2HWB4

A comparison of the anti-rhinoviral drug binding pocket in hrv14 and hrv1a
Total Genus 2
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
40
structure length
40
Chain Sequence
INYYKDAASTSSAGQSLSMDPSKFTEPVKDLMLKGAPALN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A.
pubmed doi rcsb
molecule tags Virus
source organism Human rhinovirus 14
molecule keywords HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1)
total genus 2
structure length 40
sequence length 40
ec nomenclature ec 2.7.7.48: RNA-directed RNA polymerase.
pdb deposition date 1994-01-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
4 PF02226 Pico_P1A Picornavirus coat protein (VP4)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.80.10 Few Secondary Structures Irregular Rhinovirus 14, subunit 4 Picornavirus coat protein VP4 2hwb400
2R044 3JBG4 2PLV4 4Q4Y4 1K5MD 1AL24 1HRI4 1PO24 4GB34 1AR64 1VBB4 2RS14 1VBD4 3J8F4 1D4M4 1AR74 2RS54 1R094 2X5ID 2RMU4 1EAH4 1AR84 1H8TD 1RUD4 1RHI4 1VBC4 4RHV4 1VBA4 1MQTD 1NCQD 1HRV4 1HXS4 1RUC4 3JD74 4PDWD 4Q4W4 1ASJ4 1EV14 1RUF4 1NA1D 2RS34 1OOPD 1RVF4 2RR14 1COV4 1BEV4 1PO14 1R084 1PIV4 4Q4V4 2RM24 2HWC4 1RUG4 1RUI4 1RMU4 1Z7S4 2R064 1PVC4 1VBE4 1VRH4 2HWB4 1POV0 1RUE4 2R074 4Q4X4 1RUJ4 1AR94 1RUH4
chains in the Genus database with same CATH superfamily
3SFEA 1L0VA 1XHXA 3GQHA 1R094 2X5ID 2RMU4 2PY5A 2FBWA 4YT0A 1RHI4 4RHV4 2EX3A 3P4RA 4YSZA 1ASJ4 1EV14 3AE8A 1NA1D 1RVF4 3P4PA 4YTPA 4Q4V4 4YSYA 4KX6A 5C3JA 1PVC4 2WQYA 1RUE4 1YQ3A 2WDVA 1AR94 3VRAA 4Q4Y4 5C2TA 1K5MD 1HRI4 3GQKA 3AE9A 3AEDA 3AE2A 1H8TD 1HRV4 1VBA4 1NCQD 3AEEA 3VR8A 4YSXA 1HXS4 3AE7A 3CIRA 3ABVA 1NEKA 1ZOYA 3AEAA 3P4SA 3VRBA 4YXDA 1KF6A 1YQ4A 1NENA 2RM24 2HWC4 2H88A 2PYJA 2PW9A 2R074 3FI7A 4Q4X4 2RS14 1RUJ4 3AE5A 2ACZA 2R044 1AL24 2WU5A 1VBB4 1VBD4 3VR9A 2PZSA 3AEBA 3AECA 1AR84 1ZP0A 2B76A 1KFYA 4PDWD 3AE4A 3AE6A 1OOPD 1COV4 1BEV4 1PO14 1R084 1PIV4 2WS3A 1RUG4 1XHZA 1RUI4 2R064 2WDRA 3P4QA 1VBE4 1VRH4 3AEFA 3SFDA 2H89A 3AE3A 3JD74 4YTMA 2RR14 2RS34 2R7FA 3JBG4 2PLV4 3AE1A 1PO24 4GB34 4YTNA 1AR64 3J8F4 1D4M4 1AR74 2RS54 1EAH4 1RUD4 1VBC4 1MQTD 4Q4W4 1RUC4 1RUF4 3SUCA 1XI1A 2WDQA 3AEGA 1Z7S4 1RMU4 2PYLA 2WP9A 2HWB4 1POV0 2WU2A 1RUH4
chains in the Genus database with same CATH topology
2R044 3JBG4 2PLV4 4Q4Y4 1K5MD 1AL24 1HRI4 1PO24 4GB34 1AR64 1VBB4 2RS14 1VBD4 3J8F4 1D4M4 1AR74 2RS54 1R094 2X5ID 2RMU4 1EAH4 1AR84 1H8TD 1RUD4 1RHI4 1VBC4 4RHV4 1VBA4 1MQTD 1NCQD 1HRV4 1HXS4 1RUC4 3JD74 4PDWD 4Q4W4 1ASJ4 1EV14 1RUF4 1NA1D 2RS34 1OOPD 1RVF4 2RR14 1COV4 1BEV4 1PO14 1R084 1PIV4 4Q4V4 2RM24 2HWC4 1RUG4 1RUI4 1RMU4 1Z7S4 2R064 1PVC4 1VBE4 1VRH4 2HWB4 1POV0 1RUE4 2R074 4Q4X4 1RUJ4 1AR94 1RUH4
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2R04 4;  3JBG 4;  2PLV 4;  4Q4Y 4;  1K5M D;  1AL2 4;  1HRI 4;  1PO2 4;  4GB3 4;  1AR6 4;  1VBB 4;  2RS1 4;  1VBD 4;  3J8F 4;  1D4M 4;  1AR7 4;  2RS5 4;  1R09 4;  2X5I D;  2RMU 4;  1EAH 4;  1AR8 4;  1H8T D;  1RUD 4;  1RHI 4;  1VBC 4;  4RHV 4;  1VBA 4;  1MQT D;  1NCQ D;  1HRV 4;  1HXS 4;  1RUC 4;  3JD7 4;  4PDW D;  4Q4W 4;  1ASJ 4;  1EV1 4;  1RUF 4;  1NA1 D;  2RS3 4;  1OOP D;  1RVF 4;  2RR1 4;  1COV 4;  1BEV 4;  1PO1 4;  1R08 4;  1PIV 4;  4Q4V 4;  2RM2 4;  2HWC 4;  1RUG 4;  1RUI 4;  1RMU 4;  1Z7S 4;  2R06 4;  1PVC 4;  1VBE 4;  1VRH 4;  2HWB 4;  1POV 0;  1RUE 4;  2R07 4;  4Q4X 4;  1RUJ 4;  1AR9 4;  1RUH 4; 
#chains in the Genus database with same CATH topology
 3SFE A;  1L0V A;  1XHX A;  3GQH A;  1R09 4;  2X5I D;  2RMU 4;  2PY5 A;  2FBW A;  4YT0 A;  1RHI 4;  4RHV 4;  2EX3 A;  3P4R A;  4YSZ A;  1ASJ 4;  1EV1 4;  3AE8 A;  1NA1 D;  1RVF 4;  3P4P A;  4YTP A;  4Q4V 4;  4YSY A;  4KX6 A;  5C3J A;  1PVC 4;  2WQY A;  1RUE 4;  1YQ3 A;  2WDV A;  1AR9 4;  3VRA A;  4Q4Y 4;  5C2T A;  1K5M D;  1HRI 4;  3GQK A;  3AE9 A;  3AED A;  3AE2 A;  1H8T D;  1HRV 4;  1VBA 4;  1NCQ D;  3AEE A;  3VR8 A;  4YSX A;  1HXS 4;  3AE7 A;  3CIR A;  3ABV A;  1NEK A;  1ZOY A;  3AEA A;  3P4S A;  3VRB A;  4YXD A;  1KF6 A;  1YQ4 A;  1NEN A;  2RM2 4;  2HWC 4;  2H88 A;  2PYJ A;  2PW9 A;  2R07 4;  3FI7 A;  4Q4X 4;  2RS1 4;  1RUJ 4;  3AE5 A;  2ACZ A;  2R04 4;  1AL2 4;  2WU5 A;  1VBB 4;  1VBD 4;  3VR9 A;  2PZS A;  3AEB A;  3AEC A;  1AR8 4;  1ZP0 A;  2B76 A;  1KFY A;  4PDW D;  3AE4 A;  3AE6 A;  1OOP D;  1COV 4;  1BEV 4;  1PO1 4;  1R08 4;  1PIV 4;  2WS3 A;  1RUG 4;  1XHZ A;  1RUI 4;  2R06 4;  2WDR A;  3P4Q A;  1VBE 4;  1VRH 4;  3AEF A;  3SFD A;  2H89 A;  3AE3 A;  3JD7 4;  4YTM A;  2RR1 4;  2RS3 4;  2R7F A;  3JBG 4;  2PLV 4;  3AE1 A;  1PO2 4;  4GB3 4;  4YTN A;  1AR6 4;  3J8F 4;  1D4M 4;  1AR7 4;  2RS5 4;  1EAH 4;  1RUD 4;  1VBC 4;  1MQT D;  4Q4W 4;  1RUC 4;  1RUF 4;  3SUC A;  1XI1 A;  2WDQ A;  3AEG A;  1Z7S 4;  1RMU 4;  2PYL A;  2WP9 A;  2HWB 4;  1POV 0;  2WU2 A;  1RUH 4; 
#chains in the Genus database with same CATH homology
 2R04 4;  3JBG 4;  2PLV 4;  4Q4Y 4;  1K5M D;  1AL2 4;  1HRI 4;  1PO2 4;  4GB3 4;  1AR6 4;  1VBB 4;  2RS1 4;  1VBD 4;  3J8F 4;  1D4M 4;  1AR7 4;  2RS5 4;  1R09 4;  2X5I D;  2RMU 4;  1EAH 4;  1AR8 4;  1H8T D;  1RUD 4;  1RHI 4;  1VBC 4;  4RHV 4;  1VBA 4;  1MQT D;  1NCQ D;  1HRV 4;  1HXS 4;  1RUC 4;  3JD7 4;  4PDW D;  4Q4W 4;  1ASJ 4;  1EV1 4;  1RUF 4;  1NA1 D;  2RS3 4;  1OOP D;  1RVF 4;  2RR1 4;  1COV 4;  1BEV 4;  1PO1 4;  1R08 4;  1PIV 4;  4Q4V 4;  2RM2 4;  2HWC 4;  1RUG 4;  1RUI 4;  1RMU 4;  1Z7S 4;  2R06 4;  1PVC 4;  1VBE 4;  1VRH 4;  2HWB 4;  1POV 0;  1RUE 4;  2R07 4;  4Q4X 4;  1RUJ 4;  1AR9 4;  1RUH 4; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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