2HWC4

A comparison of the anti-rhinoviral drug binding pocket in hrv14 and hrv1a
Total Genus 2
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
40
structure length
40
Chain Sequence
INYYKDAASTSSAGQSLSMDPSKFTEPVKDLMLKGAPALN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A.
pubmed doi rcsb
molecule tags Virus
source organism Human rhinovirus 14
molecule keywords HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1)
total genus 2
structure length 40
sequence length 40
ec nomenclature ec 2.7.7.48: RNA-directed RNA polymerase.
pdb deposition date 1994-01-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
4 PF02226 Pico_P1A Picornavirus coat protein (VP4)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.80.10 Few Secondary Structures Irregular Rhinovirus 14, subunit 4 Picornavirus coat protein VP4 2hwc400
1ASJ4 1COV4 1OOPD 1PO24 1RUC4 1RUE4 2HWB4 2RMU4 1RUI4 1EAH4 1RMU4 3JD74 1NA1D 1NCQD 1POV0 1RUJ4 1RVF4 2PLV4 4GB34 4Q4W4 4Q4X4 1BEV4 1VBE4 2R064 1EV14 1PVC4 1AR74 1Z7S4 2X5ID 1D4M4 1AR94 1AR64 1R084 1RUG4 1VBD4 1AR84 1VRH4 1RUH4 1RUF4 2RR14 1VBA4 3JBG4 3J8F4 1RUD4 1H8TD 2RM24 1R094 1RHI4 1AL24 1HRI4 1VBB4 2HWC4 2RS34 2RS54 2R074 1PO14 4Q4V4 4RHV4 1MQTD 4PDWD 1HRV4 1K5MD 1VBC4 2RS14 4Q4Y4 2R044 1HXS4 1PIV4
chains in the Genus database with same CATH superfamily
1OOPD 3AE6A 2HWB4 3GQHA 2WP9A 3VRBA 3AE5A 3AE3A 4YSZA 1NA1D 1NCQD 4GB34 1RVF4 2PY5A 3SUCA 2R064 1ZOYA 2H88A 1VBD4 1R084 1VRH4 1AR84 3AE4A 2WDVA 3AE8A 3AEAA 2WDRA 5C2TA 3FI7A 1PO14 2ACZA 1VBC4 2WU5A 1NEKA 2PYJA 4Q4Y4 4YTMA 3AEDA 3P4RA 3VRAA 3JD74 1BEV4 2PZSA 1NENA 3AE7A 3P4QA 1AR74 1Z7S4 2WS3A 3P4SA 2H89A 3AE9A 2WQYA 1L0VA 4YSXA 1RUF4 1VBA4 3J8F4 4YTPA 1RHI4 4YT0A 5C3JA 1ZP0A 1HRV4 3AECA 2PYLA 1ASJ4 1PO24 1RUE4 2RMU4 4Q4X4 1POV0 1RUJ4 2PLV4 1KF6A 1YQ3A 3VR8A 1VBE4 1YQ4A 1KFYA 2X5ID 3VR9A 4YXDA 2WU2A 1XHXA 2RR14 3JBG4 1RUD4 1H8TD 2RM24 1R094 2R074 2B76A 3GQKA 2RS14 2R044 3P4PA 1COV4 2FBWA 2PW9A 1RUC4 2WDQA 3AEBA 1RUI4 1EAH4 1RMU4 3AEFA 4Q4W4 3SFEA 2EX3A 3AEGA 1EV14 3AE1A 1PVC4 1D4M4 1AR94 1AR64 1RUG4 2R7FA 4KX6A 1RUH4 1XI1A 3AE2A 1VBB4 3AEEA 1AL24 1HRI4 2RS54 2HWC4 2RS34 3ABVA 4Q4V4 4YSYA 4YTNA 1XHZA 3CIRA 1MQTD 4RHV4 4PDWD 1K5MD 3SFDA 1HXS4 1PIV4
chains in the Genus database with same CATH topology
1ASJ4 1COV4 1OOPD 1PO24 1RUC4 1RUE4 2HWB4 2RMU4 1RUI4 1EAH4 1RMU4 3JD74 1NA1D 1NCQD 1POV0 1RUJ4 1RVF4 2PLV4 4GB34 4Q4W4 4Q4X4 1BEV4 1VBE4 2R064 1EV14 1PVC4 1AR74 1Z7S4 2X5ID 1D4M4 1AR94 1AR64 1R084 1RUG4 1VBD4 1AR84 1VRH4 1RUH4 1RUF4 2RR14 1VBA4 3JBG4 3J8F4 1RUD4 1H8TD 2RM24 1R094 1RHI4 1AL24 1HRI4 1VBB4 2HWC4 2RS34 2RS54 2R074 1PO14 4Q4V4 4RHV4 1MQTD 4PDWD 1HRV4 1K5MD 1VBC4 2RS14 4Q4Y4 2R044 1HXS4 1PIV4
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ASJ 4;  1COV 4;  1OOP D;  1PO2 4;  1RUC 4;  1RUE 4;  2HWB 4;  2RMU 4;  1RUI 4;  1EAH 4;  1RMU 4;  3JD7 4;  1NA1 D;  1NCQ D;  1POV 0;  1RUJ 4;  1RVF 4;  2PLV 4;  4GB3 4;  4Q4W 4;  4Q4X 4;  1BEV 4;  1VBE 4;  2R06 4;  1EV1 4;  1PVC 4;  1AR7 4;  1Z7S 4;  2X5I D;  1D4M 4;  1AR9 4;  1AR6 4;  1R08 4;  1RUG 4;  1VBD 4;  1AR8 4;  1VRH 4;  1RUH 4;  1RUF 4;  2RR1 4;  1VBA 4;  3JBG 4;  3J8F 4;  1RUD 4;  1H8T D;  2RM2 4;  1R09 4;  1RHI 4;  1AL2 4;  1HRI 4;  1VBB 4;  2HWC 4;  2RS3 4;  2RS5 4;  2R07 4;  1PO1 4;  4Q4V 4;  4RHV 4;  1MQT D;  4PDW D;  1HRV 4;  1K5M D;  1VBC 4;  2RS1 4;  4Q4Y 4;  2R04 4;  1HXS 4;  1PIV 4; 
#chains in the Genus database with same CATH topology
 1OOP D;  3AE6 A;  2HWB 4;  3GQH A;  2WP9 A;  3VRB A;  3AE5 A;  3AE3 A;  4YSZ A;  1NA1 D;  1NCQ D;  4GB3 4;  1RVF 4;  2PY5 A;  3SUC A;  2R06 4;  1ZOY A;  2H88 A;  1VBD 4;  1R08 4;  1VRH 4;  1AR8 4;  3AE4 A;  2WDV A;  3AE8 A;  3AEA A;  2WDR A;  5C2T A;  3FI7 A;  1PO1 4;  2ACZ A;  1VBC 4;  2WU5 A;  1NEK A;  2PYJ A;  4Q4Y 4;  4YTM A;  3AED A;  3P4R A;  3VRA A;  3JD7 4;  1BEV 4;  2PZS A;  1NEN A;  3AE7 A;  3P4Q A;  1AR7 4;  1Z7S 4;  2WS3 A;  3P4S A;  2H89 A;  3AE9 A;  2WQY A;  1L0V A;  4YSX A;  1RUF 4;  1VBA 4;  3J8F 4;  4YTP A;  1RHI 4;  4YT0 A;  5C3J A;  1ZP0 A;  1HRV 4;  3AEC A;  2PYL A;  1ASJ 4;  1PO2 4;  1RUE 4;  2RMU 4;  4Q4X 4;  1POV 0;  1RUJ 4;  2PLV 4;  1KF6 A;  1YQ3 A;  3VR8 A;  1VBE 4;  1YQ4 A;  1KFY A;  2X5I D;  3VR9 A;  4YXD A;  2WU2 A;  1XHX A;  2RR1 4;  3JBG 4;  1RUD 4;  1H8T D;  2RM2 4;  1R09 4;  2R07 4;  2B76 A;  3GQK A;  2RS1 4;  2R04 4;  3P4P A;  1COV 4;  2FBW A;  2PW9 A;  1RUC 4;  2WDQ A;  3AEB A;  1RUI 4;  1EAH 4;  1RMU 4;  3AEF A;  4Q4W 4;  3SFE A;  2EX3 A;  3AEG A;  1EV1 4;  3AE1 A;  1PVC 4;  1D4M 4;  1AR9 4;  1AR6 4;  1RUG 4;  2R7F A;  4KX6 A;  1RUH 4;  1XI1 A;  3AE2 A;  1VBB 4;  3AEE A;  1AL2 4;  1HRI 4;  2RS5 4;  2HWC 4;  2RS3 4;  3ABV A;  4Q4V 4;  4YSY A;  4YTN A;  1XHZ A;  3CIR A;  1MQT D;  4RHV 4;  4PDW D;  1K5M D;  3SFD A;  1HXS 4;  1PIV 4; 
#chains in the Genus database with same CATH homology
 1ASJ 4;  1COV 4;  1OOP D;  1PO2 4;  1RUC 4;  1RUE 4;  2HWB 4;  2RMU 4;  1RUI 4;  1EAH 4;  1RMU 4;  3JD7 4;  1NA1 D;  1NCQ D;  1POV 0;  1RUJ 4;  1RVF 4;  2PLV 4;  4GB3 4;  4Q4W 4;  4Q4X 4;  1BEV 4;  1VBE 4;  2R06 4;  1EV1 4;  1PVC 4;  1AR7 4;  1Z7S 4;  2X5I D;  1D4M 4;  1AR9 4;  1AR6 4;  1R08 4;  1RUG 4;  1VBD 4;  1AR8 4;  1VRH 4;  1RUH 4;  1RUF 4;  2RR1 4;  1VBA 4;  3JBG 4;  3J8F 4;  1RUD 4;  1H8T D;  2RM2 4;  1R09 4;  1RHI 4;  1AL2 4;  1HRI 4;  1VBB 4;  2HWC 4;  2RS3 4;  2RS5 4;  2R07 4;  1PO1 4;  4Q4V 4;  4RHV 4;  1MQT D;  4PDW D;  1HRV 4;  1K5M D;  1VBC 4;  2RS1 4;  4Q4Y 4;  2R04 4;  1HXS 4;  1PIV 4; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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