4A28A

Eg5-2
Total Genus 103
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
103
sequence length
349
structure length
332
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSEEDPLDGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSERAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Motor protein
total genus 103
structure length 332
sequence length 349
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-09-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4a28A00
3COBA 1MMAA 4LNUK 1X88A 2V26A 1D0ZA 3WPNA 2MYSA 3L1CA 1II6A 4BN2A 4DBRA 2FKYA 4BBGA 5LT0A 3X2TA 4ANJA 1SDMA 4HNAK 1V8KA 2HEHA 2WOGA 3H4SA 1CZ7A 2X7DA 1GOJA 2FL6A 1BR1A 1F9WA 3K5EA 2XAEA 1YRSA 1VOMA 4A5YA 3WRDA 1KK7A 1MNEA 1D1BA 4ETPA 2IEHA 5LT3A 4PJNA 1BR4A 3CJOA 1Q0BA 1VFWA 5LT2A 3BFNA 4PJLA 2GRYA 3GBJA 3KINA 2ZFJA 2GM1A 2X51A 2VVGA 1I6IA 4GKRA 5HLEA 1VFZA 4AP0A 4H1GA 1MKJA 5LT1A 1BR2A 4ZHIA 1I5SA 2UYMA 2FMEA 1D1CA 1F9UA 2X7CA 4A1ZA 2VB6A 1LKXA 1RY6A 1MMGA 2VASA 2Q2YA 4AS7A 4DBQA 4PFOA 2OWMA 2NCDA 2ZFLA 1F9VA 4E7ZA 3DC4A 3ZFDA 3DCBA 4Y05A 1T5CA 2XT3A 4PJJA 4BXNA 5GSZA 2G1QA 1LVKA 4PFPA 3T0QA 1D0XA 3U06A 4UBFA 4B7BA 3B6UA 3HQDA 2Y65A 2X7EA 2X2RA 1G8XA 3KARA 3LREA 1D0YA 4PJMA 4ZCAA 4A51A 2PG2A 4A28A 2KINA 3PXNA 4FRZA 4E7SA 2Q2ZA 3NWNA 4A14A 3L9HA 1MMDA 1VFVA 2FL2A 1V8JA 2Y5WA 1VFXA 2ZFIA 4A50A 1BG2A 3ZFCA 1MMNA 3B6VA 3CNZA 1F9TA 1N6MA 2UYIA 1D1AA 1FMVA 3K3BA 2ZFKA 3KENA 4PK4A 1FMWA 2ZFMA 5LT4A 3ZCWA
chains in the Genus database with same CATH superfamily
3COBA 1MMAA 4LNUK 1X88A 2V26A 1D0ZA 3WPNA 2MYSA 3L1CA 1II6A 4BN2A 4DBRA 2FKYA 4BBGA 5LT0A 3X2TA 4ANJA 1SDMA 4HNAK 1V8KA 2HEHA 2WOGA 3H4SA 1CZ7A 2X7DA 1GOJA 2FL6A 1BR1A 1F9WA 3K5EA 2XAEA 1YRSA 1VOMA 4A5YA 3WRDA 1KK7A 1MNEA 1D1BA 4ETPA 2IEHA 5LT3A 4PJNA 1BR4A 3CJOA 1Q0BA 1VFWA 5LT2A 3BFNA 4PJLA 2GRYA 3GBJA 3KINA 2ZFJA 2GM1A 2X51A 2VVGA 1I6IA 4GKRA 5HLEA 1VFZA 4AP0A 4H1GA 1MKJA 5LT1A 1BR2A 4ZHIA 1I5SA 2UYMA 2FMEA 1D1CA 1F9UA 2X7CA 4A1ZA 2VB6A 1LKXA 1RY6A 1MMGA 2VASA 2Q2YA 4AS7A 4DBQA 4PFOA 2OWMA 2NCDA 2ZFLA 1F9VA 4E7ZA 3DC4A 3ZFDA 3DCBA 4Y05A 1T5CA 2XT3A 4PJJA 4BXNA 5GSZA 2G1QA 1LVKA 4PFPA 3T0QA 4GKPA 1D0XA 3U06A 4UBFA 4B7BA 3B6UA 3HQDA 2Y65A 2X7EA 2X2RA 1G8XA 3KARA 3LREA 1D0YA 4PJMA 4ZCAA 4A51A 2PG2A 4A28A 2KINA 3PXNA 4FRZA 4E7SA 2Q2ZA 3NWNA 4A14A 3L9HA 1MMDA 1VFVA 4ETPB 2FL2A 2O0AA 1V8JA 2Y5WA 1VFXA 2ZFIA 4A50A 1BG2A 3ZFCA 1MMNA 3B6VA 3CNZA 1F9TA 1N6MA 2UYIA 4GKQA 1D1AA 1FMVA 3K3BA 2ZFKA 3KENA 4PK4A 1FMWA 2ZFMA 5LT4A 3ZCWA
chains in the Genus database with same CATH topology
3COBA 1MMAA 4LNUK 1X88A 2V26A 1D0ZA 3WPNA 2MYSA 3L1CA 1II6A 4BN2A 4DBRA 2FKYA 4BBGA 5LT0A 3X2TA 4ANJA 1SDMA 4HNAK 1V8KA 2HEHA 2WOGA 3H4SA 1CZ7A 2X7DA 1GOJA 2FL6A 1BR1A 1F9WA 3K5EA 2XAEA 1YRSA 1VOMA 4A5YA 3WRDA 1KK7A 1MNEA 1D1BA 4ETPA 2IEHA 5LT3A 4PJNA 1BR4A 3CJOA 1Q0BA 1VFWA 5LT2A 3BFNA 4PJLA 2GRYA 3GBJA 3KINA 2ZFJA 2GM1A 2X51A 2VVGA 1I6IA 4GKRA 5HLEA 1VFZA 4AP0A 4H1GA 1MKJA 5LT1A 1BR2A 4ZHIA 1I5SA 2UYMA 2FMEA 1D1CA 1F9UA 2X7CA 4A1ZA 2VB6A 1LKXA 1RY6A 1MMGA 2VASA 2Q2YA 4AS7A 4DBQA 4PFOA 2OWMA 2NCDA 2ZFLA 1F9VA 4E7ZA 3DC4A 3ZFDA 3DCBA 4Y05A 1T5CA 2XT3A 4PJJA 4BXNA 5GSZA 2G1QA 1LVKA 4PFPA 3T0QA 1D0XA 3U06A 4UBFA 4B7BA 3B6UA 3HQDA 2Y65A 2X7EA 2X2RA 1G8XA 3KARA 3LREA 1D0YA 4PJMA 4ZCAA 4A51A 2PG2A 4A28A 2KINA 3PXNA 4FRZA 4E7SA 2Q2ZA 3NWNA 4A14A 3L9HA 1MMDA 1VFVA 2FL2A 1V8JA 2Y5WA 1VFXA 2ZFIA 4A50A 1BG2A 3ZFCA 1MMNA 3B6VA 3CNZA 1F9TA 1N6MA 2UYIA 1D1AA 1FMVA 3K3BA 2ZFKA 3KENA 4PK4A 1FMWA 2ZFMA 5LT4A 3ZCWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3COB A;  1MMA A;  4LNU K;  1X88 A;  2V26 A;  1D0Z A;  3WPN A;  2MYS A;  3L1C A;  1II6 A;  4BN2 A;  4DBR A;  2FKY A;  4BBG A;  5LT0 A;  3X2T A;  4ANJ A;  1SDM A;  4HNA K;  1V8K A;  2HEH A;  2WOG A;  3H4S A;  1CZ7 A;  2X7D A;  1GOJ A;  2FL6 A;  1BR1 A;  1F9W A;  3K5E A;  2XAE A;  1YRS A;  1VOM A;  4A5Y A;  3WRD A;  1KK7 A;  1MNE A;  1D1B A;  4ETP A;  2IEH A;  5LT3 A;  4PJN A;  1BR4 A;  3CJO A;  1Q0B A;  1VFW A;  5LT2 A;  3BFN A;  4PJL A;  2GRY A;  3GBJ A;  3KIN A;  2ZFJ A;  2GM1 A;  2X51 A;  2VVG A;  1I6I A;  4GKR A;  5HLE A;  1VFZ A;  4AP0 A;  4H1G A;  1MKJ A;  5LT1 A;  1BR2 A;  4ZHI A;  1I5S A;  2UYM A;  2FME A;  1D1C A;  1F9U A;  2X7C A;  4A1Z A;  2VB6 A;  1LKX A;  1RY6 A;  1MMG A;  2VAS A;  2Q2Y A;  4AS7 A;  4DBQ A;  4PFO A;  2OWM A;  2NCD A;  2ZFL A;  1F9V A;  4E7Z A;  3DC4 A;  3ZFD A;  3DCB A;  4Y05 A;  1T5C A;  2XT3 A;  4PJJ A;  4BXN A;  5GSZ A;  2G1Q A;  1LVK A;  4PFP A;  3T0Q A;  1D0X A;  3U06 A;  4UBF A;  4B7B A;  3B6U A;  3HQD A;  2Y65 A;  2X7E A;  2X2R A;  1G8X A;  3KAR A;  3LRE A;  1D0Y A;  4PJM A;  4ZCA A;  4A51 A;  2PG2 A;  4A28 A;  2KIN A;  3PXN A;  4FRZ A;  4E7S A;  2Q2Z A;  3NWN A;  4A14 A;  3L9H A;  1MMD A;  1VFV A;  2FL2 A;  1V8J A;  2Y5W A;  1VFX A;  2ZFI A;  4A50 A;  1BG2 A;  3ZFC A;  1MMN A;  3B6V A;  3CNZ A;  1F9T A;  1N6M A;  2UYI A;  1D1A A;  1FMV A;  3K3B A;  2ZFK A;  3KEN A;  4PK4 A;  1FMW A;  2ZFM A;  5LT4 A;  3ZCW A; 
#chains in the Genus database with same CATH topology
 3COB A;  1MMA A;  4LNU K;  1X88 A;  2V26 A;  1D0Z A;  3WPN A;  2MYS A;  3L1C A;  1II6 A;  4BN2 A;  4DBR A;  2FKY A;  4BBG A;  5LT0 A;  3X2T A;  4ANJ A;  1SDM A;  4HNA K;  1V8K A;  2HEH A;  2WOG A;  3H4S A;  1CZ7 A;  2X7D A;  1GOJ A;  2FL6 A;  1BR1 A;  1F9W A;  3K5E A;  2XAE A;  1YRS A;  1VOM A;  4A5Y A;  3WRD A;  1KK7 A;  1MNE A;  1D1B A;  4ETP A;  2IEH A;  5LT3 A;  4PJN A;  1BR4 A;  3CJO A;  1Q0B A;  1VFW A;  5LT2 A;  3BFN A;  4PJL A;  2GRY A;  3GBJ A;  3KIN A;  2ZFJ A;  2GM1 A;  2X51 A;  2VVG A;  1I6I A;  4GKR A;  5HLE A;  1VFZ A;  4AP0 A;  4H1G A;  1MKJ A;  5LT1 A;  1BR2 A;  4ZHI A;  1I5S A;  2UYM A;  2FME A;  1D1C A;  1F9U A;  2X7C A;  4A1Z A;  2VB6 A;  1LKX A;  1RY6 A;  1MMG A;  2VAS A;  2Q2Y A;  4AS7 A;  4DBQ A;  4PFO A;  2OWM A;  2NCD A;  2ZFL A;  1F9V A;  4E7Z A;  3DC4 A;  3ZFD A;  3DCB A;  4Y05 A;  1T5C A;  2XT3 A;  4PJJ A;  4BXN A;  5GSZ A;  2G1Q A;  1LVK A;  4PFP A;  3T0Q A;  4GKP A;  1D0X A;  3U06 A;  4UBF A;  4B7B A;  3B6U A;  3HQD A;  2Y65 A;  2X7E A;  2X2R A;  1G8X A;  3KAR A;  3LRE A;  1D0Y A;  4PJM A;  4ZCA A;  4A51 A;  2PG2 A;  4A28 A;  2KIN A;  3PXN A;  4FRZ A;  4E7S A;  2Q2Z A;  3NWN A;  4A14 A;  3L9H A;  1MMD A;  1VFV A;  4ETP B;  2FL2 A;  2O0A A;  1V8J A;  2Y5W A;  1VFX A;  2ZFI A;  4A50 A;  1BG2 A;  3ZFC A;  1MMN A;  3B6V A;  3CNZ A;  1F9T A;  1N6M A;  2UYI A;  4GKQ A;  1D1A A;  1FMV A;  3K3B A;  2ZFK A;  3KEN A;  4PK4 A;  1FMW A;  2ZFM A;  5LT4 A;  3ZCW A; 
#chains in the Genus database with same CATH homology
 3COB A;  1MMA A;  4LNU K;  1X88 A;  2V26 A;  1D0Z A;  3WPN A;  2MYS A;  3L1C A;  1II6 A;  4BN2 A;  4DBR A;  2FKY A;  4BBG A;  5LT0 A;  3X2T A;  4ANJ A;  1SDM A;  4HNA K;  1V8K A;  2HEH A;  2WOG A;  3H4S A;  1CZ7 A;  2X7D A;  1GOJ A;  2FL6 A;  1BR1 A;  1F9W A;  3K5E A;  2XAE A;  1YRS A;  1VOM A;  4A5Y A;  3WRD A;  1KK7 A;  1MNE A;  1D1B A;  4ETP A;  2IEH A;  5LT3 A;  4PJN A;  1BR4 A;  3CJO A;  1Q0B A;  1VFW A;  5LT2 A;  3BFN A;  4PJL A;  2GRY A;  3GBJ A;  3KIN A;  2ZFJ A;  2GM1 A;  2X51 A;  2VVG A;  1I6I A;  4GKR A;  5HLE A;  1VFZ A;  4AP0 A;  4H1G A;  1MKJ A;  5LT1 A;  1BR2 A;  4ZHI A;  1I5S A;  2UYM A;  2FME A;  1D1C A;  1F9U A;  2X7C A;  4A1Z A;  2VB6 A;  1LKX A;  1RY6 A;  1MMG A;  2VAS A;  2Q2Y A;  4AS7 A;  4DBQ A;  4PFO A;  2OWM A;  2NCD A;  2ZFL A;  1F9V A;  4E7Z A;  3DC4 A;  3ZFD A;  3DCB A;  4Y05 A;  1T5C A;  2XT3 A;  4PJJ A;  4BXN A;  5GSZ A;  2G1Q A;  1LVK A;  4PFP A;  3T0Q A;  1D0X A;  3U06 A;  4UBF A;  4B7B A;  3B6U A;  3HQD A;  2Y65 A;  2X7E A;  2X2R A;  1G8X A;  3KAR A;  3LRE A;  1D0Y A;  4PJM A;  4ZCA A;  4A51 A;  2PG2 A;  4A28 A;  2KIN A;  3PXN A;  4FRZ A;  4E7S A;  2Q2Z A;  3NWN A;  4A14 A;  3L9H A;  1MMD A;  1VFV A;  2FL2 A;  1V8J A;  2Y5W A;  1VFX A;  2ZFI A;  4A50 A;  1BG2 A;  3ZFC A;  1MMN A;  3B6V A;  3CNZ A;  1F9T A;  1N6M A;  2UYI A;  1D1A A;  1FMV A;  3K3B A;  2ZFK A;  3KEN A;  4PK4 A;  1FMW A;  2ZFM A;  5LT4 A;  3ZCW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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