2XAEA

Crystal structure of human kinesin eg5 in complex with (r)-2-amino-3-((s)-2-methyl-1,1-diphenylbutylthio)propanoic acid
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
348
structure length
328
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKEEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 104
structure length 328
sequence length 348
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2010-03-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2xaeA00
5LT2A 3K3BA 4LNUK 4PJMA 1VFVA 1V8KA 3COBA 2Y5WA 2GRYA 2PG2A 2UYIA 1F9TA 4PJJA 2UYMA 2VVGA 2NCDA 4AS7A 3BFNA 2X7EA 1T5CA 3ZFDA 2FMEA 1G8XA 1D0YA 2ZFIA 1SDMA 3WPNA 3LREA 2FKYA 2XT3A 3CNZA 4A14A 4GKRA 2X7DA 1LKXA 4PFPA 4A5YA 2ZFJA 4E7ZA 1MMNA 3PXNA 4ETPA 2IEHA 4UBFA 4DBRA 4PJLA 2Y65A 2X2RA 1X88A 3X2TA 2HEHA 4A1ZA 5LT1A 1I6IA 1D1CA 1GOJA 5LT0A 3KINA 1F9WA 3WRDA 2ZFLA 3DC4A 4FRZA 3ZCWA 1KK7A 3NWNA 2WOGA 3L1CA 2X7CA 3ZFCA 3T0QA 4BBGA 4BXNA 3GBJA 4ZCAA 5LT3A 3K5EA 2Q2ZA 1BR2A 2FL2A 2VASA 1YRSA 2FL6A 4A51A 1VOMA 2X51A 1V8JA 1LVKA 2XAEA 2ZFMA 2V26A 4H1GA 1II6A 4DBQA 1CZ7A 4A50A 4E7SA 1D1BA 1VFZA 4BN2A 4PK4A 5LT4A 3U06A 4HNAK 1F9UA 1MNEA 1MMGA 1BR4A 1FMVA 5GSZA 4PFOA 4ZHIA 2ZFKA 3B6VA 5HLEA 1RY6A 1D0XA 3KENA 2VB6A 1MMDA 1MMAA 2GM1A 1VFXA 4B7BA 1BR1A 1D1AA 4A28A 1MKJA 1VFWA 1FMWA 1D0ZA 3HQDA 1BG2A 3CJOA 4ANJA 2Q2YA 1F9VA 1I5SA 3L9HA 1N6MA 4PJNA 4Y05A 3KARA 2KINA 2OWMA 1Q0BA 3H4SA 3B6UA 2MYSA 4AP0A 3DCBA 2G1QA
chains in the Genus database with same CATH superfamily
5LT2A 3K3BA 4LNUK 4PJMA 1VFVA 1V8KA 3COBA 2Y5WA 2GRYA 2PG2A 2UYIA 1F9TA 4PJJA 2UYMA 2VVGA 2NCDA 4AS7A 3BFNA 2X7EA 1T5CA 3ZFDA 2FMEA 1G8XA 1D0YA 2ZFIA 1SDMA 3WPNA 3LREA 2FKYA 2XT3A 3CNZA 4A14A 4GKRA 2X7DA 1LKXA 4PFPA 4A5YA 2ZFJA 4E7ZA 1MMNA 3PXNA 4ETPA 2IEHA 4UBFA 4DBRA 4PJLA 2Y65A 2X2RA 1X88A 3X2TA 4GKQA 2HEHA 4A1ZA 5LT1A 1I6IA 1D1CA 1GOJA 5LT0A 3KINA 1F9WA 3WRDA 2ZFLA 3DC4A 4FRZA 3ZCWA 1KK7A 3NWNA 2WOGA 3L1CA 2X7CA 3ZFCA 3T0QA 4BBGA 4BXNA 3GBJA 4ZCAA 5LT3A 3K5EA 2Q2ZA 1BR2A 2FL2A 2VASA 1YRSA 2FL6A 4A51A 1VOMA 2X51A 1V8JA 1LVKA 2XAEA 2ZFMA 4GKPA 2V26A 4H1GA 1II6A 4DBQA 1CZ7A 4A50A 4E7SA 1D1BA 1VFZA 4BN2A 4PK4A 5LT4A 3U06A 4HNAK 1F9UA 1MNEA 1MMGA 1BR4A 1FMVA 5GSZA 4PFOA 4ZHIA 2ZFKA 3B6VA 5HLEA 1RY6A 1D0XA 3KENA 2VB6A 1MMDA 1MMAA 2GM1A 1VFXA 4B7BA 1BR1A 1D1AA 4A28A 1MKJA 1VFWA 1FMWA 1D0ZA 3HQDA 1BG2A 3CJOA 4ANJA 2Q2YA 1F9VA 2O0AA 1I5SA 3L9HA 4ETPB 1N6MA 4PJNA 4Y05A 3KARA 2KINA 2OWMA 1Q0BA 3H4SA 3B6UA 2MYSA 4AP0A 3DCBA 2G1QA
chains in the Genus database with same CATH topology
5LT2A 3K3BA 4LNUK 4PJMA 1VFVA 1V8KA 3COBA 2Y5WA 2GRYA 2PG2A 2UYIA 1F9TA 4PJJA 2UYMA 2VVGA 2NCDA 4AS7A 3BFNA 2X7EA 1T5CA 3ZFDA 2FMEA 1G8XA 1D0YA 2ZFIA 1SDMA 3WPNA 3LREA 2FKYA 2XT3A 3CNZA 4A14A 4GKRA 2X7DA 1LKXA 4PFPA 4A5YA 2ZFJA 4E7ZA 1MMNA 3PXNA 4ETPA 2IEHA 4UBFA 4DBRA 4PJLA 2Y65A 2X2RA 1X88A 3X2TA 2HEHA 4A1ZA 5LT1A 1I6IA 1D1CA 1GOJA 5LT0A 3KINA 1F9WA 3WRDA 2ZFLA 3DC4A 4FRZA 3ZCWA 1KK7A 3NWNA 2WOGA 3L1CA 2X7CA 3ZFCA 3T0QA 4BBGA 4BXNA 3GBJA 4ZCAA 5LT3A 3K5EA 2Q2ZA 1BR2A 2FL2A 2VASA 1YRSA 2FL6A 4A51A 1VOMA 2X51A 1V8JA 1LVKA 2XAEA 2ZFMA 2V26A 4H1GA 1II6A 4DBQA 1CZ7A 4A50A 4E7SA 1D1BA 1VFZA 4BN2A 4PK4A 5LT4A 3U06A 4HNAK 1F9UA 1MNEA 1MMGA 1BR4A 1FMVA 5GSZA 4PFOA 4ZHIA 2ZFKA 3B6VA 5HLEA 1RY6A 1D0XA 3KENA 2VB6A 1MMDA 1MMAA 2GM1A 1VFXA 4B7BA 1BR1A 1D1AA 4A28A 1MKJA 1VFWA 1FMWA 1D0ZA 3HQDA 1BG2A 3CJOA 4ANJA 2Q2YA 1F9VA 1I5SA 3L9HA 1N6MA 4PJNA 4Y05A 3KARA 2KINA 2OWMA 1Q0BA 3H4SA 3B6UA 2MYSA 4AP0A 3DCBA 2G1QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LT2 A;  3K3B A;  4LNU K;  4PJM A;  1VFV A;  1V8K A;  3COB A;  2Y5W A;  2GRY A;  2PG2 A;  2UYI A;  1F9T A;  4PJJ A;  2UYM A;  2VVG A;  2NCD A;  4AS7 A;  3BFN A;  2X7E A;  1T5C A;  3ZFD A;  2FME A;  1G8X A;  1D0Y A;  2ZFI A;  1SDM A;  3WPN A;  3LRE A;  2FKY A;  2XT3 A;  3CNZ A;  4A14 A;  4GKR A;  2X7D A;  1LKX A;  4PFP A;  4A5Y A;  2ZFJ A;  4E7Z A;  1MMN A;  3PXN A;  4ETP A;  2IEH A;  4UBF A;  4DBR A;  4PJL A;  2Y65 A;  2X2R A;  1X88 A;  3X2T A;  2HEH A;  4A1Z A;  5LT1 A;  1I6I A;  1D1C A;  1GOJ A;  5LT0 A;  3KIN A;  1F9W A;  3WRD A;  2ZFL A;  3DC4 A;  4FRZ A;  3ZCW A;  1KK7 A;  3NWN A;  2WOG A;  3L1C A;  2X7C A;  3ZFC A;  3T0Q A;  4BBG A;  4BXN A;  3GBJ A;  4ZCA A;  5LT3 A;  3K5E A;  2Q2Z A;  1BR2 A;  2FL2 A;  2VAS A;  1YRS A;  2FL6 A;  4A51 A;  1VOM A;  2X51 A;  1V8J A;  1LVK A;  2XAE A;  2ZFM A;  2V26 A;  4H1G A;  1II6 A;  4DBQ A;  1CZ7 A;  4A50 A;  4E7S A;  1D1B A;  1VFZ A;  4BN2 A;  4PK4 A;  5LT4 A;  3U06 A;  4HNA K;  1F9U A;  1MNE A;  1MMG A;  1BR4 A;  1FMV A;  5GSZ A;  4PFO A;  4ZHI A;  2ZFK A;  3B6V A;  5HLE A;  1RY6 A;  1D0X A;  3KEN A;  2VB6 A;  1MMD A;  1MMA A;  2GM1 A;  1VFX A;  4B7B A;  1BR1 A;  1D1A A;  4A28 A;  1MKJ A;  1VFW A;  1FMW A;  1D0Z A;  3HQD A;  1BG2 A;  3CJO A;  4ANJ A;  2Q2Y A;  1F9V A;  1I5S A;  3L9H A;  1N6M A;  4PJN A;  4Y05 A;  3KAR A;  2KIN A;  2OWM A;  1Q0B A;  3H4S A;  3B6U A;  2MYS A;  4AP0 A;  3DCB A;  2G1Q A; 
#chains in the Genus database with same CATH topology
 5LT2 A;  3K3B A;  4LNU K;  4PJM A;  1VFV A;  1V8K A;  3COB A;  2Y5W A;  2GRY A;  2PG2 A;  2UYI A;  1F9T A;  4PJJ A;  2UYM A;  2VVG A;  2NCD A;  4AS7 A;  3BFN A;  2X7E A;  1T5C A;  3ZFD A;  2FME A;  1G8X A;  1D0Y A;  2ZFI A;  1SDM A;  3WPN A;  3LRE A;  2FKY A;  2XT3 A;  3CNZ A;  4A14 A;  4GKR A;  2X7D A;  1LKX A;  4PFP A;  4A5Y A;  2ZFJ A;  4E7Z A;  1MMN A;  3PXN A;  4ETP A;  2IEH A;  4UBF A;  4DBR A;  4PJL A;  2Y65 A;  2X2R A;  1X88 A;  3X2T A;  4GKQ A;  2HEH A;  4A1Z A;  5LT1 A;  1I6I A;  1D1C A;  1GOJ A;  5LT0 A;  3KIN A;  1F9W A;  3WRD A;  2ZFL A;  3DC4 A;  4FRZ A;  3ZCW A;  1KK7 A;  3NWN A;  2WOG A;  3L1C A;  2X7C A;  3ZFC A;  3T0Q A;  4BBG A;  4BXN A;  3GBJ A;  4ZCA A;  5LT3 A;  3K5E A;  2Q2Z A;  1BR2 A;  2FL2 A;  2VAS A;  1YRS A;  2FL6 A;  4A51 A;  1VOM A;  2X51 A;  1V8J A;  1LVK A;  2XAE A;  2ZFM A;  4GKP A;  2V26 A;  4H1G A;  1II6 A;  4DBQ A;  1CZ7 A;  4A50 A;  4E7S A;  1D1B A;  1VFZ A;  4BN2 A;  4PK4 A;  5LT4 A;  3U06 A;  4HNA K;  1F9U A;  1MNE A;  1MMG A;  1BR4 A;  1FMV A;  5GSZ A;  4PFO A;  4ZHI A;  2ZFK A;  3B6V A;  5HLE A;  1RY6 A;  1D0X A;  3KEN A;  2VB6 A;  1MMD A;  1MMA A;  2GM1 A;  1VFX A;  4B7B A;  1BR1 A;  1D1A A;  4A28 A;  1MKJ A;  1VFW A;  1FMW A;  1D0Z A;  3HQD A;  1BG2 A;  3CJO A;  4ANJ A;  2Q2Y A;  1F9V A;  2O0A A;  1I5S A;  3L9H A;  4ETP B;  1N6M A;  4PJN A;  4Y05 A;  3KAR A;  2KIN A;  2OWM A;  1Q0B A;  3H4S A;  3B6U A;  2MYS A;  4AP0 A;  3DCB A;  2G1Q A; 
#chains in the Genus database with same CATH homology
 5LT2 A;  3K3B A;  4LNU K;  4PJM A;  1VFV A;  1V8K A;  3COB A;  2Y5W A;  2GRY A;  2PG2 A;  2UYI A;  1F9T A;  4PJJ A;  2UYM A;  2VVG A;  2NCD A;  4AS7 A;  3BFN A;  2X7E A;  1T5C A;  3ZFD A;  2FME A;  1G8X A;  1D0Y A;  2ZFI A;  1SDM A;  3WPN A;  3LRE A;  2FKY A;  2XT3 A;  3CNZ A;  4A14 A;  4GKR A;  2X7D A;  1LKX A;  4PFP A;  4A5Y A;  2ZFJ A;  4E7Z A;  1MMN A;  3PXN A;  4ETP A;  2IEH A;  4UBF A;  4DBR A;  4PJL A;  2Y65 A;  2X2R A;  1X88 A;  3X2T A;  2HEH A;  4A1Z A;  5LT1 A;  1I6I A;  1D1C A;  1GOJ A;  5LT0 A;  3KIN A;  1F9W A;  3WRD A;  2ZFL A;  3DC4 A;  4FRZ A;  3ZCW A;  1KK7 A;  3NWN A;  2WOG A;  3L1C A;  2X7C A;  3ZFC A;  3T0Q A;  4BBG A;  4BXN A;  3GBJ A;  4ZCA A;  5LT3 A;  3K5E A;  2Q2Z A;  1BR2 A;  2FL2 A;  2VAS A;  1YRS A;  2FL6 A;  4A51 A;  1VOM A;  2X51 A;  1V8J A;  1LVK A;  2XAE A;  2ZFM A;  2V26 A;  4H1G A;  1II6 A;  4DBQ A;  1CZ7 A;  4A50 A;  4E7S A;  1D1B A;  1VFZ A;  4BN2 A;  4PK4 A;  5LT4 A;  3U06 A;  4HNA K;  1F9U A;  1MNE A;  1MMG A;  1BR4 A;  1FMV A;  5GSZ A;  4PFO A;  4ZHI A;  2ZFK A;  3B6V A;  5HLE A;  1RY6 A;  1D0X A;  3KEN A;  2VB6 A;  1MMD A;  1MMA A;  2GM1 A;  1VFX A;  4B7B A;  1BR1 A;  1D1A A;  4A28 A;  1MKJ A;  1VFW A;  1FMW A;  1D0Z A;  3HQD A;  1BG2 A;  3CJO A;  4ANJ A;  2Q2Y A;  1F9V A;  1I5S A;  3L9H A;  1N6M A;  4PJN A;  4Y05 A;  3KAR A;  2KIN A;  2OWM A;  1Q0B A;  3H4S A;  3B6U A;  2MYS A;  4AP0 A;  3DCB A;  2G1Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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