2HWB4

A comparison of the anti-rhinoviral drug binding pocket in hrv14 and hrv1a
Total Genus 2
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
40
structure length
40
Chain Sequence
INYYKDAASTSSAGQSLSMDPSKFTEPVKDLMLKGAPALN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Virus
source organism Human rhinovirus 14
publication title A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A.
pubmed doi rcsb
molecule keywords HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1)
total genus 2
structure length 40
sequence length 40
ec nomenclature ec 2.7.7.48: RNA-directed RNA polymerase.
pdb deposition date 1994-01-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
4 PF02226 Pico_P1A Picornavirus coat protein (VP4)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.80.10 Few Secondary Structures Irregular Rhinovirus 14, subunit 4 Picornavirus coat protein VP4 2hwb400
1RMU4 1RUC4 4RHV4 1HRI4 1VBB4 1H8TD 1AR64 1R094 1RUG4 2RS14 2RMU4 1HRV4 1VBD4 2RS34 1PIV4 1PVC4 4Q4X4 4GB34 2R064 1AR94 1HXS4 1VRH4 1COV4 1R084 2HWB4 1RUD4 2R074 1AL24 1VBC4 1BEV4 1NA1D 3JBG4 1EV14 1MQTD 1POV0 1RUJ4 1OOPD 1D4M4 3J8F4 1AR74 1RUI4 2RM24 4PDWD 1RHI4 1RUE4 1RUH4 2X5ID 1NCQD 1EAH4 1ASJ4 2RR14 2R044 2HWC4 1PO14 2PLV4 2RS54 1Z7S4 1RVF4 4Q4W4 1RUF4 3JD74 1PO24 1K5MD 4Q4V4 4Q4Y4 1VBA4 1AR84 1VBE4
chains in the Genus database with same CATH superfamily
2WU5A 3AE1A 3AEFA 2H88A 2RS14 3P4PA 4YTPA 2WU2A 1PVC4 1L0VA 4Q4W4 1HXS4 1NA1D 1POV0 2PY5A 2PW9A 1RUE4 1NCQD 2WDVA 2R044 1PO14 2PLV4 1Z7S4 1YQ4A 2B76A 3JD74 4Q4Y4 4Q4V4 1VBA4 3AE6A 3AE2A 3AE4A 4YTMA 3P4SA 1VBB4 1AR64 1XHZA 1HRV4 1PIV4 3AE7A 2R064 1AR94 3AEGA 1ZP0A 2R074 1VBC4 1BEV4 1OOPD 3J8F4 2WS3A 4PDWD 3AEBA 2PYJA 2X5ID 3AE5A 2RS54 1NEKA 4KX6A 1NENA 2EX3A 3AECA 1K5MD 3CIRA 4YTNA 1VBE4 1RMU4 4RHV4 1H8TD 1R094 1RUG4 2RMU4 3AEDA 1VBD4 3GQHA 3SUCA 2PZSA 5C3JA 2HWB4 4YSZA 1RUD4 1AL24 3JBG4 1EV14 1MQTD 2FBWA 1RUJ4 2PYLA 1RUI4 3SFDA 1RHI4 1RUH4 1YQ3A 2RR14 3AE9A 1KF6A 5C2TA 3AEEA 2ACZA 3FI7A 1XHXA 1RUF4 2R7FA 4YSXA 3GQKA 3AE8A 4YT0A 3SFEA 2WDRA 4YSYA 2H89A 1RUC4 1HRI4 3VRAA 4Q4X4 3VR9A 2RS34 2WP9A 3AEAA 4GB34 1VRH4 1COV4 1R084 3VR8A 1D4M4 3AE3A 1AR74 2RM24 3P4QA 1KFYA 1ZOYA 2WDQA 1EAH4 1ASJ4 2HWC4 1RVF4 4YXDA 3VRBA 2WQYA 1PO24 3ABVA 1AR84 1XI1A 3P4RA
chains in the Genus database with same CATH topology
1RMU4 1RUC4 4RHV4 1HRI4 1VBB4 1H8TD 1AR64 1R094 1RUG4 2RS14 2RMU4 1HRV4 1VBD4 2RS34 1PIV4 1PVC4 4Q4X4 4GB34 2R064 1AR94 1HXS4 1VRH4 1COV4 1R084 2HWB4 1RUD4 2R074 1AL24 1VBC4 1BEV4 1NA1D 3JBG4 1EV14 1MQTD 1POV0 1RUJ4 1OOPD 1D4M4 3J8F4 1AR74 1RUI4 2RM24 4PDWD 1RHI4 1RUE4 1RUH4 2X5ID 1NCQD 1EAH4 1ASJ4 2RR14 2R044 2HWC4 1PO14 2PLV4 2RS54 1Z7S4 1RVF4 4Q4W4 1RUF4 3JD74 1PO24 1K5MD 4Q4V4 4Q4Y4 1VBA4 1AR84 1VBE4
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RMU 4;  1RUC 4;  4RHV 4;  1HRI 4;  1VBB 4;  1H8T D;  1AR6 4;  1R09 4;  1RUG 4;  2RS1 4;  2RMU 4;  1HRV 4;  1VBD 4;  2RS3 4;  1PIV 4;  1PVC 4;  4Q4X 4;  4GB3 4;  2R06 4;  1AR9 4;  1HXS 4;  1VRH 4;  1COV 4;  1R08 4;  2HWB 4;  1RUD 4;  2R07 4;  1AL2 4;  1VBC 4;  1BEV 4;  1NA1 D;  3JBG 4;  1EV1 4;  1MQT D;  1POV 0;  1RUJ 4;  1OOP D;  1D4M 4;  3J8F 4;  1AR7 4;  1RUI 4;  2RM2 4;  4PDW D;  1RHI 4;  1RUE 4;  1RUH 4;  2X5I D;  1NCQ D;  1EAH 4;  1ASJ 4;  2RR1 4;  2R04 4;  2HWC 4;  1PO1 4;  2PLV 4;  2RS5 4;  1Z7S 4;  1RVF 4;  4Q4W 4;  1RUF 4;  3JD7 4;  1PO2 4;  1K5M D;  4Q4V 4;  4Q4Y 4;  1VBA 4;  1AR8 4;  1VBE 4; 
#chains in the Genus database with same CATH topology
 2WU5 A;  3AE1 A;  3AEF A;  2H88 A;  2RS1 4;  3P4P A;  4YTP A;  2WU2 A;  1PVC 4;  1L0V A;  4Q4W 4;  1HXS 4;  1NA1 D;  1POV 0;  2PY5 A;  2PW9 A;  1RUE 4;  1NCQ D;  2WDV A;  2R04 4;  1PO1 4;  2PLV 4;  1Z7S 4;  1YQ4 A;  2B76 A;  3JD7 4;  4Q4Y 4;  4Q4V 4;  1VBA 4;  3AE6 A;  3AE2 A;  3AE4 A;  4YTM A;  3P4S A;  1VBB 4;  1AR6 4;  1XHZ A;  1HRV 4;  1PIV 4;  3AE7 A;  2R06 4;  1AR9 4;  3AEG A;  1ZP0 A;  2R07 4;  1VBC 4;  1BEV 4;  1OOP D;  3J8F 4;  2WS3 A;  4PDW D;  3AEB A;  2PYJ A;  2X5I D;  3AE5 A;  2RS5 4;  1NEK A;  4KX6 A;  1NEN A;  2EX3 A;  3AEC A;  1K5M D;  3CIR A;  4YTN A;  1VBE 4;  1RMU 4;  4RHV 4;  1H8T D;  1R09 4;  1RUG 4;  2RMU 4;  3AED A;  1VBD 4;  3GQH A;  3SUC A;  2PZS A;  5C3J A;  2HWB 4;  4YSZ A;  1RUD 4;  1AL2 4;  3JBG 4;  1EV1 4;  1MQT D;  2FBW A;  1RUJ 4;  2PYL A;  1RUI 4;  3SFD A;  1RHI 4;  1RUH 4;  1YQ3 A;  2RR1 4;  3AE9 A;  1KF6 A;  5C2T A;  3AEE A;  2ACZ A;  3FI7 A;  1XHX A;  1RUF 4;  2R7F A;  4YSX A;  3GQK A;  3AE8 A;  4YT0 A;  3SFE A;  2WDR A;  4YSY A;  2H89 A;  1RUC 4;  1HRI 4;  3VRA A;  4Q4X 4;  3VR9 A;  2RS3 4;  2WP9 A;  3AEA A;  4GB3 4;  1VRH 4;  1COV 4;  1R08 4;  3VR8 A;  1D4M 4;  3AE3 A;  1AR7 4;  2RM2 4;  3P4Q A;  1KFY A;  1ZOY A;  2WDQ A;  1EAH 4;  1ASJ 4;  2HWC 4;  1RVF 4;  4YXD A;  3VRB A;  2WQY A;  1PO2 4;  3ABV A;  1AR8 4;  1XI1 A;  3P4R A; 
#chains in the Genus database with same CATH homology
 1RMU 4;  1RUC 4;  4RHV 4;  1HRI 4;  1VBB 4;  1H8T D;  1AR6 4;  1R09 4;  1RUG 4;  2RS1 4;  2RMU 4;  1HRV 4;  1VBD 4;  2RS3 4;  1PIV 4;  1PVC 4;  4Q4X 4;  4GB3 4;  2R06 4;  1AR9 4;  1HXS 4;  1VRH 4;  1COV 4;  1R08 4;  2HWB 4;  1RUD 4;  2R07 4;  1AL2 4;  1VBC 4;  1BEV 4;  1NA1 D;  3JBG 4;  1EV1 4;  1MQT D;  1POV 0;  1RUJ 4;  1OOP D;  1D4M 4;  3J8F 4;  1AR7 4;  1RUI 4;  2RM2 4;  4PDW D;  1RHI 4;  1RUE 4;  1RUH 4;  2X5I D;  1NCQ D;  1EAH 4;  1ASJ 4;  2RR1 4;  2R04 4;  2HWC 4;  1PO1 4;  2PLV 4;  2RS5 4;  1Z7S 4;  1RVF 4;  4Q4W 4;  1RUF 4;  3JD7 4;  1PO2 4;  1K5M D;  4Q4V 4;  4Q4Y 4;  1VBA 4;  1AR8 4;  1VBE 4; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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