2H43C

Crystal structure of human fragment d complexed with ala-his-arg-pro-amide
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
290
structure length
290
Chain Sequence
HDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Differences in Binding Specificity for the Homologous gamma- and beta-Chain "Holes" on Fibrinogen: Exclusive Binding of Ala-His-Arg-Pro-amide by the beta-Chain Hole.
pubmed doi rcsb
molecule keywords Fibrinogen alpha chain
molecule tags Blood clotting
total genus 75
structure length 290
sequence length 290
chains with identical sequence F
ec nomenclature
pdb deposition date 2006-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00147 Fibrinogen_C Fibrinogen beta and gamma chains, C-terminal globular domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.215.10 Alpha Beta Alpha-Beta Complex Gamma Fibrinogen; Chain A, domain 1 Gamma Fibrinogen, chain A, domain 1 2h43C01
4.10.530.10 Few Secondary Structures Irregular Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2 Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 2h43C02
2J60A 3E1IB 1FZGB 2J61B 3H32B 1Z3SA 2HODC 1N73B 1FICA 2GY7A 2J2PA 2Q9IB 1FZCB 1LT9B 1FZAB 3E1IC 2J3FA 2J3UA 2J5ZA 4EPUA 2JHMF 1N73C 2FIBA 2Q9IC 1M1JB 1FZCC 1LT9C 1FZAC 3BVHB 1LWUC 2XNXB 4M7HA 4JZCA 1RE4B 2OYHC 2OYIB 2Z4EB 3HUSB 1M1JC 3BVHC 1LWUB 2J64A 3GHGC 1RF1B 1FZDA 1JC9A 2J3GA 1FZFB 2J0GA 2XNXC 3FIBA 2OYHB 2HPCB 1RE4C 2FFDB 2JHLF 2OYIC 4M7FA 2Z4EC 3HUSC 4ZFGA 1RF1C 2J0YA 2HLOC 2D39A 4NYTA 1FZFC 2H43B 1RF0B 1FIBA 1LTJC 2HPCC 1N86B 1Z3UA 2FFDC 1RE3B 2HLOB 2H43C 4R9JA 1LTJB 1RF0C 1FZEB 2JHKF 2J3FD 1N86C 1FZBB 1RE3C 1FIDA 2JHHC 2JHIF 4JYOX 2J0HA 1FZEC 1FZGC 2J3OA 2HODB 3H32C 4R9TA 2J61A 2WNPF 1FZBC 2J1GA
chains in the Genus database with same CATH superfamily
2J60A 3E1IB 1FZGB 2J61B 3H32B 1Z3SA 2HODC 1N73B 1FICA 2GY7A 2J2PA 2Q9IB 1FZCB 1LT9B 1FZAB 3E1IC 2J3FA 2J3UA 2J5ZA 4EPUA 2JHMF 1N73C 2FIBA 2Q9IC 1M1JB 1FZCC 1LT9C 1FZAC 3BVHB 3GHGB 1LWUC 2XNXB 4M7HA 4JZCA 1RE4B 2OYHC 2OYIB 2Z4EB 3HUSB 1M1JC 3BVHC 1LWUB 2J64A 3GHGC 1RF1B 1FZDA 1JC9A 2J3GA 1FZFB 2J0GA 2XNXC 3FIBA 2OYHB 2HPCB 1RE4C 2FFDB 2JHLF 2OYIC 4M7FA 2Z4EC 3HUSC 4ZFGA 1RF1C 2J0YA 2HLOC 2D39A 4NYTA 1FZFC 2H43B 1RF0B 1FIBA 1LTJC 2HPCC 1N86B 1Z3UA 2FFDC 1RE3B 2HLOB 2H43C 4R9JA 1LTJB 1RF0C 1FZEB 2JHKF 2J3FD 1N86C 1FZBB 1RE3C 1FIDA 2JHHC 2JHIF 4JYOX 2J0HA 1FZEC 1FZGC 2J3OA 2HODB 3H32C 4R9TA 2J61A 2WNPF 1FZBC 2J1GA
chains in the Genus database with same CATH topology
2J60A 3E1IB 1FZGB 2J61B 3H32B 1Z3SA 2HODC 1N73B 1FICA 2GY7A 2J2PA 2Q9IB 1FZCB 1LT9B 1FZAB 3E1IC 2J3FA 2J3UA 2J5ZA 4EPUA 2JHMF 1N73C 2FIBA 2Q9IC 1M1JB 1FZCC 1LT9C 1FZAC 3BVHB 1LWUC 2XNXB 4M7HA 4JZCA 1RE4B 2OYHC 2OYIB 2Z4EB 3HUSB 1M1JC 3BVHC 1LWUB 2J64A 3GHGC 1RF1B 1FZDA 1JC9A 2J3GA 1FZFB 2J0GA 2XNXC 3FIBA 2OYHB 2HPCB 1RE4C 2FFDB 2JHLF 2OYIC 4M7FA 2Z4EC 3HUSC 4ZFGA 1RF1C 2J0YA 2HLOC 2D39A 4NYTA 1FZFC 2H43B 1RF0B 1FIBA 1LTJC 2HPCC 1N86B 1Z3UA 2FFDC 1RE3B 2HLOB 2H43C 4R9JA 1LTJB 1RF0C 1FZEB 2JHKF 2J3FD 1N86C 1FZBB 1RE3C 1FIDA 2JHHC 2JHIF 4JYOX 2J0HA 1FZEC 1FZGC 2J3OA 2HODB 3H32C 4R9TA 2J61A 2WNPF 1FZBC 2J1GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2J60 A;  3E1I B;  1FZG B;  2J61 B;  3H32 B;  1Z3S A;  2HOD C;  1N73 B;  1FIC A;  2GY7 A;  2J2P A;  2Q9I B;  1FZC B;  1LT9 B;  1FZA B;  3E1I C;  2J3F A;  2J3U A;  2J5Z A;  4EPU A;  2JHM F;  1N73 C;  2FIB A;  2Q9I C;  1M1J B;  1FZC C;  1LT9 C;  1FZA C;  3BVH B;  1LWU C;  2XNX B;  4M7H A;  4JZC A;  1RE4 B;  2OYH C;  2OYI B;  2Z4E B;  3HUS B;  1M1J C;  3BVH C;  1LWU B;  2J64 A;  3GHG C;  1RF1 B;  1FZD A;  1JC9 A;  2J3G A;  1FZF B;  2J0G A;  2XNX C;  3FIB A;  2OYH B;  2HPC B;  1RE4 C;  2FFD B;  2JHL F;  2OYI C;  4M7F A;  2Z4E C;  3HUS C;  4ZFG A;  1RF1 C;  2J0Y A;  2HLO C;  2D39 A;  4NYT A;  1FZF C;  2H43 B;  1RF0 B;  1FIB A;  1LTJ C;  2HPC C;  1N86 B;  1Z3U A;  2FFD C;  1RE3 B;  2HLO B;  2H43 C;  4R9J A;  1LTJ B;  1RF0 C;  1FZE B;  2JHK F;  2J3F D;  1N86 C;  1FZB B;  1RE3 C;  1FID A;  2JHH C;  2JHI F;  4JYO X;  2J0H A;  1FZE C;  1FZG C;  2J3O A;  2HOD B;  3H32 C;  4R9T A;  2J61 A;  2WNP F;  1FZB C;  2J1G A; 
#chains in the Genus database with same CATH topology
 2J60 A;  3E1I B;  1FZG B;  2J61 B;  3H32 B;  1Z3S A;  2HOD C;  1N73 B;  1FIC A;  2GY7 A;  2J2P A;  2Q9I B;  1FZC B;  1LT9 B;  1FZA B;  3E1I C;  2J3F A;  2J3U A;  2J5Z A;  4EPU A;  2JHM F;  1N73 C;  2FIB A;  2Q9I C;  1M1J B;  1FZC C;  1LT9 C;  1FZA C;  3BVH B;  3GHG B;  1LWU C;  2XNX B;  4M7H A;  4JZC A;  1RE4 B;  2OYH C;  2OYI B;  2Z4E B;  3HUS B;  1M1J C;  3BVH C;  1LWU B;  2J64 A;  3GHG C;  1RF1 B;  1FZD A;  1JC9 A;  2J3G A;  1FZF B;  2J0G A;  2XNX C;  3FIB A;  2OYH B;  2HPC B;  1RE4 C;  2FFD B;  2JHL F;  2OYI C;  4M7F A;  2Z4E C;  3HUS C;  4ZFG A;  1RF1 C;  2J0Y A;  2HLO C;  2D39 A;  4NYT A;  1FZF C;  2H43 B;  1RF0 B;  1FIB A;  1LTJ C;  2HPC C;  1N86 B;  1Z3U A;  2FFD C;  1RE3 B;  2HLO B;  2H43 C;  4R9J A;  1LTJ B;  1RF0 C;  1FZE B;  2JHK F;  2J3F D;  1N86 C;  1FZB B;  1RE3 C;  1FID A;  2JHH C;  2JHI F;  4JYO X;  2J0H A;  1FZE C;  1FZG C;  2J3O A;  2HOD B;  3H32 C;  4R9T A;  2J61 A;  2WNP F;  1FZB C;  2J1G A; 
#chains in the Genus database with same CATH homology
 2J60 A;  3E1I B;  1FZG B;  2J61 B;  3H32 B;  1Z3S A;  2HOD C;  1N73 B;  1FIC A;  2GY7 A;  2J2P A;  2Q9I B;  1FZC B;  1LT9 B;  1FZA B;  3E1I C;  2J3F A;  2J3U A;  2J5Z A;  4EPU A;  2JHM F;  1N73 C;  2FIB A;  2Q9I C;  1M1J B;  1FZC C;  1LT9 C;  1FZA C;  3BVH B;  1LWU C;  2XNX B;  4M7H A;  4JZC A;  1RE4 B;  2OYH C;  2OYI B;  2Z4E B;  3HUS B;  1M1J C;  3BVH C;  1LWU B;  2J64 A;  3GHG C;  1RF1 B;  1FZD A;  1JC9 A;  2J3G A;  1FZF B;  2J0G A;  2XNX C;  3FIB A;  2OYH B;  2HPC B;  1RE4 C;  2FFD B;  2JHL F;  2OYI C;  4M7F A;  2Z4E C;  3HUS C;  4ZFG A;  1RF1 C;  2J0Y A;  2HLO C;  2D39 A;  4NYT A;  1FZF C;  2H43 B;  1RF0 B;  1FIB A;  1LTJ C;  2HPC C;  1N86 B;  1Z3U A;  2FFD C;  1RE3 B;  2HLO B;  2H43 C;  4R9J A;  1LTJ B;  1RF0 C;  1FZE B;  2JHK F;  2J3F D;  1N86 C;  1FZB B;  1RE3 C;  1FID A;  2JHH C;  2JHI F;  4JYO X;  2J0H A;  1FZE C;  1FZG C;  2J3O A;  2HOD B;  3H32 C;  4R9T A;  2J61 A;  2WNP F;  1FZB C;  2J1G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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