2H43C

Crystal structure of human fragment d complexed with ala-his-arg-pro-amide
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
290
structure length
290
Chain Sequence
HDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Blood clotting
publication title Differences in Binding Specificity for the Homologous gamma- and beta-Chain "Holes" on Fibrinogen: Exclusive Binding of Ala-His-Arg-Pro-amide by the beta-Chain Hole.
pubmed doi rcsb
molecule keywords Fibrinogen alpha chain
total genus 75
structure length 290
sequence length 290
chains with identical sequence F
ec nomenclature
pdb deposition date 2006-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00147 Fibrinogen_C Fibrinogen beta and gamma chains, C-terminal globular domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.215.10 Alpha Beta Alpha-Beta Complex Gamma Fibrinogen; Chain A, domain 1 Gamma Fibrinogen, chain A, domain 1 2h43C01
4.10.530.10 Few Secondary Structures Irregular Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2 Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 2h43C02
2JHKF 2FIBA 2H43B 1RF0B 2XNXC 1N86B 1FIDA 4EPUA 3H32B 2FFDB 2Z4EC 2JHIF 1N73B 2D39A 1FZCB 1FZGC 2HODC 2J3UA 3FIBA 2XNXB 4M7FA 1LTJC 1JC9A 2HPCC 2Z4EB 2J0YA 1FIBA 3BVHC 4NYTA 1FZGB 2HODB 2J2PA 1LTJB 2J1GA 2JHLF 2J64A 2J3FD 2HPCB 1M1JC 3GHGC 1FZBC 3BVHB 1Z3UA 2J0HA 1FZFC 1LT9C 2OYIC 4ZFGA 4R9TA 2J61B 1FICA 4JYOX 1M1JB 4JZCA 1RE3C 2WNPF 1LWUC 3E1IC 2J5ZA 1FZBB 3HUSB 4M7HA 2Q9IC 1FZDA 1FZFB 1LT9B 2OYIB 1RE4C 2J0GA 3HUSC 2GY7A 2HLOB 2OYHC 1FZEC 2JHMF 1Z3SA 2J3GA 1RE3B 1LWUB 3E1IB 1FZAC 2Q9IB 2J3OA 2JHHC 2HLOC 1RF1B 2J3FA 2H43C 1RF0C 1RE4B 1N86C 2J60A 3H32C 2FFDC 2OYHB 4R9JA 1FZEB 1RF1C 1N73C 1FZCC 1FZAB 2J61A
chains in the Genus database with same CATH superfamily
2JHKF 2FIBA 2H43B 1RF0B 2XNXC 1N86B 1FIDA 4EPUA 3H32B 2FFDB 2Z4EC 2JHIF 1N73B 2D39A 1FZCB 1FZGC 2HODC 2J3UA 3FIBA 2XNXB 4M7FA 1LTJC 1JC9A 2HPCC 2Z4EB 2J0YA 1FIBA 3BVHC 4NYTA 1FZGB 2HODB 2J2PA 1LTJB 2J1GA 2JHLF 2J64A 2J3FD 2HPCB 1M1JC 3GHGC 1FZBC 3BVHB 1Z3UA 2J0HA 1FZFC 1LT9C 2OYIC 4ZFGA 4R9TA 2J61B 1FICA 4JYOX 1M1JB 4JZCA 3GHGB 1RE3C 2WNPF 1LWUC 3E1IC 2J5ZA 1FZBB 3HUSB 4M7HA 2Q9IC 1FZDA 1FZFB 1LT9B 2OYIB 1RE4C 2J0GA 3HUSC 2GY7A 2HLOB 2OYHC 1FZEC 2JHMF 1Z3SA 2J3GA 1RE3B 1LWUB 3E1IB 1FZAC 2Q9IB 2J3OA 2JHHC 2HLOC 1RF1B 2J3FA 2H43C 1RF0C 1RE4B 1N86C 2J60A 3H32C 2FFDC 2OYHB 4R9JA 1FZEB 1RF1C 1N73C 1FZCC 1FZAB 2J61A
chains in the Genus database with same CATH topology
2JHKF 2FIBA 2H43B 1RF0B 2XNXC 1N86B 1FIDA 4EPUA 3H32B 2FFDB 2Z4EC 2JHIF 1N73B 2D39A 1FZCB 1FZGC 2HODC 2J3UA 3FIBA 2XNXB 4M7FA 1LTJC 1JC9A 2HPCC 2Z4EB 2J0YA 1FIBA 3BVHC 4NYTA 1FZGB 2HODB 2J2PA 1LTJB 2J1GA 2JHLF 2J64A 2J3FD 2HPCB 1M1JC 3GHGC 1FZBC 3BVHB 1Z3UA 2J0HA 1FZFC 1LT9C 2OYIC 4ZFGA 4R9TA 2J61B 1FICA 4JYOX 1M1JB 4JZCA 1RE3C 2WNPF 1LWUC 3E1IC 2J5ZA 1FZBB 3HUSB 4M7HA 2Q9IC 1FZDA 1FZFB 1LT9B 2OYIB 1RE4C 2J0GA 3HUSC 2GY7A 2HLOB 2OYHC 1FZEC 2JHMF 1Z3SA 2J3GA 1RE3B 1LWUB 3E1IB 1FZAC 2Q9IB 2J3OA 2JHHC 2HLOC 1RF1B 2J3FA 2H43C 1RF0C 1RE4B 1N86C 2J60A 3H32C 2FFDC 2OYHB 4R9JA 1FZEB 1RF1C 1N73C 1FZCC 1FZAB 2J61A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JHK F;  2FIB A;  2H43 B;  1RF0 B;  2XNX C;  1N86 B;  1FID A;  4EPU A;  3H32 B;  2FFD B;  2Z4E C;  2JHI F;  1N73 B;  2D39 A;  1FZC B;  1FZG C;  2HOD C;  2J3U A;  3FIB A;  2XNX B;  4M7F A;  1LTJ C;  1JC9 A;  2HPC C;  2Z4E B;  2J0Y A;  1FIB A;  3BVH C;  4NYT A;  1FZG B;  2HOD B;  2J2P A;  1LTJ B;  2J1G A;  2JHL F;  2J64 A;  2J3F D;  2HPC B;  1M1J C;  3GHG C;  1FZB C;  3BVH B;  1Z3U A;  2J0H A;  1FZF C;  1LT9 C;  2OYI C;  4ZFG A;  4R9T A;  2J61 B;  1FIC A;  4JYO X;  1M1J B;  4JZC A;  1RE3 C;  2WNP F;  1LWU C;  3E1I C;  2J5Z A;  1FZB B;  3HUS B;  4M7H A;  2Q9I C;  1FZD A;  1FZF B;  1LT9 B;  2OYI B;  1RE4 C;  2J0G A;  3HUS C;  2GY7 A;  2HLO B;  2OYH C;  1FZE C;  2JHM F;  1Z3S A;  2J3G A;  1RE3 B;  1LWU B;  3E1I B;  1FZA C;  2Q9I B;  2J3O A;  2JHH C;  2HLO C;  1RF1 B;  2J3F A;  2H43 C;  1RF0 C;  1RE4 B;  1N86 C;  2J60 A;  3H32 C;  2FFD C;  2OYH B;  4R9J A;  1FZE B;  1RF1 C;  1N73 C;  1FZC C;  1FZA B;  2J61 A; 
#chains in the Genus database with same CATH topology
 2JHK F;  2FIB A;  2H43 B;  1RF0 B;  2XNX C;  1N86 B;  1FID A;  4EPU A;  3H32 B;  2FFD B;  2Z4E C;  2JHI F;  1N73 B;  2D39 A;  1FZC B;  1FZG C;  2HOD C;  2J3U A;  3FIB A;  2XNX B;  4M7F A;  1LTJ C;  1JC9 A;  2HPC C;  2Z4E B;  2J0Y A;  1FIB A;  3BVH C;  4NYT A;  1FZG B;  2HOD B;  2J2P A;  1LTJ B;  2J1G A;  2JHL F;  2J64 A;  2J3F D;  2HPC B;  1M1J C;  3GHG C;  1FZB C;  3BVH B;  1Z3U A;  2J0H A;  1FZF C;  1LT9 C;  2OYI C;  4ZFG A;  4R9T A;  2J61 B;  1FIC A;  4JYO X;  1M1J B;  4JZC A;  3GHG B;  1RE3 C;  2WNP F;  1LWU C;  3E1I C;  2J5Z A;  1FZB B;  3HUS B;  4M7H A;  2Q9I C;  1FZD A;  1FZF B;  1LT9 B;  2OYI B;  1RE4 C;  2J0G A;  3HUS C;  2GY7 A;  2HLO B;  2OYH C;  1FZE C;  2JHM F;  1Z3S A;  2J3G A;  1RE3 B;  1LWU B;  3E1I B;  1FZA C;  2Q9I B;  2J3O A;  2JHH C;  2HLO C;  1RF1 B;  2J3F A;  2H43 C;  1RF0 C;  1RE4 B;  1N86 C;  2J60 A;  3H32 C;  2FFD C;  2OYH B;  4R9J A;  1FZE B;  1RF1 C;  1N73 C;  1FZC C;  1FZA B;  2J61 A; 
#chains in the Genus database with same CATH homology
 2JHK F;  2FIB A;  2H43 B;  1RF0 B;  2XNX C;  1N86 B;  1FID A;  4EPU A;  3H32 B;  2FFD B;  2Z4E C;  2JHI F;  1N73 B;  2D39 A;  1FZC B;  1FZG C;  2HOD C;  2J3U A;  3FIB A;  2XNX B;  4M7F A;  1LTJ C;  1JC9 A;  2HPC C;  2Z4E B;  2J0Y A;  1FIB A;  3BVH C;  4NYT A;  1FZG B;  2HOD B;  2J2P A;  1LTJ B;  2J1G A;  2JHL F;  2J64 A;  2J3F D;  2HPC B;  1M1J C;  3GHG C;  1FZB C;  3BVH B;  1Z3U A;  2J0H A;  1FZF C;  1LT9 C;  2OYI C;  4ZFG A;  4R9T A;  2J61 B;  1FIC A;  4JYO X;  1M1J B;  4JZC A;  1RE3 C;  2WNP F;  1LWU C;  3E1I C;  2J5Z A;  1FZB B;  3HUS B;  4M7H A;  2Q9I C;  1FZD A;  1FZF B;  1LT9 B;  2OYI B;  1RE4 C;  2J0G A;  3HUS C;  2GY7 A;  2HLO B;  2OYH C;  1FZE C;  2JHM F;  1Z3S A;  2J3G A;  1RE3 B;  1LWU B;  3E1I B;  1FZA C;  2Q9I B;  2J3O A;  2JHH C;  2HLO C;  1RF1 B;  2J3F A;  2H43 C;  1RF0 C;  1RE4 B;  1N86 C;  2J60 A;  3H32 C;  2FFD C;  2OYH B;  4R9J A;  1FZE B;  1RF1 C;  1N73 C;  1FZC C;  1FZA B;  2J61 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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