1FZGC

Crystal structure of fragment d from human fibrinogen with the peptide ligand gly-his-arg-pro-amide
Total Genus 87
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
292
structure length
292
Chain Sequence
THDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.
pubmed doi rcsb
molecule tags Blood coagulation
molecule keywords FIBRINOGEN
total genus 87
structure length 292
sequence length 292
chains with identical sequence F
ec nomenclature
pdb deposition date 1999-01-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00147 Fibrinogen_C Fibrinogen beta and gamma chains, C-terminal globular domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.215.10 Alpha Beta Alpha-Beta Complex Gamma Fibrinogen; Chain A, domain 1 Gamma Fibrinogen, chain A, domain 1 1fzgC01
4.10.530.10 Few Secondary Structures Irregular Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2 Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 1fzgC02
2J61B 1FZBC 2J5ZA 3GHGC 1FZCC 4M7HA 3BVHC 1FZAC 2FIBA 2J1GA 3H32B 4JZCA 4M7FA 1FZEB 1Z3SA 1RE4C 2OYHB 1LWUC 1LTJC 3H32C 1FZGC 2GY7A 1FZEC 2J61A 2JHHC 2J64A 2J3FA 2OYHC 2J0HA 2JHLF 1N86B 1M1JC 4ZFGA 1FIBA 4NYTA 1FIDA 2H43B 3HUSB 2Q9IB 2OYIB 2J0GA 2J3FD 1N86C 2HPCB 2H43C 2Z4EB 3HUSC 2Q9IC 2FFDB 4JYOX 1RF0B 1FZFB 2HODB 1N73B 2JHKF 2J3GA 1RE3B 2J3OA 2J0YA 4EPUA 1FZBB 2FFDC 1FZDA 2XNXB 1JC9A 1RF0C 1FZFC 2HODC 2HLOB 1FZAB 1LT9B 2WNPF 1RF1B 2J3UA 3E1IB 2J2PA 2XNXC 2D39A 1Z3UA 1RE4B 2OYIC 2HLOC 2JHIF 1LT9C 1LWUB 1LTJB 2HPCC 1FICA 1FZGB 2Z4EC 1RF1C 2JHMF 3E1IC 4R9JA 3FIBA 4R9TA 1N73C 1FZCB 1M1JB 3BVHB 2J60A 1RE3C
chains in the Genus database with same CATH superfamily
2J61B 1FZBC 2J5ZA 3GHGC 1FZCC 4M7HA 3BVHC 1FZAC 2FIBA 2J1GA 3H32B 4JZCA 4M7FA 1FZEB 1Z3SA 1RE4C 2OYHB 1LWUC 1LTJC 3H32C 1FZGC 2GY7A 1FZEC 2J61A 2JHHC 2J64A 2J3FA 2OYHC 2J0HA 2JHLF 1N86B 1M1JC 4ZFGA 1FIBA 4NYTA 1FIDA 2H43B 3HUSB 2Q9IB 2OYIB 2J0GA 2J3FD 1N86C 2HPCB 2H43C 2Z4EB 3HUSC 2Q9IC 2FFDB 4JYOX 1RF0B 1FZFB 2HODB 1N73B 2JHKF 2J3GA 1RE3B 2J3OA 2J0YA 4EPUA 1FZBB 2FFDC 1FZDA 2XNXB 1JC9A 1RF0C 3GHGB 1FZFC 2HODC 2HLOB 1FZAB 1LT9B 2WNPF 1RF1B 2J3UA 3E1IB 2J2PA 2XNXC 2D39A 1Z3UA 1RE4B 2OYIC 2HLOC 2JHIF 1LT9C 1LWUB 1LTJB 2HPCC 1FICA 1FZGB 2Z4EC 1RF1C 2JHMF 3E1IC 4R9JA 3FIBA 4R9TA 1N73C 1FZCB 1M1JB 3BVHB 2J60A 1RE3C
chains in the Genus database with same CATH topology
2J61B 1FZBC 2J5ZA 3GHGC 1FZCC 4M7HA 3BVHC 1FZAC 2FIBA 2J1GA 3H32B 4JZCA 4M7FA 1FZEB 1Z3SA 1RE4C 2OYHB 1LWUC 1LTJC 3H32C 1FZGC 2GY7A 1FZEC 2J61A 2JHHC 2J64A 2J3FA 2OYHC 2J0HA 2JHLF 1N86B 1M1JC 4ZFGA 1FIBA 4NYTA 1FIDA 2H43B 3HUSB 2Q9IB 2OYIB 2J0GA 2J3FD 1N86C 2HPCB 2H43C 2Z4EB 3HUSC 2Q9IC 2FFDB 4JYOX 1RF0B 1FZFB 2HODB 1N73B 2JHKF 2J3GA 1RE3B 2J3OA 2J0YA 4EPUA 1FZBB 2FFDC 1FZDA 2XNXB 1JC9A 1RF0C 1FZFC 2HODC 2HLOB 1FZAB 1LT9B 2WNPF 1RF1B 2J3UA 3E1IB 2J2PA 2XNXC 2D39A 1Z3UA 1RE4B 2OYIC 2HLOC 2JHIF 1LT9C 1LWUB 1LTJB 2HPCC 1FICA 1FZGB 2Z4EC 1RF1C 2JHMF 3E1IC 4R9JA 3FIBA 4R9TA 1N73C 1FZCB 1M1JB 3BVHB 2J60A 1RE3C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2J61 B;  1FZB C;  2J5Z A;  3GHG C;  1FZC C;  4M7H A;  3BVH C;  1FZA C;  2FIB A;  2J1G A;  3H32 B;  4JZC A;  4M7F A;  1FZE B;  1Z3S A;  1RE4 C;  2OYH B;  1LWU C;  1LTJ C;  3H32 C;  1FZG C;  2GY7 A;  1FZE C;  2J61 A;  2JHH C;  2J64 A;  2J3F A;  2OYH C;  2J0H A;  2JHL F;  1N86 B;  1M1J C;  4ZFG A;  1FIB A;  4NYT A;  1FID A;  2H43 B;  3HUS B;  2Q9I B;  2OYI B;  2J0G A;  2J3F D;  1N86 C;  2HPC B;  2H43 C;  2Z4E B;  3HUS C;  2Q9I C;  2FFD B;  4JYO X;  1RF0 B;  1FZF B;  2HOD B;  1N73 B;  2JHK F;  2J3G A;  1RE3 B;  2J3O A;  2J0Y A;  4EPU A;  1FZB B;  2FFD C;  1FZD A;  2XNX B;  1JC9 A;  1RF0 C;  1FZF C;  2HOD C;  2HLO B;  1FZA B;  1LT9 B;  2WNP F;  1RF1 B;  2J3U A;  3E1I B;  2J2P A;  2XNX C;  2D39 A;  1Z3U A;  1RE4 B;  2OYI C;  2HLO C;  2JHI F;  1LT9 C;  1LWU B;  1LTJ B;  2HPC C;  1FIC A;  1FZG B;  2Z4E C;  1RF1 C;  2JHM F;  3E1I C;  4R9J A;  3FIB A;  4R9T A;  1N73 C;  1FZC B;  1M1J B;  3BVH B;  2J60 A;  1RE3 C; 
#chains in the Genus database with same CATH topology
 2J61 B;  1FZB C;  2J5Z A;  3GHG C;  1FZC C;  4M7H A;  3BVH C;  1FZA C;  2FIB A;  2J1G A;  3H32 B;  4JZC A;  4M7F A;  1FZE B;  1Z3S A;  1RE4 C;  2OYH B;  1LWU C;  1LTJ C;  3H32 C;  1FZG C;  2GY7 A;  1FZE C;  2J61 A;  2JHH C;  2J64 A;  2J3F A;  2OYH C;  2J0H A;  2JHL F;  1N86 B;  1M1J C;  4ZFG A;  1FIB A;  4NYT A;  1FID A;  2H43 B;  3HUS B;  2Q9I B;  2OYI B;  2J0G A;  2J3F D;  1N86 C;  2HPC B;  2H43 C;  2Z4E B;  3HUS C;  2Q9I C;  2FFD B;  4JYO X;  1RF0 B;  1FZF B;  2HOD B;  1N73 B;  2JHK F;  2J3G A;  1RE3 B;  2J3O A;  2J0Y A;  4EPU A;  1FZB B;  2FFD C;  1FZD A;  2XNX B;  1JC9 A;  1RF0 C;  3GHG B;  1FZF C;  2HOD C;  2HLO B;  1FZA B;  1LT9 B;  2WNP F;  1RF1 B;  2J3U A;  3E1I B;  2J2P A;  2XNX C;  2D39 A;  1Z3U A;  1RE4 B;  2OYI C;  2HLO C;  2JHI F;  1LT9 C;  1LWU B;  1LTJ B;  2HPC C;  1FIC A;  1FZG B;  2Z4E C;  1RF1 C;  2JHM F;  3E1I C;  4R9J A;  3FIB A;  4R9T A;  1N73 C;  1FZC B;  1M1J B;  3BVH B;  2J60 A;  1RE3 C; 
#chains in the Genus database with same CATH homology
 2J61 B;  1FZB C;  2J5Z A;  3GHG C;  1FZC C;  4M7H A;  3BVH C;  1FZA C;  2FIB A;  2J1G A;  3H32 B;  4JZC A;  4M7F A;  1FZE B;  1Z3S A;  1RE4 C;  2OYH B;  1LWU C;  1LTJ C;  3H32 C;  1FZG C;  2GY7 A;  1FZE C;  2J61 A;  2JHH C;  2J64 A;  2J3F A;  2OYH C;  2J0H A;  2JHL F;  1N86 B;  1M1J C;  4ZFG A;  1FIB A;  4NYT A;  1FID A;  2H43 B;  3HUS B;  2Q9I B;  2OYI B;  2J0G A;  2J3F D;  1N86 C;  2HPC B;  2H43 C;  2Z4E B;  3HUS C;  2Q9I C;  2FFD B;  4JYO X;  1RF0 B;  1FZF B;  2HOD B;  1N73 B;  2JHK F;  2J3G A;  1RE3 B;  2J3O A;  2J0Y A;  4EPU A;  1FZB B;  2FFD C;  1FZD A;  2XNX B;  1JC9 A;  1RF0 C;  1FZF C;  2HOD C;  2HLO B;  1FZA B;  1LT9 B;  2WNP F;  1RF1 B;  2J3U A;  3E1I B;  2J2P A;  2XNX C;  2D39 A;  1Z3U A;  1RE4 B;  2OYI C;  2HLO C;  2JHI F;  1LT9 C;  1LWU B;  1LTJ B;  2HPC C;  1FIC A;  1FZG B;  2Z4E C;  1RF1 C;  2JHM F;  3E1I C;  4R9J A;  3FIB A;  4R9T A;  1N73 C;  1FZC B;  1M1J B;  3BVH B;  2J60 A;  1RE3 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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