2HWB4

A comparison of the anti-rhinoviral drug binding pocket in hrv14 and hrv1a
Total Genus 2
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
40
structure length
40
Chain Sequence
INYYKDAASTSSAGQSLSMDPSKFTEPVKDLMLKGAPALN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A.
pubmed doi rcsb
molecule tags Virus
source organism Human rhinovirus 14
molecule keywords HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1)
total genus 2
structure length 40
sequence length 40
ec nomenclature ec 2.7.7.48: RNA-directed RNA polymerase.
pdb deposition date 1994-01-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
4 PF02226 Pico_P1A Picornavirus coat protein (VP4)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.80.10 Few Secondary Structures Irregular Rhinovirus 14, subunit 4 Picornavirus coat protein VP4 2hwb400
1ASJ4 1H8TD 2X5ID 1VRH4 2RMU4 3J8F4 1AR64 1RVF4 1AR84 1Z7S4 1EAH4 2HWB4 1RUH4 1VBB4 2R044 1PO24 1VBA4 2RS54 4Q4X4 1RUE4 1VBD4 4RHV4 1PIV4 1RUC4 2RS14 1AR74 2RM24 4Q4V4 4Q4Y4 1VBE4 1BEV4 1NA1D 1D4M4 1PVC4 1RUG4 1RUJ4 1COV4 1RUF4 4GB34 1RHI4 1HRV4 2R064 1RMU4 2HWC4 3JD74 1POV0 1MQTD 1OOPD 1HRI4 1RUD4 4Q4W4 1VBC4 4PDWD 1EV14 1HXS4 1NCQD 1RUI4 3JBG4 1R094 1R084 1PO14 2R074 2RS34 2RR14 1K5MD 1AL24 1AR94 2PLV4
chains in the Genus database with same CATH superfamily
3AE8A 1ASJ4 2X5ID 1KFYA 2WP9A 3AEBA 3P4RA 3GQHA 1Z7S4 2R044 4Q4X4 1VBA4 4YTMA 4YXDA 1PIV4 1RUC4 1AR74 1KF6A 3AE4A 3VR9A 1BEV4 1NA1D 1D4M4 3AE6A 4GB34 1RHI4 4KX6A 4YSXA 3P4SA 1OOPD 3AEAA 3AEEA 1VBC4 1NCQD 2WS3A 1ZP0A 3AE2A 2WDQA 2R074 2WDVA 2RR14 1AL24 2WU2A 2ACZA 2PW9A 3AEFA 3AE7A 3SFEA 1AR64 1EAH4 2HWB4 2WDRA 1RUE4 3GQKA 4RHV4 2PYLA 4YTPA 4Q4V4 4Q4Y4 1RUJ4 1RUF4 3FI7A 4YSYA 3CIRA 5C2TA 1RMU4 2HWC4 4YSZA 3AE3A 1MQTD 1NEKA 4Q4W4 2PYJA 2PZSA 1ZOYA 3JBG4 2WU5A 4PDWD 3ABVA 3VRAA 1NENA 1H8TD 1L0VA 2RMU4 3J8F4 1RVF4 2B76A 1RUH4 1VBB4 2RS54 1VBD4 3SFDA 2RS14 1YQ4A 2R7FA 1PVC4 1XHXA 3AE9A 3JD74 3P4PA 2PY5A 4YTNA 1RUD4 1HRI4 5C3JA 3AEDA 3P4QA 1EV14 1HXS4 1R094 1PO14 3VRBA 1XI1A 2EX3A 1VRH4 3AEGA 1XHZA 1AR84 1PO24 2H89A 2RM24 1VBE4 1HRV4 1RUG4 1COV4 3AE5A 3VR8A 4YT0A 2R064 3AECA 1POV0 3AE1A 1RUI4 1YQ3A 3SUCA 2FBWA 1R084 2WQYA 2RS34 1K5MD 1AR94 2PLV4 2H88A
chains in the Genus database with same CATH topology
1ASJ4 1H8TD 2X5ID 1VRH4 2RMU4 3J8F4 1AR64 1RVF4 1AR84 1Z7S4 1EAH4 2HWB4 1RUH4 1VBB4 2R044 1PO24 1VBA4 2RS54 4Q4X4 1RUE4 1VBD4 4RHV4 1PIV4 1RUC4 2RS14 1AR74 2RM24 4Q4V4 4Q4Y4 1VBE4 1BEV4 1NA1D 1D4M4 1PVC4 1RUG4 1RUJ4 1COV4 1RUF4 4GB34 1RHI4 1HRV4 2R064 1RMU4 2HWC4 3JD74 1POV0 1MQTD 1OOPD 1HRI4 1RUD4 4Q4W4 1VBC4 4PDWD 1EV14 1HXS4 1NCQD 1RUI4 3JBG4 1R094 1R084 1PO14 2R074 2RS34 2RR14 1K5MD 1AL24 1AR94 2PLV4
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ASJ 4;  1H8T D;  2X5I D;  1VRH 4;  2RMU 4;  3J8F 4;  1AR6 4;  1RVF 4;  1AR8 4;  1Z7S 4;  1EAH 4;  2HWB 4;  1RUH 4;  1VBB 4;  2R04 4;  1PO2 4;  1VBA 4;  2RS5 4;  4Q4X 4;  1RUE 4;  1VBD 4;  4RHV 4;  1PIV 4;  1RUC 4;  2RS1 4;  1AR7 4;  2RM2 4;  4Q4V 4;  4Q4Y 4;  1VBE 4;  1BEV 4;  1NA1 D;  1D4M 4;  1PVC 4;  1RUG 4;  1RUJ 4;  1COV 4;  1RUF 4;  4GB3 4;  1RHI 4;  1HRV 4;  2R06 4;  1RMU 4;  2HWC 4;  3JD7 4;  1POV 0;  1MQT D;  1OOP D;  1HRI 4;  1RUD 4;  4Q4W 4;  1VBC 4;  4PDW D;  1EV1 4;  1HXS 4;  1NCQ D;  1RUI 4;  3JBG 4;  1R09 4;  1R08 4;  1PO1 4;  2R07 4;  2RS3 4;  2RR1 4;  1K5M D;  1AL2 4;  1AR9 4;  2PLV 4; 
#chains in the Genus database with same CATH topology
 3AE8 A;  1ASJ 4;  2X5I D;  1KFY A;  2WP9 A;  3AEB A;  3P4R A;  3GQH A;  1Z7S 4;  2R04 4;  4Q4X 4;  1VBA 4;  4YTM A;  4YXD A;  1PIV 4;  1RUC 4;  1AR7 4;  1KF6 A;  3AE4 A;  3VR9 A;  1BEV 4;  1NA1 D;  1D4M 4;  3AE6 A;  4GB3 4;  1RHI 4;  4KX6 A;  4YSX A;  3P4S A;  1OOP D;  3AEA A;  3AEE A;  1VBC 4;  1NCQ D;  2WS3 A;  1ZP0 A;  3AE2 A;  2WDQ A;  2R07 4;  2WDV A;  2RR1 4;  1AL2 4;  2WU2 A;  2ACZ A;  2PW9 A;  3AEF A;  3AE7 A;  3SFE A;  1AR6 4;  1EAH 4;  2HWB 4;  2WDR A;  1RUE 4;  3GQK A;  4RHV 4;  2PYL A;  4YTP A;  4Q4V 4;  4Q4Y 4;  1RUJ 4;  1RUF 4;  3FI7 A;  4YSY A;  3CIR A;  5C2T A;  1RMU 4;  2HWC 4;  4YSZ A;  3AE3 A;  1MQT D;  1NEK A;  4Q4W 4;  2PYJ A;  2PZS A;  1ZOY A;  3JBG 4;  2WU5 A;  4PDW D;  3ABV A;  3VRA A;  1NEN A;  1H8T D;  1L0V A;  2RMU 4;  3J8F 4;  1RVF 4;  2B76 A;  1RUH 4;  1VBB 4;  2RS5 4;  1VBD 4;  3SFD A;  2RS1 4;  1YQ4 A;  2R7F A;  1PVC 4;  1XHX A;  3AE9 A;  3JD7 4;  3P4P A;  2PY5 A;  4YTN A;  1RUD 4;  1HRI 4;  5C3J A;  3AED A;  3P4Q A;  1EV1 4;  1HXS 4;  1R09 4;  1PO1 4;  3VRB A;  1XI1 A;  2EX3 A;  1VRH 4;  3AEG A;  1XHZ A;  1AR8 4;  1PO2 4;  2H89 A;  2RM2 4;  1VBE 4;  1HRV 4;  1RUG 4;  1COV 4;  3AE5 A;  3VR8 A;  4YT0 A;  2R06 4;  3AEC A;  1POV 0;  3AE1 A;  1RUI 4;  1YQ3 A;  3SUC A;  2FBW A;  1R08 4;  2WQY A;  2RS3 4;  1K5M D;  1AR9 4;  2PLV 4;  2H88 A; 
#chains in the Genus database with same CATH homology
 1ASJ 4;  1H8T D;  2X5I D;  1VRH 4;  2RMU 4;  3J8F 4;  1AR6 4;  1RVF 4;  1AR8 4;  1Z7S 4;  1EAH 4;  2HWB 4;  1RUH 4;  1VBB 4;  2R04 4;  1PO2 4;  1VBA 4;  2RS5 4;  4Q4X 4;  1RUE 4;  1VBD 4;  4RHV 4;  1PIV 4;  1RUC 4;  2RS1 4;  1AR7 4;  2RM2 4;  4Q4V 4;  4Q4Y 4;  1VBE 4;  1BEV 4;  1NA1 D;  1D4M 4;  1PVC 4;  1RUG 4;  1RUJ 4;  1COV 4;  1RUF 4;  4GB3 4;  1RHI 4;  1HRV 4;  2R06 4;  1RMU 4;  2HWC 4;  3JD7 4;  1POV 0;  1MQT D;  1OOP D;  1HRI 4;  1RUD 4;  4Q4W 4;  1VBC 4;  4PDW D;  1EV1 4;  1HXS 4;  1NCQ D;  1RUI 4;  3JBG 4;  1R09 4;  1R08 4;  1PO1 4;  2R07 4;  2RS3 4;  2RR1 4;  1K5M D;  1AL2 4;  1AR9 4;  2PLV 4; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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