2Z4EC

Crystal structure of d-dimer from human fibrin complexed with gly-his-arg-pro-tyr-amide
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
292
structure length
292
Chain Sequence
THDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Probing the beta-chain hole of fibrinogen with synthetic peptides that differ at their amino termini
pubmed doi rcsb
molecule tags Blood clotting
molecule keywords Fibrinogen alpha chain
total genus 89
structure length 292
sequence length 292
chains with identical sequence F
ec nomenclature
pdb deposition date 2007-06-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00147 Fibrinogen_C Fibrinogen beta and gamma chains, C-terminal globular domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.215.10 Alpha Beta Alpha-Beta Complex Gamma Fibrinogen; Chain A, domain 1 Gamma Fibrinogen, chain A, domain 1 2z4eC01
4.10.530.10 Few Secondary Structures Irregular Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2 Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 2z4eC02
3GHGC 1FZFC 3HUSC 2J61B 1RF1B 1FZEB 2J3FD 2HLOC 2J3FA 1RF0C 2HPCC 2HPCB 2HODC 1FZAB 1FZBB 1LWUC 1FZGC 2J2PA 2WNPF 3H32C 4M7HA 2JHHC 4M7FA 3BVHB 2J5ZA 2OYIC 1FIDA 2Q9IB 2J0YA 2J0GA 4JYOX 1N86C 1FZFB 3HUSB 2J3UA 4NYTA 1LTJC 2J0HA 2GY7A 2FIBA 2J3OA 2HLOB 1RE3C 2OYHC 2J61A 2J64A 1FZCC 4JZCA 1RF0B 2XNXC 1FIBA 2HODB 1LWUB 2H43C 2JHMF 3E1IC 1JC9A 1FZGB 2FFDC 1RE4C 3H32B 2Z4EC 1Z3SA 2OYIB 4R9TA 1N86B 4ZFGA 1N73C 2J1GA 4EPUA 1LTJB 2OYHB 1RE3B 1M1JC 1FZCB 1LT9C 2XNXB 2D39A 2H43B 3E1IB 2FFDB 1RE4B 2JHKF 2J3GA 1FICA 2Z4EB 1RF1C 1FZEC 2JHLF 1N73B 2J60A 1Z3UA 4R9JA 2JHIF 1FZAC 1FZBC 1M1JB 1FZDA 1LT9B 3BVHC 3FIBA 2Q9IC
chains in the Genus database with same CATH superfamily
3GHGC 1FZFC 3HUSC 2J61B 1RF1B 1FZEB 2J3FD 2HLOC 2J3FA 1RF0C 2HPCC 2HPCB 2HODC 1FZAB 1FZBB 1LWUC 1FZGC 2J2PA 2WNPF 3H32C 4M7HA 2JHHC 4M7FA 3BVHB 2J5ZA 2OYIC 1FIDA 2Q9IB 2J0YA 2J0GA 3GHGB 4JYOX 1N86C 1FZFB 3HUSB 2J3UA 4NYTA 1LTJC 2J0HA 2GY7A 2FIBA 2J3OA 2HLOB 1RE3C 2OYHC 2J61A 2J64A 1FZCC 4JZCA 1RF0B 2XNXC 1FIBA 2HODB 1LWUB 2H43C 2JHMF 3E1IC 1JC9A 1FZGB 2FFDC 1RE4C 3H32B 2Z4EC 1Z3SA 2OYIB 4R9TA 1N86B 4ZFGA 1N73C 2J1GA 4EPUA 1LTJB 2OYHB 1RE3B 1M1JC 1FZCB 1LT9C 2XNXB 2D39A 2H43B 3E1IB 2FFDB 1RE4B 2JHKF 2J3GA 1FICA 2Z4EB 1RF1C 1FZEC 2JHLF 1N73B 2J60A 1Z3UA 4R9JA 2JHIF 1FZAC 1FZBC 1M1JB 1FZDA 1LT9B 3BVHC 3FIBA 2Q9IC
chains in the Genus database with same CATH topology
3GHGC 1FZFC 3HUSC 2J61B 1RF1B 1FZEB 2J3FD 2HLOC 2J3FA 1RF0C 2HPCC 2HPCB 2HODC 1FZAB 1FZBB 1LWUC 1FZGC 2J2PA 2WNPF 3H32C 4M7HA 2JHHC 4M7FA 3BVHB 2J5ZA 2OYIC 1FIDA 2Q9IB 2J0YA 2J0GA 4JYOX 1N86C 1FZFB 3HUSB 2J3UA 4NYTA 1LTJC 2J0HA 2GY7A 2FIBA 2J3OA 2HLOB 1RE3C 2OYHC 2J61A 2J64A 1FZCC 4JZCA 1RF0B 2XNXC 1FIBA 2HODB 1LWUB 2H43C 2JHMF 3E1IC 1JC9A 1FZGB 2FFDC 1RE4C 3H32B 2Z4EC 1Z3SA 2OYIB 4R9TA 1N86B 4ZFGA 1N73C 2J1GA 4EPUA 1LTJB 2OYHB 1RE3B 1M1JC 1FZCB 1LT9C 2XNXB 2D39A 2H43B 3E1IB 2FFDB 1RE4B 2JHKF 2J3GA 1FICA 2Z4EB 1RF1C 1FZEC 2JHLF 1N73B 2J60A 1Z3UA 4R9JA 2JHIF 1FZAC 1FZBC 1M1JB 1FZDA 1LT9B 3BVHC 3FIBA 2Q9IC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GHG C;  1FZF C;  3HUS C;  2J61 B;  1RF1 B;  1FZE B;  2J3F D;  2HLO C;  2J3F A;  1RF0 C;  2HPC C;  2HPC B;  2HOD C;  1FZA B;  1FZB B;  1LWU C;  1FZG C;  2J2P A;  2WNP F;  3H32 C;  4M7H A;  2JHH C;  4M7F A;  3BVH B;  2J5Z A;  2OYI C;  1FID A;  2Q9I B;  2J0Y A;  2J0G A;  4JYO X;  1N86 C;  1FZF B;  3HUS B;  2J3U A;  4NYT A;  1LTJ C;  2J0H A;  2GY7 A;  2FIB A;  2J3O A;  2HLO B;  1RE3 C;  2OYH C;  2J61 A;  2J64 A;  1FZC C;  4JZC A;  1RF0 B;  2XNX C;  1FIB A;  2HOD B;  1LWU B;  2H43 C;  2JHM F;  3E1I C;  1JC9 A;  1FZG B;  2FFD C;  1RE4 C;  3H32 B;  2Z4E C;  1Z3S A;  2OYI B;  4R9T A;  1N86 B;  4ZFG A;  1N73 C;  2J1G A;  4EPU A;  1LTJ B;  2OYH B;  1RE3 B;  1M1J C;  1FZC B;  1LT9 C;  2XNX B;  2D39 A;  2H43 B;  3E1I B;  2FFD B;  1RE4 B;  2JHK F;  2J3G A;  1FIC A;  2Z4E B;  1RF1 C;  1FZE C;  2JHL F;  1N73 B;  2J60 A;  1Z3U A;  4R9J A;  2JHI F;  1FZA C;  1FZB C;  1M1J B;  1FZD A;  1LT9 B;  3BVH C;  3FIB A;  2Q9I C; 
#chains in the Genus database with same CATH topology
 3GHG C;  1FZF C;  3HUS C;  2J61 B;  1RF1 B;  1FZE B;  2J3F D;  2HLO C;  2J3F A;  1RF0 C;  2HPC C;  2HPC B;  2HOD C;  1FZA B;  1FZB B;  1LWU C;  1FZG C;  2J2P A;  2WNP F;  3H32 C;  4M7H A;  2JHH C;  4M7F A;  3BVH B;  2J5Z A;  2OYI C;  1FID A;  2Q9I B;  2J0Y A;  2J0G A;  3GHG B;  4JYO X;  1N86 C;  1FZF B;  3HUS B;  2J3U A;  4NYT A;  1LTJ C;  2J0H A;  2GY7 A;  2FIB A;  2J3O A;  2HLO B;  1RE3 C;  2OYH C;  2J61 A;  2J64 A;  1FZC C;  4JZC A;  1RF0 B;  2XNX C;  1FIB A;  2HOD B;  1LWU B;  2H43 C;  2JHM F;  3E1I C;  1JC9 A;  1FZG B;  2FFD C;  1RE4 C;  3H32 B;  2Z4E C;  1Z3S A;  2OYI B;  4R9T A;  1N86 B;  4ZFG A;  1N73 C;  2J1G A;  4EPU A;  1LTJ B;  2OYH B;  1RE3 B;  1M1J C;  1FZC B;  1LT9 C;  2XNX B;  2D39 A;  2H43 B;  3E1I B;  2FFD B;  1RE4 B;  2JHK F;  2J3G A;  1FIC A;  2Z4E B;  1RF1 C;  1FZE C;  2JHL F;  1N73 B;  2J60 A;  1Z3U A;  4R9J A;  2JHI F;  1FZA C;  1FZB C;  1M1J B;  1FZD A;  1LT9 B;  3BVH C;  3FIB A;  2Q9I C; 
#chains in the Genus database with same CATH homology
 3GHG C;  1FZF C;  3HUS C;  2J61 B;  1RF1 B;  1FZE B;  2J3F D;  2HLO C;  2J3F A;  1RF0 C;  2HPC C;  2HPC B;  2HOD C;  1FZA B;  1FZB B;  1LWU C;  1FZG C;  2J2P A;  2WNP F;  3H32 C;  4M7H A;  2JHH C;  4M7F A;  3BVH B;  2J5Z A;  2OYI C;  1FID A;  2Q9I B;  2J0Y A;  2J0G A;  4JYO X;  1N86 C;  1FZF B;  3HUS B;  2J3U A;  4NYT A;  1LTJ C;  2J0H A;  2GY7 A;  2FIB A;  2J3O A;  2HLO B;  1RE3 C;  2OYH C;  2J61 A;  2J64 A;  1FZC C;  4JZC A;  1RF0 B;  2XNX C;  1FIB A;  2HOD B;  1LWU B;  2H43 C;  2JHM F;  3E1I C;  1JC9 A;  1FZG B;  2FFD C;  1RE4 C;  3H32 B;  2Z4E C;  1Z3S A;  2OYI B;  4R9T A;  1N86 B;  4ZFG A;  1N73 C;  2J1G A;  4EPU A;  1LTJ B;  2OYH B;  1RE3 B;  1M1J C;  1FZC B;  1LT9 C;  2XNX B;  2D39 A;  2H43 B;  3E1I B;  2FFD B;  1RE4 B;  2JHK F;  2J3G A;  1FIC A;  2Z4E B;  1RF1 C;  1FZE C;  2JHL F;  1N73 B;  2J60 A;  1Z3U A;  4R9J A;  2JHI F;  1FZA C;  1FZB C;  1M1J B;  1FZD A;  1LT9 B;  3BVH C;  3FIB A;  2Q9I C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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