2Z4EC

Crystal structure of d-dimer from human fibrin complexed with gly-his-arg-pro-tyr-amide
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
292
structure length
292
Chain Sequence
THDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Blood clotting
publication title Probing the beta-chain hole of fibrinogen with synthetic peptides that differ at their amino termini
pubmed doi rcsb
molecule keywords Fibrinogen alpha chain
total genus 89
structure length 292
sequence length 292
chains with identical sequence F
ec nomenclature
pdb deposition date 2007-06-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00147 Fibrinogen_C Fibrinogen beta and gamma chains, C-terminal globular domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.215.10 Alpha Beta Alpha-Beta Complex Gamma Fibrinogen; Chain A, domain 1 Gamma Fibrinogen, chain A, domain 1 2z4eC01
4.10.530.10 Few Secondary Structures Irregular Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2 Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 2z4eC02
2XNXC 1FZEC 1FZAC 1RE4C 4ZFGA 1N86C 1FZGB 2OYHC 4NYTA 2J5ZA 3E1IC 3HUSB 2Z4EB 1FICA 2HPCC 2J1GA 2J2PA 2J3OA 3H32B 1RF0B 4M7HA 2HLOB 2JHKF 3FIBA 2H43C 2OYIB 1LWUC 1N73C 2J3FA 2J0HA 1RE3B 2FFDB 3BVHC 3HUSC 1FIDA 1LTJB 2J3GA 1FZCB 2FIBA 4JZCA 2JHIF 2JHHC 1Z3SA 2JHLF 2HLOC 1LT9C 2OYIC 1RE4B 1FZAB 2Q9IB 2J64A 2D39A 1RF1B 4R9JA 1RE3C 1FZGC 1FZBB 2FFDC 3E1IB 4EPUA 1LTJC 2Z4EC 1M1JB 2WNPF 2J60A 3GHGC 2HPCB 2JHMF 3H32C 4M7FA 2J0GA 1RF0C 1JC9A 1Z3UA 2J0YA 1N73B 2HODB 1FZFB 2Q9IC 2J3FD 2XNXB 1FZEB 1RF1C 2J61B 4JYOX 1N86B 2OYHB 1FZBC 3BVHB 4R9TA 2J61A 1FZDA 1M1JC 1FZCC 1FZFC 1FIBA 2GY7A 1LT9B 2H43B 2HODC 2J3UA 1LWUB
chains in the Genus database with same CATH superfamily
2XNXC 1FZEC 1FZAC 1RE4C 4ZFGA 1N86C 1FZGB 2OYHC 4NYTA 2J5ZA 3E1IC 3HUSB 2Z4EB 1FICA 2HPCC 2J1GA 2J2PA 2J3OA 3H32B 1RF0B 4M7HA 2HLOB 2JHKF 3FIBA 2H43C 2OYIB 1LWUC 1N73C 2J3FA 2J0HA 1RE3B 2FFDB 3BVHC 3HUSC 1FIDA 1LTJB 2J3GA 1FZCB 2FIBA 4JZCA 2JHIF 2JHHC 3GHGB 1Z3SA 2JHLF 2HLOC 1LT9C 2OYIC 1RE4B 1FZAB 2Q9IB 2J64A 2D39A 1RF1B 4R9JA 1RE3C 1FZGC 1FZBB 2FFDC 3E1IB 4EPUA 1LTJC 2Z4EC 1M1JB 2WNPF 2J60A 3GHGC 2HPCB 2JHMF 3H32C 4M7FA 2J0GA 1RF0C 1JC9A 1Z3UA 2J0YA 1N73B 2HODB 1FZFB 2Q9IC 2J3FD 2XNXB 1FZEB 1RF1C 2J61B 4JYOX 1N86B 2OYHB 1FZBC 3BVHB 4R9TA 2J61A 1FZDA 1M1JC 1FZCC 1FZFC 1FIBA 2GY7A 1LT9B 2H43B 2HODC 2J3UA 1LWUB
chains in the Genus database with same CATH topology
2XNXC 1FZEC 1FZAC 1RE4C 4ZFGA 1N86C 1FZGB 2OYHC 4NYTA 2J5ZA 3E1IC 3HUSB 2Z4EB 1FICA 2HPCC 2J1GA 2J2PA 2J3OA 3H32B 1RF0B 4M7HA 2HLOB 2JHKF 3FIBA 2H43C 2OYIB 1LWUC 1N73C 2J3FA 2J0HA 1RE3B 2FFDB 3BVHC 3HUSC 1FIDA 1LTJB 2J3GA 1FZCB 2FIBA 4JZCA 2JHIF 2JHHC 1Z3SA 2JHLF 2HLOC 1LT9C 2OYIC 1RE4B 1FZAB 2Q9IB 2J64A 2D39A 1RF1B 4R9JA 1RE3C 1FZGC 1FZBB 2FFDC 3E1IB 4EPUA 1LTJC 2Z4EC 1M1JB 2WNPF 2J60A 3GHGC 2HPCB 2JHMF 3H32C 4M7FA 2J0GA 1RF0C 1JC9A 1Z3UA 2J0YA 1N73B 2HODB 1FZFB 2Q9IC 2J3FD 2XNXB 1FZEB 1RF1C 2J61B 4JYOX 1N86B 2OYHB 1FZBC 3BVHB 4R9TA 2J61A 1FZDA 1M1JC 1FZCC 1FZFC 1FIBA 2GY7A 1LT9B 2H43B 2HODC 2J3UA 1LWUB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XNX C;  1FZE C;  1FZA C;  1RE4 C;  4ZFG A;  1N86 C;  1FZG B;  2OYH C;  4NYT A;  2J5Z A;  3E1I C;  3HUS B;  2Z4E B;  1FIC A;  2HPC C;  2J1G A;  2J2P A;  2J3O A;  3H32 B;  1RF0 B;  4M7H A;  2HLO B;  2JHK F;  3FIB A;  2H43 C;  2OYI B;  1LWU C;  1N73 C;  2J3F A;  2J0H A;  1RE3 B;  2FFD B;  3BVH C;  3HUS C;  1FID A;  1LTJ B;  2J3G A;  1FZC B;  2FIB A;  4JZC A;  2JHI F;  2JHH C;  1Z3S A;  2JHL F;  2HLO C;  1LT9 C;  2OYI C;  1RE4 B;  1FZA B;  2Q9I B;  2J64 A;  2D39 A;  1RF1 B;  4R9J A;  1RE3 C;  1FZG C;  1FZB B;  2FFD C;  3E1I B;  4EPU A;  1LTJ C;  2Z4E C;  1M1J B;  2WNP F;  2J60 A;  3GHG C;  2HPC B;  2JHM F;  3H32 C;  4M7F A;  2J0G A;  1RF0 C;  1JC9 A;  1Z3U A;  2J0Y A;  1N73 B;  2HOD B;  1FZF B;  2Q9I C;  2J3F D;  2XNX B;  1FZE B;  1RF1 C;  2J61 B;  4JYO X;  1N86 B;  2OYH B;  1FZB C;  3BVH B;  4R9T A;  2J61 A;  1FZD A;  1M1J C;  1FZC C;  1FZF C;  1FIB A;  2GY7 A;  1LT9 B;  2H43 B;  2HOD C;  2J3U A;  1LWU B; 
#chains in the Genus database with same CATH topology
 2XNX C;  1FZE C;  1FZA C;  1RE4 C;  4ZFG A;  1N86 C;  1FZG B;  2OYH C;  4NYT A;  2J5Z A;  3E1I C;  3HUS B;  2Z4E B;  1FIC A;  2HPC C;  2J1G A;  2J2P A;  2J3O A;  3H32 B;  1RF0 B;  4M7H A;  2HLO B;  2JHK F;  3FIB A;  2H43 C;  2OYI B;  1LWU C;  1N73 C;  2J3F A;  2J0H A;  1RE3 B;  2FFD B;  3BVH C;  3HUS C;  1FID A;  1LTJ B;  2J3G A;  1FZC B;  2FIB A;  4JZC A;  2JHI F;  2JHH C;  3GHG B;  1Z3S A;  2JHL F;  2HLO C;  1LT9 C;  2OYI C;  1RE4 B;  1FZA B;  2Q9I B;  2J64 A;  2D39 A;  1RF1 B;  4R9J A;  1RE3 C;  1FZG C;  1FZB B;  2FFD C;  3E1I B;  4EPU A;  1LTJ C;  2Z4E C;  1M1J B;  2WNP F;  2J60 A;  3GHG C;  2HPC B;  2JHM F;  3H32 C;  4M7F A;  2J0G A;  1RF0 C;  1JC9 A;  1Z3U A;  2J0Y A;  1N73 B;  2HOD B;  1FZF B;  2Q9I C;  2J3F D;  2XNX B;  1FZE B;  1RF1 C;  2J61 B;  4JYO X;  1N86 B;  2OYH B;  1FZB C;  3BVH B;  4R9T A;  2J61 A;  1FZD A;  1M1J C;  1FZC C;  1FZF C;  1FIB A;  2GY7 A;  1LT9 B;  2H43 B;  2HOD C;  2J3U A;  1LWU B; 
#chains in the Genus database with same CATH homology
 2XNX C;  1FZE C;  1FZA C;  1RE4 C;  4ZFG A;  1N86 C;  1FZG B;  2OYH C;  4NYT A;  2J5Z A;  3E1I C;  3HUS B;  2Z4E B;  1FIC A;  2HPC C;  2J1G A;  2J2P A;  2J3O A;  3H32 B;  1RF0 B;  4M7H A;  2HLO B;  2JHK F;  3FIB A;  2H43 C;  2OYI B;  1LWU C;  1N73 C;  2J3F A;  2J0H A;  1RE3 B;  2FFD B;  3BVH C;  3HUS C;  1FID A;  1LTJ B;  2J3G A;  1FZC B;  2FIB A;  4JZC A;  2JHI F;  2JHH C;  1Z3S A;  2JHL F;  2HLO C;  1LT9 C;  2OYI C;  1RE4 B;  1FZA B;  2Q9I B;  2J64 A;  2D39 A;  1RF1 B;  4R9J A;  1RE3 C;  1FZG C;  1FZB B;  2FFD C;  3E1I B;  4EPU A;  1LTJ C;  2Z4E C;  1M1J B;  2WNP F;  2J60 A;  3GHG C;  2HPC B;  2JHM F;  3H32 C;  4M7F A;  2J0G A;  1RF0 C;  1JC9 A;  1Z3U A;  2J0Y A;  1N73 B;  2HOD B;  1FZF B;  2Q9I C;  2J3F D;  2XNX B;  1FZE B;  1RF1 C;  2J61 B;  4JYO X;  1N86 B;  2OYH B;  1FZB C;  3BVH B;  4R9T A;  2J61 A;  1FZD A;  1M1J C;  1FZC C;  1FZF C;  1FIB A;  2GY7 A;  1LT9 B;  2H43 B;  2HOD C;  2J3U A;  1LWU B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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