2H43B

Crystal structure of human fragment d complexed with ala-his-arg-pro-amide
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
302
structure length
302
Chain Sequence
VNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Differences in Binding Specificity for the Homologous gamma- and beta-Chain "Holes" on Fibrinogen: Exclusive Binding of Ala-His-Arg-Pro-amide by the beta-Chain Hole.
pubmed doi rcsb
molecule tags Blood clotting
molecule keywords Fibrinogen alpha chain
total genus 88
structure length 302
sequence length 302
chains with identical sequence E
ec nomenclature
pdb deposition date 2006-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00147 Fibrinogen_C Fibrinogen beta and gamma chains, C-terminal globular domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.215.10 Alpha Beta Alpha-Beta Complex Gamma Fibrinogen; Chain A, domain 1 Gamma Fibrinogen, chain A, domain 1 2h43B01
4.10.530.10 Few Secondary Structures Irregular Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2 Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 2h43B02
1RE3B 2OYHB 1LT9C 4R9JA 4M7FA 2XNXC 2OYIC 2D39A 4NYTA 2J61A 1RE4C 1FZGB 4EPUA 1N73B 1FZAB 3BVHC 4R9TA 1FIDA 1RF1C 2JHHC 1FZBC 2Z4EC 1FZEB 3HUSC 1LTJC 3H32C 1JC9A 1RF0B 1Z3SA 3E1IC 2J3OA 2JHKF 2J61B 2HODB 2JHLF 4JYOX 2JHIF 3FIBA 1FZAC 1N86C 2J1GA 4M7HA 1FZFB 1FZCB 2HPCC 1LWUC 2HLOC 2FFDB 1M1JC 2JHMF 2Q9IB 3GHGC 1FIBA 2H43B 1RE3C 2OYHC 2J5ZA 2J60A 1LT9B 1FZGC 2XNXB 2J64A 1N73C 1RE4B 1FZDA 1FICA 3BVHB 2J0GA 1FZEC 2FIBA 1RF1B 1RF0C 1FZBB 2Z4EB 2J3GA 3HUSB 1LTJB 2J2PA 3H32B 2HODC 2J3FD 3E1IB 1FZFC 2J3FA 2J0YA 1FZCC 2OYIB 1N86B 2J3UA 2HPCB 1Z3UA 1LWUB 4ZFGA 2J0HA 2WNPF 2FFDC 4JZCA 2Q9IC 2H43C 2HLOB 1M1JB 2GY7A
chains in the Genus database with same CATH superfamily
1RE3B 2OYHB 1LT9C 4R9JA 4M7FA 2XNXC 2OYIC 2D39A 4NYTA 2J61A 1RE4C 1FZGB 4EPUA 1N73B 1FZAB 3BVHC 4R9TA 1FIDA 1RF1C 2JHHC 1FZBC 2Z4EC 1FZEB 3HUSC 1LTJC 3H32C 3GHGB 1JC9A 1RF0B 1Z3SA 3E1IC 2J3OA 2JHKF 2J61B 2HODB 2JHLF 4JYOX 2JHIF 3FIBA 1FZAC 1N86C 2J1GA 4M7HA 1FZFB 1FZCB 2HPCC 1LWUC 2HLOC 2FFDB 1M1JC 2JHMF 2Q9IB 3GHGC 1FIBA 2H43B 1RE3C 2OYHC 2J5ZA 2J60A 1LT9B 1FZGC 2XNXB 2J64A 1N73C 1RE4B 1FZDA 1FICA 3BVHB 2J0GA 1FZEC 2FIBA 1RF1B 1RF0C 1FZBB 2Z4EB 2J3GA 3HUSB 1LTJB 2J2PA 3H32B 2HODC 2J3FD 3E1IB 1FZFC 2J3FA 2J0YA 1FZCC 2OYIB 1N86B 2J3UA 2HPCB 1Z3UA 1LWUB 4ZFGA 2J0HA 2WNPF 2FFDC 4JZCA 2Q9IC 2H43C 2HLOB 1M1JB 2GY7A
chains in the Genus database with same CATH topology
1RE3B 2OYHB 1LT9C 4R9JA 4M7FA 2XNXC 2OYIC 2D39A 4NYTA 2J61A 1RE4C 1FZGB 4EPUA 1N73B 1FZAB 3BVHC 4R9TA 1FIDA 1RF1C 2JHHC 1FZBC 2Z4EC 1FZEB 3HUSC 1LTJC 3H32C 1JC9A 1RF0B 1Z3SA 3E1IC 2J3OA 2JHKF 2J61B 2HODB 2JHLF 4JYOX 2JHIF 3FIBA 1FZAC 1N86C 2J1GA 4M7HA 1FZFB 1FZCB 2HPCC 1LWUC 2HLOC 2FFDB 1M1JC 2JHMF 2Q9IB 3GHGC 1FIBA 2H43B 1RE3C 2OYHC 2J5ZA 2J60A 1LT9B 1FZGC 2XNXB 2J64A 1N73C 1RE4B 1FZDA 1FICA 3BVHB 2J0GA 1FZEC 2FIBA 1RF1B 1RF0C 1FZBB 2Z4EB 2J3GA 3HUSB 1LTJB 2J2PA 3H32B 2HODC 2J3FD 3E1IB 1FZFC 2J3FA 2J0YA 1FZCC 2OYIB 1N86B 2J3UA 2HPCB 1Z3UA 1LWUB 4ZFGA 2J0HA 2WNPF 2FFDC 4JZCA 2Q9IC 2H43C 2HLOB 1M1JB 2GY7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RE3 B;  2OYH B;  1LT9 C;  4R9J A;  4M7F A;  2XNX C;  2OYI C;  2D39 A;  4NYT A;  2J61 A;  1RE4 C;  1FZG B;  4EPU A;  1N73 B;  1FZA B;  3BVH C;  4R9T A;  1FID A;  1RF1 C;  2JHH C;  1FZB C;  2Z4E C;  1FZE B;  3HUS C;  1LTJ C;  3H32 C;  1JC9 A;  1RF0 B;  1Z3S A;  3E1I C;  2J3O A;  2JHK F;  2J61 B;  2HOD B;  2JHL F;  4JYO X;  2JHI F;  3FIB A;  1FZA C;  1N86 C;  2J1G A;  4M7H A;  1FZF B;  1FZC B;  2HPC C;  1LWU C;  2HLO C;  2FFD B;  1M1J C;  2JHM F;  2Q9I B;  3GHG C;  1FIB A;  2H43 B;  1RE3 C;  2OYH C;  2J5Z A;  2J60 A;  1LT9 B;  1FZG C;  2XNX B;  2J64 A;  1N73 C;  1RE4 B;  1FZD A;  1FIC A;  3BVH B;  2J0G A;  1FZE C;  2FIB A;  1RF1 B;  1RF0 C;  1FZB B;  2Z4E B;  2J3G A;  3HUS B;  1LTJ B;  2J2P A;  3H32 B;  2HOD C;  2J3F D;  3E1I B;  1FZF C;  2J3F A;  2J0Y A;  1FZC C;  2OYI B;  1N86 B;  2J3U A;  2HPC B;  1Z3U A;  1LWU B;  4ZFG A;  2J0H A;  2WNP F;  2FFD C;  4JZC A;  2Q9I C;  2H43 C;  2HLO B;  1M1J B;  2GY7 A; 
#chains in the Genus database with same CATH topology
 1RE3 B;  2OYH B;  1LT9 C;  4R9J A;  4M7F A;  2XNX C;  2OYI C;  2D39 A;  4NYT A;  2J61 A;  1RE4 C;  1FZG B;  4EPU A;  1N73 B;  1FZA B;  3BVH C;  4R9T A;  1FID A;  1RF1 C;  2JHH C;  1FZB C;  2Z4E C;  1FZE B;  3HUS C;  1LTJ C;  3H32 C;  3GHG B;  1JC9 A;  1RF0 B;  1Z3S A;  3E1I C;  2J3O A;  2JHK F;  2J61 B;  2HOD B;  2JHL F;  4JYO X;  2JHI F;  3FIB A;  1FZA C;  1N86 C;  2J1G A;  4M7H A;  1FZF B;  1FZC B;  2HPC C;  1LWU C;  2HLO C;  2FFD B;  1M1J C;  2JHM F;  2Q9I B;  3GHG C;  1FIB A;  2H43 B;  1RE3 C;  2OYH C;  2J5Z A;  2J60 A;  1LT9 B;  1FZG C;  2XNX B;  2J64 A;  1N73 C;  1RE4 B;  1FZD A;  1FIC A;  3BVH B;  2J0G A;  1FZE C;  2FIB A;  1RF1 B;  1RF0 C;  1FZB B;  2Z4E B;  2J3G A;  3HUS B;  1LTJ B;  2J2P A;  3H32 B;  2HOD C;  2J3F D;  3E1I B;  1FZF C;  2J3F A;  2J0Y A;  1FZC C;  2OYI B;  1N86 B;  2J3U A;  2HPC B;  1Z3U A;  1LWU B;  4ZFG A;  2J0H A;  2WNP F;  2FFD C;  4JZC A;  2Q9I C;  2H43 C;  2HLO B;  1M1J B;  2GY7 A; 
#chains in the Genus database with same CATH homology
 1RE3 B;  2OYH B;  1LT9 C;  4R9J A;  4M7F A;  2XNX C;  2OYI C;  2D39 A;  4NYT A;  2J61 A;  1RE4 C;  1FZG B;  4EPU A;  1N73 B;  1FZA B;  3BVH C;  4R9T A;  1FID A;  1RF1 C;  2JHH C;  1FZB C;  2Z4E C;  1FZE B;  3HUS C;  1LTJ C;  3H32 C;  1JC9 A;  1RF0 B;  1Z3S A;  3E1I C;  2J3O A;  2JHK F;  2J61 B;  2HOD B;  2JHL F;  4JYO X;  2JHI F;  3FIB A;  1FZA C;  1N86 C;  2J1G A;  4M7H A;  1FZF B;  1FZC B;  2HPC C;  1LWU C;  2HLO C;  2FFD B;  1M1J C;  2JHM F;  2Q9I B;  3GHG C;  1FIB A;  2H43 B;  1RE3 C;  2OYH C;  2J5Z A;  2J60 A;  1LT9 B;  1FZG C;  2XNX B;  2J64 A;  1N73 C;  1RE4 B;  1FZD A;  1FIC A;  3BVH B;  2J0G A;  1FZE C;  2FIB A;  1RF1 B;  1RF0 C;  1FZB B;  2Z4E B;  2J3G A;  3HUS B;  1LTJ B;  2J2P A;  3H32 B;  2HOD C;  2J3F D;  3E1I B;  1FZF C;  2J3F A;  2J0Y A;  1FZC C;  2OYI B;  1N86 B;  2J3U A;  2HPC B;  1Z3U A;  1LWU B;  4ZFG A;  2J0H A;  2WNP F;  2FFD C;  4JZC A;  2Q9I C;  2H43 C;  2HLO B;  1M1J B;  2GY7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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