3FG7A

The crystal structure of villin domain 6
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
106
structure length
106
Chain Sequence
NLVITPRLFECSNKTGRFLATEIPDFNQDDLEEDDVFLLDVWDQVFFWIGKHANEEEKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Helix-straightening as an activation mechanism in the gelsolin superfamily of actin regulatory proteins
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Villin-1
total genus 26
structure length 106
sequence length 106
chains with identical sequence B
ec nomenclature
pdb deposition date 2008-12-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 3fg7A00
3A5OS 2QTVA 2FH1A 3EH1A 1NMDG 1WM4A 1F7SA 1D4XG 1AK7A 1RGIG 4KEEA 5KYUB 2LJ8A 1M2VB 2MP4A 4LIZA 2D8BA 3CI5G 2VILA 2VACA 3TU5B 1SVQA 1ESVS 1NPHA 5HVKD 2KVKA 4PKGG 3EGDA 2FH4A 2MV2A 3A5MS 1DEJS 1H1VG 2FH2A 5KYYA 1HQZ1 2FH3A 1KCQA 2FF3A 5A1MA 5KYXB 3FG7A 1C0FS 4KEDA 1M2OA 2MOTA 2FF6G 4JD2H 5FAEA 5KYWA 1X67A 2NUTB 1QPVA 4PKHB 4KEFA 1NLVG 3A5LS 4CBXG 2FGHA 1D0NA 1JHWA 3DAWB 3FFNA 2NUPB 4BEX1 2LXXA 3EG9A 3EGXA 5FAFA 2LLFA 1AK6A 1TVJA 1VKKA 2L72A 1M4JA 2I2QA 1P8XA 1WFSA 3EH2A 1T3YA 3FG6A 3Q2BA 1PD0A 5KYNA 1V6FA 5KYUA 1M2VA 5DD2A 1T3XA 1CFYA 3EFOA 1Q8GA 1PD1A 5IVUA 1YAGG 2VIKA 3EGDB 3L50A 1CNUA 3CJCG 3FFKA 5KYYB 1SVYA 1J72A 1TMWA 2W0IA 5KYXA 2XF1A 4S10C 3CIPG 5L6WC 1T44G 5KYWB 1EQYS 1C0GS 2HD7A 2NUTA 1T2LA 4CBUG 1MDUA 1WNJA 3EFOB 1PCXA 1Q8XA 2XFAA 1AHQA 1NM1G 2NUPA 1UDMA 3A5NS 3EG9B 3EGXB 1SVRA 1P8ZG 4PKIG 1COFA 1VFQA 5HVKB 3CJBG 4Z94G 1YVNG 4CBWG
chains in the Genus database with same CATH superfamily
3A5OS 2QTVA 2FH1A 3EH1A 1NMDG 1WM4A 1F7SA 1D4XG 3DA7A 1AK7A 1RGIG 4KEEA 5KYUB 2LJ8A 1M2VB 2MP4A 4LIZA 2D8BA 3CI5G 2VILA 2VACA 3TU5B 1SVQA 1ESVS 1NPHA 5HVKD 2KVKA 4PKGG 3EGDA 2FH4A 2MV2A 3A5MS 1DEJS 1H1VG 2FH2A 5KYYA 1HQZ1 2FH3A 1KCQA 2FF3A 5A1MA 5KYXB 3FG7A 1C0FS 4KEDA 1M2OA 2MOTA 2FF6G 4JD2H 5FAEA 5KYWA 1X67A 2NUTB 1QPVA 4PKHB 4KEFA 1NLVG 3A5LS 4CBXG 2FGHA 1D0NA 1JHWA 3DAWB 3FFNA 2NUPB 4BEX1 2LXXA 3EG9A 3EGXA 5FAFA 2LLFA 1AK6A 1TVJA 1VKKA 2L72A 1M4JA 2I2QA 1P8XA 1WFSA 3EH2A 1T3YA 3FG6A 3Q2BA 1PD0A 5KYNA 1V6FA 5KYUA 1M2VA 5DD2A 1T3XA 1CFYA 3EFOA 1Q8GA 1PD1A 5IVUA 1YAGG 2VIKA 3EGDB 3L50A 1CNUA 3CJCG 3FFKA 5KYYB 1SVYA 1J72A 1TMWA 2W0IA 5KYXA 2XF1A 4S10C 3CIPG 5L6WC 1T44G 5KYWB 1EQYS 1C0GS 2HD7A 2NUTA 1T2LA 4CBUG 1MDUA 1WNJA 3EFOB 1PCXA 1Q8XA 2XFAA 1AHQA 1NM1G 2NUPA 1UDMA 3A5NS 3EG9B 3EGXB 1SVRA 1P8ZG 4PKIG 1COFA 1VFQA 5HVKB 3CJBG 4Z94G 1YVNG 4CBWG
chains in the Genus database with same CATH topology
3A5OS 2QTVA 2FH1A 3EH1A 1NMDG 1WM4A 1F7SA 1D4XG 3DA7A 1AK7A 1RGIG 4KEEA 5KYUB 2LJ8A 1M2VB 2MP4A 4LIZA 2D8BA 3CI5G 2VILA 2VACA 3TU5B 1SVQA 1ESVS 1NPHA 5HVKD 2KVKA 4PKGG 3EGDA 2FH4A 2MV2A 3A5MS 1DEJS 1H1VG 2FH2A 5KYYA 1HQZ1 2FH3A 1KCQA 2FF3A 5A1MA 5KYXB 3FG7A 1C0FS 4KEDA 1M2OA 2MOTA 2FF6G 4JD2H 5FAEA 5KYWA 1X67A 2NUTB 1QPVA 4PKHB 4KEFA 1NLVG 3A5LS 4CBXG 2FGHA 1D0NA 1JHWA 3DAWB 3FFNA 2NUPB 4BEX1 2LXXA 3EG9A 3EGXA 5FAFA 2LLFA 1AK6A 1TVJA 1VKKA 2L72A 1M4JA 2I2QA 1P8XA 1WFSA 3EH2A 1T3YA 3FG6A 3Q2BA 1PD0A 5KYNA 1V6FA 5KYUA 1M2VA 5DD2A 1T3XA 1CFYA 3EFOA 1Q8GA 1PD1A 5IVUA 1YAGG 2VIKA 3EGDB 3L50A 1CNUA 3CJCG 3FFKA 5KYYB 1SVYA 1J72A 1TMWA 2W0IA 5KYXA 2XF1A 4S10C 3CIPG 5L6WC 1T44G 5KYWB 1EQYS 1C0GS 2HD7A 2NUTA 1T2LA 4CBUG 1MDUA 1WNJA 3EFOB 1PCXA 1Q8XA 2XFAA 1AHQA 1NM1G 2NUPA 1UDMA 3A5NS 3EG9B 3EGXB 1SVRA 1P8ZG 4PKIG 1COFA 1VFQA 5HVKB 3CJBG 4Z94G 1YVNG 4CBWG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3A5O S;  2QTV A;  2FH1 A;  3EH1 A;  1NMD G;  1WM4 A;  1F7S A;  1D4X G;  1AK7 A;  1RGI G;  4KEE A;  5KYU B;  2LJ8 A;  1M2V B;  2MP4 A;  4LIZ A;  2D8B A;  3CI5 G;  2VIL A;  2VAC A;  3TU5 B;  1SVQ A;  1ESV S;  1NPH A;  5HVK D;  2KVK A;  4PKG G;  3EGD A;  2FH4 A;  2MV2 A;  3A5M S;  1DEJ S;  1H1V G;  2FH2 A;  5KYY A;  1HQZ 1;  2FH3 A;  1KCQ A;  2FF3 A;  5A1M A;  5KYX B;  3FG7 A;  1C0F S;  4KED A;  1M2O A;  2MOT A;  2FF6 G;  4JD2 H;  5FAE A;  5KYW A;  1X67 A;  2NUT B;  1QPV A;  4PKH B;  4KEF A;  1NLV G;  3A5L S;  4CBX G;  2FGH A;  1D0N A;  1JHW A;  3DAW B;  3FFN A;  2NUP B;  4BEX 1;  2LXX A;  3EG9 A;  3EGX A;  5FAF A;  2LLF A;  1AK6 A;  1TVJ A;  1VKK A;  2L72 A;  1M4J A;  2I2Q A;  1P8X A;  1WFS A;  3EH2 A;  1T3Y A;  3FG6 A;  3Q2B A;  1PD0 A;  5KYN A;  1V6F A;  5KYU A;  1M2V A;  5DD2 A;  1T3X A;  1CFY A;  3EFO A;  1Q8G A;  1PD1 A;  5IVU A;  1YAG G;  2VIK A;  3EGD B;  3L50 A;  1CNU A;  3CJC G;  3FFK A;  5KYY B;  1SVY A;  1J72 A;  1TMW A;  2W0I A;  5KYX A;  2XF1 A;  4S10 C;  3CIP G;  5L6W C;  1T44 G;  5KYW B;  1EQY S;  1C0G S;  2HD7 A;  2NUT A;  1T2L A;  4CBU G;  1MDU A;  1WNJ A;  3EFO B;  1PCX A;  1Q8X A;  2XFA A;  1AHQ A;  1NM1 G;  2NUP A;  1UDM A;  3A5N S;  3EG9 B;  3EGX B;  1SVR A;  1P8Z G;  4PKI G;  1COF A;  1VFQ A;  5HVK B;  3CJB G;  4Z94 G;  1YVN G;  4CBW G; 
#chains in the Genus database with same CATH topology
 3A5O S;  2QTV A;  2FH1 A;  3EH1 A;  1NMD G;  1WM4 A;  1F7S A;  1D4X G;  3DA7 A;  1AK7 A;  1RGI G;  4KEE A;  5KYU B;  2LJ8 A;  1M2V B;  2MP4 A;  4LIZ A;  2D8B A;  3CI5 G;  2VIL A;  2VAC A;  3TU5 B;  1SVQ A;  1ESV S;  1NPH A;  5HVK D;  2KVK A;  4PKG G;  3EGD A;  2FH4 A;  2MV2 A;  3A5M S;  1DEJ S;  1H1V G;  2FH2 A;  5KYY A;  1HQZ 1;  2FH3 A;  1KCQ A;  2FF3 A;  5A1M A;  5KYX B;  3FG7 A;  1C0F S;  4KED A;  1M2O A;  2MOT A;  2FF6 G;  4JD2 H;  5FAE A;  5KYW A;  1X67 A;  2NUT B;  1QPV A;  4PKH B;  4KEF A;  1NLV G;  3A5L S;  4CBX G;  2FGH A;  1D0N A;  1JHW A;  3DAW B;  3FFN A;  2NUP B;  4BEX 1;  2LXX A;  3EG9 A;  3EGX A;  5FAF A;  2LLF A;  1AK6 A;  1TVJ A;  1VKK A;  2L72 A;  1M4J A;  2I2Q A;  1P8X A;  1WFS A;  3EH2 A;  1T3Y A;  3FG6 A;  3Q2B A;  1PD0 A;  5KYN A;  1V6F A;  5KYU A;  1M2V A;  5DD2 A;  1T3X A;  1CFY A;  3EFO A;  1Q8G A;  1PD1 A;  5IVU A;  1YAG G;  2VIK A;  3EGD B;  3L50 A;  1CNU A;  3CJC G;  3FFK A;  5KYY B;  1SVY A;  1J72 A;  1TMW A;  2W0I A;  5KYX A;  2XF1 A;  4S10 C;  3CIP G;  5L6W C;  1T44 G;  5KYW B;  1EQY S;  1C0G S;  2HD7 A;  2NUT A;  1T2L A;  4CBU G;  1MDU A;  1WNJ A;  3EFO B;  1PCX A;  1Q8X A;  2XFA A;  1AHQ A;  1NM1 G;  2NUP A;  1UDM A;  3A5N S;  3EG9 B;  3EGX B;  1SVR A;  1P8Z G;  4PKI G;  1COF A;  1VFQ A;  5HVK B;  3CJB G;  4Z94 G;  1YVN G;  4CBW G; 
#chains in the Genus database with same CATH homology
 3A5O S;  2QTV A;  2FH1 A;  3EH1 A;  1NMD G;  1WM4 A;  1F7S A;  1D4X G;  3DA7 A;  1AK7 A;  1RGI G;  4KEE A;  5KYU B;  2LJ8 A;  1M2V B;  2MP4 A;  4LIZ A;  2D8B A;  3CI5 G;  2VIL A;  2VAC A;  3TU5 B;  1SVQ A;  1ESV S;  1NPH A;  5HVK D;  2KVK A;  4PKG G;  3EGD A;  2FH4 A;  2MV2 A;  3A5M S;  1DEJ S;  1H1V G;  2FH2 A;  5KYY A;  1HQZ 1;  2FH3 A;  1KCQ A;  2FF3 A;  5A1M A;  5KYX B;  3FG7 A;  1C0F S;  4KED A;  1M2O A;  2MOT A;  2FF6 G;  4JD2 H;  5FAE A;  5KYW A;  1X67 A;  2NUT B;  1QPV A;  4PKH B;  4KEF A;  1NLV G;  3A5L S;  4CBX G;  2FGH A;  1D0N A;  1JHW A;  3DAW B;  3FFN A;  2NUP B;  4BEX 1;  2LXX A;  3EG9 A;  3EGX A;  5FAF A;  2LLF A;  1AK6 A;  1TVJ A;  1VKK A;  2L72 A;  1M4J A;  2I2Q A;  1P8X A;  1WFS A;  3EH2 A;  1T3Y A;  3FG6 A;  3Q2B A;  1PD0 A;  5KYN A;  1V6F A;  5KYU A;  1M2V A;  5DD2 A;  1T3X A;  1CFY A;  3EFO A;  1Q8G A;  1PD1 A;  5IVU A;  1YAG G;  2VIK A;  3EGD B;  3L50 A;  1CNU A;  3CJC G;  3FFK A;  5KYY B;  1SVY A;  1J72 A;  1TMW A;  2W0I A;  5KYX A;  2XF1 A;  4S10 C;  3CIP G;  5L6W C;  1T44 G;  5KYW B;  1EQY S;  1C0G S;  2HD7 A;  2NUT A;  1T2L A;  4CBU G;  1MDU A;  1WNJ A;  3EFO B;  1PCX A;  1Q8X A;  2XFA A;  1AHQ A;  1NM1 G;  2NUP A;  1UDM A;  3A5N S;  3EG9 B;  3EGX B;  1SVR A;  1P8Z G;  4PKI G;  1COF A;  1VFQ A;  5HVK B;  3CJB G;  4Z94 G;  1YVN G;  4CBW G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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