3CJBG

Actin dimer cross-linked by v. cholerae martx toxin and complexed with gelsolin-segment 1
Total Genus 36
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
36
sequence length
125
structure length
125
Chain Sequence
MVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Actin, alpha skeletal muscle
total genus 36
structure length 125
sequence length 125
ec nomenclature
pdb deposition date 2008-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 3cjbG00
1C0GS 3CJBG 1Q8XA 3CJCG 1F7SA 1SVRA 1M4JA 1EQYS 3Q2BA 3FFKA 1AK7A 1C0FS 4PKGG 4PKHB 1VKKA 2XFAA 5KYWA 5L6WC 2FH2A 2D8BA 1SVYA 5A1MA 5KYNA 1HQZ1 2L72A 2FH1A 3EG9A 3A5LS 1TVJA 1VFQA 3EGDA 3EH1A 3FG6A 1M2VA 1WM4A 2QTVA 4CBWG 5KYXA 2MP4A 4KEEA 1CFYA 4Z94G 2LXXA 1M2OA 4KEDA 2HD7A 4S10C 2KVKA 2VILA 1PCXA 1WNJA 2FGHA 4KEFA 5KYWB 2LJ8A 1AK6A 5KYYA 1TMWA 1NLVG 5KYUA 1V6FA 1NM1G 1PD0A 1YAGG 3FFNA 1Q8GA 1P8ZG 3CI5G 1MDUA 2LLFA 1AHQA 3EGDB 1M2VB 2I2QA 2VACA 1JHWA 4CBXG 1SVQA 5KYXB 2FF3A 3EH2A 4JD2H 3TU5B 2NUPA 1NMDG 1D0NA 2FF6G 5KYYB 5FAFA 2FH4A 3EFOA 3FG7A 1KCQA 4LIZA 4BEX1 1T2LA 2XF1A 1RGIG 5FAEA 3EGXA 1P8XA 5HVKD 1UDMA 2VIKA 1T3XA 3EG9B 1T3YA 2NUTA 2NUPB 2FH3A 1NPHA 1CNUA 1COFA 2W0IA 5DD2A 1YVNG 2MV2A 4CBUG 3EFOB 1PD1A 4PKIG 3A5OS 3EGXB 2MOTA 5KYUB 3A5NS 1D4XG 1QPVA 1ESVS 2NUTB 1DEJS 3A5MS 1H1VG 1WFSA 1J72A 5IVUA 3L50A 1T44G 3CIPG 5HVKB 1X67A 3DAWB
chains in the Genus database with same CATH superfamily
1C0GS 3CJBG 1Q8XA 3CJCG 1F7SA 1SVRA 1M4JA 1EQYS 3Q2BA 3FFKA 1AK7A 1C0FS 4PKGG 3DA7A 1VKKA 4PKHB 2XFAA 5KYWA 5L6WC 2FH2A 2D8BA 1SVYA 5A1MA 5KYNA 1HQZ1 2L72A 2FH1A 3EG9A 3A5LS 1TVJA 1VFQA 3EGDA 3EH1A 3FG6A 1M2VA 1WM4A 2QTVA 4CBWG 5KYXA 2MP4A 4KEEA 1CFYA 4Z94G 2LXXA 1M2OA 4KEDA 2HD7A 4S10C 2KVKA 2VILA 1PCXA 1WNJA 2FGHA 4KEFA 5KYWB 2LJ8A 1AK6A 5KYYA 1TMWA 1NLVG 5KYUA 1V6FA 1NM1G 1PD0A 1YAGG 3FFNA 1Q8GA 1P8ZG 3CI5G 1MDUA 2LLFA 1AHQA 3EGDB 1M2VB 2I2QA 2VACA 1JHWA 4CBXG 1SVQA 5KYXB 2FF3A 3EH2A 4JD2H 3TU5B 2NUPA 1NMDG 1D0NA 2FF6G 5KYYB 5FAFA 2FH4A 3EFOA 3FG7A 1KCQA 4LIZA 4BEX1 1T2LA 2XF1A 1RGIG 5FAEA 3EGXA 1P8XA 5HVKD 1UDMA 2VIKA 1T3XA 3EG9B 1T3YA 2NUTA 2NUPB 2FH3A 1NPHA 1CNUA 1COFA 2W0IA 5DD2A 1YVNG 2MV2A 4CBUG 3EFOB 1PD1A 4PKIG 3A5OS 3EGXB 2MOTA 5KYUB 3A5NS 1D4XG 1QPVA 1ESVS 2NUTB 1DEJS 3A5MS 1H1VG 1WFSA 1J72A 5IVUA 3L50A 1T44G 3CIPG 5HVKB 1X67A 3DAWB
chains in the Genus database with same CATH topology
1C0GS 3CJBG 1Q8XA 3CJCG 1F7SA 1SVRA 1M4JA 1EQYS 3Q2BA 3FFKA 1AK7A 1C0FS 4PKGG 3DA7A 1VKKA 4PKHB 2XFAA 5KYWA 5L6WC 2FH2A 2D8BA 1SVYA 5A1MA 5KYNA 1HQZ1 2L72A 2FH1A 3EG9A 3A5LS 1TVJA 1VFQA 3EGDA 3EH1A 3FG6A 1M2VA 1WM4A 2QTVA 4CBWG 5KYXA 2MP4A 4KEEA 1CFYA 4Z94G 2LXXA 1M2OA 4KEDA 2HD7A 4S10C 2KVKA 2VILA 1PCXA 1WNJA 2FGHA 4KEFA 5KYWB 2LJ8A 1AK6A 5KYYA 1TMWA 1NLVG 5KYUA 1V6FA 1NM1G 1PD0A 1YAGG 3FFNA 1Q8GA 1P8ZG 3CI5G 1MDUA 2LLFA 1AHQA 3EGDB 1M2VB 2I2QA 2VACA 1JHWA 4CBXG 1SVQA 5KYXB 2FF3A 3EH2A 4JD2H 3TU5B 2NUPA 1NMDG 1D0NA 2FF6G 5KYYB 5FAFA 2FH4A 3EFOA 3FG7A 1KCQA 4LIZA 4BEX1 1T2LA 2XF1A 1RGIG 5FAEA 3EGXA 1P8XA 5HVKD 1UDMA 2VIKA 1T3XA 3EG9B 1T3YA 2NUTA 2NUPB 2FH3A 1NPHA 1CNUA 1COFA 2W0IA 5DD2A 1YVNG 2MV2A 4CBUG 3EFOB 1PD1A 4PKIG 3A5OS 3EGXB 2MOTA 5KYUB 3A5NS 1D4XG 1QPVA 1ESVS 2NUTB 1DEJS 3A5MS 1H1VG 1WFSA 1J72A 5IVUA 3L50A 1T44G 3CIPG 5HVKB 1X67A 3DAWB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C0G S;  3CJB G;  1Q8X A;  3CJC G;  1F7S A;  1SVR A;  1M4J A;  1EQY S;  3Q2B A;  3FFK A;  1AK7 A;  1C0F S;  4PKG G;  4PKH B;  1VKK A;  2XFA A;  5KYW A;  5L6W C;  2FH2 A;  2D8B A;  1SVY A;  5A1M A;  5KYN A;  1HQZ 1;  2L72 A;  2FH1 A;  3EG9 A;  3A5L S;  1TVJ A;  1VFQ A;  3EGD A;  3EH1 A;  3FG6 A;  1M2V A;  1WM4 A;  2QTV A;  4CBW G;  5KYX A;  2MP4 A;  4KEE A;  1CFY A;  4Z94 G;  2LXX A;  1M2O A;  4KED A;  2HD7 A;  4S10 C;  2KVK A;  2VIL A;  1PCX A;  1WNJ A;  2FGH A;  4KEF A;  5KYW B;  2LJ8 A;  1AK6 A;  5KYY A;  1TMW A;  1NLV G;  5KYU A;  1V6F A;  1NM1 G;  1PD0 A;  1YAG G;  3FFN A;  1Q8G A;  1P8Z G;  3CI5 G;  1MDU A;  2LLF A;  1AHQ A;  3EGD B;  1M2V B;  2I2Q A;  2VAC A;  1JHW A;  4CBX G;  1SVQ A;  5KYX B;  2FF3 A;  3EH2 A;  4JD2 H;  3TU5 B;  2NUP A;  1NMD G;  1D0N A;  2FF6 G;  5KYY B;  5FAF A;  2FH4 A;  3EFO A;  3FG7 A;  1KCQ A;  4LIZ A;  4BEX 1;  1T2L A;  2XF1 A;  1RGI G;  5FAE A;  3EGX A;  1P8X A;  5HVK D;  1UDM A;  2VIK A;  1T3X A;  3EG9 B;  1T3Y A;  2NUT A;  2NUP B;  2FH3 A;  1NPH A;  1CNU A;  1COF A;  2W0I A;  5DD2 A;  1YVN G;  2MV2 A;  4CBU G;  3EFO B;  1PD1 A;  4PKI G;  3A5O S;  3EGX B;  2MOT A;  5KYU B;  3A5N S;  1D4X G;  1QPV A;  1ESV S;  2NUT B;  1DEJ S;  3A5M S;  1H1V G;  1WFS A;  1J72 A;  5IVU A;  3L50 A;  1T44 G;  3CIP G;  5HVK B;  1X67 A;  3DAW B; 
#chains in the Genus database with same CATH topology
 1C0G S;  3CJB G;  1Q8X A;  3CJC G;  1F7S A;  1SVR A;  1M4J A;  1EQY S;  3Q2B A;  3FFK A;  1AK7 A;  1C0F S;  4PKG G;  3DA7 A;  1VKK A;  4PKH B;  2XFA A;  5KYW A;  5L6W C;  2FH2 A;  2D8B A;  1SVY A;  5A1M A;  5KYN A;  1HQZ 1;  2L72 A;  2FH1 A;  3EG9 A;  3A5L S;  1TVJ A;  1VFQ A;  3EGD A;  3EH1 A;  3FG6 A;  1M2V A;  1WM4 A;  2QTV A;  4CBW G;  5KYX A;  2MP4 A;  4KEE A;  1CFY A;  4Z94 G;  2LXX A;  1M2O A;  4KED A;  2HD7 A;  4S10 C;  2KVK A;  2VIL A;  1PCX A;  1WNJ A;  2FGH A;  4KEF A;  5KYW B;  2LJ8 A;  1AK6 A;  5KYY A;  1TMW A;  1NLV G;  5KYU A;  1V6F A;  1NM1 G;  1PD0 A;  1YAG G;  3FFN A;  1Q8G A;  1P8Z G;  3CI5 G;  1MDU A;  2LLF A;  1AHQ A;  3EGD B;  1M2V B;  2I2Q A;  2VAC A;  1JHW A;  4CBX G;  1SVQ A;  5KYX B;  2FF3 A;  3EH2 A;  4JD2 H;  3TU5 B;  2NUP A;  1NMD G;  1D0N A;  2FF6 G;  5KYY B;  5FAF A;  2FH4 A;  3EFO A;  3FG7 A;  1KCQ A;  4LIZ A;  4BEX 1;  1T2L A;  2XF1 A;  1RGI G;  5FAE A;  3EGX A;  1P8X A;  5HVK D;  1UDM A;  2VIK A;  1T3X A;  3EG9 B;  1T3Y A;  2NUT A;  2NUP B;  2FH3 A;  1NPH A;  1CNU A;  1COF A;  2W0I A;  5DD2 A;  1YVN G;  2MV2 A;  4CBU G;  3EFO B;  1PD1 A;  4PKI G;  3A5O S;  3EGX B;  2MOT A;  5KYU B;  3A5N S;  1D4X G;  1QPV A;  1ESV S;  2NUT B;  1DEJ S;  3A5M S;  1H1V G;  1WFS A;  1J72 A;  5IVU A;  3L50 A;  1T44 G;  3CIP G;  5HVK B;  1X67 A;  3DAW B; 
#chains in the Genus database with same CATH homology
 1C0G S;  3CJB G;  1Q8X A;  3CJC G;  1F7S A;  1SVR A;  1M4J A;  1EQY S;  3Q2B A;  3FFK A;  1AK7 A;  1C0F S;  4PKG G;  3DA7 A;  1VKK A;  4PKH B;  2XFA A;  5KYW A;  5L6W C;  2FH2 A;  2D8B A;  1SVY A;  5A1M A;  5KYN A;  1HQZ 1;  2L72 A;  2FH1 A;  3EG9 A;  3A5L S;  1TVJ A;  1VFQ A;  3EGD A;  3EH1 A;  3FG6 A;  1M2V A;  1WM4 A;  2QTV A;  4CBW G;  5KYX A;  2MP4 A;  4KEE A;  1CFY A;  4Z94 G;  2LXX A;  1M2O A;  4KED A;  2HD7 A;  4S10 C;  2KVK A;  2VIL A;  1PCX A;  1WNJ A;  2FGH A;  4KEF A;  5KYW B;  2LJ8 A;  1AK6 A;  5KYY A;  1TMW A;  1NLV G;  5KYU A;  1V6F A;  1NM1 G;  1PD0 A;  1YAG G;  3FFN A;  1Q8G A;  1P8Z G;  3CI5 G;  1MDU A;  2LLF A;  1AHQ A;  3EGD B;  1M2V B;  2I2Q A;  2VAC A;  1JHW A;  4CBX G;  1SVQ A;  5KYX B;  2FF3 A;  3EH2 A;  4JD2 H;  3TU5 B;  2NUP A;  1NMD G;  1D0N A;  2FF6 G;  5KYY B;  5FAF A;  2FH4 A;  3EFO A;  3FG7 A;  1KCQ A;  4LIZ A;  4BEX 1;  1T2L A;  2XF1 A;  1RGI G;  5FAE A;  3EGX A;  1P8X A;  5HVK D;  1UDM A;  2VIK A;  1T3X A;  3EG9 B;  1T3Y A;  2NUT A;  2NUP B;  2FH3 A;  1NPH A;  1CNU A;  1COF A;  2W0I A;  5DD2 A;  1YVN G;  2MV2 A;  4CBU G;  3EFO B;  1PD1 A;  4PKI G;  3A5O S;  3EGX B;  2MOT A;  5KYU B;  3A5N S;  1D4X G;  1QPV A;  1ESV S;  2NUT B;  1DEJ S;  3A5M S;  1H1V G;  1WFS A;  1J72 A;  5IVU A;  3L50 A;  1T44 G;  3CIP G;  5HVK B;  1X67 A;  3DAW B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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