5FAEA

N184k pathological variant of gelsolin domain 2 (trigonal form)
Total Genus 31
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
31
sequence length
110
structure length
108
Chain Sequence
GSHHVVPNVVQRLFQVKGRRVVRATEVPVSWESFKNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant.
pubmed doi rcsb
molecule keywords Gelsolin
molecule tags Structural protein
source organism Homo sapiens
total genus 31
structure length 108
sequence length 110
ec nomenclature
pdb deposition date 2015-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 5faeA00
3A5LS 1NM1G 1RGIG 2MOTA 3TU5B 4KEEA 1Q8XA 1KCQA 4PKHB 2MP4A 2LJ8A 5KYYB 1H1VG 2MV2A 3EGXB 3EFOA 5KYUA 5FAEA 2NUPA 3FFKA 2I2QA 1X67A 1Q8GA 3CJBG 2XF1A 2XFAA 3EGDB 1EQYS 3EH1A 2FH3A 2HD7A 3FG7A 1M4JA 1T3XA 1M2VA 2D8BA 1ESVS 5DD2A 1DEJS 5A1MA 1PD0A 2NUTB 1AK6A 1V6FA 2FGHA 1PCXA 1D0NA 4CBWG 1WFSA 2W0IA 1VKKA 3EG9B 4KEFA 1SVYA 1AHQA 3A5MS 1M2OA 5KYNA 1COFA 1JHWA 1TMWA 3EH2A 1WM4A 1SVQA 5KYXA 2QTVA 5KYUB 3EFOB 1UDMA 4S10C 2VILA 4CBUG 1YAGG 1CFYA 5KYYA 1NPHA 1PD1A 3CIPG 2FH2A 1T44G 1QPVA 1M2VB 3Q2BA 1MDUA 2FH1A 2FF3A 5L6WC 5KYWA 1WNJA 3EGDA 1CNUA 1NLVG 3A5OS 2FH4A 3FFNA 3DAWB 1SVRA 3CJCG 5HVKD 4LIZA 2NUPB 5KYXB 1F7SA 2NUTA 4PKGG 4KEDA 4JD2H 1C0FS 3A5NS 1P8ZG 1T3YA 4BEX1 1D4XG 2L72A 5IVUA 1T2LA 3EG9A 5HVKB 2FF6G 3EGXA 1J72A 2VACA 1HQZ1 4PKIG 4Z94G 4CBXG 1P8XA 3L50A 5FAFA 1YVNG 2LLFA 1NMDG 1TVJA 2KVKA 3CI5G 5KYWB 1C0GS 2VIKA 3FG6A 1VFQA 2LXXA 1AK7A
chains in the Genus database with same CATH superfamily
3A5LS 1NM1G 1RGIG 2MOTA 3TU5B 4KEEA 1Q8XA 1KCQA 4PKHB 2MP4A 2LJ8A 5KYYB 1H1VG 2MV2A 3EGXB 3EFOA 5KYUA 5FAEA 2NUPA 3FFKA 2I2QA 1X67A 1Q8GA 3CJBG 2XF1A 2XFAA 3EGDB 1EQYS 3EH1A 2FH3A 2HD7A 3FG7A 1M4JA 1T3XA 1M2VA 2D8BA 1ESVS 5DD2A 1DEJS 5A1MA 1PD0A 2NUTB 1AK6A 1V6FA 2FGHA 1PCXA 1D0NA 4CBWG 1WFSA 2W0IA 1VKKA 3EG9B 4KEFA 1SVYA 1AHQA 3A5MS 1M2OA 5KYNA 1COFA 1JHWA 1TMWA 3EH2A 1WM4A 1SVQA 5KYXA 2QTVA 5KYUB 3EFOB 1UDMA 4S10C 2VILA 3DA7A 4CBUG 1YAGG 1CFYA 5KYYA 1NPHA 1PD1A 3CIPG 2FH2A 1T44G 1QPVA 1M2VB 3Q2BA 1MDUA 2FH1A 2FF3A 5L6WC 5KYWA 1WNJA 3EGDA 1CNUA 1NLVG 3A5OS 2FH4A 3FFNA 3DAWB 1SVRA 3CJCG 5HVKD 4LIZA 2NUPB 5KYXB 1F7SA 2NUTA 4PKGG 4KEDA 4JD2H 1C0FS 3A5NS 1P8ZG 1T3YA 4BEX1 1D4XG 2L72A 5IVUA 1T2LA 3EG9A 5HVKB 2FF6G 3EGXA 1J72A 2VACA 1HQZ1 4PKIG 4Z94G 4CBXG 1P8XA 3L50A 5FAFA 1YVNG 2LLFA 1NMDG 1TVJA 2KVKA 3CI5G 5KYWB 1C0GS 2VIKA 3FG6A 1VFQA 2LXXA 1AK7A
chains in the Genus database with same CATH topology
3A5LS 1NM1G 1RGIG 2MOTA 3TU5B 4KEEA 1Q8XA 1KCQA 4PKHB 2MP4A 2LJ8A 5KYYB 1H1VG 2MV2A 3EGXB 3EFOA 5KYUA 5FAEA 2NUPA 3FFKA 2I2QA 1X67A 1Q8GA 3CJBG 2XF1A 2XFAA 3EGDB 1EQYS 3EH1A 2FH3A 2HD7A 3FG7A 1M4JA 1T3XA 1M2VA 2D8BA 1ESVS 5DD2A 1DEJS 5A1MA 1PD0A 2NUTB 1AK6A 1V6FA 2FGHA 1PCXA 1D0NA 4CBWG 1WFSA 2W0IA 1VKKA 3EG9B 4KEFA 1SVYA 1AHQA 3A5MS 1M2OA 5KYNA 1COFA 1JHWA 1TMWA 3EH2A 1WM4A 1SVQA 5KYXA 2QTVA 5KYUB 3EFOB 1UDMA 4S10C 2VILA 3DA7A 4CBUG 1YAGG 1CFYA 5KYYA 1NPHA 1PD1A 3CIPG 2FH2A 1T44G 1QPVA 1M2VB 3Q2BA 1MDUA 2FH1A 2FF3A 5L6WC 5KYWA 1WNJA 3EGDA 1CNUA 1NLVG 3A5OS 2FH4A 3FFNA 3DAWB 1SVRA 3CJCG 5HVKD 4LIZA 2NUPB 5KYXB 1F7SA 2NUTA 4PKGG 4KEDA 4JD2H 1C0FS 3A5NS 1P8ZG 1T3YA 4BEX1 1D4XG 2L72A 5IVUA 1T2LA 3EG9A 5HVKB 2FF6G 3EGXA 1J72A 2VACA 1HQZ1 4PKIG 4Z94G 4CBXG 1P8XA 3L50A 5FAFA 1YVNG 2LLFA 1NMDG 1TVJA 2KVKA 3CI5G 5KYWB 1C0GS 2VIKA 3FG6A 1VFQA 2LXXA 1AK7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3A5L S;  1NM1 G;  1RGI G;  2MOT A;  3TU5 B;  4KEE A;  1Q8X A;  1KCQ A;  4PKH B;  2MP4 A;  2LJ8 A;  5KYY B;  1H1V G;  2MV2 A;  3EGX B;  3EFO A;  5KYU A;  5FAE A;  2NUP A;  3FFK A;  2I2Q A;  1X67 A;  1Q8G A;  3CJB G;  2XF1 A;  2XFA A;  3EGD B;  1EQY S;  3EH1 A;  2FH3 A;  2HD7 A;  3FG7 A;  1M4J A;  1T3X A;  1M2V A;  2D8B A;  1ESV S;  5DD2 A;  1DEJ S;  5A1M A;  1PD0 A;  2NUT B;  1AK6 A;  1V6F A;  2FGH A;  1PCX A;  1D0N A;  4CBW G;  1WFS A;  2W0I A;  1VKK A;  3EG9 B;  4KEF A;  1SVY A;  1AHQ A;  3A5M S;  1M2O A;  5KYN A;  1COF A;  1JHW A;  1TMW A;  3EH2 A;  1WM4 A;  1SVQ A;  5KYX A;  2QTV A;  5KYU B;  3EFO B;  1UDM A;  4S10 C;  2VIL A;  4CBU G;  1YAG G;  1CFY A;  5KYY A;  1NPH A;  1PD1 A;  3CIP G;  2FH2 A;  1T44 G;  1QPV A;  1M2V B;  3Q2B A;  1MDU A;  2FH1 A;  2FF3 A;  5L6W C;  5KYW A;  1WNJ A;  3EGD A;  1CNU A;  1NLV G;  3A5O S;  2FH4 A;  3FFN A;  3DAW B;  1SVR A;  3CJC G;  5HVK D;  4LIZ A;  2NUP B;  5KYX B;  1F7S A;  2NUT A;  4PKG G;  4KED A;  4JD2 H;  1C0F S;  3A5N S;  1P8Z G;  1T3Y A;  4BEX 1;  1D4X G;  2L72 A;  5IVU A;  1T2L A;  3EG9 A;  5HVK B;  2FF6 G;  3EGX A;  1J72 A;  2VAC A;  1HQZ 1;  4PKI G;  4Z94 G;  4CBX G;  1P8X A;  3L50 A;  5FAF A;  1YVN G;  2LLF A;  1NMD G;  1TVJ A;  2KVK A;  3CI5 G;  5KYW B;  1C0G S;  2VIK A;  3FG6 A;  1VFQ A;  2LXX A;  1AK7 A; 
#chains in the Genus database with same CATH topology
 3A5L S;  1NM1 G;  1RGI G;  2MOT A;  3TU5 B;  4KEE A;  1Q8X A;  1KCQ A;  4PKH B;  2MP4 A;  2LJ8 A;  5KYY B;  1H1V G;  2MV2 A;  3EGX B;  3EFO A;  5KYU A;  5FAE A;  2NUP A;  3FFK A;  2I2Q A;  1X67 A;  1Q8G A;  3CJB G;  2XF1 A;  2XFA A;  3EGD B;  1EQY S;  3EH1 A;  2FH3 A;  2HD7 A;  3FG7 A;  1M4J A;  1T3X A;  1M2V A;  2D8B A;  1ESV S;  5DD2 A;  1DEJ S;  5A1M A;  1PD0 A;  2NUT B;  1AK6 A;  1V6F A;  2FGH A;  1PCX A;  1D0N A;  4CBW G;  1WFS A;  2W0I A;  1VKK A;  3EG9 B;  4KEF A;  1SVY A;  1AHQ A;  3A5M S;  1M2O A;  5KYN A;  1COF A;  1JHW A;  1TMW A;  3EH2 A;  1WM4 A;  1SVQ A;  5KYX A;  2QTV A;  5KYU B;  3EFO B;  1UDM A;  4S10 C;  2VIL A;  3DA7 A;  4CBU G;  1YAG G;  1CFY A;  5KYY A;  1NPH A;  1PD1 A;  3CIP G;  2FH2 A;  1T44 G;  1QPV A;  1M2V B;  3Q2B A;  1MDU A;  2FH1 A;  2FF3 A;  5L6W C;  5KYW A;  1WNJ A;  3EGD A;  1CNU A;  1NLV G;  3A5O S;  2FH4 A;  3FFN A;  3DAW B;  1SVR A;  3CJC G;  5HVK D;  4LIZ A;  2NUP B;  5KYX B;  1F7S A;  2NUT A;  4PKG G;  4KED A;  4JD2 H;  1C0F S;  3A5N S;  1P8Z G;  1T3Y A;  4BEX 1;  1D4X G;  2L72 A;  5IVU A;  1T2L A;  3EG9 A;  5HVK B;  2FF6 G;  3EGX A;  1J72 A;  2VAC A;  1HQZ 1;  4PKI G;  4Z94 G;  4CBX G;  1P8X A;  3L50 A;  5FAF A;  1YVN G;  2LLF A;  1NMD G;  1TVJ A;  2KVK A;  3CI5 G;  5KYW B;  1C0G S;  2VIK A;  3FG6 A;  1VFQ A;  2LXX A;  1AK7 A; 
#chains in the Genus database with same CATH homology
 3A5L S;  1NM1 G;  1RGI G;  2MOT A;  3TU5 B;  4KEE A;  1Q8X A;  1KCQ A;  4PKH B;  2MP4 A;  2LJ8 A;  5KYY B;  1H1V G;  2MV2 A;  3EGX B;  3EFO A;  5KYU A;  5FAE A;  2NUP A;  3FFK A;  2I2Q A;  1X67 A;  1Q8G A;  3CJB G;  2XF1 A;  2XFA A;  3EGD B;  1EQY S;  3EH1 A;  2FH3 A;  2HD7 A;  3FG7 A;  1M4J A;  1T3X A;  1M2V A;  2D8B A;  1ESV S;  5DD2 A;  1DEJ S;  5A1M A;  1PD0 A;  2NUT B;  1AK6 A;  1V6F A;  2FGH A;  1PCX A;  1D0N A;  4CBW G;  1WFS A;  2W0I A;  1VKK A;  3EG9 B;  4KEF A;  1SVY A;  1AHQ A;  3A5M S;  1M2O A;  5KYN A;  1COF A;  1JHW A;  1TMW A;  3EH2 A;  1WM4 A;  1SVQ A;  5KYX A;  2QTV A;  5KYU B;  3EFO B;  1UDM A;  4S10 C;  2VIL A;  3DA7 A;  4CBU G;  1YAG G;  1CFY A;  5KYY A;  1NPH A;  1PD1 A;  3CIP G;  2FH2 A;  1T44 G;  1QPV A;  1M2V B;  3Q2B A;  1MDU A;  2FH1 A;  2FF3 A;  5L6W C;  5KYW A;  1WNJ A;  3EGD A;  1CNU A;  1NLV G;  3A5O S;  2FH4 A;  3FFN A;  3DAW B;  1SVR A;  3CJC G;  5HVK D;  4LIZ A;  2NUP B;  5KYX B;  1F7S A;  2NUT A;  4PKG G;  4KED A;  4JD2 H;  1C0F S;  3A5N S;  1P8Z G;  1T3Y A;  4BEX 1;  1D4X G;  2L72 A;  5IVU A;  1T2L A;  3EG9 A;  5HVK B;  2FF6 G;  3EGX A;  1J72 A;  2VAC A;  1HQZ 1;  4PKI G;  4Z94 G;  4CBX G;  1P8X A;  3L50 A;  5FAF A;  1YVN G;  2LLF A;  1NMD G;  1TVJ A;  2KVK A;  3CI5 G;  5KYW B;  1C0G S;  2VIK A;  3FG6 A;  1VFQ A;  2LXX A;  1AK7 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...