2HWC4

A comparison of the anti-rhinoviral drug binding pocket in hrv14 and hrv1a
Total Genus 2
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
40
structure length
40
Chain Sequence
INYYKDAASTSSAGQSLSMDPSKFTEPVKDLMLKGAPALN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Virus
molecule keywords HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1)
publication title A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A.
pubmed doi rcsb
source organism Human rhinovirus 14
total genus 2
structure length 40
sequence length 40
ec nomenclature ec 2.7.7.48: RNA-directed RNA polymerase.
pdb deposition date 1994-01-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
4 PF02226 Pico_P1A Picornavirus coat protein (VP4)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.80.10 Few Secondary Structures Irregular Rhinovirus 14, subunit 4 Picornavirus coat protein VP4 2hwc400
1EV14 1PIV4 2RS14 1H8TD 2RS54 1ASJ4 1NA1D 2R044 1PO24 2R074 1VBE4 2HWB4 1RMU4 3JBG4 1AR94 1AR74 4Q4Y4 4Q4X4 1RHI4 4RHV4 2RMU4 2HWC4 1RUF4 1HRV4 2PLV4 1HXS4 2RR14 1HRI4 1EAH4 2X5ID 1BEV4 1RUH4 4GB34 1RUG4 1AL24 1VBD4 1VRH4 1POV0 1RUD4 1Z7S4 4Q4V4 1RUC4 2R064 1D4M4 1RUJ4 1RUE4 1VBC4 1OOPD 1PVC4 1VBB4 1COV4 1AR84 1VBA4 1RVF4 1NCQD 1RUI4 1PO14 3J8F4 1MQTD 1R094 2RM24 4PDWD 1AR64 1K5MD 3JD74 1R084 4Q4W4 2RS34
chains in the Genus database with same CATH superfamily
1YQ4A 2RS54 1NA1D 1XI1A 2PY5A 4YTMA 2H88A 3AE3A 3JBG4 3AECA 4Q4Y4 2WQYA 4YT0A 3P4RA 3AE9A 1RUF4 1HRV4 3VRBA 5C2TA 1EAH4 1RUH4 4GB34 3VR8A 4Q4V4 2R064 1RUJ4 1VBB4 2PYLA 4PDWD 1XHZA 1PIV4 1NENA 2RS14 3AE6A 2R044 1PO24 3SUCA 2R074 3AE2A 1AR74 4YTNA 4RHV4 1L0VA 2PZSA 2WP9A 1HXS4 2RR14 3AE8A 1AL24 1VBD4 1VRH4 3AEAA 3VR9A 1D4M4 3AE4A 3GQKA 1COV4 1VBA4 2FBWA 1MQTD 4YSZA 3AE5A 3CIRA 3AEEA 1R084 2WU2A 4Q4W4 3AEDA 1KFYA 1EV14 1NEKA 2WS3A 3SFDA 1VBE4 2HWB4 2ACZA 1RMU4 2EX3A 1AR94 4Q4X4 2PW9A 2HWC4 3GQHA 1KF6A 4YTPA 2X5ID 4YXDA 1HRI4 1ZOYA 1RUG4 1Z7S4 2B76A 4YSXA 1OOPD 2H89A 1AR84 3J8F4 1RVF4 1RUI4 2R7FA 3VRAA 2WDVA 2RM24 5C3JA 1YQ3A 1H8TD 1ASJ4 1XHXA 4YSYA 2WU5A 3P4PA 3AEGA 3P4QA 1RHI4 4KX6A 2RMU4 2PYJA 2PLV4 3SFEA 1BEV4 3FI7A 1POV0 1RUD4 3P4SA 3AEFA 3AE1A 1RUC4 1VBC4 1PVC4 3ABVA 1NCQD 1ZP0A 1PO14 2WDRA 1R094 1AR64 1K5MD 3JD74 1RUE4 2WDQA 3AEBA 2RS34 3AE7A
chains in the Genus database with same CATH topology
1EV14 1PIV4 2RS14 1H8TD 2RS54 1ASJ4 1NA1D 2R044 1PO24 2R074 1VBE4 2HWB4 1RMU4 3JBG4 1AR94 1AR74 4Q4Y4 4Q4X4 1RHI4 4RHV4 2RMU4 2HWC4 1RUF4 1HRV4 2PLV4 1HXS4 2RR14 1HRI4 1EAH4 2X5ID 1BEV4 1RUH4 4GB34 1RUG4 1AL24 1VBD4 1VRH4 1POV0 1RUD4 1Z7S4 4Q4V4 1RUC4 2R064 1D4M4 1RUJ4 1RUE4 1VBC4 1OOPD 1PVC4 1VBB4 1COV4 1AR84 1VBA4 1RVF4 1NCQD 1RUI4 1PO14 3J8F4 1MQTD 1R094 2RM24 4PDWD 1AR64 1K5MD 3JD74 1R084 4Q4W4 2RS34
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EV1 4;  1PIV 4;  2RS1 4;  1H8T D;  2RS5 4;  1ASJ 4;  1NA1 D;  2R04 4;  1PO2 4;  2R07 4;  1VBE 4;  2HWB 4;  1RMU 4;  3JBG 4;  1AR9 4;  1AR7 4;  4Q4Y 4;  4Q4X 4;  1RHI 4;  4RHV 4;  2RMU 4;  2HWC 4;  1RUF 4;  1HRV 4;  2PLV 4;  1HXS 4;  2RR1 4;  1HRI 4;  1EAH 4;  2X5I D;  1BEV 4;  1RUH 4;  4GB3 4;  1RUG 4;  1AL2 4;  1VBD 4;  1VRH 4;  1POV 0;  1RUD 4;  1Z7S 4;  4Q4V 4;  1RUC 4;  2R06 4;  1D4M 4;  1RUJ 4;  1RUE 4;  1VBC 4;  1OOP D;  1PVC 4;  1VBB 4;  1COV 4;  1AR8 4;  1VBA 4;  1RVF 4;  1NCQ D;  1RUI 4;  1PO1 4;  3J8F 4;  1MQT D;  1R09 4;  2RM2 4;  4PDW D;  1AR6 4;  1K5M D;  3JD7 4;  1R08 4;  4Q4W 4;  2RS3 4; 
#chains in the Genus database with same CATH topology
 1YQ4 A;  2RS5 4;  1NA1 D;  1XI1 A;  2PY5 A;  4YTM A;  2H88 A;  3AE3 A;  3JBG 4;  3AEC A;  4Q4Y 4;  2WQY A;  4YT0 A;  3P4R A;  3AE9 A;  1RUF 4;  1HRV 4;  3VRB A;  5C2T A;  1EAH 4;  1RUH 4;  4GB3 4;  3VR8 A;  4Q4V 4;  2R06 4;  1RUJ 4;  1VBB 4;  2PYL A;  4PDW D;  1XHZ A;  1PIV 4;  1NEN A;  2RS1 4;  3AE6 A;  2R04 4;  1PO2 4;  3SUC A;  2R07 4;  3AE2 A;  1AR7 4;  4YTN A;  4RHV 4;  1L0V A;  2PZS A;  2WP9 A;  1HXS 4;  2RR1 4;  3AE8 A;  1AL2 4;  1VBD 4;  1VRH 4;  3AEA A;  3VR9 A;  1D4M 4;  3AE4 A;  3GQK A;  1COV 4;  1VBA 4;  2FBW A;  1MQT D;  4YSZ A;  3AE5 A;  3CIR A;  3AEE A;  1R08 4;  2WU2 A;  4Q4W 4;  3AED A;  1KFY A;  1EV1 4;  1NEK A;  2WS3 A;  3SFD A;  1VBE 4;  2HWB 4;  2ACZ A;  1RMU 4;  2EX3 A;  1AR9 4;  4Q4X 4;  2PW9 A;  2HWC 4;  3GQH A;  1KF6 A;  4YTP A;  2X5I D;  4YXD A;  1HRI 4;  1ZOY A;  1RUG 4;  1Z7S 4;  2B76 A;  4YSX A;  1OOP D;  2H89 A;  1AR8 4;  3J8F 4;  1RVF 4;  1RUI 4;  2R7F A;  3VRA A;  2WDV A;  2RM2 4;  5C3J A;  1YQ3 A;  1H8T D;  1ASJ 4;  1XHX A;  4YSY A;  2WU5 A;  3P4P A;  3AEG A;  3P4Q A;  1RHI 4;  4KX6 A;  2RMU 4;  2PYJ A;  2PLV 4;  3SFE A;  1BEV 4;  3FI7 A;  1POV 0;  1RUD 4;  3P4S A;  3AEF A;  3AE1 A;  1RUC 4;  1VBC 4;  1PVC 4;  3ABV A;  1NCQ D;  1ZP0 A;  1PO1 4;  2WDR A;  1R09 4;  1AR6 4;  1K5M D;  3JD7 4;  1RUE 4;  2WDQ A;  3AEB A;  2RS3 4;  3AE7 A; 
#chains in the Genus database with same CATH homology
 1EV1 4;  1PIV 4;  2RS1 4;  1H8T D;  2RS5 4;  1ASJ 4;  1NA1 D;  2R04 4;  1PO2 4;  2R07 4;  1VBE 4;  2HWB 4;  1RMU 4;  3JBG 4;  1AR9 4;  1AR7 4;  4Q4Y 4;  4Q4X 4;  1RHI 4;  4RHV 4;  2RMU 4;  2HWC 4;  1RUF 4;  1HRV 4;  2PLV 4;  1HXS 4;  2RR1 4;  1HRI 4;  1EAH 4;  2X5I D;  1BEV 4;  1RUH 4;  4GB3 4;  1RUG 4;  1AL2 4;  1VBD 4;  1VRH 4;  1POV 0;  1RUD 4;  1Z7S 4;  4Q4V 4;  1RUC 4;  2R06 4;  1D4M 4;  1RUJ 4;  1RUE 4;  1VBC 4;  1OOP D;  1PVC 4;  1VBB 4;  1COV 4;  1AR8 4;  1VBA 4;  1RVF 4;  1NCQ D;  1RUI 4;  1PO1 4;  3J8F 4;  1MQT D;  1R09 4;  2RM2 4;  4PDW D;  1AR6 4;  1K5M D;  3JD7 4;  1R08 4;  4Q4W 4;  2RS3 4; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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