2HWC4

A comparison of the anti-rhinoviral drug binding pocket in hrv14 and hrv1a
Total Genus 2
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
40
structure length
40
Chain Sequence
INYYKDAASTSSAGQSLSMDPSKFTEPVKDLMLKGAPALN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A.
pubmed doi rcsb
molecule tags Virus
source organism Human rhinovirus 14
molecule keywords HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1)
total genus 2
structure length 40
sequence length 40
ec nomenclature ec 2.7.7.48: RNA-directed RNA polymerase.
pdb deposition date 1994-01-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
4 PF02226 Pico_P1A Picornavirus coat protein (VP4)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.80.10 Few Secondary Structures Irregular Rhinovirus 14, subunit 4 Picornavirus coat protein VP4 2hwc400
1VBE4 3JD74 1HXS4 1EAH4 1RUI4 1Z7S4 1VBD4 2R044 1RUH4 2RS34 4PDWD 2RS54 1EV14 1HRI4 1RUD4 4Q4W4 1AL24 1RUC4 1R084 1K5MD 1AR74 1VRH4 2R074 2RS14 2X5ID 1HRV4 1MQTD 1ASJ4 1POV0 2PLV4 1RUF4 1PO14 2HWB4 1VBA4 1COV4 1PO24 1RMU4 2HWC4 1NCQD 1AR94 1RHI4 4RHV4 2RR14 1D4M4 1PIV4 1VBB4 1H8TD 3J8F4 1NA1D 1RUE4 2R064 2RM24 1AR84 1RVF4 1OOPD 3JBG4 1AR64 1PVC4 4Q4V4 1RUJ4 1VBC4 4Q4Y4 4Q4X4 1RUG4 2RMU4 1BEV4 4GB34 1R094
chains in the Genus database with same CATH superfamily
3JD74 2R044 4PDWD 3AE9A 2RS54 2PW9A 2WU2A 1HRI4 1RUD4 1RUC4 1VRH4 1K5MD 2PYJA 3AEEA 1ASJ4 1POV0 4YSYA 1PO14 2HWB4 1VBA4 1RHI4 4RHV4 2RR14 1VBB4 3SUCA 1XHXA 2EX3A 2WDQA 1AR84 1OOPD 3FI7A 4YSZA 4YT0A 1NENA 4YTPA 1YQ3A 2WDRA 3AECA 4Q4X4 3AE6A 3AE5A 5C3JA 1BEV4 1R094 1VBE4 3P4RA 2WDVA 3P4SA 3AEDA 2B76A 1RUH4 3AE7A 3VRBA 2PZSA 3GQKA 1R084 1AR74 2PLV4 3CIRA 1L0VA 1RMU4 1XI1A 1KFYA 3GQHA 3VR9A 1D4M4 1PIV4 3J8F4 1NA1D 2WS3A 3JBG4 1PVC4 4Q4V4 1VBC4 1YQ4A 5C2TA 1RUG4 3ABVA 1RVF4 1HXS4 3VRAA 1EAH4 1RUI4 1EV14 1NEKA 2FBWA 2R074 4KX6A 2X5ID 1HRV4 3AEBA 1RUF4 4YTMA 1COV4 3AEFA 2HWC4 1NCQD 1H8TD 3AE4A 1RUE4 2R064 2RM24 3AEAA 3SFEA 1RUJ4 4YSXA 2H88A 3P4QA 2RMU4 3AEGA 2H89A 2WQYA 1Z7S4 1VBD4 2RS34 2PY5A 1XHZA 1ZOYA 4Q4W4 1ZP0A 1AL24 1KF6A 2RS14 3AE8A 2R7FA 1MQTD 2ACZA 1PO24 3VR8A 2PYLA 4YTNA 4YXDA 1AR94 2WP9A 2WU5A 3P4PA 1AR64 3AE2A 3SFDA 4Q4Y4 3AE1A 3AE3A 4GB34
chains in the Genus database with same CATH topology
1VBE4 3JD74 1HXS4 1EAH4 1RUI4 1Z7S4 1VBD4 2R044 1RUH4 2RS34 4PDWD 2RS54 1EV14 1HRI4 1RUD4 4Q4W4 1AL24 1RUC4 1R084 1K5MD 1AR74 1VRH4 2R074 2RS14 2X5ID 1HRV4 1MQTD 1ASJ4 1POV0 2PLV4 1RUF4 1PO14 2HWB4 1VBA4 1COV4 1PO24 1RMU4 2HWC4 1NCQD 1AR94 1RHI4 4RHV4 2RR14 1D4M4 1PIV4 1VBB4 1H8TD 3J8F4 1NA1D 1RUE4 2R064 2RM24 1AR84 1RVF4 1OOPD 3JBG4 1AR64 1PVC4 4Q4V4 1RUJ4 1VBC4 4Q4Y4 4Q4X4 1RUG4 2RMU4 1BEV4 4GB34 1R094
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1VBE 4;  3JD7 4;  1HXS 4;  1EAH 4;  1RUI 4;  1Z7S 4;  1VBD 4;  2R04 4;  1RUH 4;  2RS3 4;  4PDW D;  2RS5 4;  1EV1 4;  1HRI 4;  1RUD 4;  4Q4W 4;  1AL2 4;  1RUC 4;  1R08 4;  1K5M D;  1AR7 4;  1VRH 4;  2R07 4;  2RS1 4;  2X5I D;  1HRV 4;  1MQT D;  1ASJ 4;  1POV 0;  2PLV 4;  1RUF 4;  1PO1 4;  2HWB 4;  1VBA 4;  1COV 4;  1PO2 4;  1RMU 4;  2HWC 4;  1NCQ D;  1AR9 4;  1RHI 4;  4RHV 4;  2RR1 4;  1D4M 4;  1PIV 4;  1VBB 4;  1H8T D;  3J8F 4;  1NA1 D;  1RUE 4;  2R06 4;  2RM2 4;  1AR8 4;  1RVF 4;  1OOP D;  3JBG 4;  1AR6 4;  1PVC 4;  4Q4V 4;  1RUJ 4;  1VBC 4;  4Q4Y 4;  4Q4X 4;  1RUG 4;  2RMU 4;  1BEV 4;  4GB3 4;  1R09 4; 
#chains in the Genus database with same CATH topology
 3JD7 4;  2R04 4;  4PDW D;  3AE9 A;  2RS5 4;  2PW9 A;  2WU2 A;  1HRI 4;  1RUD 4;  1RUC 4;  1VRH 4;  1K5M D;  2PYJ A;  3AEE A;  1ASJ 4;  1POV 0;  4YSY A;  1PO1 4;  2HWB 4;  1VBA 4;  1RHI 4;  4RHV 4;  2RR1 4;  1VBB 4;  3SUC A;  1XHX A;  2EX3 A;  2WDQ A;  1AR8 4;  1OOP D;  3FI7 A;  4YSZ A;  4YT0 A;  1NEN A;  4YTP A;  1YQ3 A;  2WDR A;  3AEC A;  4Q4X 4;  3AE6 A;  3AE5 A;  5C3J A;  1BEV 4;  1R09 4;  1VBE 4;  3P4R A;  2WDV A;  3P4S A;  3AED A;  2B76 A;  1RUH 4;  3AE7 A;  3VRB A;  2PZS A;  3GQK A;  1R08 4;  1AR7 4;  2PLV 4;  3CIR A;  1L0V A;  1RMU 4;  1XI1 A;  1KFY A;  3GQH A;  3VR9 A;  1D4M 4;  1PIV 4;  3J8F 4;  1NA1 D;  2WS3 A;  3JBG 4;  1PVC 4;  4Q4V 4;  1VBC 4;  1YQ4 A;  5C2T A;  1RUG 4;  3ABV A;  1RVF 4;  1HXS 4;  3VRA A;  1EAH 4;  1RUI 4;  1EV1 4;  1NEK A;  2FBW A;  2R07 4;  4KX6 A;  2X5I D;  1HRV 4;  3AEB A;  1RUF 4;  4YTM A;  1COV 4;  3AEF A;  2HWC 4;  1NCQ D;  1H8T D;  3AE4 A;  1RUE 4;  2R06 4;  2RM2 4;  3AEA A;  3SFE A;  1RUJ 4;  4YSX A;  2H88 A;  3P4Q A;  2RMU 4;  3AEG A;  2H89 A;  2WQY A;  1Z7S 4;  1VBD 4;  2RS3 4;  2PY5 A;  1XHZ A;  1ZOY A;  4Q4W 4;  1ZP0 A;  1AL2 4;  1KF6 A;  2RS1 4;  3AE8 A;  2R7F A;  1MQT D;  2ACZ A;  1PO2 4;  3VR8 A;  2PYL A;  4YTN A;  4YXD A;  1AR9 4;  2WP9 A;  2WU5 A;  3P4P A;  1AR6 4;  3AE2 A;  3SFD A;  4Q4Y 4;  3AE1 A;  3AE3 A;  4GB3 4; 
#chains in the Genus database with same CATH homology
 1VBE 4;  3JD7 4;  1HXS 4;  1EAH 4;  1RUI 4;  1Z7S 4;  1VBD 4;  2R04 4;  1RUH 4;  2RS3 4;  4PDW D;  2RS5 4;  1EV1 4;  1HRI 4;  1RUD 4;  4Q4W 4;  1AL2 4;  1RUC 4;  1R08 4;  1K5M D;  1AR7 4;  1VRH 4;  2R07 4;  2RS1 4;  2X5I D;  1HRV 4;  1MQT D;  1ASJ 4;  1POV 0;  2PLV 4;  1RUF 4;  1PO1 4;  2HWB 4;  1VBA 4;  1COV 4;  1PO2 4;  1RMU 4;  2HWC 4;  1NCQ D;  1AR9 4;  1RHI 4;  4RHV 4;  2RR1 4;  1D4M 4;  1PIV 4;  1VBB 4;  1H8T D;  3J8F 4;  1NA1 D;  1RUE 4;  2R06 4;  2RM2 4;  1AR8 4;  1RVF 4;  1OOP D;  3JBG 4;  1AR6 4;  1PVC 4;  4Q4V 4;  1RUJ 4;  1VBC 4;  4Q4Y 4;  4Q4X 4;  1RUG 4;  2RMU 4;  1BEV 4;  4GB3 4;  1R09 4; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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