3ZCWA

Eg5 - new allosteric binding site
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
346
structure length
321
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGDKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Structural Insights Into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 106
structure length 321
sequence length 346
ec nomenclature
pdb deposition date 2012-11-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 3zcwA00
2ZFMA 5LT0A 1MKJA 3KARA 3BFNA 1F9UA 2OWMA 2GRYA 4ZCAA 1VFXA 1BR2A 4ANJA 1G8XA 2VVGA 4PJLA 4FRZA 1LKXA 2X7CA 4BN2A 2HEHA 1BR4A 4E7ZA 5LT2A 1F9TA 1II6A 1MMDA 2NCDA 2ZFKA 1BG2A 2ZFIA 1D0YA 1MMNA 1V8JA 4AS7A 3CNZA 1D0ZA 3ZCWA 3WRDA 3DCBA 2VASA 3X2TA 4ZHIA 4GKRA 2FMEA 2WOGA 4DBRA 1FMWA 3LREA 4UBFA 2GM1A 4A28A 3L1CA 2Y5WA 4HNAK 4LNUK 2X2RA 2XAEA 4PJMA 4A50A 3B6VA 3ZFDA 1BR1A 1V8KA 2MYSA 2XT3A 2Q2YA 4BXNA 2IEHA 1MMGA 4DBQA 5GSZA 1SDMA 1MMAA 4E7SA 4PJJA 1VFWA 3DC4A 5LT3A 4B7BA 3HQDA 4AP0A 4A14A 1X88A 3CJOA 1D0XA 2G1QA 2X7EA 3KINA 3NWNA 4H1GA 1F9WA 3KENA 3L9HA 1I5SA 1LVKA 1N6MA 3COBA 1YRSA 2UYMA 1CZ7A 3GBJA 1VFVA 1D1CA 1MNEA 4ETPA 1D1BA 1F9VA 2FL2A 4PJNA 4Y05A 3B6UA 4PFPA 3H4SA 5HLEA 3T0QA 2PG2A 4PFOA 1FMVA 2Q2ZA 2UYIA 1RY6A 1I6IA 2ZFLA 3K3BA 2Y65A 2FL6A 4PK4A 2X51A 2ZFJA 4A1ZA 3U06A 4BBGA 1GOJA 4A51A 3PXNA 2KINA 2VB6A 2X7DA 3WPNA 1KK7A 1VOMA 2V26A 1D1AA 5LT4A 2FKYA 5LT1A 1T5CA 4A5YA 1VFZA 1Q0BA 3K5EA 3ZFCA
chains in the Genus database with same CATH superfamily
2ZFMA 5LT0A 1MKJA 3KARA 3BFNA 1F9UA 2OWMA 2GRYA 4ZCAA 1VFXA 1BR2A 4ANJA 1G8XA 2VVGA 4PJLA 4FRZA 1LKXA 2O0AA 2X7CA 2HEHA 4BN2A 1BR4A 4E7ZA 5LT2A 1F9TA 1II6A 1MMDA 2NCDA 2ZFKA 1BG2A 2ZFIA 1D0YA 1MMNA 1V8JA 4AS7A 3CNZA 1D0ZA 3ZCWA 3WRDA 3DCBA 2VASA 3X2TA 4ZHIA 4GKRA 2FMEA 2WOGA 4DBRA 1FMWA 3LREA 4UBFA 2GM1A 4A28A 3L1CA 2Y5WA 4HNAK 4LNUK 2X2RA 2XAEA 4PJMA 4A50A 3B6VA 3ZFDA 1BR1A 1V8KA 2MYSA 2XT3A 2Q2YA 4BXNA 2IEHA 1MMGA 4DBQA 5GSZA 1SDMA 1MMAA 4E7SA 4PJJA 1VFWA 3DC4A 5LT3A 4B7BA 3HQDA 4AP0A 4A14A 1X88A 3CJOA 1D0XA 2G1QA 2X7EA 3KINA 3NWNA 4H1GA 1F9WA 3KENA 3L9HA 1I5SA 1LVKA 1N6MA 3COBA 1YRSA 2UYMA 1CZ7A 3GBJA 1VFVA 1D1CA 1MNEA 4ETPA 1D1BA 1F9VA 4ETPB 2FL2A 4PJNA 4Y05A 3B6UA 4PFPA 3H4SA 5HLEA 3T0QA 2PG2A 4PFOA 1FMVA 2Q2ZA 2UYIA 1RY6A 1I6IA 2ZFLA 3K3BA 2Y65A 2FL6A 4PK4A 2X51A 2ZFJA 4GKPA 4A1ZA 3U06A 4BBGA 1GOJA 4A51A 3PXNA 2KINA 4GKQA 2VB6A 2X7DA 3WPNA 1KK7A 1VOMA 2V26A 1D1AA 5LT4A 2FKYA 5LT1A 1T5CA 4A5YA 1VFZA 1Q0BA 3K5EA 3ZFCA
chains in the Genus database with same CATH topology
2ZFMA 5LT0A 1MKJA 3KARA 3BFNA 1F9UA 2OWMA 2GRYA 4ZCAA 1VFXA 1BR2A 4ANJA 1G8XA 2VVGA 4PJLA 4FRZA 1LKXA 2X7CA 4BN2A 2HEHA 1BR4A 4E7ZA 5LT2A 1F9TA 1II6A 1MMDA 2NCDA 2ZFKA 1BG2A 2ZFIA 1D0YA 1MMNA 1V8JA 4AS7A 3CNZA 1D0ZA 3ZCWA 3WRDA 3DCBA 2VASA 3X2TA 4ZHIA 4GKRA 2FMEA 2WOGA 4DBRA 1FMWA 3LREA 4UBFA 2GM1A 4A28A 3L1CA 2Y5WA 4HNAK 4LNUK 2X2RA 2XAEA 4PJMA 4A50A 3B6VA 3ZFDA 1BR1A 1V8KA 2MYSA 2XT3A 2Q2YA 4BXNA 2IEHA 1MMGA 4DBQA 5GSZA 1SDMA 1MMAA 4E7SA 4PJJA 1VFWA 3DC4A 5LT3A 4B7BA 3HQDA 4AP0A 4A14A 1X88A 3CJOA 1D0XA 2G1QA 2X7EA 3KINA 3NWNA 4H1GA 1F9WA 3KENA 3L9HA 1I5SA 1LVKA 1N6MA 3COBA 1YRSA 2UYMA 1CZ7A 3GBJA 1VFVA 1D1CA 1MNEA 4ETPA 1D1BA 1F9VA 2FL2A 4PJNA 4Y05A 3B6UA 4PFPA 3H4SA 5HLEA 3T0QA 2PG2A 4PFOA 1FMVA 2Q2ZA 2UYIA 1RY6A 1I6IA 2ZFLA 3K3BA 2Y65A 2FL6A 4PK4A 2X51A 2ZFJA 4A1ZA 3U06A 4BBGA 1GOJA 4A51A 3PXNA 2KINA 2VB6A 2X7DA 3WPNA 1KK7A 1VOMA 2V26A 1D1AA 5LT4A 2FKYA 5LT1A 1T5CA 4A5YA 1VFZA 1Q0BA 3K5EA 3ZFCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZFM A;  5LT0 A;  1MKJ A;  3KAR A;  3BFN A;  1F9U A;  2OWM A;  2GRY A;  4ZCA A;  1VFX A;  1BR2 A;  4ANJ A;  1G8X A;  2VVG A;  4PJL A;  4FRZ A;  1LKX A;  2X7C A;  4BN2 A;  2HEH A;  1BR4 A;  4E7Z A;  5LT2 A;  1F9T A;  1II6 A;  1MMD A;  2NCD A;  2ZFK A;  1BG2 A;  2ZFI A;  1D0Y A;  1MMN A;  1V8J A;  4AS7 A;  3CNZ A;  1D0Z A;  3ZCW A;  3WRD A;  3DCB A;  2VAS A;  3X2T A;  4ZHI A;  4GKR A;  2FME A;  2WOG A;  4DBR A;  1FMW A;  3LRE A;  4UBF A;  2GM1 A;  4A28 A;  3L1C A;  2Y5W A;  4HNA K;  4LNU K;  2X2R A;  2XAE A;  4PJM A;  4A50 A;  3B6V A;  3ZFD A;  1BR1 A;  1V8K A;  2MYS A;  2XT3 A;  2Q2Y A;  4BXN A;  2IEH A;  1MMG A;  4DBQ A;  5GSZ A;  1SDM A;  1MMA A;  4E7S A;  4PJJ A;  1VFW A;  3DC4 A;  5LT3 A;  4B7B A;  3HQD A;  4AP0 A;  4A14 A;  1X88 A;  3CJO A;  1D0X A;  2G1Q A;  2X7E A;  3KIN A;  3NWN A;  4H1G A;  1F9W A;  3KEN A;  3L9H A;  1I5S A;  1LVK A;  1N6M A;  3COB A;  1YRS A;  2UYM A;  1CZ7 A;  3GBJ A;  1VFV A;  1D1C A;  1MNE A;  4ETP A;  1D1B A;  1F9V A;  2FL2 A;  4PJN A;  4Y05 A;  3B6U A;  4PFP A;  3H4S A;  5HLE A;  3T0Q A;  2PG2 A;  4PFO A;  1FMV A;  2Q2Z A;  2UYI A;  1RY6 A;  1I6I A;  2ZFL A;  3K3B A;  2Y65 A;  2FL6 A;  4PK4 A;  2X51 A;  2ZFJ A;  4A1Z A;  3U06 A;  4BBG A;  1GOJ A;  4A51 A;  3PXN A;  2KIN A;  2VB6 A;  2X7D A;  3WPN A;  1KK7 A;  1VOM A;  2V26 A;  1D1A A;  5LT4 A;  2FKY A;  5LT1 A;  1T5C A;  4A5Y A;  1VFZ A;  1Q0B A;  3K5E A;  3ZFC A; 
#chains in the Genus database with same CATH topology
 2ZFM A;  5LT0 A;  1MKJ A;  3KAR A;  3BFN A;  1F9U A;  2OWM A;  2GRY A;  4ZCA A;  1VFX A;  1BR2 A;  4ANJ A;  1G8X A;  2VVG A;  4PJL A;  4FRZ A;  1LKX A;  2O0A A;  2X7C A;  2HEH A;  4BN2 A;  1BR4 A;  4E7Z A;  5LT2 A;  1F9T A;  1II6 A;  1MMD A;  2NCD A;  2ZFK A;  1BG2 A;  2ZFI A;  1D0Y A;  1MMN A;  1V8J A;  4AS7 A;  3CNZ A;  1D0Z A;  3ZCW A;  3WRD A;  3DCB A;  2VAS A;  3X2T A;  4ZHI A;  4GKR A;  2FME A;  2WOG A;  4DBR A;  1FMW A;  3LRE A;  4UBF A;  2GM1 A;  4A28 A;  3L1C A;  2Y5W A;  4HNA K;  4LNU K;  2X2R A;  2XAE A;  4PJM A;  4A50 A;  3B6V A;  3ZFD A;  1BR1 A;  1V8K A;  2MYS A;  2XT3 A;  2Q2Y A;  4BXN A;  2IEH A;  1MMG A;  4DBQ A;  5GSZ A;  1SDM A;  1MMA A;  4E7S A;  4PJJ A;  1VFW A;  3DC4 A;  5LT3 A;  4B7B A;  3HQD A;  4AP0 A;  4A14 A;  1X88 A;  3CJO A;  1D0X A;  2G1Q A;  2X7E A;  3KIN A;  3NWN A;  4H1G A;  1F9W A;  3KEN A;  3L9H A;  1I5S A;  1LVK A;  1N6M A;  3COB A;  1YRS A;  2UYM A;  1CZ7 A;  3GBJ A;  1VFV A;  1D1C A;  1MNE A;  4ETP A;  1D1B A;  1F9V A;  4ETP B;  2FL2 A;  4PJN A;  4Y05 A;  3B6U A;  4PFP A;  3H4S A;  5HLE A;  3T0Q A;  2PG2 A;  4PFO A;  1FMV A;  2Q2Z A;  2UYI A;  1RY6 A;  1I6I A;  2ZFL A;  3K3B A;  2Y65 A;  2FL6 A;  4PK4 A;  2X51 A;  2ZFJ A;  4GKP A;  4A1Z A;  3U06 A;  4BBG A;  1GOJ A;  4A51 A;  3PXN A;  2KIN A;  4GKQ A;  2VB6 A;  2X7D A;  3WPN A;  1KK7 A;  1VOM A;  2V26 A;  1D1A A;  5LT4 A;  2FKY A;  5LT1 A;  1T5C A;  4A5Y A;  1VFZ A;  1Q0B A;  3K5E A;  3ZFC A; 
#chains in the Genus database with same CATH homology
 2ZFM A;  5LT0 A;  1MKJ A;  3KAR A;  3BFN A;  1F9U A;  2OWM A;  2GRY A;  4ZCA A;  1VFX A;  1BR2 A;  4ANJ A;  1G8X A;  2VVG A;  4PJL A;  4FRZ A;  1LKX A;  2X7C A;  4BN2 A;  2HEH A;  1BR4 A;  4E7Z A;  5LT2 A;  1F9T A;  1II6 A;  1MMD A;  2NCD A;  2ZFK A;  1BG2 A;  2ZFI A;  1D0Y A;  1MMN A;  1V8J A;  4AS7 A;  3CNZ A;  1D0Z A;  3ZCW A;  3WRD A;  3DCB A;  2VAS A;  3X2T A;  4ZHI A;  4GKR A;  2FME A;  2WOG A;  4DBR A;  1FMW A;  3LRE A;  4UBF A;  2GM1 A;  4A28 A;  3L1C A;  2Y5W A;  4HNA K;  4LNU K;  2X2R A;  2XAE A;  4PJM A;  4A50 A;  3B6V A;  3ZFD A;  1BR1 A;  1V8K A;  2MYS A;  2XT3 A;  2Q2Y A;  4BXN A;  2IEH A;  1MMG A;  4DBQ A;  5GSZ A;  1SDM A;  1MMA A;  4E7S A;  4PJJ A;  1VFW A;  3DC4 A;  5LT3 A;  4B7B A;  3HQD A;  4AP0 A;  4A14 A;  1X88 A;  3CJO A;  1D0X A;  2G1Q A;  2X7E A;  3KIN A;  3NWN A;  4H1G A;  1F9W A;  3KEN A;  3L9H A;  1I5S A;  1LVK A;  1N6M A;  3COB A;  1YRS A;  2UYM A;  1CZ7 A;  3GBJ A;  1VFV A;  1D1C A;  1MNE A;  4ETP A;  1D1B A;  1F9V A;  2FL2 A;  4PJN A;  4Y05 A;  3B6U A;  4PFP A;  3H4S A;  5HLE A;  3T0Q A;  2PG2 A;  4PFO A;  1FMV A;  2Q2Z A;  2UYI A;  1RY6 A;  1I6I A;  2ZFL A;  3K3B A;  2Y65 A;  2FL6 A;  4PK4 A;  2X51 A;  2ZFJ A;  4A1Z A;  3U06 A;  4BBG A;  1GOJ A;  4A51 A;  3PXN A;  2KIN A;  2VB6 A;  2X7D A;  3WPN A;  1KK7 A;  1VOM A;  2V26 A;  1D1A A;  5LT4 A;  2FKY A;  5LT1 A;  1T5C A;  4A5Y A;  1VFZ A;  1Q0B A;  3K5E A;  3ZFC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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