1II6A

Crystal structure of the mitotic kinesin eg5 in complex with mg-adp.
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
350
structure length
340
Chain Sequence
b'GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSERAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEV'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-RELATED MOTOR PROTEIN Eg5
publication title Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 106
structure length 340
sequence length 350
chains with identical sequence B
ec nomenclature
pdb deposition date 2001-04-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 1ii6A00
2KINA 3KINA 3CNZA 3L1CA 1G8XA 4PJMA 1D1BA 1VFZA 1D1CA 1CZ7A 3KENA 3PXNA 2V26A 3ZCWA 2FKYA 2IEHA 2X7CA 4Y05A 1VOMA 2FL2A 2Q2ZA 4GKRA 3GBJA 4BXNA 4AP0A 3KARA 4DBQA 1YRSA 2OWMA 4PJNA 2ZFKA 2PG2A 2UYMA 3H4SA 3NWNA 1D0ZA 4PJLA 4AS7A 2FMEA 4E7SA 2ZFJA 4ETPA 1LKXA 1BR1A 4ANJA 5LT1A 3LREA 2GRYA 2ZFIA 4A5YA 1I5SA 1MMAA 1MMDA 1V8KA 2X7EA 2Q2YA 1II6A 4BBGA 3ZFCA 1MMNA 1BR2A 3K3BA 3WPNA 4HNAK 3BFNA 4E7ZA 3DC4A 1RY6A 5GSZA 2VB6A 3ZFDA 3T0QA 4ZCAA 3B6VA 1D0YA 1F9VA 1BG2A 1Q0BA 2X51A 1I6IA 1VFWA 2X7DA 4ZHIA 3U06A 3COBA 1F9UA 1N6MA 2VASA 1F9TA 3L9HA 3X2TA 1KK7A 2GM1A 4A1ZA 1MMGA 1MNEA 2X2RA 1F9WA 4PK4A 2ZFMA 2XT3A 3HQDA 4BN2A 1VFVA 1FMWA 3K5EA 2Y5WA 4B7BA 1LVKA 1VFXA 1BR4A 3DCBA 2HEHA 2UYIA 1V8JA 2NCDA 4PJJA 4A14A 4PFOA 5LT2A 1FMVA 5LT0A 1SDMA 1MKJA 1X88A 4A51A 2WOGA 2G1QA 2Y65A 3CJOA 4LNUK 4UBFA 2VVGA 2XAEA 5LT4A 2MYSA 4DBRA 4A50A 3B6UA 1D0XA 4FRZA 5HLEA 1GOJA 4PFPA 2ZFLA 1T5CA 1D1AA 2FL6A 3WRDA 4H1GA 4A28A 5LT3A
chains in the Genus database with same CATH superfamily
2KINA 3KINA 3CNZA 3L1CA 1G8XA 4PJMA 1D1BA 1VFZA 1D1CA 1CZ7A 3KENA 3PXNA 2V26A 3ZCWA 2FKYA 2IEHA 2X7CA 4Y05A 1VOMA 2FL2A 2Q2ZA 4GKRA 3GBJA 4BXNA 4ETPB 4AP0A 3KARA 4DBQA 1YRSA 2OWMA 4PJNA 2ZFKA 2PG2A 2UYMA 3H4SA 3NWNA 1D0ZA 4PJLA 4AS7A 2FMEA 4E7SA 2ZFJA 4ETPA 1LKXA 1BR1A 4ANJA 5LT1A 3LREA 2GRYA 2ZFIA 4GKQA 4A5YA 1I5SA 1MMAA 1MMDA 1V8KA 2X7EA 2Q2YA 1II6A 4BBGA 3ZFCA 1MMNA 1BR2A 3K3BA 3WPNA 4HNAK 3BFNA 4E7ZA 3DC4A 1RY6A 5GSZA 2VB6A 3ZFDA 3T0QA 4ZCAA 3B6VA 1D0YA 1F9VA 1BG2A 1Q0BA 2X51A 1I6IA 1VFWA 2X7DA 4ZHIA 3U06A 3COBA 1F9UA 1N6MA 2VASA 1F9TA 3L9HA 3X2TA 1KK7A 2GM1A 4A1ZA 1MMGA 1MNEA 2X2RA 1F9WA 4PK4A 2ZFMA 2XT3A 3HQDA 4BN2A 1VFVA 1FMWA 3K5EA 2Y5WA 4B7BA 1LVKA 1VFXA 1BR4A 3DCBA 2HEHA 2UYIA 1V8JA 2NCDA 4PJJA 4A14A 4PFOA 5LT2A 1FMVA 5LT0A 1SDMA 1MKJA 1X88A 4A51A 2WOGA 2G1QA 2Y65A 3CJOA 2O0AA 4LNUK 2VVGA 4GKPA 4UBFA 2XAEA 5LT4A 2MYSA 4DBRA 4A50A 3B6UA 1D0XA 4FRZA 5HLEA 1GOJA 4PFPA 2ZFLA 1T5CA 1D1AA 2FL6A 3WRDA 4H1GA 4A28A 5LT3A
chains in the Genus database with same CATH topology
2KINA 3KINA 3CNZA 3L1CA 1G8XA 4PJMA 1D1BA 1VFZA 1D1CA 1CZ7A 3KENA 3PXNA 2V26A 3ZCWA 2FKYA 2IEHA 2X7CA 4Y05A 1VOMA 2FL2A 2Q2ZA 4GKRA 3GBJA 4BXNA 4AP0A 3KARA 4DBQA 1YRSA 2OWMA 4PJNA 2ZFKA 2PG2A 2UYMA 3H4SA 3NWNA 1D0ZA 4PJLA 4AS7A 2FMEA 4E7SA 2ZFJA 4ETPA 1LKXA 1BR1A 4ANJA 5LT1A 3LREA 2GRYA 2ZFIA 4A5YA 1I5SA 1MMAA 1MMDA 1V8KA 2X7EA 2Q2YA 1II6A 4BBGA 3ZFCA 1MMNA 1BR2A 3K3BA 3WPNA 4HNAK 3BFNA 4E7ZA 3DC4A 1RY6A 5GSZA 2VB6A 3ZFDA 3T0QA 4ZCAA 3B6VA 1D0YA 1F9VA 1BG2A 1Q0BA 2X51A 1I6IA 1VFWA 2X7DA 4ZHIA 3U06A 3COBA 1F9UA 1N6MA 2VASA 1F9TA 3L9HA 3X2TA 1KK7A 2GM1A 4A1ZA 1MMGA 1MNEA 2X2RA 1F9WA 4PK4A 2ZFMA 2XT3A 3HQDA 4BN2A 1VFVA 1FMWA 3K5EA 2Y5WA 4B7BA 1LVKA 1VFXA 1BR4A 3DCBA 2HEHA 2UYIA 1V8JA 2NCDA 4PJJA 4A14A 4PFOA 5LT2A 1FMVA 5LT0A 1SDMA 1MKJA 1X88A 4A51A 2WOGA 2G1QA 2Y65A 3CJOA 4LNUK 4UBFA 2VVGA 2XAEA 5LT4A 2MYSA 4DBRA 4A50A 3B6UA 1D0XA 4FRZA 5HLEA 1GOJA 4PFPA 2ZFLA 1T5CA 1D1AA 2FL6A 3WRDA 4H1GA 4A28A 5LT3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KIN A;  3KIN A;  3CNZ A;  3L1C A;  1G8X A;  4PJM A;  1D1B A;  1VFZ A;  1D1C A;  1CZ7 A;  3KEN A;  3PXN A;  2V26 A;  3ZCW A;  2FKY A;  2IEH A;  2X7C A;  4Y05 A;  1VOM A;  2FL2 A;  2Q2Z A;  4GKR A;  3GBJ A;  4BXN A;  4AP0 A;  3KAR A;  4DBQ A;  1YRS A;  2OWM A;  4PJN A;  2ZFK A;  2PG2 A;  2UYM A;  3H4S A;  3NWN A;  1D0Z A;  4PJL A;  4AS7 A;  2FME A;  4E7S A;  2ZFJ A;  4ETP A;  1LKX A;  1BR1 A;  4ANJ A;  5LT1 A;  3LRE A;  2GRY A;  2ZFI A;  4A5Y A;  1I5S A;  1MMA A;  1MMD A;  1V8K A;  2X7E A;  2Q2Y A;  1II6 A;  4BBG A;  3ZFC A;  1MMN A;  1BR2 A;  3K3B A;  3WPN A;  4HNA K;  3BFN A;  4E7Z A;  3DC4 A;  1RY6 A;  5GSZ A;  2VB6 A;  3ZFD A;  3T0Q A;  4ZCA A;  3B6V A;  1D0Y A;  1F9V A;  1BG2 A;  1Q0B A;  2X51 A;  1I6I A;  1VFW A;  2X7D A;  4ZHI A;  3U06 A;  3COB A;  1F9U A;  1N6M A;  2VAS A;  1F9T A;  3L9H A;  3X2T A;  1KK7 A;  2GM1 A;  4A1Z A;  1MMG A;  1MNE A;  2X2R A;  1F9W A;  4PK4 A;  2ZFM A;  2XT3 A;  3HQD A;  4BN2 A;  1VFV A;  1FMW A;  3K5E A;  2Y5W A;  4B7B A;  1LVK A;  1VFX A;  1BR4 A;  3DCB A;  2HEH A;  2UYI A;  1V8J A;  2NCD A;  4PJJ A;  4A14 A;  4PFO A;  5LT2 A;  1FMV A;  5LT0 A;  1SDM A;  1MKJ A;  1X88 A;  4A51 A;  2WOG A;  2G1Q A;  2Y65 A;  3CJO A;  4LNU K;  4UBF A;  2VVG A;  2XAE A;  5LT4 A;  2MYS A;  4DBR A;  4A50 A;  3B6U A;  1D0X A;  4FRZ A;  5HLE A;  1GOJ A;  4PFP A;  2ZFL A;  1T5C A;  1D1A A;  2FL6 A;  3WRD A;  4H1G A;  4A28 A;  5LT3 A; 
#chains in the Genus database with same CATH topology
 2KIN A;  3KIN A;  3CNZ A;  3L1C A;  1G8X A;  4PJM A;  1D1B A;  1VFZ A;  1D1C A;  1CZ7 A;  3KEN A;  3PXN A;  2V26 A;  3ZCW A;  2FKY A;  2IEH A;  2X7C A;  4Y05 A;  1VOM A;  2FL2 A;  2Q2Z A;  4GKR A;  3GBJ A;  4BXN A;  4ETP B;  4AP0 A;  3KAR A;  4DBQ A;  1YRS A;  2OWM A;  4PJN A;  2ZFK A;  2PG2 A;  2UYM A;  3H4S A;  3NWN A;  1D0Z A;  4PJL A;  4AS7 A;  2FME A;  4E7S A;  2ZFJ A;  4ETP A;  1LKX A;  1BR1 A;  4ANJ A;  5LT1 A;  3LRE A;  2GRY A;  2ZFI A;  4GKQ A;  4A5Y A;  1I5S A;  1MMA A;  1MMD A;  1V8K A;  2X7E A;  2Q2Y A;  1II6 A;  4BBG A;  3ZFC A;  1MMN A;  1BR2 A;  3K3B A;  3WPN A;  4HNA K;  3BFN A;  4E7Z A;  3DC4 A;  1RY6 A;  5GSZ A;  2VB6 A;  3ZFD A;  3T0Q A;  4ZCA A;  3B6V A;  1D0Y A;  1F9V A;  1BG2 A;  1Q0B A;  2X51 A;  1I6I A;  1VFW A;  2X7D A;  4ZHI A;  3U06 A;  3COB A;  1F9U A;  1N6M A;  2VAS A;  1F9T A;  3L9H A;  3X2T A;  1KK7 A;  2GM1 A;  4A1Z A;  1MMG A;  1MNE A;  2X2R A;  1F9W A;  4PK4 A;  2ZFM A;  2XT3 A;  3HQD A;  4BN2 A;  1VFV A;  1FMW A;  3K5E A;  2Y5W A;  4B7B A;  1LVK A;  1VFX A;  1BR4 A;  3DCB A;  2HEH A;  2UYI A;  1V8J A;  2NCD A;  4PJJ A;  4A14 A;  4PFO A;  5LT2 A;  1FMV A;  5LT0 A;  1SDM A;  1MKJ A;  1X88 A;  4A51 A;  2WOG A;  2G1Q A;  2Y65 A;  3CJO A;  2O0A A;  4LNU K;  2VVG A;  4GKP A;  4UBF A;  2XAE A;  5LT4 A;  2MYS A;  4DBR A;  4A50 A;  3B6U A;  1D0X A;  4FRZ A;  5HLE A;  1GOJ A;  4PFP A;  2ZFL A;  1T5C A;  1D1A A;  2FL6 A;  3WRD A;  4H1G A;  4A28 A;  5LT3 A; 
#chains in the Genus database with same CATH homology
 2KIN A;  3KIN A;  3CNZ A;  3L1C A;  1G8X A;  4PJM A;  1D1B A;  1VFZ A;  1D1C A;  1CZ7 A;  3KEN A;  3PXN A;  2V26 A;  3ZCW A;  2FKY A;  2IEH A;  2X7C A;  4Y05 A;  1VOM A;  2FL2 A;  2Q2Z A;  4GKR A;  3GBJ A;  4BXN A;  4AP0 A;  3KAR A;  4DBQ A;  1YRS A;  2OWM A;  4PJN A;  2ZFK A;  2PG2 A;  2UYM A;  3H4S A;  3NWN A;  1D0Z A;  4PJL A;  4AS7 A;  2FME A;  4E7S A;  2ZFJ A;  4ETP A;  1LKX A;  1BR1 A;  4ANJ A;  5LT1 A;  3LRE A;  2GRY A;  2ZFI A;  4A5Y A;  1I5S A;  1MMA A;  1MMD A;  1V8K A;  2X7E A;  2Q2Y A;  1II6 A;  4BBG A;  3ZFC A;  1MMN A;  1BR2 A;  3K3B A;  3WPN A;  4HNA K;  3BFN A;  4E7Z A;  3DC4 A;  1RY6 A;  5GSZ A;  2VB6 A;  3ZFD A;  3T0Q A;  4ZCA A;  3B6V A;  1D0Y A;  1F9V A;  1BG2 A;  1Q0B A;  2X51 A;  1I6I A;  1VFW A;  2X7D A;  4ZHI A;  3U06 A;  3COB A;  1F9U A;  1N6M A;  2VAS A;  1F9T A;  3L9H A;  3X2T A;  1KK7 A;  2GM1 A;  4A1Z A;  1MMG A;  1MNE A;  2X2R A;  1F9W A;  4PK4 A;  2ZFM A;  2XT3 A;  3HQD A;  4BN2 A;  1VFV A;  1FMW A;  3K5E A;  2Y5W A;  4B7B A;  1LVK A;  1VFX A;  1BR4 A;  3DCB A;  2HEH A;  2UYI A;  1V8J A;  2NCD A;  4PJJ A;  4A14 A;  4PFO A;  5LT2 A;  1FMV A;  5LT0 A;  1SDM A;  1MKJ A;  1X88 A;  4A51 A;  2WOG A;  2G1Q A;  2Y65 A;  3CJO A;  4LNU K;  4UBF A;  2VVG A;  2XAE A;  5LT4 A;  2MYS A;  4DBR A;  4A50 A;  3B6U A;  1D0X A;  4FRZ A;  5HLE A;  1GOJ A;  4PFP A;  2ZFL A;  1T5C A;  1D1A A;  2FL6 A;  3WRD A;  4H1G A;  4A28 A;  5LT3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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