4JZCA

Angiopoietin-2 fibrinogen domain tag mutant
Total Genus 68

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
sequence length
218
structure length
218
Chain Sequence
ISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYTAGQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
AH1 (6-12)S2 (30-36)O1 (6-35)TI1 (24-27)S5 (75-76)TI'1 (39-42)TIV1 (36-39)S3 (44-50)TIV2 (38-41)S11 (208-215)EMPTYTI2 (70-73)TI4 (147-150)AH2 (61-66)O3 (159-172)S4 (68-69)TIV3 (71-74)AH3 (79-87)TIV4 (119-122)S7 (104-114)TI3 (99-102)TVIII2 (133-136)S10 (195-196)TIV5 (130-133)TVIII3 (136-139)S9 (175-176)TI8 (196-199)AH4 (159-163)TIV7 (155-158)TIV8 (169-172)TI5 (176-179)TI6 (183-186)TIV11 (187-190)TIV10 (184-187)TI7 (190-193)TI9 (201-204)TIV12 (197-200)TIV13 (198-201)S1 (18-23)S6 (91-98)3H1 (117-119)S8 (123-130)Updating...
connected with : NaN
molecule tags Signaling protein
source organism Homo sapiens
publication title Structural basis for angiopoietin-1-mediated signaling initiation.
pubmed doi rcsb
molecule keywords Angiopoietin-2
total genus 68
structure length 218
sequence length 218
ec nomenclature
pdb deposition date 2013-04-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00147 Fibrinogen_C Fibrinogen beta and gamma chains, C-terminal globular domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.215.10 Alpha Beta Alpha-Beta Complex Gamma Fibrinogen; Chain A, domain 1 Gamma Fibrinogen, chain A, domain 1 4jzcA01
4.10.530.10 Few Secondary Structures Irregular Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2 Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 4jzcA02
1Z3UA 1FZAC 1LTJC 4JYOX 2JHKF 1FZEB 1N86C 2Q9IB 2FIBA 2J0HA 1LWUB 4EPUA 2HLOB 1FZBB 2J61B 2D39A 4R9JA 3E1IC 2HODC 3H32B 2H43C 1FICA 1N73C 3BVHC 1RE4B 1RF1C 3HUSB 2OYHC 2OYIC 1FZDA 1RE3B 2JHLF 2Z4EB 2J1GA 2JHMF 4NYTA 1FZCB 2J0YA 2J0GA 2JHHC 2J64A 2XNXB 2J60A 1RF0B 4R9TA 2J3FD 2J61A 1FZEC 2HPCB 2Q9IC 1M1JB 1LWUC 4M7HA 1JC9A 2HLOC 1FZGB 1FZBC 2J5ZA 2JHIF 1FZFB 2FFDB 1LT9B 1FIDA 2J3FA 1RE4C 3HUSC 1FZAB 1LTJB 1RE3C 2Z4EC 4M7FA 1FZCC 1N86B 3FIBA 2WNPF 2XNXC 1RF0C 4ZFGA 3GHGC 2HPCC 3E1IB 1M1JC 2HODB 4JZCA 3H32C 2H43B 1FZGC 1N73B 1FIBA 3BVHB 2J3UA 2J3OA 1RF1B 1Z3SA 1FZFC 2J3GA 2OYHB 2J2PA 2OYIB 2FFDC 2GY7A 1LT9C
chains in the Genus database with same CATH superfamily
1Z3UA 1FZAC 1LTJC 4JYOX 2JHKF 1FZEB 1N86C 2Q9IB 2FIBA 2J0HA 1LWUB 4EPUA 2HLOB 1FZBB 2J61B 2D39A 4R9JA 3GHGB 3E1IC 2HODC 3H32B 2H43C 1FICA 1N73C 3BVHC 1RE4B 1RF1C 3HUSB 2OYHC 2OYIC 1FZDA 1RE3B 2JHLF 2Z4EB 2J1GA 2JHMF 4NYTA 1FZCB 2J0YA 2J0GA 2JHHC 2J64A 2XNXB 2J60A 1RF0B 4R9TA 2J3FD 2J61A 1FZEC 2HPCB 2Q9IC 1M1JB 1LWUC 4M7HA 1JC9A 2HLOC 1FZGB 1FZBC 2J5ZA 2JHIF 1FZFB 2FFDB 1LT9B 1FIDA 2J3FA 1RE4C 3HUSC 1FZAB 1LTJB 1RE3C 2Z4EC 4M7FA 1FZCC 1N86B 3FIBA 2WNPF 2XNXC 1RF0C 4ZFGA 3GHGC 2HPCC 3E1IB 1M1JC 2HODB 4JZCA 3H32C 2H43B 1FZGC 1N73B 1FIBA 3BVHB 2J3UA 2J3OA 1RF1B 1Z3SA 1FZFC 2J3GA 2OYHB 2J2PA 2OYIB 2FFDC 2GY7A 1LT9C
chains in the Genus database with same CATH topology
1Z3UA 1FZAC 1LTJC 4JYOX 2JHKF 1FZEB 1N86C 2Q9IB 2FIBA 2J0HA 1LWUB 4EPUA 2HLOB 1FZBB 2J61B 2D39A 4R9JA 3E1IC 2HODC 3H32B 2H43C 1FICA 1N73C 3BVHC 1RE4B 1RF1C 3HUSB 2OYHC 2OYIC 1FZDA 1RE3B 2JHLF 2Z4EB 2J1GA 2JHMF 4NYTA 1FZCB 2J0YA 2J0GA 2JHHC 2J64A 2XNXB 2J60A 1RF0B 4R9TA 2J3FD 2J61A 1FZEC 2HPCB 2Q9IC 1M1JB 1LWUC 4M7HA 1JC9A 2HLOC 1FZGB 1FZBC 2J5ZA 2JHIF 1FZFB 2FFDB 1LT9B 1FIDA 2J3FA 1RE4C 3HUSC 1FZAB 1LTJB 1RE3C 2Z4EC 4M7FA 1FZCC 1N86B 3FIBA 2WNPF 2XNXC 1RF0C 4ZFGA 3GHGC 2HPCC 3E1IB 1M1JC 2HODB 4JZCA 3H32C 2H43B 1FZGC 1N73B 1FIBA 3BVHB 2J3UA 2J3OA 1RF1B 1Z3SA 1FZFC 2J3GA 2OYHB 2J2PA 2OYIB 2FFDC 2GY7A 1LT9C
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1Z3U A;  1FZA C;  1LTJ C;  4JYO X;  2JHK F;  1FZE B;  1N86 C;  2Q9I B;  2FIB A;  2J0H A;  1LWU B;  4EPU A;  2HLO B;  1FZB B;  2J61 B;  2D39 A;  4R9J A;  3E1I C;  2HOD C;  3H32 B;  2H43 C;  1FIC A;  1N73 C;  3BVH C;  1RE4 B;  1RF1 C;  3HUS B;  2OYH C;  2OYI C;  1FZD A;  1RE3 B;  2JHL F;  2Z4E B;  2J1G A;  2JHM F;  4NYT A;  1FZC B;  2J0Y A;  2J0G A;  2JHH C;  2J64 A;  2XNX B;  2J60 A;  1RF0 B;  4R9T A;  2J3F D;  2J61 A;  1FZE C;  2HPC B;  2Q9I C;  1M1J B;  1LWU C;  4M7H A;  1JC9 A;  2HLO C;  1FZG B;  1FZB C;  2J5Z A;  2JHI F;  1FZF B;  2FFD B;  1LT9 B;  1FID A;  2J3F A;  1RE4 C;  3HUS C;  1FZA B;  1LTJ B;  1RE3 C;  2Z4E C;  4M7F A;  1FZC C;  1N86 B;  3FIB A;  2WNP F;  2XNX C;  1RF0 C;  4ZFG A;  3GHG C;  2HPC C;  3E1I B;  1M1J C;  2HOD B;  4JZC A;  3H32 C;  2H43 B;  1FZG C;  1N73 B;  1FIB A;  3BVH B;  2J3U A;  2J3O A;  1RF1 B;  1Z3S A;  1FZF C;  2J3G A;  2OYH B;  2J2P A;  2OYI B;  2FFD C;  2GY7 A;  1LT9 C; 
#chains in the Genus database with same CATH topology
 1Z3U A;  1FZA C;  1LTJ C;  4JYO X;  2JHK F;  1FZE B;  1N86 C;  2Q9I B;  2FIB A;  2J0H A;  1LWU B;  4EPU A;  2HLO B;  1FZB B;  2J61 B;  2D39 A;  4R9J A;  3GHG B;  3E1I C;  2HOD C;  3H32 B;  2H43 C;  1FIC A;  1N73 C;  3BVH C;  1RE4 B;  1RF1 C;  3HUS B;  2OYH C;  2OYI C;  1FZD A;  1RE3 B;  2JHL F;  2Z4E B;  2J1G A;  2JHM F;  4NYT A;  1FZC B;  2J0Y A;  2J0G A;  2JHH C;  2J64 A;  2XNX B;  2J60 A;  1RF0 B;  4R9T A;  2J3F D;  2J61 A;  1FZE C;  2HPC B;  2Q9I C;  1M1J B;  1LWU C;  4M7H A;  1JC9 A;  2HLO C;  1FZG B;  1FZB C;  2J5Z A;  2JHI F;  1FZF B;  2FFD B;  1LT9 B;  1FID A;  2J3F A;  1RE4 C;  3HUS C;  1FZA B;  1LTJ B;  1RE3 C;  2Z4E C;  4M7F A;  1FZC C;  1N86 B;  3FIB A;  2WNP F;  2XNX C;  1RF0 C;  4ZFG A;  3GHG C;  2HPC C;  3E1I B;  1M1J C;  2HOD B;  4JZC A;  3H32 C;  2H43 B;  1FZG C;  1N73 B;  1FIB A;  3BVH B;  2J3U A;  2J3O A;  1RF1 B;  1Z3S A;  1FZF C;  2J3G A;  2OYH B;  2J2P A;  2OYI B;  2FFD C;  2GY7 A;  1LT9 C; 
#chains in the Genus database with same CATH homology
 1Z3U A;  1FZA C;  1LTJ C;  4JYO X;  2JHK F;  1FZE B;  1N86 C;  2Q9I B;  2FIB A;  2J0H A;  1LWU B;  4EPU A;  2HLO B;  1FZB B;  2J61 B;  2D39 A;  4R9J A;  3E1I C;  2HOD C;  3H32 B;  2H43 C;  1FIC A;  1N73 C;  3BVH C;  1RE4 B;  1RF1 C;  3HUS B;  2OYH C;  2OYI C;  1FZD A;  1RE3 B;  2JHL F;  2Z4E B;  2J1G A;  2JHM F;  4NYT A;  1FZC B;  2J0Y A;  2J0G A;  2JHH C;  2J64 A;  2XNX B;  2J60 A;  1RF0 B;  4R9T A;  2J3F D;  2J61 A;  1FZE C;  2HPC B;  2Q9I C;  1M1J B;  1LWU C;  4M7H A;  1JC9 A;  2HLO C;  1FZG B;  1FZB C;  2J5Z A;  2JHI F;  1FZF B;  2FFD B;  1LT9 B;  1FID A;  2J3F A;  1RE4 C;  3HUS C;  1FZA B;  1LTJ B;  1RE3 C;  2Z4E C;  4M7F A;  1FZC C;  1N86 B;  3FIB A;  2WNP F;  2XNX C;  1RF0 C;  4ZFG A;  3GHG C;  2HPC C;  3E1I B;  1M1J C;  2HOD B;  4JZC A;  3H32 C;  2H43 B;  1FZG C;  1N73 B;  1FIB A;  3BVH B;  2J3U A;  2J3O A;  1RF1 B;  1Z3S A;  1FZF C;  2J3G A;  2OYH B;  2J2P A;  2OYI B;  2FFD C;  2GY7 A;  1LT9 C;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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