1II6A

Crystal structure of the mitotic kinesin eg5 in complex with mg-adp.
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
350
structure length
340
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSERAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker.
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords KINESIN-RELATED MOTOR PROTEIN Eg5
total genus 106
structure length 340
sequence length 350
chains with identical sequence B
ec nomenclature
pdb deposition date 2001-04-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 1ii6A00
3ZFDA 1N6MA 2VASA 1D1AA 3H4SA 3LREA 2FKYA 1F9UA 1MMDA 1X88A 1F9TA 2PG2A 4AS7A 2KINA 2Q2YA 3X2TA 2ZFJA 2XT3A 4E7SA 4BBGA 2G1QA 3PXNA 1FMVA 5LT0A 3CNZA 1BR2A 4GKRA 3BFNA 2HEHA 4DBQA 3B6VA 1MMAA 4A28A 4A51A 3T0QA 2WOGA 1VFXA 2UYIA 1Q0BA 3HQDA 1G8XA 3NWNA 3L1CA 2X7CA 4ZCAA 2FL2A 4H1GA 1D0XA 2NCDA 3K3BA 4A5YA 4ZHIA 2Y5WA 5LT1A 5HLEA 4BN2A 5LT4A 2ZFLA 1VFZA 3CJOA 3ZCWA 2Y65A 2FMEA 4A1ZA 4DBRA 4ETPA 1LVKA 4FRZA 3KENA 2VVGA 2MYSA 3K5EA 2FL6A 4LNUK 1VOMA 2GM1A 1MMNA 1II6A 1F9WA 2X7DA 1V8KA 1D1CA 2X2RA 2VB6A 4A50A 4PJNA 3KARA 1D1BA 4PJMA 4A14A 3L9HA 1BR1A 1F9VA 2IEHA 2ZFIA 3WPNA 4UBFA 2ZFKA 1MNEA 2XAEA 1V8JA 2Q2ZA 1BG2A 1RY6A 1KK7A 3B6UA 1I5SA 1FMWA 1I6IA 2X51A 3GBJA 3DC4A 3WRDA 4PFPA 4BXNA 1D0YA 1CZ7A 4ANJA 2UYMA 1BR4A 2OWMA 2GRYA 5LT2A 4PFOA 3COBA 3KINA 4PJLA 3ZFCA 5GSZA 4Y05A 1VFWA 1MMGA 1SDMA 1VFVA 5LT3A 4HNAK 3U06A 2ZFMA 1D0ZA 4B7BA 4PK4A 1MKJA 4PJJA 4E7ZA 1YRSA 1GOJA 4AP0A 2V26A 2X7EA 1T5CA 1LKXA 3DCBA
chains in the Genus database with same CATH superfamily
3ZFDA 1N6MA 2VASA 1D1AA 3H4SA 3LREA 2FKYA 1F9UA 1MMDA 1X88A 1F9TA 2PG2A 4AS7A 2KINA 2Q2YA 3X2TA 2ZFJA 2XT3A 4E7SA 4BBGA 2G1QA 3PXNA 1FMVA 5LT0A 3CNZA 1BR2A 4GKRA 3BFNA 2HEHA 4DBQA 3B6VA 1MMAA 4A28A 4A51A 4GKQA 3T0QA 2WOGA 1VFXA 2UYIA 1Q0BA 3HQDA 1G8XA 3NWNA 3L1CA 2X7CA 4ZCAA 2FL2A 4H1GA 1D0XA 2NCDA 3K3BA 4A5YA 4ZHIA 2Y5WA 5LT1A 5HLEA 4BN2A 5LT4A 2ZFLA 4ETPB 1VFZA 3CJOA 3ZCWA 2Y65A 2FMEA 4A1ZA 4DBRA 4ETPA 1LVKA 4FRZA 3KENA 4GKPA 2VVGA 2MYSA 3K5EA 2FL6A 4LNUK 1VOMA 2GM1A 1MMNA 1II6A 2O0AA 1F9WA 2X7DA 1V8KA 1D1CA 2X2RA 2VB6A 4A50A 4PJNA 3KARA 1D1BA 4PJMA 4A14A 3L9HA 1BR1A 1F9VA 2IEHA 2ZFIA 3WPNA 4UBFA 2ZFKA 1MNEA 2XAEA 1V8JA 2Q2ZA 1BG2A 1RY6A 1KK7A 3B6UA 1I5SA 1FMWA 1I6IA 2X51A 3GBJA 3DC4A 3WRDA 4PFPA 4BXNA 1D0YA 1CZ7A 4ANJA 2UYMA 1BR4A 2OWMA 2GRYA 5LT2A 4PFOA 3COBA 3KINA 4PJLA 3ZFCA 5GSZA 4Y05A 1VFWA 1MMGA 1SDMA 1VFVA 5LT3A 4HNAK 3U06A 2ZFMA 1D0ZA 4B7BA 4PK4A 1MKJA 4PJJA 4E7ZA 1YRSA 1GOJA 4AP0A 2V26A 2X7EA 1T5CA 1LKXA 3DCBA
chains in the Genus database with same CATH topology
3ZFDA 1N6MA 2VASA 1D1AA 3H4SA 3LREA 2FKYA 1F9UA 1MMDA 1X88A 1F9TA 2PG2A 4AS7A 2KINA 2Q2YA 3X2TA 2ZFJA 2XT3A 4E7SA 4BBGA 2G1QA 3PXNA 1FMVA 5LT0A 3CNZA 1BR2A 4GKRA 3BFNA 2HEHA 4DBQA 3B6VA 1MMAA 4A28A 4A51A 3T0QA 2WOGA 1VFXA 2UYIA 1Q0BA 3HQDA 1G8XA 3NWNA 3L1CA 2X7CA 4ZCAA 2FL2A 4H1GA 1D0XA 2NCDA 3K3BA 4A5YA 4ZHIA 2Y5WA 5LT1A 5HLEA 4BN2A 5LT4A 2ZFLA 1VFZA 3CJOA 3ZCWA 2Y65A 2FMEA 4A1ZA 4DBRA 4ETPA 1LVKA 4FRZA 3KENA 2VVGA 2MYSA 3K5EA 2FL6A 4LNUK 1VOMA 2GM1A 1MMNA 1II6A 1F9WA 2X7DA 1V8KA 1D1CA 2X2RA 2VB6A 4A50A 4PJNA 3KARA 1D1BA 4PJMA 4A14A 3L9HA 1BR1A 1F9VA 2IEHA 2ZFIA 3WPNA 4UBFA 2ZFKA 1MNEA 2XAEA 1V8JA 2Q2ZA 1BG2A 1RY6A 1KK7A 3B6UA 1I5SA 1FMWA 1I6IA 2X51A 3GBJA 3DC4A 3WRDA 4PFPA 4BXNA 1D0YA 1CZ7A 4ANJA 2UYMA 1BR4A 2OWMA 2GRYA 5LT2A 4PFOA 3COBA 3KINA 4PJLA 3ZFCA 5GSZA 4Y05A 1VFWA 1MMGA 1SDMA 1VFVA 5LT3A 4HNAK 3U06A 2ZFMA 1D0ZA 4B7BA 4PK4A 1MKJA 4PJJA 4E7ZA 1YRSA 1GOJA 4AP0A 2V26A 2X7EA 1T5CA 1LKXA 3DCBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3ZFD A;  1N6M A;  2VAS A;  1D1A A;  3H4S A;  3LRE A;  2FKY A;  1F9U A;  1MMD A;  1X88 A;  1F9T A;  2PG2 A;  4AS7 A;  2KIN A;  2Q2Y A;  3X2T A;  2ZFJ A;  2XT3 A;  4E7S A;  4BBG A;  2G1Q A;  3PXN A;  1FMV A;  5LT0 A;  3CNZ A;  1BR2 A;  4GKR A;  3BFN A;  2HEH A;  4DBQ A;  3B6V A;  1MMA A;  4A28 A;  4A51 A;  3T0Q A;  2WOG A;  1VFX A;  2UYI A;  1Q0B A;  3HQD A;  1G8X A;  3NWN A;  3L1C A;  2X7C A;  4ZCA A;  2FL2 A;  4H1G A;  1D0X A;  2NCD A;  3K3B A;  4A5Y A;  4ZHI A;  2Y5W A;  5LT1 A;  5HLE A;  4BN2 A;  5LT4 A;  2ZFL A;  1VFZ A;  3CJO A;  3ZCW A;  2Y65 A;  2FME A;  4A1Z A;  4DBR A;  4ETP A;  1LVK A;  4FRZ A;  3KEN A;  2VVG A;  2MYS A;  3K5E A;  2FL6 A;  4LNU K;  1VOM A;  2GM1 A;  1MMN A;  1II6 A;  1F9W A;  2X7D A;  1V8K A;  1D1C A;  2X2R A;  2VB6 A;  4A50 A;  4PJN A;  3KAR A;  1D1B A;  4PJM A;  4A14 A;  3L9H A;  1BR1 A;  1F9V A;  2IEH A;  2ZFI A;  3WPN A;  4UBF A;  2ZFK A;  1MNE A;  2XAE A;  1V8J A;  2Q2Z A;  1BG2 A;  1RY6 A;  1KK7 A;  3B6U A;  1I5S A;  1FMW A;  1I6I A;  2X51 A;  3GBJ A;  3DC4 A;  3WRD A;  4PFP A;  4BXN A;  1D0Y A;  1CZ7 A;  4ANJ A;  2UYM A;  1BR4 A;  2OWM A;  2GRY A;  5LT2 A;  4PFO A;  3COB A;  3KIN A;  4PJL A;  3ZFC A;  5GSZ A;  4Y05 A;  1VFW A;  1MMG A;  1SDM A;  1VFV A;  5LT3 A;  4HNA K;  3U06 A;  2ZFM A;  1D0Z A;  4B7B A;  4PK4 A;  1MKJ A;  4PJJ A;  4E7Z A;  1YRS A;  1GOJ A;  4AP0 A;  2V26 A;  2X7E A;  1T5C A;  1LKX A;  3DCB A; 
#chains in the Genus database with same CATH topology
 3ZFD A;  1N6M A;  2VAS A;  1D1A A;  3H4S A;  3LRE A;  2FKY A;  1F9U A;  1MMD A;  1X88 A;  1F9T A;  2PG2 A;  4AS7 A;  2KIN A;  2Q2Y A;  3X2T A;  2ZFJ A;  2XT3 A;  4E7S A;  4BBG A;  2G1Q A;  3PXN A;  1FMV A;  5LT0 A;  3CNZ A;  1BR2 A;  4GKR A;  3BFN A;  2HEH A;  4DBQ A;  3B6V A;  1MMA A;  4A28 A;  4A51 A;  4GKQ A;  3T0Q A;  2WOG A;  1VFX A;  2UYI A;  1Q0B A;  3HQD A;  1G8X A;  3NWN A;  3L1C A;  2X7C A;  4ZCA A;  2FL2 A;  4H1G A;  1D0X A;  2NCD A;  3K3B A;  4A5Y A;  4ZHI A;  2Y5W A;  5LT1 A;  5HLE A;  4BN2 A;  5LT4 A;  2ZFL A;  4ETP B;  1VFZ A;  3CJO A;  3ZCW A;  2Y65 A;  2FME A;  4A1Z A;  4DBR A;  4ETP A;  1LVK A;  4FRZ A;  3KEN A;  4GKP A;  2VVG A;  2MYS A;  3K5E A;  2FL6 A;  4LNU K;  1VOM A;  2GM1 A;  1MMN A;  1II6 A;  2O0A A;  1F9W A;  2X7D A;  1V8K A;  1D1C A;  2X2R A;  2VB6 A;  4A50 A;  4PJN A;  3KAR A;  1D1B A;  4PJM A;  4A14 A;  3L9H A;  1BR1 A;  1F9V A;  2IEH A;  2ZFI A;  3WPN A;  4UBF A;  2ZFK A;  1MNE A;  2XAE A;  1V8J A;  2Q2Z A;  1BG2 A;  1RY6 A;  1KK7 A;  3B6U A;  1I5S A;  1FMW A;  1I6I A;  2X51 A;  3GBJ A;  3DC4 A;  3WRD A;  4PFP A;  4BXN A;  1D0Y A;  1CZ7 A;  4ANJ A;  2UYM A;  1BR4 A;  2OWM A;  2GRY A;  5LT2 A;  4PFO A;  3COB A;  3KIN A;  4PJL A;  3ZFC A;  5GSZ A;  4Y05 A;  1VFW A;  1MMG A;  1SDM A;  1VFV A;  5LT3 A;  4HNA K;  3U06 A;  2ZFM A;  1D0Z A;  4B7B A;  4PK4 A;  1MKJ A;  4PJJ A;  4E7Z A;  1YRS A;  1GOJ A;  4AP0 A;  2V26 A;  2X7E A;  1T5C A;  1LKX A;  3DCB A; 
#chains in the Genus database with same CATH homology
 3ZFD A;  1N6M A;  2VAS A;  1D1A A;  3H4S A;  3LRE A;  2FKY A;  1F9U A;  1MMD A;  1X88 A;  1F9T A;  2PG2 A;  4AS7 A;  2KIN A;  2Q2Y A;  3X2T A;  2ZFJ A;  2XT3 A;  4E7S A;  4BBG A;  2G1Q A;  3PXN A;  1FMV A;  5LT0 A;  3CNZ A;  1BR2 A;  4GKR A;  3BFN A;  2HEH A;  4DBQ A;  3B6V A;  1MMA A;  4A28 A;  4A51 A;  3T0Q A;  2WOG A;  1VFX A;  2UYI A;  1Q0B A;  3HQD A;  1G8X A;  3NWN A;  3L1C A;  2X7C A;  4ZCA A;  2FL2 A;  4H1G A;  1D0X A;  2NCD A;  3K3B A;  4A5Y A;  4ZHI A;  2Y5W A;  5LT1 A;  5HLE A;  4BN2 A;  5LT4 A;  2ZFL A;  1VFZ A;  3CJO A;  3ZCW A;  2Y65 A;  2FME A;  4A1Z A;  4DBR A;  4ETP A;  1LVK A;  4FRZ A;  3KEN A;  2VVG A;  2MYS A;  3K5E A;  2FL6 A;  4LNU K;  1VOM A;  2GM1 A;  1MMN A;  1II6 A;  1F9W A;  2X7D A;  1V8K A;  1D1C A;  2X2R A;  2VB6 A;  4A50 A;  4PJN A;  3KAR A;  1D1B A;  4PJM A;  4A14 A;  3L9H A;  1BR1 A;  1F9V A;  2IEH A;  2ZFI A;  3WPN A;  4UBF A;  2ZFK A;  1MNE A;  2XAE A;  1V8J A;  2Q2Z A;  1BG2 A;  1RY6 A;  1KK7 A;  3B6U A;  1I5S A;  1FMW A;  1I6I A;  2X51 A;  3GBJ A;  3DC4 A;  3WRD A;  4PFP A;  4BXN A;  1D0Y A;  1CZ7 A;  4ANJ A;  2UYM A;  1BR4 A;  2OWM A;  2GRY A;  5LT2 A;  4PFO A;  3COB A;  3KIN A;  4PJL A;  3ZFC A;  5GSZ A;  4Y05 A;  1VFW A;  1MMG A;  1SDM A;  1VFV A;  5LT3 A;  4HNA K;  3U06 A;  2ZFM A;  1D0Z A;  4B7B A;  4PK4 A;  1MKJ A;  4PJJ A;  4E7Z A;  1YRS A;  1GOJ A;  4AP0 A;  2V26 A;  2X7E A;  1T5C A;  1LKX A;  3DCB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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