2H43C

Crystal structure of human fragment d complexed with ala-his-arg-pro-amide
Total Genus 75
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
290
structure length
290
Chain Sequence
HDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Differences in Binding Specificity for the Homologous gamma- and beta-Chain "Holes" on Fibrinogen: Exclusive Binding of Ala-His-Arg-Pro-amide by the beta-Chain Hole.
pubmed doi rcsb
molecule tags Blood clotting
molecule keywords Fibrinogen alpha chain
total genus 75
structure length 290
sequence length 290
chains with identical sequence F
ec nomenclature
pdb deposition date 2006-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00147 Fibrinogen_C Fibrinogen beta and gamma chains, C-terminal globular domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.215.10 Alpha Beta Alpha-Beta Complex Gamma Fibrinogen; Chain A, domain 1 Gamma Fibrinogen, chain A, domain 1 2h43C01
4.10.530.10 Few Secondary Structures Irregular Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2 Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 2h43C02
1M1JB 1FZAB 1N86B 2J3FD 3E1IC 2OYHC 2H43C 2JHMF 2J3FA 2JHLF 1FZBB 2OYIB 2HPCB 1FZCB 1FZFB 2HLOB 4NYTA 1LTJC 1FZBC 1Z3UA 2HODC 1FZCC 1Z3SA 2J0HA 2J3UA 4JYOX 2FIBA 2J0YA 2J3OA 3HUSB 1FZEB 1FIBA 3H32C 1LT9C 4ZFGA 2FFDB 1RE4B 1N73B 1M1JC 1FZAC 1FZEC 4R9TA 1FZGB 1N86C 2J60A 2FFDC 1LWUB 3GHGC 2OYIC 1RF1B 2HPCC 1RE3B 2J61A 2JHKF 1FZFC 2HLOC 2XNXB 1JC9A 4JZCA 2JHIF 4M7FA 1FICA 3BVHB 2GY7A 4R9JA 3HUSC 1FIDA 4M7HA 2D39A 3FIBA 2Z4EB 1RE4C 1N73C 4EPUA 2J1GA 1FZGC 3E1IB 2OYHB 2H43B 2J64A 1LWUC 1RF0B 1RF1C 2Q9IB 1RE3C 2J3GA 2XNXC 1LTJB 1RF0C 2Q9IC 2HODB 2J61B 2J2PA 2J0GA 1FZDA 3BVHC 3H32B 1LT9B 2JHHC 2Z4EC 2WNPF 2J5ZA
chains in the Genus database with same CATH superfamily
1M1JB 1FZAB 1N86B 2J3FD 3E1IC 2OYHC 2H43C 2JHMF 2J3FA 3GHGB 2JHLF 1FZBB 2OYIB 2HPCB 1FZCB 1FZFB 2HLOB 4NYTA 1LTJC 1FZBC 1Z3UA 2HODC 1FZCC 1Z3SA 2J0HA 2J3UA 4JYOX 2FIBA 2J0YA 2J3OA 3HUSB 1FZEB 1FIBA 3H32C 1LT9C 4ZFGA 2FFDB 1RE4B 1N73B 1M1JC 1FZAC 1FZEC 4R9TA 1FZGB 1N86C 2J60A 2FFDC 1LWUB 3GHGC 2OYIC 1RF1B 2HPCC 1RE3B 2J61A 2JHKF 1FZFC 2HLOC 2XNXB 1JC9A 4JZCA 2JHIF 4M7FA 1FICA 3BVHB 2GY7A 4R9JA 3HUSC 1FIDA 4M7HA 2D39A 3FIBA 2Z4EB 1RE4C 1N73C 4EPUA 2J1GA 1FZGC 3E1IB 2OYHB 2H43B 2J64A 1LWUC 1RF0B 1RF1C 2Q9IB 1RE3C 2J3GA 2XNXC 1LTJB 1RF0C 2Q9IC 2HODB 2J61B 2J2PA 2J0GA 1FZDA 3BVHC 3H32B 1LT9B 2JHHC 2Z4EC 2WNPF 2J5ZA
chains in the Genus database with same CATH topology
1M1JB 1FZAB 1N86B 2J3FD 3E1IC 2OYHC 2H43C 2JHMF 2J3FA 2JHLF 1FZBB 2OYIB 2HPCB 1FZCB 1FZFB 2HLOB 4NYTA 1LTJC 1FZBC 1Z3UA 2HODC 1FZCC 1Z3SA 2J0HA 2J3UA 4JYOX 2FIBA 2J0YA 2J3OA 3HUSB 1FZEB 1FIBA 3H32C 1LT9C 4ZFGA 2FFDB 1RE4B 1N73B 1M1JC 1FZAC 1FZEC 4R9TA 1FZGB 1N86C 2J60A 2FFDC 1LWUB 3GHGC 2OYIC 1RF1B 2HPCC 1RE3B 2J61A 2JHKF 1FZFC 2HLOC 2XNXB 1JC9A 4JZCA 2JHIF 4M7FA 1FICA 3BVHB 2GY7A 4R9JA 3HUSC 1FIDA 4M7HA 2D39A 3FIBA 2Z4EB 1RE4C 1N73C 4EPUA 2J1GA 1FZGC 3E1IB 2OYHB 2H43B 2J64A 1LWUC 1RF0B 1RF1C 2Q9IB 1RE3C 2J3GA 2XNXC 1LTJB 1RF0C 2Q9IC 2HODB 2J61B 2J2PA 2J0GA 1FZDA 3BVHC 3H32B 1LT9B 2JHHC 2Z4EC 2WNPF 2J5ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1M1J B;  1FZA B;  1N86 B;  2J3F D;  3E1I C;  2OYH C;  2H43 C;  2JHM F;  2J3F A;  2JHL F;  1FZB B;  2OYI B;  2HPC B;  1FZC B;  1FZF B;  2HLO B;  4NYT A;  1LTJ C;  1FZB C;  1Z3U A;  2HOD C;  1FZC C;  1Z3S A;  2J0H A;  2J3U A;  4JYO X;  2FIB A;  2J0Y A;  2J3O A;  3HUS B;  1FZE B;  1FIB A;  3H32 C;  1LT9 C;  4ZFG A;  2FFD B;  1RE4 B;  1N73 B;  1M1J C;  1FZA C;  1FZE C;  4R9T A;  1FZG B;  1N86 C;  2J60 A;  2FFD C;  1LWU B;  3GHG C;  2OYI C;  1RF1 B;  2HPC C;  1RE3 B;  2J61 A;  2JHK F;  1FZF C;  2HLO C;  2XNX B;  1JC9 A;  4JZC A;  2JHI F;  4M7F A;  1FIC A;  3BVH B;  2GY7 A;  4R9J A;  3HUS C;  1FID A;  4M7H A;  2D39 A;  3FIB A;  2Z4E B;  1RE4 C;  1N73 C;  4EPU A;  2J1G A;  1FZG C;  3E1I B;  2OYH B;  2H43 B;  2J64 A;  1LWU C;  1RF0 B;  1RF1 C;  2Q9I B;  1RE3 C;  2J3G A;  2XNX C;  1LTJ B;  1RF0 C;  2Q9I C;  2HOD B;  2J61 B;  2J2P A;  2J0G A;  1FZD A;  3BVH C;  3H32 B;  1LT9 B;  2JHH C;  2Z4E C;  2WNP F;  2J5Z A; 
#chains in the Genus database with same CATH topology
 1M1J B;  1FZA B;  1N86 B;  2J3F D;  3E1I C;  2OYH C;  2H43 C;  2JHM F;  2J3F A;  3GHG B;  2JHL F;  1FZB B;  2OYI B;  2HPC B;  1FZC B;  1FZF B;  2HLO B;  4NYT A;  1LTJ C;  1FZB C;  1Z3U A;  2HOD C;  1FZC C;  1Z3S A;  2J0H A;  2J3U A;  4JYO X;  2FIB A;  2J0Y A;  2J3O A;  3HUS B;  1FZE B;  1FIB A;  3H32 C;  1LT9 C;  4ZFG A;  2FFD B;  1RE4 B;  1N73 B;  1M1J C;  1FZA C;  1FZE C;  4R9T A;  1FZG B;  1N86 C;  2J60 A;  2FFD C;  1LWU B;  3GHG C;  2OYI C;  1RF1 B;  2HPC C;  1RE3 B;  2J61 A;  2JHK F;  1FZF C;  2HLO C;  2XNX B;  1JC9 A;  4JZC A;  2JHI F;  4M7F A;  1FIC A;  3BVH B;  2GY7 A;  4R9J A;  3HUS C;  1FID A;  4M7H A;  2D39 A;  3FIB A;  2Z4E B;  1RE4 C;  1N73 C;  4EPU A;  2J1G A;  1FZG C;  3E1I B;  2OYH B;  2H43 B;  2J64 A;  1LWU C;  1RF0 B;  1RF1 C;  2Q9I B;  1RE3 C;  2J3G A;  2XNX C;  1LTJ B;  1RF0 C;  2Q9I C;  2HOD B;  2J61 B;  2J2P A;  2J0G A;  1FZD A;  3BVH C;  3H32 B;  1LT9 B;  2JHH C;  2Z4E C;  2WNP F;  2J5Z A; 
#chains in the Genus database with same CATH homology
 1M1J B;  1FZA B;  1N86 B;  2J3F D;  3E1I C;  2OYH C;  2H43 C;  2JHM F;  2J3F A;  2JHL F;  1FZB B;  2OYI B;  2HPC B;  1FZC B;  1FZF B;  2HLO B;  4NYT A;  1LTJ C;  1FZB C;  1Z3U A;  2HOD C;  1FZC C;  1Z3S A;  2J0H A;  2J3U A;  4JYO X;  2FIB A;  2J0Y A;  2J3O A;  3HUS B;  1FZE B;  1FIB A;  3H32 C;  1LT9 C;  4ZFG A;  2FFD B;  1RE4 B;  1N73 B;  1M1J C;  1FZA C;  1FZE C;  4R9T A;  1FZG B;  1N86 C;  2J60 A;  2FFD C;  1LWU B;  3GHG C;  2OYI C;  1RF1 B;  2HPC C;  1RE3 B;  2J61 A;  2JHK F;  1FZF C;  2HLO C;  2XNX B;  1JC9 A;  4JZC A;  2JHI F;  4M7F A;  1FIC A;  3BVH B;  2GY7 A;  4R9J A;  3HUS C;  1FID A;  4M7H A;  2D39 A;  3FIB A;  2Z4E B;  1RE4 C;  1N73 C;  4EPU A;  2J1G A;  1FZG C;  3E1I B;  2OYH B;  2H43 B;  2J64 A;  1LWU C;  1RF0 B;  1RF1 C;  2Q9I B;  1RE3 C;  2J3G A;  2XNX C;  1LTJ B;  1RF0 C;  2Q9I C;  2HOD B;  2J61 B;  2J2P A;  2J0G A;  1FZD A;  3BVH C;  3H32 B;  1LT9 B;  2JHH C;  2Z4E C;  2WNP F;  2J5Z A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...