4A28A

Eg5-2
Total Genus 103
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
103
sequence length
349
structure length
332
Chain Sequence
b'GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSEEDPLDGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSERAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Motor protein
total genus 103
structure length 332
sequence length 349
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-09-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4a28A00
1VFZA 1T5CA 3KARA 2FKYA 1I5SA 4ZCAA 2UYMA 1VFXA 4A50A 2Y5WA 4ETPA 5LT1A 3BFNA 4DBQA 1GOJA 4FRZA 3ZCWA 1MNEA 5LT3A 2XAEA 2X2RA 1F9TA 4B7BA 4E7ZA 2Q2ZA 4PFOA 1X88A 3KINA 1BG2A 2VASA 2NCDA 2ZFKA 1BR1A 4PJLA 2X7DA 3DC4A 4BBGA 1LKXA 1N6MA 3T0QA 1YRSA 4A51A 4A1ZA 1MMDA 4A5YA 4Y05A 2ZFLA 4BXNA 4HNAK 2GRYA 1D1CA 3ZFCA 4A14A 2UYIA 4PJMA 2G1QA 2ZFMA 4UBFA 2X7EA 1MMNA 4H1GA 4PJNA 1VFWA 4DBRA 1D1BA 3B6VA 1MMAA 3ZFDA 1SDMA 4ZHIA 1FMVA 3HQDA 3PXNA 5LT2A 2FL2A 2HEHA 2X51A 1VOMA 4A28A 1V8KA 2PG2A 2ZFIA 3KENA 4GKRA 1D1AA 3LREA 3NWNA 3X2TA 2MYSA 2VVGA 3WPNA 5HLEA 4PK4A 3CNZA 2X7CA 1RY6A 4BN2A 1D0ZA 1F9VA 5GSZA 1BR2A 4LNUK 1KK7A 2Y65A 3DCBA 1D0XA 2GM1A 1MMGA 3CJOA 2V26A 2WOGA 1LVKA 2FMEA 4PFPA 5LT0A 3K5EA 3U06A 4ANJA 2KINA 2XT3A 1II6A 3WRDA 2ZFJA 2Q2YA 3L9HA 1Q0BA 1V8JA 1VFVA 2OWMA 1FMWA 3GBJA 4AP0A 4AS7A 1F9WA 4PJJA 1BR4A 1MKJA 2VB6A 1G8XA 3L1CA 3H4SA 1D0YA 1I6IA 2FL6A 2IEHA 3K3BA 4E7SA 3COBA 5LT4A 1CZ7A 3B6UA 1F9UA
chains in the Genus database with same CATH superfamily
1VFZA 1T5CA 3KARA 2FKYA 1I5SA 4ZCAA 2UYMA 1VFXA 4A50A 2Y5WA 4ETPA 4GKPA 5LT1A 3BFNA 4DBQA 1GOJA 4FRZA 3ZCWA 1MNEA 5LT3A 2XAEA 2X2RA 1F9TA 4B7BA 4E7ZA 2Q2ZA 4PFOA 1X88A 3KINA 1BG2A 2VASA 2NCDA 2ZFKA 1BR1A 4PJLA 2X7DA 3DC4A 4BBGA 1LKXA 1N6MA 3T0QA 1YRSA 4A51A 4A1ZA 1MMDA 4A5YA 4Y05A 2ZFLA 4BXNA 4HNAK 2GRYA 1D1CA 3ZFCA 4A14A 2UYIA 4PJMA 2G1QA 2ZFMA 4UBFA 2X7EA 1MMNA 4H1GA 4PJNA 1VFWA 4DBRA 4GKQA 1D1BA 3B6VA 1MMAA 3ZFDA 1SDMA 4ZHIA 1FMVA 3HQDA 3PXNA 5LT2A 2FL2A 2HEHA 2X51A 1VOMA 4A28A 1V8KA 2PG2A 2ZFIA 3KENA 4GKRA 1D1AA 3LREA 3NWNA 3X2TA 2MYSA 2VVGA 3WPNA 5HLEA 4PK4A 3CNZA 2X7CA 1RY6A 4BN2A 1D0ZA 1F9VA 5GSZA 1BR2A 4LNUK 1KK7A 2Y65A 3DCBA 1D0XA 2GM1A 1MMGA 3CJOA 2V26A 2WOGA 1LVKA 4ETPB 2FMEA 4PFPA 5LT0A 3K5EA 3U06A 4ANJA 2KINA 2XT3A 1II6A 3WRDA 2ZFJA 2Q2YA 3L9HA 1Q0BA 1V8JA 1VFVA 2OWMA 1FMWA 3GBJA 4AP0A 4AS7A 1F9WA 4PJJA 1BR4A 1MKJA 2VB6A 1G8XA 3L1CA 3H4SA 1D0YA 1I6IA 2FL6A 2IEHA 3K3BA 4E7SA 3COBA 5LT4A 1CZ7A 2O0AA 3B6UA 1F9UA
chains in the Genus database with same CATH topology
1VFZA 1T5CA 3KARA 2FKYA 1I5SA 4ZCAA 2UYMA 1VFXA 4A50A 2Y5WA 4ETPA 5LT1A 3BFNA 4DBQA 1GOJA 4FRZA 3ZCWA 1MNEA 5LT3A 2XAEA 2X2RA 1F9TA 4B7BA 4E7ZA 2Q2ZA 4PFOA 1X88A 3KINA 1BG2A 2VASA 2NCDA 2ZFKA 1BR1A 4PJLA 2X7DA 3DC4A 4BBGA 1LKXA 1N6MA 3T0QA 1YRSA 4A51A 4A1ZA 1MMDA 4A5YA 4Y05A 2ZFLA 4BXNA 4HNAK 2GRYA 1D1CA 3ZFCA 4A14A 2UYIA 4PJMA 2G1QA 2ZFMA 4UBFA 2X7EA 1MMNA 4H1GA 4PJNA 1VFWA 4DBRA 1D1BA 3B6VA 1MMAA 3ZFDA 1SDMA 4ZHIA 1FMVA 3HQDA 3PXNA 5LT2A 2FL2A 2HEHA 2X51A 1VOMA 4A28A 1V8KA 2PG2A 2ZFIA 3KENA 4GKRA 1D1AA 3LREA 3NWNA 3X2TA 2MYSA 2VVGA 3WPNA 5HLEA 4PK4A 3CNZA 2X7CA 1RY6A 4BN2A 1D0ZA 1F9VA 5GSZA 1BR2A 4LNUK 1KK7A 2Y65A 3DCBA 1D0XA 2GM1A 1MMGA 3CJOA 2V26A 2WOGA 1LVKA 2FMEA 4PFPA 5LT0A 3K5EA 3U06A 4ANJA 2KINA 2XT3A 1II6A 3WRDA 2ZFJA 2Q2YA 3L9HA 1Q0BA 1V8JA 1VFVA 2OWMA 1FMWA 3GBJA 4AP0A 4AS7A 1F9WA 4PJJA 1BR4A 1MKJA 2VB6A 1G8XA 3L1CA 3H4SA 1D0YA 1I6IA 2FL6A 2IEHA 3K3BA 4E7SA 3COBA 5LT4A 1CZ7A 3B6UA 1F9UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1VFZ A;  1T5C A;  3KAR A;  2FKY A;  1I5S A;  4ZCA A;  2UYM A;  1VFX A;  4A50 A;  2Y5W A;  4ETP A;  5LT1 A;  3BFN A;  4DBQ A;  1GOJ A;  4FRZ A;  3ZCW A;  1MNE A;  5LT3 A;  2XAE A;  2X2R A;  1F9T A;  4B7B A;  4E7Z A;  2Q2Z A;  4PFO A;  1X88 A;  3KIN A;  1BG2 A;  2VAS A;  2NCD A;  2ZFK A;  1BR1 A;  4PJL A;  2X7D A;  3DC4 A;  4BBG A;  1LKX A;  1N6M A;  3T0Q A;  1YRS A;  4A51 A;  4A1Z A;  1MMD A;  4A5Y A;  4Y05 A;  2ZFL A;  4BXN A;  4HNA K;  2GRY A;  1D1C A;  3ZFC A;  4A14 A;  2UYI A;  4PJM A;  2G1Q A;  2ZFM A;  4UBF A;  2X7E A;  1MMN A;  4H1G A;  4PJN A;  1VFW A;  4DBR A;  1D1B A;  3B6V A;  1MMA A;  3ZFD A;  1SDM A;  4ZHI A;  1FMV A;  3HQD A;  3PXN A;  5LT2 A;  2FL2 A;  2HEH A;  2X51 A;  1VOM A;  4A28 A;  1V8K A;  2PG2 A;  2ZFI A;  3KEN A;  4GKR A;  1D1A A;  3LRE A;  3NWN A;  3X2T A;  2MYS A;  2VVG A;  3WPN A;  5HLE A;  4PK4 A;  3CNZ A;  2X7C A;  1RY6 A;  4BN2 A;  1D0Z A;  1F9V A;  5GSZ A;  1BR2 A;  4LNU K;  1KK7 A;  2Y65 A;  3DCB A;  1D0X A;  2GM1 A;  1MMG A;  3CJO A;  2V26 A;  2WOG A;  1LVK A;  2FME A;  4PFP A;  5LT0 A;  3K5E A;  3U06 A;  4ANJ A;  2KIN A;  2XT3 A;  1II6 A;  3WRD A;  2ZFJ A;  2Q2Y A;  3L9H A;  1Q0B A;  1V8J A;  1VFV A;  2OWM A;  1FMW A;  3GBJ A;  4AP0 A;  4AS7 A;  1F9W A;  4PJJ A;  1BR4 A;  1MKJ A;  2VB6 A;  1G8X A;  3L1C A;  3H4S A;  1D0Y A;  1I6I A;  2FL6 A;  2IEH A;  3K3B A;  4E7S A;  3COB A;  5LT4 A;  1CZ7 A;  3B6U A;  1F9U A; 
#chains in the Genus database with same CATH topology
 1VFZ A;  1T5C A;  3KAR A;  2FKY A;  1I5S A;  4ZCA A;  2UYM A;  1VFX A;  4A50 A;  2Y5W A;  4ETP A;  4GKP A;  5LT1 A;  3BFN A;  4DBQ A;  1GOJ A;  4FRZ A;  3ZCW A;  1MNE A;  5LT3 A;  2XAE A;  2X2R A;  1F9T A;  4B7B A;  4E7Z A;  2Q2Z A;  4PFO A;  1X88 A;  3KIN A;  1BG2 A;  2VAS A;  2NCD A;  2ZFK A;  1BR1 A;  4PJL A;  2X7D A;  3DC4 A;  4BBG A;  1LKX A;  1N6M A;  3T0Q A;  1YRS A;  4A51 A;  4A1Z A;  1MMD A;  4A5Y A;  4Y05 A;  2ZFL A;  4BXN A;  4HNA K;  2GRY A;  1D1C A;  3ZFC A;  4A14 A;  2UYI A;  4PJM A;  2G1Q A;  2ZFM A;  4UBF A;  2X7E A;  1MMN A;  4H1G A;  4PJN A;  1VFW A;  4DBR A;  4GKQ A;  1D1B A;  3B6V A;  1MMA A;  3ZFD A;  1SDM A;  4ZHI A;  1FMV A;  3HQD A;  3PXN A;  5LT2 A;  2FL2 A;  2HEH A;  2X51 A;  1VOM A;  4A28 A;  1V8K A;  2PG2 A;  2ZFI A;  3KEN A;  4GKR A;  1D1A A;  3LRE A;  3NWN A;  3X2T A;  2MYS A;  2VVG A;  3WPN A;  5HLE A;  4PK4 A;  3CNZ A;  2X7C A;  1RY6 A;  4BN2 A;  1D0Z A;  1F9V A;  5GSZ A;  1BR2 A;  4LNU K;  1KK7 A;  2Y65 A;  3DCB A;  1D0X A;  2GM1 A;  1MMG A;  3CJO A;  2V26 A;  2WOG A;  1LVK A;  4ETP B;  2FME A;  4PFP A;  5LT0 A;  3K5E A;  3U06 A;  4ANJ A;  2KIN A;  2XT3 A;  1II6 A;  3WRD A;  2ZFJ A;  2Q2Y A;  3L9H A;  1Q0B A;  1V8J A;  1VFV A;  2OWM A;  1FMW A;  3GBJ A;  4AP0 A;  4AS7 A;  1F9W A;  4PJJ A;  1BR4 A;  1MKJ A;  2VB6 A;  1G8X A;  3L1C A;  3H4S A;  1D0Y A;  1I6I A;  2FL6 A;  2IEH A;  3K3B A;  4E7S A;  3COB A;  5LT4 A;  1CZ7 A;  2O0A A;  3B6U A;  1F9U A; 
#chains in the Genus database with same CATH homology
 1VFZ A;  1T5C A;  3KAR A;  2FKY A;  1I5S A;  4ZCA A;  2UYM A;  1VFX A;  4A50 A;  2Y5W A;  4ETP A;  5LT1 A;  3BFN A;  4DBQ A;  1GOJ A;  4FRZ A;  3ZCW A;  1MNE A;  5LT3 A;  2XAE A;  2X2R A;  1F9T A;  4B7B A;  4E7Z A;  2Q2Z A;  4PFO A;  1X88 A;  3KIN A;  1BG2 A;  2VAS A;  2NCD A;  2ZFK A;  1BR1 A;  4PJL A;  2X7D A;  3DC4 A;  4BBG A;  1LKX A;  1N6M A;  3T0Q A;  1YRS A;  4A51 A;  4A1Z A;  1MMD A;  4A5Y A;  4Y05 A;  2ZFL A;  4BXN A;  4HNA K;  2GRY A;  1D1C A;  3ZFC A;  4A14 A;  2UYI A;  4PJM A;  2G1Q A;  2ZFM A;  4UBF A;  2X7E A;  1MMN A;  4H1G A;  4PJN A;  1VFW A;  4DBR A;  1D1B A;  3B6V A;  1MMA A;  3ZFD A;  1SDM A;  4ZHI A;  1FMV A;  3HQD A;  3PXN A;  5LT2 A;  2FL2 A;  2HEH A;  2X51 A;  1VOM A;  4A28 A;  1V8K A;  2PG2 A;  2ZFI A;  3KEN A;  4GKR A;  1D1A A;  3LRE A;  3NWN A;  3X2T A;  2MYS A;  2VVG A;  3WPN A;  5HLE A;  4PK4 A;  3CNZ A;  2X7C A;  1RY6 A;  4BN2 A;  1D0Z A;  1F9V A;  5GSZ A;  1BR2 A;  4LNU K;  1KK7 A;  2Y65 A;  3DCB A;  1D0X A;  2GM1 A;  1MMG A;  3CJO A;  2V26 A;  2WOG A;  1LVK A;  2FME A;  4PFP A;  5LT0 A;  3K5E A;  3U06 A;  4ANJ A;  2KIN A;  2XT3 A;  1II6 A;  3WRD A;  2ZFJ A;  2Q2Y A;  3L9H A;  1Q0B A;  1V8J A;  1VFV A;  2OWM A;  1FMW A;  3GBJ A;  4AP0 A;  4AS7 A;  1F9W A;  4PJJ A;  1BR4 A;  1MKJ A;  2VB6 A;  1G8X A;  3L1C A;  3H4S A;  1D0Y A;  1I6I A;  2FL6 A;  2IEH A;  3K3B A;  4E7S A;  3COB A;  5LT4 A;  1CZ7 A;  3B6U A;  1F9U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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