1II6A

Crystal structure of the mitotic kinesin eg5 in complex with mg-adp.
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
350
structure length
340
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSERAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker.
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords KINESIN-RELATED MOTOR PROTEIN Eg5
total genus 106
structure length 340
sequence length 350
chains with identical sequence B
ec nomenclature
pdb deposition date 2001-04-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 1ii6A00
1I6IA 3H4SA 1SDMA 4BXNA 4E7ZA 1BR2A 4A28A 1X88A 4A51A 2ZFLA 3DCBA 4PJNA 1II6A 2GM1A 1LKXA 1RY6A 2ZFKA 3L1CA 1N6MA 3BFNA 3NWNA 3T0QA 1V8KA 1VFWA 2G1QA 2ZFJA 3ZFCA 1MMAA 3B6UA 4PFPA 4H1GA 4BBGA 2NCDA 5GSZA 1VFZA 2VVGA 1D1AA 4ZHIA 4FRZA 2IEHA 2FL6A 2UYIA 2X7EA 4B7BA 2XAEA 1D1CA 4A50A 4HNAK 3KINA 4A14A 4PJJA 1Q0BA 4PJLA 1D0YA 4AP0A 3U06A 1F9TA 2GRYA 3KARA 4DBRA 1FMWA 1MMNA 2PG2A 2VASA 2V26A 3CNZA 5LT2A 2XT3A 4ETPA 1MNEA 2X7DA 5LT3A 2ZFMA 1MMDA 2VB6A 1D0XA 3GBJA 4GKRA 1BR1A 2Q2ZA 3ZCWA 5LT4A 1BG2A 1F9UA 3L9HA 1CZ7A 3KENA 4PFOA 1G8XA 1VFXA 3DC4A 4AS7A 2KINA 4A5YA 1F9WA 5LT0A 5HLEA 4BN2A 1BR4A 1VFVA 3K5EA 3CJOA 3WRDA 3COBA 1I5SA 4ZCAA 3X2TA 5LT1A 2FMEA 4ANJA 2HEHA 2X51A 2WOGA 4E7SA 3B6VA 4PK4A 1KK7A 2MYSA 3LREA 1LVKA 1MKJA 3WPNA 4Y05A 2X7CA 1F9VA 1MMGA 2ZFIA 1GOJA 2FKYA 2Y5WA 1YRSA 3K3BA 4PJMA 2UYMA 3ZFDA 4LNUK 1VOMA 3HQDA 3PXNA 2OWMA 2Y65A 1D1BA 1V8JA 2X2RA 4DBQA 2FL2A 4UBFA 1D0ZA 1FMVA 4A1ZA 1T5CA 2Q2YA
chains in the Genus database with same CATH superfamily
1I6IA 3H4SA 1SDMA 4BXNA 4E7ZA 1BR2A 4A28A 1X88A 4A51A 2ZFLA 3DCBA 4PJNA 1II6A 2GM1A 1LKXA 1RY6A 2ZFKA 3L1CA 1N6MA 3BFNA 3NWNA 3T0QA 1V8KA 1VFWA 2G1QA 2ZFJA 3ZFCA 1MMAA 3B6UA 4PFPA 4H1GA 4BBGA 2NCDA 5GSZA 1VFZA 2VVGA 1D1AA 4ZHIA 4FRZA 2IEHA 2FL6A 2UYIA 2X7EA 4B7BA 2XAEA 1D1CA 4A50A 4HNAK 3KINA 4A14A 4PJJA 1Q0BA 4PJLA 1D0YA 4AP0A 3U06A 1F9TA 2GRYA 3KARA 4DBRA 1FMWA 1MMNA 2PG2A 2VASA 2V26A 3CNZA 5LT2A 2XT3A 4ETPA 1MNEA 2X7DA 5LT3A 2ZFMA 1MMDA 2VB6A 1D0XA 3GBJA 4GKRA 1BR1A 2Q2ZA 3ZCWA 5LT4A 1BG2A 2O0AA 1F9UA 3L9HA 4GKPA 1CZ7A 3KENA 4PFOA 1G8XA 1VFXA 3DC4A 4AS7A 2KINA 4A5YA 1F9WA 5LT0A 5HLEA 4BN2A 1BR4A 1VFVA 3K5EA 3CJOA 3WRDA 3COBA 1I5SA 4ZCAA 3X2TA 5LT1A 2FMEA 4ANJA 2HEHA 2X51A 2WOGA 4E7SA 3B6VA 4PK4A 1KK7A 2MYSA 3LREA 1LVKA 1MKJA 3WPNA 4Y05A 2X7CA 1F9VA 1MMGA 2ZFIA 1GOJA 2FKYA 2Y5WA 1YRSA 3K3BA 4PJMA 2UYMA 3ZFDA 4LNUK 1VOMA 3HQDA 3PXNA 2OWMA 4ETPB 2Y65A 1D1BA 1V8JA 2X2RA 4GKQA 4DBQA 2FL2A 4UBFA 1D0ZA 1FMVA 4A1ZA 1T5CA 2Q2YA
chains in the Genus database with same CATH topology
1I6IA 3H4SA 1SDMA 4BXNA 4E7ZA 1BR2A 4A28A 1X88A 4A51A 2ZFLA 3DCBA 4PJNA 1II6A 2GM1A 1LKXA 1RY6A 2ZFKA 3L1CA 1N6MA 3BFNA 3NWNA 3T0QA 1V8KA 1VFWA 2G1QA 2ZFJA 3ZFCA 1MMAA 3B6UA 4PFPA 4H1GA 4BBGA 2NCDA 5GSZA 1VFZA 2VVGA 1D1AA 4ZHIA 4FRZA 2IEHA 2FL6A 2UYIA 2X7EA 4B7BA 2XAEA 1D1CA 4A50A 4HNAK 3KINA 4A14A 4PJJA 1Q0BA 4PJLA 1D0YA 4AP0A 3U06A 1F9TA 2GRYA 3KARA 4DBRA 1FMWA 1MMNA 2PG2A 2VASA 2V26A 3CNZA 5LT2A 2XT3A 4ETPA 1MNEA 2X7DA 5LT3A 2ZFMA 1MMDA 2VB6A 1D0XA 3GBJA 4GKRA 1BR1A 2Q2ZA 3ZCWA 5LT4A 1BG2A 1F9UA 3L9HA 1CZ7A 3KENA 4PFOA 1G8XA 1VFXA 3DC4A 4AS7A 2KINA 4A5YA 1F9WA 5LT0A 5HLEA 4BN2A 1BR4A 1VFVA 3K5EA 3CJOA 3WRDA 3COBA 1I5SA 4ZCAA 3X2TA 5LT1A 2FMEA 4ANJA 2HEHA 2X51A 2WOGA 4E7SA 3B6VA 4PK4A 1KK7A 2MYSA 3LREA 1LVKA 1MKJA 3WPNA 4Y05A 2X7CA 1F9VA 1MMGA 2ZFIA 1GOJA 2FKYA 2Y5WA 1YRSA 3K3BA 4PJMA 2UYMA 3ZFDA 4LNUK 1VOMA 3HQDA 3PXNA 2OWMA 2Y65A 1D1BA 1V8JA 2X2RA 4DBQA 2FL2A 4UBFA 1D0ZA 1FMVA 4A1ZA 1T5CA 2Q2YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I6I A;  3H4S A;  1SDM A;  4BXN A;  4E7Z A;  1BR2 A;  4A28 A;  1X88 A;  4A51 A;  2ZFL A;  3DCB A;  4PJN A;  1II6 A;  2GM1 A;  1LKX A;  1RY6 A;  2ZFK A;  3L1C A;  1N6M A;  3BFN A;  3NWN A;  3T0Q A;  1V8K A;  1VFW A;  2G1Q A;  2ZFJ A;  3ZFC A;  1MMA A;  3B6U A;  4PFP A;  4H1G A;  4BBG A;  2NCD A;  5GSZ A;  1VFZ A;  2VVG A;  1D1A A;  4ZHI A;  4FRZ A;  2IEH A;  2FL6 A;  2UYI A;  2X7E A;  4B7B A;  2XAE A;  1D1C A;  4A50 A;  4HNA K;  3KIN A;  4A14 A;  4PJJ A;  1Q0B A;  4PJL A;  1D0Y A;  4AP0 A;  3U06 A;  1F9T A;  2GRY A;  3KAR A;  4DBR A;  1FMW A;  1MMN A;  2PG2 A;  2VAS A;  2V26 A;  3CNZ A;  5LT2 A;  2XT3 A;  4ETP A;  1MNE A;  2X7D A;  5LT3 A;  2ZFM A;  1MMD A;  2VB6 A;  1D0X A;  3GBJ A;  4GKR A;  1BR1 A;  2Q2Z A;  3ZCW A;  5LT4 A;  1BG2 A;  1F9U A;  3L9H A;  1CZ7 A;  3KEN A;  4PFO A;  1G8X A;  1VFX A;  3DC4 A;  4AS7 A;  2KIN A;  4A5Y A;  1F9W A;  5LT0 A;  5HLE A;  4BN2 A;  1BR4 A;  1VFV A;  3K5E A;  3CJO A;  3WRD A;  3COB A;  1I5S A;  4ZCA A;  3X2T A;  5LT1 A;  2FME A;  4ANJ A;  2HEH A;  2X51 A;  2WOG A;  4E7S A;  3B6V A;  4PK4 A;  1KK7 A;  2MYS A;  3LRE A;  1LVK A;  1MKJ A;  3WPN A;  4Y05 A;  2X7C A;  1F9V A;  1MMG A;  2ZFI A;  1GOJ A;  2FKY A;  2Y5W A;  1YRS A;  3K3B A;  4PJM A;  2UYM A;  3ZFD A;  4LNU K;  1VOM A;  3HQD A;  3PXN A;  2OWM A;  2Y65 A;  1D1B A;  1V8J A;  2X2R A;  4DBQ A;  2FL2 A;  4UBF A;  1D0Z A;  1FMV A;  4A1Z A;  1T5C A;  2Q2Y A; 
#chains in the Genus database with same CATH topology
 1I6I A;  3H4S A;  1SDM A;  4BXN A;  4E7Z A;  1BR2 A;  4A28 A;  1X88 A;  4A51 A;  2ZFL A;  3DCB A;  4PJN A;  1II6 A;  2GM1 A;  1LKX A;  1RY6 A;  2ZFK A;  3L1C A;  1N6M A;  3BFN A;  3NWN A;  3T0Q A;  1V8K A;  1VFW A;  2G1Q A;  2ZFJ A;  3ZFC A;  1MMA A;  3B6U A;  4PFP A;  4H1G A;  4BBG A;  2NCD A;  5GSZ A;  1VFZ A;  2VVG A;  1D1A A;  4ZHI A;  4FRZ A;  2IEH A;  2FL6 A;  2UYI A;  2X7E A;  4B7B A;  2XAE A;  1D1C A;  4A50 A;  4HNA K;  3KIN A;  4A14 A;  4PJJ A;  1Q0B A;  4PJL A;  1D0Y A;  4AP0 A;  3U06 A;  1F9T A;  2GRY A;  3KAR A;  4DBR A;  1FMW A;  1MMN A;  2PG2 A;  2VAS A;  2V26 A;  3CNZ A;  5LT2 A;  2XT3 A;  4ETP A;  1MNE A;  2X7D A;  5LT3 A;  2ZFM A;  1MMD A;  2VB6 A;  1D0X A;  3GBJ A;  4GKR A;  1BR1 A;  2Q2Z A;  3ZCW A;  5LT4 A;  1BG2 A;  2O0A A;  1F9U A;  3L9H A;  4GKP A;  1CZ7 A;  3KEN A;  4PFO A;  1G8X A;  1VFX A;  3DC4 A;  4AS7 A;  2KIN A;  4A5Y A;  1F9W A;  5LT0 A;  5HLE A;  4BN2 A;  1BR4 A;  1VFV A;  3K5E A;  3CJO A;  3WRD A;  3COB A;  1I5S A;  4ZCA A;  3X2T A;  5LT1 A;  2FME A;  4ANJ A;  2HEH A;  2X51 A;  2WOG A;  4E7S A;  3B6V A;  4PK4 A;  1KK7 A;  2MYS A;  3LRE A;  1LVK A;  1MKJ A;  3WPN A;  4Y05 A;  2X7C A;  1F9V A;  1MMG A;  2ZFI A;  1GOJ A;  2FKY A;  2Y5W A;  1YRS A;  3K3B A;  4PJM A;  2UYM A;  3ZFD A;  4LNU K;  1VOM A;  3HQD A;  3PXN A;  2OWM A;  4ETP B;  2Y65 A;  1D1B A;  1V8J A;  2X2R A;  4GKQ A;  4DBQ A;  2FL2 A;  4UBF A;  1D0Z A;  1FMV A;  4A1Z A;  1T5C A;  2Q2Y A; 
#chains in the Genus database with same CATH homology
 1I6I A;  3H4S A;  1SDM A;  4BXN A;  4E7Z A;  1BR2 A;  4A28 A;  1X88 A;  4A51 A;  2ZFL A;  3DCB A;  4PJN A;  1II6 A;  2GM1 A;  1LKX A;  1RY6 A;  2ZFK A;  3L1C A;  1N6M A;  3BFN A;  3NWN A;  3T0Q A;  1V8K A;  1VFW A;  2G1Q A;  2ZFJ A;  3ZFC A;  1MMA A;  3B6U A;  4PFP A;  4H1G A;  4BBG A;  2NCD A;  5GSZ A;  1VFZ A;  2VVG A;  1D1A A;  4ZHI A;  4FRZ A;  2IEH A;  2FL6 A;  2UYI A;  2X7E A;  4B7B A;  2XAE A;  1D1C A;  4A50 A;  4HNA K;  3KIN A;  4A14 A;  4PJJ A;  1Q0B A;  4PJL A;  1D0Y A;  4AP0 A;  3U06 A;  1F9T A;  2GRY A;  3KAR A;  4DBR A;  1FMW A;  1MMN A;  2PG2 A;  2VAS A;  2V26 A;  3CNZ A;  5LT2 A;  2XT3 A;  4ETP A;  1MNE A;  2X7D A;  5LT3 A;  2ZFM A;  1MMD A;  2VB6 A;  1D0X A;  3GBJ A;  4GKR A;  1BR1 A;  2Q2Z A;  3ZCW A;  5LT4 A;  1BG2 A;  1F9U A;  3L9H A;  1CZ7 A;  3KEN A;  4PFO A;  1G8X A;  1VFX A;  3DC4 A;  4AS7 A;  2KIN A;  4A5Y A;  1F9W A;  5LT0 A;  5HLE A;  4BN2 A;  1BR4 A;  1VFV A;  3K5E A;  3CJO A;  3WRD A;  3COB A;  1I5S A;  4ZCA A;  3X2T A;  5LT1 A;  2FME A;  4ANJ A;  2HEH A;  2X51 A;  2WOG A;  4E7S A;  3B6V A;  4PK4 A;  1KK7 A;  2MYS A;  3LRE A;  1LVK A;  1MKJ A;  3WPN A;  4Y05 A;  2X7C A;  1F9V A;  1MMG A;  2ZFI A;  1GOJ A;  2FKY A;  2Y5W A;  1YRS A;  3K3B A;  4PJM A;  2UYM A;  3ZFD A;  4LNU K;  1VOM A;  3HQD A;  3PXN A;  2OWM A;  2Y65 A;  1D1B A;  1V8J A;  2X2R A;  4DBQ A;  2FL2 A;  4UBF A;  1D0Z A;  1FMV A;  4A1Z A;  1T5C A;  2Q2Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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