5FAFA

N184k pathological variant of gelsolin domain 2 (orthorhombic form)
Total Genus 33
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
33
sequence length
113
structure length
113
Chain Sequence
GSHHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFKNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Gelsolin
total genus 33
structure length 113
sequence length 113
ec nomenclature
pdb deposition date 2015-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 5fafA00
1D4XG 1AK6A 2MV2A 3EGDA 5KYYB 3EGXB 1M2VB 2FH4A 2KVKA 4BEX1 1CNUA 5KYYA 4JD2H 2HD7A 4CBXG 2FF3A 1DEJS 3CJCG 1P8ZG 3EFOA 2FH1A 1CFYA 3FG7A 4PKIG 5KYWB 4CBUG 1F7SA 1PD0A 1SVYA 3FFNA 5KYWA 1PCXA 2VIKA 2LLFA 5KYXB 3EG9A 3EH2A 2NUTB 1PD1A 2QTVA 3A5OS 2LJ8A 2NUTA 3CIPG 5FAEA 1T3YA 4PKHB 2FF6G 1SVRA 2MP4A 3EGXA 4KEDA 1M2VA 2L72A 1VKKA 3CI5G 1YAGG 1VFQA 1HQZ1 3FFKA 1NM1G 1TVJA 1J72A 2NUPB 3A5LS 1T44G 4KEFA 1KCQA 2I2QA 5IVUA 1JHWA 2XF1A 3Q2BA 4S10C 2XFAA 1C0FS 4Z94G 1COFA 1M2OA 1YVNG 3L50A 3A5NS 5KYXA 1ESVS 1NLVG 5KYUB 1Q8GA 5FAFA 1RGIG 1NPHA 2VACA 2VILA 3TU5B 5L6WC 1WFSA 5HVKB 1V6FA 3CJBG 1M4JA 2LXXA 1AHQA 3DAWB 3EGDB 5DD2A 2NUPA 1T2LA 1H1VG 1TMWA 1AK7A 2MOTA 1UDMA 1QPVA 4KEEA 1D0NA 5A1MA 5HVKD 3FG6A 4LIZA 3EFOB 2FH3A 1WM4A 3EH1A 5KYNA 3A5MS 4CBWG 1MDUA 5KYUA 1X67A 1Q8XA 1C0GS 1T3XA 1WNJA 2FGHA 2W0IA 3EG9B 2FH2A 1EQYS 1NMDG 4PKGG 1SVQA 2D8BA 1P8XA
chains in the Genus database with same CATH superfamily
1D4XG 1AK6A 2MV2A 3EGDA 5KYYB 3EGXB 1M2VB 2FH4A 2KVKA 4BEX1 1CNUA 5KYYA 4JD2H 2HD7A 4CBXG 2FF3A 1DEJS 3CJCG 1P8ZG 3EFOA 2FH1A 1CFYA 3FG7A 4PKIG 5KYWB 4CBUG 1F7SA 1PD0A 1SVYA 3FFNA 5KYWA 1PCXA 2VIKA 2LLFA 5KYXB 3EG9A 3EH2A 2NUTB 1PD1A 2QTVA 3A5OS 2LJ8A 2NUTA 3CIPG 5FAEA 1T3YA 4PKHB 2FF6G 1SVRA 2MP4A 3EGXA 4KEDA 1M2VA 2L72A 1VKKA 3CI5G 1YAGG 1VFQA 1HQZ1 3FFKA 1NM1G 1TVJA 1J72A 2NUPB 3A5LS 1T44G 4KEFA 1KCQA 2I2QA 5IVUA 1JHWA 2XF1A 3Q2BA 4S10C 2XFAA 1C0FS 4Z94G 1COFA 1M2OA 1YVNG 3L50A 3A5NS 5KYXA 1ESVS 1NLVG 5KYUB 1Q8GA 5FAFA 1RGIG 1NPHA 2VACA 2VILA 3TU5B 5L6WC 1WFSA 5HVKB 1V6FA 3CJBG 1M4JA 2LXXA 1AHQA 3DAWB 3EGDB 5DD2A 2NUPA 1T2LA 1H1VG 1TMWA 1AK7A 2MOTA 1UDMA 1QPVA 4KEEA 1D0NA 5A1MA 5HVKD 3FG6A 4LIZA 3EFOB 2FH3A 1WM4A 3EH1A 5KYNA 3A5MS 4CBWG 3DA7A 1MDUA 5KYUA 1X67A 1Q8XA 1C0GS 1T3XA 1WNJA 2FGHA 2W0IA 3EG9B 2FH2A 1EQYS 1NMDG 4PKGG 1SVQA 2D8BA 1P8XA
chains in the Genus database with same CATH topology
1D4XG 1AK6A 2MV2A 3EGDA 5KYYB 3EGXB 1M2VB 2FH4A 2KVKA 4BEX1 1CNUA 5KYYA 4JD2H 2HD7A 4CBXG 2FF3A 1DEJS 3CJCG 1P8ZG 3EFOA 2FH1A 1CFYA 3FG7A 4PKIG 5KYWB 4CBUG 1F7SA 1PD0A 1SVYA 3FFNA 5KYWA 1PCXA 2VIKA 2LLFA 5KYXB 3EG9A 3EH2A 2NUTB 1PD1A 2QTVA 3A5OS 2LJ8A 2NUTA 3CIPG 5FAEA 1T3YA 4PKHB 2FF6G 1SVRA 2MP4A 3EGXA 4KEDA 1M2VA 2L72A 1VKKA 3CI5G 1YAGG 1VFQA 1HQZ1 3FFKA 1NM1G 1TVJA 1J72A 2NUPB 3A5LS 1T44G 4KEFA 1KCQA 2I2QA 5IVUA 1JHWA 2XF1A 3Q2BA 4S10C 2XFAA 1C0FS 4Z94G 1COFA 1M2OA 1YVNG 3L50A 3A5NS 5KYXA 1ESVS 1NLVG 5KYUB 1Q8GA 5FAFA 1RGIG 1NPHA 2VACA 2VILA 3TU5B 5L6WC 1WFSA 5HVKB 1V6FA 3CJBG 1M4JA 2LXXA 1AHQA 3DAWB 3EGDB 5DD2A 2NUPA 1T2LA 1H1VG 1TMWA 1AK7A 2MOTA 1UDMA 1QPVA 4KEEA 1D0NA 5A1MA 5HVKD 3FG6A 4LIZA 3EFOB 2FH3A 1WM4A 3EH1A 5KYNA 3A5MS 4CBWG 3DA7A 1MDUA 5KYUA 1X67A 1Q8XA 1C0GS 1T3XA 1WNJA 2FGHA 2W0IA 3EG9B 2FH2A 1EQYS 1NMDG 4PKGG 1SVQA 2D8BA 1P8XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1D4X G;  1AK6 A;  2MV2 A;  3EGD A;  5KYY B;  3EGX B;  1M2V B;  2FH4 A;  2KVK A;  4BEX 1;  1CNU A;  5KYY A;  4JD2 H;  2HD7 A;  4CBX G;  2FF3 A;  1DEJ S;  3CJC G;  1P8Z G;  3EFO A;  2FH1 A;  1CFY A;  3FG7 A;  4PKI G;  5KYW B;  4CBU G;  1F7S A;  1PD0 A;  1SVY A;  3FFN A;  5KYW A;  1PCX A;  2VIK A;  2LLF A;  5KYX B;  3EG9 A;  3EH2 A;  2NUT B;  1PD1 A;  2QTV A;  3A5O S;  2LJ8 A;  2NUT A;  3CIP G;  5FAE A;  1T3Y A;  4PKH B;  2FF6 G;  1SVR A;  2MP4 A;  3EGX A;  4KED A;  1M2V A;  2L72 A;  1VKK A;  3CI5 G;  1YAG G;  1VFQ A;  1HQZ 1;  3FFK A;  1NM1 G;  1TVJ A;  1J72 A;  2NUP B;  3A5L S;  1T44 G;  4KEF A;  1KCQ A;  2I2Q A;  5IVU A;  1JHW A;  2XF1 A;  3Q2B A;  4S10 C;  2XFA A;  1C0F S;  4Z94 G;  1COF A;  1M2O A;  1YVN G;  3L50 A;  3A5N S;  5KYX A;  1ESV S;  1NLV G;  5KYU B;  1Q8G A;  5FAF A;  1RGI G;  1NPH A;  2VAC A;  2VIL A;  3TU5 B;  5L6W C;  1WFS A;  5HVK B;  1V6F A;  3CJB G;  1M4J A;  2LXX A;  1AHQ A;  3DAW B;  3EGD B;  5DD2 A;  2NUP A;  1T2L A;  1H1V G;  1TMW A;  1AK7 A;  2MOT A;  1UDM A;  1QPV A;  4KEE A;  1D0N A;  5A1M A;  5HVK D;  3FG6 A;  4LIZ A;  3EFO B;  2FH3 A;  1WM4 A;  3EH1 A;  5KYN A;  3A5M S;  4CBW G;  1MDU A;  5KYU A;  1X67 A;  1Q8X A;  1C0G S;  1T3X A;  1WNJ A;  2FGH A;  2W0I A;  3EG9 B;  2FH2 A;  1EQY S;  1NMD G;  4PKG G;  1SVQ A;  2D8B A;  1P8X A; 
#chains in the Genus database with same CATH topology
 1D4X G;  1AK6 A;  2MV2 A;  3EGD A;  5KYY B;  3EGX B;  1M2V B;  2FH4 A;  2KVK A;  4BEX 1;  1CNU A;  5KYY A;  4JD2 H;  2HD7 A;  4CBX G;  2FF3 A;  1DEJ S;  3CJC G;  1P8Z G;  3EFO A;  2FH1 A;  1CFY A;  3FG7 A;  4PKI G;  5KYW B;  4CBU G;  1F7S A;  1PD0 A;  1SVY A;  3FFN A;  5KYW A;  1PCX A;  2VIK A;  2LLF A;  5KYX B;  3EG9 A;  3EH2 A;  2NUT B;  1PD1 A;  2QTV A;  3A5O S;  2LJ8 A;  2NUT A;  3CIP G;  5FAE A;  1T3Y A;  4PKH B;  2FF6 G;  1SVR A;  2MP4 A;  3EGX A;  4KED A;  1M2V A;  2L72 A;  1VKK A;  3CI5 G;  1YAG G;  1VFQ A;  1HQZ 1;  3FFK A;  1NM1 G;  1TVJ A;  1J72 A;  2NUP B;  3A5L S;  1T44 G;  4KEF A;  1KCQ A;  2I2Q A;  5IVU A;  1JHW A;  2XF1 A;  3Q2B A;  4S10 C;  2XFA A;  1C0F S;  4Z94 G;  1COF A;  1M2O A;  1YVN G;  3L50 A;  3A5N S;  5KYX A;  1ESV S;  1NLV G;  5KYU B;  1Q8G A;  5FAF A;  1RGI G;  1NPH A;  2VAC A;  2VIL A;  3TU5 B;  5L6W C;  1WFS A;  5HVK B;  1V6F A;  3CJB G;  1M4J A;  2LXX A;  1AHQ A;  3DAW B;  3EGD B;  5DD2 A;  2NUP A;  1T2L A;  1H1V G;  1TMW A;  1AK7 A;  2MOT A;  1UDM A;  1QPV A;  4KEE A;  1D0N A;  5A1M A;  5HVK D;  3FG6 A;  4LIZ A;  3EFO B;  2FH3 A;  1WM4 A;  3EH1 A;  5KYN A;  3A5M S;  4CBW G;  3DA7 A;  1MDU A;  5KYU A;  1X67 A;  1Q8X A;  1C0G S;  1T3X A;  1WNJ A;  2FGH A;  2W0I A;  3EG9 B;  2FH2 A;  1EQY S;  1NMD G;  4PKG G;  1SVQ A;  2D8B A;  1P8X A; 
#chains in the Genus database with same CATH homology
 1D4X G;  1AK6 A;  2MV2 A;  3EGD A;  5KYY B;  3EGX B;  1M2V B;  2FH4 A;  2KVK A;  4BEX 1;  1CNU A;  5KYY A;  4JD2 H;  2HD7 A;  4CBX G;  2FF3 A;  1DEJ S;  3CJC G;  1P8Z G;  3EFO A;  2FH1 A;  1CFY A;  3FG7 A;  4PKI G;  5KYW B;  4CBU G;  1F7S A;  1PD0 A;  1SVY A;  3FFN A;  5KYW A;  1PCX A;  2VIK A;  2LLF A;  5KYX B;  3EG9 A;  3EH2 A;  2NUT B;  1PD1 A;  2QTV A;  3A5O S;  2LJ8 A;  2NUT A;  3CIP G;  5FAE A;  1T3Y A;  4PKH B;  2FF6 G;  1SVR A;  2MP4 A;  3EGX A;  4KED A;  1M2V A;  2L72 A;  1VKK A;  3CI5 G;  1YAG G;  1VFQ A;  1HQZ 1;  3FFK A;  1NM1 G;  1TVJ A;  1J72 A;  2NUP B;  3A5L S;  1T44 G;  4KEF A;  1KCQ A;  2I2Q A;  5IVU A;  1JHW A;  2XF1 A;  3Q2B A;  4S10 C;  2XFA A;  1C0F S;  4Z94 G;  1COF A;  1M2O A;  1YVN G;  3L50 A;  3A5N S;  5KYX A;  1ESV S;  1NLV G;  5KYU B;  1Q8G A;  5FAF A;  1RGI G;  1NPH A;  2VAC A;  2VIL A;  3TU5 B;  5L6W C;  1WFS A;  5HVK B;  1V6F A;  3CJB G;  1M4J A;  2LXX A;  1AHQ A;  3DAW B;  3EGD B;  5DD2 A;  2NUP A;  1T2L A;  1H1V G;  1TMW A;  1AK7 A;  2MOT A;  1UDM A;  1QPV A;  4KEE A;  1D0N A;  5A1M A;  5HVK D;  3FG6 A;  4LIZ A;  3EFO B;  2FH3 A;  1WM4 A;  3EH1 A;  5KYN A;  3A5M S;  4CBW G;  3DA7 A;  1MDU A;  5KYU A;  1X67 A;  1Q8X A;  1C0G S;  1T3X A;  1WNJ A;  2FGH A;  2W0I A;  3EG9 B;  2FH2 A;  1EQY S;  1NMD G;  4PKG G;  1SVQ A;  2D8B A;  1P8X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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