FG6A 4PKHB 1M4JA 1DEJS 3FFKA 1RGIG 1C0GS 4Z94G 1UDMA 2HD7A 1C0FS 4PKGG 1J72A 1VFQA 1SVYA 5HVKB 2VILA 4CBWG 1CFYA 2L72A 1COFA 1M2VB 5FAFA 3CJBG 1D4XG 4JD2H 1CNUA 1AK7A 5HVKD 1PD1A 1YVNG 2MP4A 1M2VA 4KEEA 2XF1A 2NUTB 1T44G 1NMDG 1T2LA 2W0IA 4CBUG 2NUTA 3Q2BA 1HQZ1 4PKIG 1NM1G 4KEFA 5FAEA 1MDUA 2VACA 1ESVS 1SVRA 1V6FA 3EG9B 2FH4A 1QPVA 2FH1A 1H1VG 2FF6G 1AK6A 2FGHA 3CJCG 5IVUA 3EG9A 2FF3A 1NLVG 3A5LS
chains in the Genus database with same CATH superfamily

2LLFA 2MOTA 3DAWB 2D8BA 3DA7A 3EGXB 2QTVA 3A5NS 2FH3A 3EFOB 5L6WC 1T3YA 1P8XA 4KEDA 3L50A 1WFSA 5KYWB 1WM4A 3FFNA 3EGXA 3EFOA 2XFAA 1NPHA 4S10C 1T3XA 1D0NA 1TMWA 5KYWA 1X67A 2NUPB 5KYNA 5KYYB 3TU5B 5KYUB 1EQYS 1SVQA 2KVKA 2LXXA 1P8ZG 2NUPA 5DD2A 5KYYA 2VIKA 5KYUA 4CBXG 1AHQA 4LIZA 1PCXA 1TVJA 3EH2A 3EGDB 3CI5G 3EH1A 1PD0A 2LJ8A 1Q8GA 1F7SA 2MV2A 1VKKA 1YAGG 2I2QA 3A5MS 5A1MA 1WNJA 3EGDA 1M2OA 3A5OS 1JHWA 5KYXB 2FH2A 1KCQA 3CIPG 3FG7A 1Q8XA 4BEX1 5KYXA 3FG6A 4PKHB 1M4JA 1DEJS 3FFKA 1RGIG 1C0GS 4Z94G 1UDMA 2HD7A 1C0FS 4PKGG 1J72A 1VFQA 1SVYA 5HVKB 2VILA 4CBWG 1CFYA 2L72A 1COFA 1M2VB 5FAFA 3CJBG 1D4XG 4JD2H 1CNUA 1AK7A 5HVKD 1PD1A 1YVNG 2MP4A 1M2VA 4KEEA 2XF1A 2NUTB 1T44G 1NMDG 1T2LA 2W0IA 4CBUG 2NUTA 3Q2BA 1HQZ1 4PKIG 1NM1G 4KEFA 5FAEA 1MDUA 2VACA 1ESVS 1SVRA 1V6FA 3EG9B 2FH4A 1QPVA 2FH1A 1H1VG 2FF6G 1AK6A 2FGHA 3CJCG 5IVUA 3EG9A 2FF3A 1NLVG 3A5LS
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 2LLF A;  2MOT A;  3DAW B;  2D8B A;  3EGX B;  5L6W C;  2QTV A;  3A5N S;  2FH3 A;  3EFO B;  1T3Y A;  1P8X A;  4KED A;  3L50 A;  1WFS A;  5KYW B;  1WM4 A;  3FFN A;  3EGX A;  3EFO A;  2XFA A;  1NPH A;  4S10 C;  1T3X A;  1D0N A;  1TMW A;  5KYW A;  1X67 A;  2NUP B;  5KYN A;  5KYY B;  3TU5 B;  5KYU B;  1EQY S;  1SVQ A;  2KVK A;  2LXX A;  1P8Z G;  2NUP A;  5DD2 A;  5KYY A;  2VIK A;  5KYU A;  4CBX G;  1AHQ A;  4LIZ A;  1PCX A;  1TVJ A;  3EH2 A;  3EGD B;  3CI5 G;  3EH1 A;  1PD0 A;  2LJ8 A;  1Q8G A;  1F7S A;  2MV2 A;  1VKK A;  1YAG G;  2I2Q A;  3A5M S;  5A1M A;  1WNJ A;  3EGD A;  1M2O A;  3A5O S;  1JHW A;  5KYX B;  2FH2 A;  1KCQ A;  3CIP G;  3FG7 A;  1Q8X A;  4BEX 1;  5KYX A;  3FG6 A;  4PKH B;  1M4J A;  1DEJ S;  3FFK A;  1RGI G;  1C0G S;  4Z94 G;  1UDM A;  2HD7 A;  1C0F S;  4PKG G;  1J72 A;  1VFQ A;  1SVY A;  5HVK B;  2VIL A;  4CBW G;  1CFY A;  2L72 A;  1COF A;  1M2V B;  5FAF A;  3CJB G;  1D4X G;  4JD2 H;  1CNU A;  1AK7 A;  5HVK D;  1PD1 A;  1YVN G;  2MP4 A;  1M2V A;  4KEE A;  2XF1 A;  2NUT B;  1T44 G;  1NMD G;  1T2L A;  2W0I A;  4CBU G;  2NUT A;  3Q2B A;  1HQZ 1;  4PKI G;  1NM1 G;  4KEF A;  5FAE A;  1MDU A;  2VAC A;  1ESV S;  1SVR A;  1V6F A;  3EG9 B;  2FH4 A;  1QPV A;  2FH1 A;  1H1V G;  2FF6 G;  1AK6 A;  2FGH A;  3CJC G;  5IVU A;  3EG9 A;  2FF3 A;  1NLV G;  3A5L S; 
#chains in the Genus database with same CATH topology
 2LLF A;  2MOT A;  3DAW B;  2D8B A;  3DA7 A;  3EGX B;  2QTV A;  3A5N S;  2FH3 A;  3EFO B;  5L6W C;  1T3Y A;  1P8X A;  4KED A;  3L50 A;  1WFS A;  5KYW B;  1WM4 A;  3FFN A;  3EGX A;  3EFO A;  2XFA A;  1NPH A;  4S10 C;  1T3X A;  1D0N A;  1TMW A;  5KYW A;  1X67 A;  2NUP B;  5KYN A;  5KYY B;  3TU5 B;  5KYU B;  1EQY S;  1SVQ A;  2KVK A;  2LXX A;  1P8Z G;  2NUP A;  5DD2 A;  5KYY A;  2VIK A;  5KYU A;  4CBX G;  1AHQ A;  4LIZ A;  1PCX A;  1TVJ A;  3EH2 A;  3EGD B;  3CI5 G;  3EH1 A;  1PD0 A;  2LJ8 A;  1Q8G A;  1F7S A;  2MV2 A;  1VKK A;  1YAG G;  2I2Q A;  3A5M S;  5A1M A;  1WNJ A;  3EGD A;  1M2O A;  3A5O S;  1JHW A;  5KYX B;  2FH2 A;  1KCQ A;  3CIP G;  3FG7 A;  1Q8X A;  4BEX 1;  5KYX A;  3FG6 A;  4PKH B;  1M4J A;  1DEJ S;  3FFK A;  1RGI G;  1C0G S;  4Z94 G;  1UDM A;  2HD7 A;  1C0F S;  4PKG G;  1J72 A;  1VFQ A;  1SVY A;  5HVK B;  2VIL A;  4CBW G;  1CFY A;  2L72 A;  1COF A;  1M2V B;  5FAF A;  3CJB G;  1D4X G;  4JD2 H;  1CNU A;  1AK7 A;  5HVK D;  1PD1 A;  1YVN G;  2MP4 A;  1M2V A;  4KEE A;  2XF1 A;  2NUT B;  1T44 G;  1NMD G;  1T2L A;  2W0I A;  4CBU G;  2NUT A;  3Q2B A;  1HQZ 1;  4PKI G;  1NM1 G;  4KEF A;  5FAE A;  1MDU A;  2VAC A;  1ESV S;  1SVR A;  1V6F A;  3EG9 B;  2FH4 A;  1QPV A;  2FH1 A;  1H1V G;  2FF6 G;  1AK6 A;  2FGH A;  3CJC G;  5IVU A;  3EG9 A;  2FF3 A;  1NLV G;  3A5L S; 
#chains in the Genus database with same CATH homology
 2LLF A;  2MOT A;  3DAW B;  2D8B A;  3DA7 A;  3EGX B;  2QTV A;  3A5N S;  2FH3 A;  3EFO B;  5L6W C;  1T3Y A;  1P8X A;  4KED A;  3L50 A;  1WFS A;  5KYW B;  1WM4 A;  3FFN A;  3EGX A;  3EFO A;  2XFA A;  1NPH A;  4S10 C;  1T3X A;  1D0N A;  1TMW A;  5KYW A;  1X67 A;  2NUP B;  5KYN A;  5KYY B;  3TU5 B;  5KYU B;  1EQY S;  1SVQ A;  2KVK A;  2LXX A;  1P8Z G;  2NUP A;  5DD2 A;  5KYY A;  2VIK A;  5KYU A;  4CBX G;  1AHQ A;  4LIZ A;  1PCX A;  1TVJ A;  3EH2 A;  3EGD B;  3CI5 G;  3EH1 A;  1PD0 A;  2LJ8 A;  1Q8G A;  1F7S A;  2MV2 A;  1VKK A;  1YAG G;  2I2Q A;  3A5M S;  5A1M A;  1WNJ A;  3EGD A;  1M2O A;  3A5O S;  1JHW A;  5KYX B;  2FH2 A;  1KCQ A;  3CIP G;  3FG7 A;  1Q8X A;  4BEX 1;  5KYX A;  3FG6 A;  4PKH B;  1M4J A;  1DEJ S;  3FFK A;  1RGI G;  1C0G S;  4Z94 G;  1UDM A;  2HD7 A;  1C0F S;  4PKG G;  1J72 A;  1VFQ A;  1SVY A;  5HVK B;  2VIL A;  4CBW G;  1CFY A;  2L72 A;  1COF A;  1M2V B;  5FAF A;  3CJB G;  1D4X G;  4JD2 H;  1CNU A;  1AK7 A;  5HVK D;  1PD1 A;  1YVN G;  2MP4 A;  1M2V A;  4KEE A;  2XF1 A;  2NUT B;  1T44 G;  1NMD G;  1T2L A;  2W0I A;  4CBU G;  2NUT A;  3Q2B A;  1HQZ 1;  4PKI G;  1NM1 G;  4KEF A;  5FAE A;  1MDU A;  2VAC A;  1ESV S;  1SVR A;  1V6F A;  3EG9 B;  2FH4 A;  1QPV A;  2FH1 A;  1H1V G;  2FF6 G;  1AK6 A;  2FGH A;  3CJC G;  5IVU A;  3EG9 A;  2FF3 A;  1NLV G;  3A5L S;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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2W0IA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations