3ZCWA

Eg5 - new allosteric binding site
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
346
structure length
321
Chain Sequence
b'NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGDKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKP'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Structural Insights Into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 106
structure length 321
sequence length 346
ec nomenclature
pdb deposition date 2012-11-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 3zcwA00
4E7ZA 4A28A 2ZFJA 3KENA 1LVKA 1D0ZA 2Y65A 3T0QA 2VB6A 5GSZA 1VFWA 2X51A 3HQDA 4BXNA 3K5EA 4BN2A 4A5YA 3B6VA 2X7DA 3WRDA 4PJMA 3KINA 4DBRA 3GBJA 1VFVA 3U06A 4B7BA 1BR1A 2ZFKA 3H4SA 1VFZA 4E7SA 3KARA 4PJNA 4ZHIA 1II6A 5HLEA 2GRYA 3NWNA 4PJLA 1I6IA 2ZFIA 4AP0A 1FMWA 2X7CA 1GOJA 1YRSA 1V8KA 4ETPA 3L9HA 4PJJA 1MKJA 4GKRA 1MMNA 3COBA 4H1GA 2X7EA 4PFOA 2MYSA 1CZ7A 4PK4A 2XAEA 1V8JA 1LKXA 1Q0BA 2UYIA 4FRZA 3CNZA 4AS7A 2OWMA 1BR4A 1D0XA 2IEHA 2ZFLA 3LREA 5LT2A 2FMEA 1I5SA 1MMAA 2VASA 1D0YA 2HEHA 3DCBA 4UBFA 4A1ZA 4BBGA 1X88A 5LT3A 3L1CA 4Y05A 1F9WA 1KK7A 3ZFDA 1F9VA 5LT1A 2Y5WA 2G1QA 4ANJA 1D1BA 2ZFMA 4LNUK 4ZCAA 2V26A 3K3BA 3PXNA 2UYMA 2KINA 1N6MA 2FL2A 3X2TA 3ZCWA 1SDMA 3B6UA 1F9UA 5LT4A 3ZFCA 1BR2A 3CJOA 4A14A 1RY6A 3WPNA 4A51A 1VOMA 3BFNA 2XT3A 1T5CA 4PFPA 2PG2A 2Q2YA 1MMGA 2WOGA 4A50A 1FMVA 2FL6A 2GM1A 1D1AA 2Q2ZA 1VFXA 1F9TA 4DBQA 1G8XA 2X2RA 2NCDA 5LT0A 1D1CA 1MMDA 2VVGA 4HNAK 2FKYA 3DC4A 1BG2A 1MNEA
chains in the Genus database with same CATH superfamily
4GKPA 4E7ZA 4A28A 2ZFJA 3KENA 1LVKA 1D0ZA 2Y65A 3T0QA 2VB6A 5GSZA 1VFWA 2X51A 3HQDA 4BXNA 3K5EA 4BN2A 4A5YA 3B6VA 2X7DA 3WRDA 4PJMA 3KINA 4DBRA 3GBJA 1VFVA 3U06A 4B7BA 1BR1A 2ZFKA 3H4SA 4ETPB 1VFZA 4E7SA 3KARA 4PJNA 4ZHIA 1II6A 5HLEA 2GRYA 3NWNA 4PJLA 1I6IA 2ZFIA 4AP0A 1FMWA 2X7CA 1GOJA 1YRSA 1V8KA 4ETPA 3L9HA 4PJJA 1MKJA 4GKRA 1MMNA 3COBA 4H1GA 2X7EA 4PFOA 2MYSA 1CZ7A 4PK4A 2XAEA 2O0AA 1V8JA 1LKXA 1Q0BA 2UYIA 4FRZA 3CNZA 4AS7A 2OWMA 1BR4A 1D0XA 2IEHA 2ZFLA 3LREA 5LT2A 2FMEA 1I5SA 1MMAA 2VASA 1D0YA 2HEHA 3DCBA 4UBFA 4A1ZA 4BBGA 1X88A 5LT3A 3L1CA 4Y05A 1F9WA 1KK7A 3ZFDA 1F9VA 5LT1A 2Y5WA 2G1QA 4ANJA 1D1BA 2ZFMA 4LNUK 4ZCAA 2V26A 3K3BA 3PXNA 2UYMA 2KINA 1N6MA 2FL2A 3X2TA 3ZCWA 1SDMA 3B6UA 1F9UA 5LT4A 3ZFCA 1BR2A 3CJOA 4A14A 1RY6A 4GKQA 3WPNA 4A51A 1VOMA 3BFNA 2XT3A 1T5CA 4PFPA 2PG2A 2Q2YA 1MMGA 2WOGA 4A50A 1FMVA 2FL6A 2GM1A 1D1AA 2Q2ZA 1VFXA 1F9TA 4DBQA 1G8XA 2X2RA 2NCDA 5LT0A 1D1CA 1MMDA 2VVGA 4HNAK 2FKYA 3DC4A 1BG2A 1MNEA
chains in the Genus database with same CATH topology
4E7ZA 4A28A 2ZFJA 3KENA 1LVKA 1D0ZA 2Y65A 3T0QA 2VB6A 5GSZA 1VFWA 2X51A 3HQDA 4BXNA 3K5EA 4BN2A 4A5YA 3B6VA 2X7DA 3WRDA 4PJMA 3KINA 4DBRA 3GBJA 1VFVA 3U06A 4B7BA 1BR1A 2ZFKA 3H4SA 1VFZA 4E7SA 3KARA 4PJNA 4ZHIA 1II6A 5HLEA 2GRYA 3NWNA 4PJLA 1I6IA 2ZFIA 4AP0A 1FMWA 2X7CA 1GOJA 1YRSA 1V8KA 4ETPA 3L9HA 4PJJA 1MKJA 4GKRA 1MMNA 3COBA 4H1GA 2X7EA 4PFOA 2MYSA 1CZ7A 4PK4A 2XAEA 1V8JA 1LKXA 1Q0BA 2UYIA 4FRZA 3CNZA 4AS7A 2OWMA 1BR4A 1D0XA 2IEHA 2ZFLA 3LREA 5LT2A 2FMEA 1I5SA 1MMAA 2VASA 1D0YA 2HEHA 3DCBA 4UBFA 4A1ZA 4BBGA 1X88A 5LT3A 3L1CA 4Y05A 1F9WA 1KK7A 3ZFDA 1F9VA 5LT1A 2Y5WA 2G1QA 4ANJA 1D1BA 2ZFMA 4LNUK 4ZCAA 2V26A 3K3BA 3PXNA 2UYMA 2KINA 1N6MA 2FL2A 3X2TA 3ZCWA 1SDMA 3B6UA 1F9UA 5LT4A 3ZFCA 1BR2A 3CJOA 4A14A 1RY6A 3WPNA 4A51A 1VOMA 3BFNA 2XT3A 1T5CA 4PFPA 2PG2A 2Q2YA 1MMGA 2WOGA 4A50A 1FMVA 2FL6A 2GM1A 1D1AA 2Q2ZA 1VFXA 1F9TA 4DBQA 1G8XA 2X2RA 2NCDA 5LT0A 1D1CA 1MMDA 2VVGA 4HNAK 2FKYA 3DC4A 1BG2A 1MNEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4E7Z A;  4A28 A;  2ZFJ A;  3KEN A;  1LVK A;  1D0Z A;  2Y65 A;  3T0Q A;  2VB6 A;  5GSZ A;  1VFW A;  2X51 A;  3HQD A;  4BXN A;  3K5E A;  4BN2 A;  4A5Y A;  3B6V A;  2X7D A;  3WRD A;  4PJM A;  3KIN A;  4DBR A;  3GBJ A;  1VFV A;  3U06 A;  4B7B A;  1BR1 A;  2ZFK A;  3H4S A;  1VFZ A;  4E7S A;  3KAR A;  4PJN A;  4ZHI A;  1II6 A;  5HLE A;  2GRY A;  3NWN A;  4PJL A;  1I6I A;  2ZFI A;  4AP0 A;  1FMW A;  2X7C A;  1GOJ A;  1YRS A;  1V8K A;  4ETP A;  3L9H A;  4PJJ A;  1MKJ A;  4GKR A;  1MMN A;  3COB A;  4H1G A;  2X7E A;  4PFO A;  2MYS A;  1CZ7 A;  4PK4 A;  2XAE A;  1V8J A;  1LKX A;  1Q0B A;  2UYI A;  4FRZ A;  3CNZ A;  4AS7 A;  2OWM A;  1BR4 A;  1D0X A;  2IEH A;  2ZFL A;  3LRE A;  5LT2 A;  2FME A;  1I5S A;  1MMA A;  2VAS A;  1D0Y A;  2HEH A;  3DCB A;  4UBF A;  4A1Z A;  4BBG A;  1X88 A;  5LT3 A;  3L1C A;  4Y05 A;  1F9W A;  1KK7 A;  3ZFD A;  1F9V A;  5LT1 A;  2Y5W A;  2G1Q A;  4ANJ A;  1D1B A;  2ZFM A;  4LNU K;  4ZCA A;  2V26 A;  3K3B A;  3PXN A;  2UYM A;  2KIN A;  1N6M A;  2FL2 A;  3X2T A;  3ZCW A;  1SDM A;  3B6U A;  1F9U A;  5LT4 A;  3ZFC A;  1BR2 A;  3CJO A;  4A14 A;  1RY6 A;  3WPN A;  4A51 A;  1VOM A;  3BFN A;  2XT3 A;  1T5C A;  4PFP A;  2PG2 A;  2Q2Y A;  1MMG A;  2WOG A;  4A50 A;  1FMV A;  2FL6 A;  2GM1 A;  1D1A A;  2Q2Z A;  1VFX A;  1F9T A;  4DBQ A;  1G8X A;  2X2R A;  2NCD A;  5LT0 A;  1D1C A;  1MMD A;  2VVG A;  4HNA K;  2FKY A;  3DC4 A;  1BG2 A;  1MNE A; 
#chains in the Genus database with same CATH topology
 4GKP A;  4E7Z A;  4A28 A;  2ZFJ A;  3KEN A;  1LVK A;  1D0Z A;  2Y65 A;  3T0Q A;  2VB6 A;  5GSZ A;  1VFW A;  2X51 A;  3HQD A;  4BXN A;  3K5E A;  4BN2 A;  4A5Y A;  3B6V A;  2X7D A;  3WRD A;  4PJM A;  3KIN A;  4DBR A;  3GBJ A;  1VFV A;  3U06 A;  4B7B A;  1BR1 A;  2ZFK A;  3H4S A;  4ETP B;  1VFZ A;  4E7S A;  3KAR A;  4PJN A;  4ZHI A;  1II6 A;  5HLE A;  2GRY A;  3NWN A;  4PJL A;  1I6I A;  2ZFI A;  4AP0 A;  1FMW A;  2X7C A;  1GOJ A;  1YRS A;  1V8K A;  4ETP A;  3L9H A;  4PJJ A;  1MKJ A;  4GKR A;  1MMN A;  3COB A;  4H1G A;  2X7E A;  4PFO A;  2MYS A;  1CZ7 A;  4PK4 A;  2XAE A;  2O0A A;  1V8J A;  1LKX A;  1Q0B A;  2UYI A;  4FRZ A;  3CNZ A;  4AS7 A;  2OWM A;  1BR4 A;  1D0X A;  2IEH A;  2ZFL A;  3LRE A;  5LT2 A;  2FME A;  1I5S A;  1MMA A;  2VAS A;  1D0Y A;  2HEH A;  3DCB A;  4UBF A;  4A1Z A;  4BBG A;  1X88 A;  5LT3 A;  3L1C A;  4Y05 A;  1F9W A;  1KK7 A;  3ZFD A;  1F9V A;  5LT1 A;  2Y5W A;  2G1Q A;  4ANJ A;  1D1B A;  2ZFM A;  4LNU K;  4ZCA A;  2V26 A;  3K3B A;  3PXN A;  2UYM A;  2KIN A;  1N6M A;  2FL2 A;  3X2T A;  3ZCW A;  1SDM A;  3B6U A;  1F9U A;  5LT4 A;  3ZFC A;  1BR2 A;  3CJO A;  4A14 A;  1RY6 A;  4GKQ A;  3WPN A;  4A51 A;  1VOM A;  3BFN A;  2XT3 A;  1T5C A;  4PFP A;  2PG2 A;  2Q2Y A;  1MMG A;  2WOG A;  4A50 A;  1FMV A;  2FL6 A;  2GM1 A;  1D1A A;  2Q2Z A;  1VFX A;  1F9T A;  4DBQ A;  1G8X A;  2X2R A;  2NCD A;  5LT0 A;  1D1C A;  1MMD A;  2VVG A;  4HNA K;  2FKY A;  3DC4 A;  1BG2 A;  1MNE A; 
#chains in the Genus database with same CATH homology
 4E7Z A;  4A28 A;  2ZFJ A;  3KEN A;  1LVK A;  1D0Z A;  2Y65 A;  3T0Q A;  2VB6 A;  5GSZ A;  1VFW A;  2X51 A;  3HQD A;  4BXN A;  3K5E A;  4BN2 A;  4A5Y A;  3B6V A;  2X7D A;  3WRD A;  4PJM A;  3KIN A;  4DBR A;  3GBJ A;  1VFV A;  3U06 A;  4B7B A;  1BR1 A;  2ZFK A;  3H4S A;  1VFZ A;  4E7S A;  3KAR A;  4PJN A;  4ZHI A;  1II6 A;  5HLE A;  2GRY A;  3NWN A;  4PJL A;  1I6I A;  2ZFI A;  4AP0 A;  1FMW A;  2X7C A;  1GOJ A;  1YRS A;  1V8K A;  4ETP A;  3L9H A;  4PJJ A;  1MKJ A;  4GKR A;  1MMN A;  3COB A;  4H1G A;  2X7E A;  4PFO A;  2MYS A;  1CZ7 A;  4PK4 A;  2XAE A;  1V8J A;  1LKX A;  1Q0B A;  2UYI A;  4FRZ A;  3CNZ A;  4AS7 A;  2OWM A;  1BR4 A;  1D0X A;  2IEH A;  2ZFL A;  3LRE A;  5LT2 A;  2FME A;  1I5S A;  1MMA A;  2VAS A;  1D0Y A;  2HEH A;  3DCB A;  4UBF A;  4A1Z A;  4BBG A;  1X88 A;  5LT3 A;  3L1C A;  4Y05 A;  1F9W A;  1KK7 A;  3ZFD A;  1F9V A;  5LT1 A;  2Y5W A;  2G1Q A;  4ANJ A;  1D1B A;  2ZFM A;  4LNU K;  4ZCA A;  2V26 A;  3K3B A;  3PXN A;  2UYM A;  2KIN A;  1N6M A;  2FL2 A;  3X2T A;  3ZCW A;  1SDM A;  3B6U A;  1F9U A;  5LT4 A;  3ZFC A;  1BR2 A;  3CJO A;  4A14 A;  1RY6 A;  3WPN A;  4A51 A;  1VOM A;  3BFN A;  2XT3 A;  1T5C A;  4PFP A;  2PG2 A;  2Q2Y A;  1MMG A;  2WOG A;  4A50 A;  1FMV A;  2FL6 A;  2GM1 A;  1D1A A;  2Q2Z A;  1VFX A;  1F9T A;  4DBQ A;  1G8X A;  2X2R A;  2NCD A;  5LT0 A;  1D1C A;  1MMD A;  2VVG A;  4HNA K;  2FKY A;  3DC4 A;  1BG2 A;  1MNE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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