2Z4EC

Crystal structure of d-dimer from human fibrin complexed with gly-his-arg-pro-tyr-amide
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
292
structure length
292
Chain Sequence
THDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Probing the beta-chain hole of fibrinogen with synthetic peptides that differ at their amino termini
pubmed doi rcsb
molecule tags Blood clotting
molecule keywords Fibrinogen alpha chain
total genus 89
structure length 292
sequence length 292
chains with identical sequence F
ec nomenclature
pdb deposition date 2007-06-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00147 Fibrinogen_C Fibrinogen beta and gamma chains, C-terminal globular domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.215.10 Alpha Beta Alpha-Beta Complex Gamma Fibrinogen; Chain A, domain 1 Gamma Fibrinogen, chain A, domain 1 2z4eC01
4.10.530.10 Few Secondary Structures Irregular Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2 Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 2z4eC02
2JHKF 1Z3SA 1LTJB 2D39A 2OYIB 1N73B 1LT9B 1N86B 2FFDC 2J5ZA 2J1GA 2XNXB 4JZCA 1RE4C 1M1JC 3HUSC 3E1IC 2FFDB 1LWUB 1RE3C 1FZEC 1RE4B 2J3UA 1M1JB 3HUSB 3E1IB 2HLOC 2OYIC 1LTJC 1RE3B 1N73C 4NYTA 1FZCB 2HLOB 2J64A 3BVHB 2XNXC 1RF0C 1Z3UA 1JC9A 4M7HA 1LWUC 1FICA 2JHLF 2OYHB 1RF0B 1FZAB 3GHGC 2Z4EC 2Z4EB 2Q9IC 4JYOX 2JHIF 1FZCC 1FIBA 3BVHC 4R9JA 2J0GA 1FZFC 1RF1C 2Q9IB 4M7FA 2J3FA 2HPCB 2OYHC 4ZFGA 1FZAC 2J2PA 1RF1B 1FZFB 2J61B 1FIDA 2J3FD 1FZBB 2J3GA 2GY7A 2JHMF 2JHHC 1FZDA 2HODB 2J3OA 2HPCC 2J60A 4EPUA 2FIBA 1FZGB 2J0HA 3H32B 2WNPF 2J0YA 1FZBC 3FIBA 2H43C 2J61A 2HODC 2H43B 1FZGC 1FZEB 1LT9C 3H32C 1N86C 4R9TA
chains in the Genus database with same CATH superfamily
2JHKF 1Z3SA 1LTJB 2D39A 2OYIB 1N73B 1LT9B 1N86B 2FFDC 2J5ZA 2J1GA 2XNXB 4JZCA 1RE4C 1M1JC 3HUSC 3E1IC 2FFDB 1LWUB 1RE3C 1FZEC 1RE4B 3GHGB 2J3UA 1M1JB 3HUSB 3E1IB 2HLOC 2OYIC 1LTJC 1RE3B 1N73C 4NYTA 1FZCB 2HLOB 2J64A 3BVHB 2XNXC 1RF0C 1Z3UA 1JC9A 4M7HA 1LWUC 1FICA 2JHLF 2OYHB 1RF0B 1FZAB 3GHGC 2Z4EC 2Z4EB 2Q9IC 4JYOX 2JHIF 1FZCC 1FIBA 3BVHC 4R9JA 2J0GA 1FZFC 1RF1C 2Q9IB 4M7FA 2J3FA 2HPCB 2OYHC 4ZFGA 1FZAC 2J2PA 1RF1B 1FZFB 2J61B 1FIDA 2J3FD 1FZBB 2J3GA 2GY7A 2JHMF 2JHHC 1FZDA 2HODB 2J3OA 2HPCC 2J60A 4EPUA 2FIBA 1FZGB 2J0HA 3H32B 2WNPF 2J0YA 1FZBC 3FIBA 2H43C 2J61A 2HODC 2H43B 1FZGC 1FZEB 1LT9C 3H32C 1N86C 4R9TA
chains in the Genus database with same CATH topology
2JHKF 1Z3SA 1LTJB 2D39A 2OYIB 1N73B 1LT9B 1N86B 2FFDC 2J5ZA 2J1GA 2XNXB 4JZCA 1RE4C 1M1JC 3HUSC 3E1IC 2FFDB 1LWUB 1RE3C 1FZEC 1RE4B 2J3UA 1M1JB 3HUSB 3E1IB 2HLOC 2OYIC 1LTJC 1RE3B 1N73C 4NYTA 1FZCB 2HLOB 2J64A 3BVHB 2XNXC 1RF0C 1Z3UA 1JC9A 4M7HA 1LWUC 1FICA 2JHLF 2OYHB 1RF0B 1FZAB 3GHGC 2Z4EC 2Z4EB 2Q9IC 4JYOX 2JHIF 1FZCC 1FIBA 3BVHC 4R9JA 2J0GA 1FZFC 1RF1C 2Q9IB 4M7FA 2J3FA 2HPCB 2OYHC 4ZFGA 1FZAC 2J2PA 1RF1B 1FZFB 2J61B 1FIDA 2J3FD 1FZBB 2J3GA 2GY7A 2JHMF 2JHHC 1FZDA 2HODB 2J3OA 2HPCC 2J60A 4EPUA 2FIBA 1FZGB 2J0HA 3H32B 2WNPF 2J0YA 1FZBC 3FIBA 2H43C 2J61A 2HODC 2H43B 1FZGC 1FZEB 1LT9C 3H32C 1N86C 4R9TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JHK F;  1Z3S A;  1LTJ B;  2D39 A;  2OYI B;  1N73 B;  1LT9 B;  1N86 B;  2FFD C;  2J5Z A;  2J1G A;  2XNX B;  4JZC A;  1RE4 C;  1M1J C;  3HUS C;  3E1I C;  2FFD B;  1LWU B;  1RE3 C;  1FZE C;  1RE4 B;  2J3U A;  1M1J B;  3HUS B;  3E1I B;  2HLO C;  2OYI C;  1LTJ C;  1RE3 B;  1N73 C;  4NYT A;  1FZC B;  2HLO B;  2J64 A;  3BVH B;  2XNX C;  1RF0 C;  1Z3U A;  1JC9 A;  4M7H A;  1LWU C;  1FIC A;  2JHL F;  2OYH B;  1RF0 B;  1FZA B;  3GHG C;  2Z4E C;  2Z4E B;  2Q9I C;  4JYO X;  2JHI F;  1FZC C;  1FIB A;  3BVH C;  4R9J A;  2J0G A;  1FZF C;  1RF1 C;  2Q9I B;  4M7F A;  2J3F A;  2HPC B;  2OYH C;  4ZFG A;  1FZA C;  2J2P A;  1RF1 B;  1FZF B;  2J61 B;  1FID A;  2J3F D;  1FZB B;  2J3G A;  2GY7 A;  2JHM F;  2JHH C;  1FZD A;  2HOD B;  2J3O A;  2HPC C;  2J60 A;  4EPU A;  2FIB A;  1FZG B;  2J0H A;  3H32 B;  2WNP F;  2J0Y A;  1FZB C;  3FIB A;  2H43 C;  2J61 A;  2HOD C;  2H43 B;  1FZG C;  1FZE B;  1LT9 C;  3H32 C;  1N86 C;  4R9T A; 
#chains in the Genus database with same CATH topology
 2JHK F;  1Z3S A;  1LTJ B;  2D39 A;  2OYI B;  1N73 B;  1LT9 B;  1N86 B;  2FFD C;  2J5Z A;  2J1G A;  2XNX B;  4JZC A;  1RE4 C;  1M1J C;  3HUS C;  3E1I C;  2FFD B;  1LWU B;  1RE3 C;  1FZE C;  1RE4 B;  3GHG B;  2J3U A;  1M1J B;  3HUS B;  3E1I B;  2HLO C;  2OYI C;  1LTJ C;  1RE3 B;  1N73 C;  4NYT A;  1FZC B;  2HLO B;  2J64 A;  3BVH B;  2XNX C;  1RF0 C;  1Z3U A;  1JC9 A;  4M7H A;  1LWU C;  1FIC A;  2JHL F;  2OYH B;  1RF0 B;  1FZA B;  3GHG C;  2Z4E C;  2Z4E B;  2Q9I C;  4JYO X;  2JHI F;  1FZC C;  1FIB A;  3BVH C;  4R9J A;  2J0G A;  1FZF C;  1RF1 C;  2Q9I B;  4M7F A;  2J3F A;  2HPC B;  2OYH C;  4ZFG A;  1FZA C;  2J2P A;  1RF1 B;  1FZF B;  2J61 B;  1FID A;  2J3F D;  1FZB B;  2J3G A;  2GY7 A;  2JHM F;  2JHH C;  1FZD A;  2HOD B;  2J3O A;  2HPC C;  2J60 A;  4EPU A;  2FIB A;  1FZG B;  2J0H A;  3H32 B;  2WNP F;  2J0Y A;  1FZB C;  3FIB A;  2H43 C;  2J61 A;  2HOD C;  2H43 B;  1FZG C;  1FZE B;  1LT9 C;  3H32 C;  1N86 C;  4R9T A; 
#chains in the Genus database with same CATH homology
 2JHK F;  1Z3S A;  1LTJ B;  2D39 A;  2OYI B;  1N73 B;  1LT9 B;  1N86 B;  2FFD C;  2J5Z A;  2J1G A;  2XNX B;  4JZC A;  1RE4 C;  1M1J C;  3HUS C;  3E1I C;  2FFD B;  1LWU B;  1RE3 C;  1FZE C;  1RE4 B;  2J3U A;  1M1J B;  3HUS B;  3E1I B;  2HLO C;  2OYI C;  1LTJ C;  1RE3 B;  1N73 C;  4NYT A;  1FZC B;  2HLO B;  2J64 A;  3BVH B;  2XNX C;  1RF0 C;  1Z3U A;  1JC9 A;  4M7H A;  1LWU C;  1FIC A;  2JHL F;  2OYH B;  1RF0 B;  1FZA B;  3GHG C;  2Z4E C;  2Z4E B;  2Q9I C;  4JYO X;  2JHI F;  1FZC C;  1FIB A;  3BVH C;  4R9J A;  2J0G A;  1FZF C;  1RF1 C;  2Q9I B;  4M7F A;  2J3F A;  2HPC B;  2OYH C;  4ZFG A;  1FZA C;  2J2P A;  1RF1 B;  1FZF B;  2J61 B;  1FID A;  2J3F D;  1FZB B;  2J3G A;  2GY7 A;  2JHM F;  2JHH C;  1FZD A;  2HOD B;  2J3O A;  2HPC C;  2J60 A;  4EPU A;  2FIB A;  1FZG B;  2J0H A;  3H32 B;  2WNP F;  2J0Y A;  1FZB C;  3FIB A;  2H43 C;  2J61 A;  2HOD C;  2H43 B;  1FZG C;  1FZE B;  1LT9 C;  3H32 C;  1N86 C;  4R9T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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