1FZFC

Crystal structure of fragment double-d from human fibrin with the peptide ligand gly-his-arg-pro-amide
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
292
structure length
292
Chain Sequence
THDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.
pubmed doi rcsb
molecule tags Blood coagulation
molecule keywords FIBRINOGEN
total genus 84
structure length 292
sequence length 292
chains with identical sequence F
ec nomenclature
pdb deposition date 1998-12-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00147 Fibrinogen_C Fibrinogen beta and gamma chains, C-terminal globular domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.215.10 Alpha Beta Alpha-Beta Complex Gamma Fibrinogen; Chain A, domain 1 Gamma Fibrinogen, chain A, domain 1 1fzfC01
4.10.530.10 Few Secondary Structures Irregular Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2 Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 1fzfC02
2HLOC 4EPUA 1N86C 3FIBA 4R9TA 2J5ZA 2XNXB 1FZEB 3BVHB 2XNXC 1FZEC 3BVHC 1FZCB 2J0HA 1FZCC 2J3UA 4JZCA 2J61A 2J0YA 1RF1B 1RF1C 1FZBB 2JHLF 1FZBC 4M7HA 1FZGB 1FZGC 2J2PA 2J64A 2Q9IB 1JC9A 4NYTA 2Q9IC 2HPCB 1FZDA 2OYIB 2FFDB 2J3FD 2HPCC 2H43B 2OYIC 4M7FA 2FFDC 2J61B 2H43C 2GY7A 1LTJB 1LTJC 1LWUB 1LWUC 2J0GA 1LT9B 2HODB 1RE3B 1LT9C 2HODC 2J3OA 1RE3C 2JHIF 2JHHC 4ZFGA 4R9JA 1RE4B 1RE4C 1FIBA 1M1JB 2J3GA 1FZAB 1M1JC 3GHGC 1RF0B 1FZAC 1RF0C 2WNPF 3E1IB 2J3FA 1FZFB 3HUSB 3E1IC 1FZFC 3HUSC 2J1GA 2JHMF 2FIBA 1Z3SA 1FICA 2OYHB 2JHKF 2OYHC 2Z4EB 2Z4EC 1Z3UA 3H32B 2D39A 1N73B 3H32C 1N73C 4JYOX 2J60A 1FIDA 2HLOB 1N86B
chains in the Genus database with same CATH superfamily
2HLOC 4EPUA 1N86C 3FIBA 4R9TA 2J5ZA 2XNXB 1FZEB 3BVHB 2XNXC 1FZEC 3BVHC 1FZCB 2J0HA 1FZCC 2J3UA 4JZCA 2J61A 2J0YA 1RF1B 1RF1C 1FZBB 2JHLF 1FZBC 4M7HA 1FZGB 1FZGC 2J2PA 2J64A 2Q9IB 1JC9A 4NYTA 2Q9IC 2HPCB 1FZDA 2OYIB 2FFDB 2J3FD 2HPCC 2H43B 2OYIC 4M7FA 2FFDC 2J61B 2H43C 2GY7A 1LTJB 1LTJC 1LWUB 1LWUC 2J0GA 1LT9B 2HODB 1RE3B 1LT9C 2HODC 2J3OA 1RE3C 2JHIF 2JHHC 4ZFGA 4R9JA 1RE4B 1RE4C 1FIBA 1M1JB 2J3GA 3GHGB 1FZAB 1M1JC 3GHGC 1RF0B 1FZAC 1RF0C 2WNPF 3E1IB 2J3FA 1FZFB 3HUSB 3E1IC 1FZFC 3HUSC 2J1GA 2JHMF 2FIBA 1Z3SA 1FICA 2OYHB 2JHKF 2OYHC 2Z4EB 2Z4EC 1Z3UA 3H32B 2D39A 1N73B 3H32C 1N73C 4JYOX 2J60A 1FIDA 2HLOB 1N86B
chains in the Genus database with same CATH topology
2HLOC 4EPUA 1N86C 3FIBA 4R9TA 2J5ZA 2XNXB 1FZEB 3BVHB 2XNXC 1FZEC 3BVHC 1FZCB 2J0HA 1FZCC 2J3UA 4JZCA 2J61A 2J0YA 1RF1B 1RF1C 1FZBB 2JHLF 1FZBC 4M7HA 1FZGB 1FZGC 2J2PA 2J64A 2Q9IB 1JC9A 4NYTA 2Q9IC 2HPCB 1FZDA 2OYIB 2FFDB 2J3FD 2HPCC 2H43B 2OYIC 4M7FA 2FFDC 2J61B 2H43C 2GY7A 1LTJB 1LTJC 1LWUB 1LWUC 2J0GA 1LT9B 2HODB 1RE3B 1LT9C 2HODC 2J3OA 1RE3C 2JHIF 2JHHC 4ZFGA 4R9JA 1RE4B 1RE4C 1FIBA 1M1JB 2J3GA 1FZAB 1M1JC 3GHGC 1RF0B 1FZAC 1RF0C 2WNPF 3E1IB 2J3FA 1FZFB 3HUSB 3E1IC 1FZFC 3HUSC 2J1GA 2JHMF 2FIBA 1Z3SA 1FICA 2OYHB 2JHKF 2OYHC 2Z4EB 2Z4EC 1Z3UA 3H32B 2D39A 1N73B 3H32C 1N73C 4JYOX 2J60A 1FIDA 2HLOB 1N86B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HLO C;  4EPU A;  1N86 C;  3FIB A;  4R9T A;  2J5Z A;  2XNX B;  1FZE B;  3BVH B;  2XNX C;  1FZE C;  3BVH C;  1FZC B;  2J0H A;  1FZC C;  2J3U A;  4JZC A;  2J61 A;  2J0Y A;  1RF1 B;  1RF1 C;  1FZB B;  2JHL F;  1FZB C;  4M7H A;  1FZG B;  1FZG C;  2J2P A;  2J64 A;  2Q9I B;  1JC9 A;  4NYT A;  2Q9I C;  2HPC B;  1FZD A;  2OYI B;  2FFD B;  2J3F D;  2HPC C;  2H43 B;  2OYI C;  4M7F A;  2FFD C;  2J61 B;  2H43 C;  2GY7 A;  1LTJ B;  1LTJ C;  1LWU B;  1LWU C;  2J0G A;  1LT9 B;  2HOD B;  1RE3 B;  1LT9 C;  2HOD C;  2J3O A;  1RE3 C;  2JHI F;  2JHH C;  4ZFG A;  4R9J A;  1RE4 B;  1RE4 C;  1FIB A;  1M1J B;  2J3G A;  1FZA B;  1M1J C;  3GHG C;  1RF0 B;  1FZA C;  1RF0 C;  2WNP F;  3E1I B;  2J3F A;  1FZF B;  3HUS B;  3E1I C;  1FZF C;  3HUS C;  2J1G A;  2JHM F;  2FIB A;  1Z3S A;  1FIC A;  2OYH B;  2JHK F;  2OYH C;  2Z4E B;  2Z4E C;  1Z3U A;  3H32 B;  2D39 A;  1N73 B;  3H32 C;  1N73 C;  4JYO X;  2J60 A;  1FID A;  2HLO B;  1N86 B; 
#chains in the Genus database with same CATH topology
 2HLO C;  4EPU A;  1N86 C;  3FIB A;  4R9T A;  2J5Z A;  2XNX B;  1FZE B;  3BVH B;  2XNX C;  1FZE C;  3BVH C;  1FZC B;  2J0H A;  1FZC C;  2J3U A;  4JZC A;  2J61 A;  2J0Y A;  1RF1 B;  1RF1 C;  1FZB B;  2JHL F;  1FZB C;  4M7H A;  1FZG B;  1FZG C;  2J2P A;  2J64 A;  2Q9I B;  1JC9 A;  4NYT A;  2Q9I C;  2HPC B;  1FZD A;  2OYI B;  2FFD B;  2J3F D;  2HPC C;  2H43 B;  2OYI C;  4M7F A;  2FFD C;  2J61 B;  2H43 C;  2GY7 A;  1LTJ B;  1LTJ C;  1LWU B;  1LWU C;  2J0G A;  1LT9 B;  2HOD B;  1RE3 B;  1LT9 C;  2HOD C;  2J3O A;  1RE3 C;  2JHI F;  2JHH C;  4ZFG A;  4R9J A;  1RE4 B;  1RE4 C;  1FIB A;  1M1J B;  2J3G A;  3GHG B;  1FZA B;  1M1J C;  3GHG C;  1RF0 B;  1FZA C;  1RF0 C;  2WNP F;  3E1I B;  2J3F A;  1FZF B;  3HUS B;  3E1I C;  1FZF C;  3HUS C;  2J1G A;  2JHM F;  2FIB A;  1Z3S A;  1FIC A;  2OYH B;  2JHK F;  2OYH C;  2Z4E B;  2Z4E C;  1Z3U A;  3H32 B;  2D39 A;  1N73 B;  3H32 C;  1N73 C;  4JYO X;  2J60 A;  1FID A;  2HLO B;  1N86 B; 
#chains in the Genus database with same CATH homology
 2HLO C;  4EPU A;  1N86 C;  3FIB A;  4R9T A;  2J5Z A;  2XNX B;  1FZE B;  3BVH B;  2XNX C;  1FZE C;  3BVH C;  1FZC B;  2J0H A;  1FZC C;  2J3U A;  4JZC A;  2J61 A;  2J0Y A;  1RF1 B;  1RF1 C;  1FZB B;  2JHL F;  1FZB C;  4M7H A;  1FZG B;  1FZG C;  2J2P A;  2J64 A;  2Q9I B;  1JC9 A;  4NYT A;  2Q9I C;  2HPC B;  1FZD A;  2OYI B;  2FFD B;  2J3F D;  2HPC C;  2H43 B;  2OYI C;  4M7F A;  2FFD C;  2J61 B;  2H43 C;  2GY7 A;  1LTJ B;  1LTJ C;  1LWU B;  1LWU C;  2J0G A;  1LT9 B;  2HOD B;  1RE3 B;  1LT9 C;  2HOD C;  2J3O A;  1RE3 C;  2JHI F;  2JHH C;  4ZFG A;  4R9J A;  1RE4 B;  1RE4 C;  1FIB A;  1M1J B;  2J3G A;  1FZA B;  1M1J C;  3GHG C;  1RF0 B;  1FZA C;  1RF0 C;  2WNP F;  3E1I B;  2J3F A;  1FZF B;  3HUS B;  3E1I C;  1FZF C;  3HUS C;  2J1G A;  2JHM F;  2FIB A;  1Z3S A;  1FIC A;  2OYH B;  2JHK F;  2OYH C;  2Z4E B;  2Z4E C;  1Z3U A;  3H32 B;  2D39 A;  1N73 B;  3H32 C;  1N73 C;  4JYO X;  2J60 A;  1FID A;  2HLO B;  1N86 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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