4A51A

Crystal structure of human kinesin eg5 in complex with 1-(3-(((2-aminoethyl)thio)diphenylmethyl)phenyl)ethanone hydrochloride
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
346
structure length
322
Chain Sequence
b'NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKLVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKP'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 100
structure length 322
sequence length 346
chains with identical sequence B, C, D, E, F, G
ec nomenclature
pdb deposition date 2011-10-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4a51A00
1RY6A 3ZCWA 3H4SA 4B7BA 2ZFIA 3B6VA 1I6IA 3X2TA 1I5SA 3U06A 1BR2A 2XAEA 2X7EA 4ZCAA 4PJNA 1F9UA 4LNUK 4ETPA 4E7ZA 2VASA 2MYSA 2XT3A 1LKXA 1VFWA 2V26A 1YRSA 2KINA 3DCBA 4A5YA 2UYIA 4PJJA 1MMAA 4PFPA 4A14A 5LT0A 2X2RA 3LREA 2WOGA 3WPNA 1F9TA 2FL2A 4GKRA 5LT2A 2X7DA 4PJLA 3T0QA 3NWNA 3DC4A 4Y05A 4A51A 1BR1A 4A28A 1Q0BA 1V8KA 3ZFDA 1FMWA 4A1ZA 4DBQA 1CZ7A 5LT3A 1D0ZA 1D1BA 2ZFLA 3KARA 1SDMA 1MMDA 3WRDA 4PJMA 5GSZA 2UYMA 2VVGA 2FMEA 2FL6A 5HLEA 1D0XA 4E7SA 1GOJA 4H1GA 3B6UA 1MNEA 2GRYA 2G1QA 2VB6A 4ANJA 2X51A 1FMVA 3KINA 1BR4A 1VOMA 4AS7A 3CNZA 2X7CA 1MKJA 1X88A 2Y65A 4AP0A 1D1AA 1BG2A 2ZFJA 1VFXA 1VFZA 4UBFA 3COBA 1G8XA 2FKYA 3HQDA 2PG2A 2Q2ZA 3CJOA 2Q2YA 4ZHIA 1V8JA 1F9VA 2GM1A 4PFOA 1LVKA 5LT1A 1MMNA 2NCDA 3KENA 1KK7A 1D0YA 1MMGA 2ZFKA 3BFNA 3L9HA 1II6A 2OWMA 2HEHA 4DBRA 2IEHA 2Y5WA 1VFVA 1N6MA 1T5CA 3K5EA 4PK4A 3GBJA 4A50A 4BBGA 4BN2A 4BXNA 3K3BA 3L1CA 4HNAK 5LT4A 3PXNA 1F9WA 2ZFMA 1D1CA 4FRZA 3ZFCA
chains in the Genus database with same CATH superfamily
1RY6A 3ZCWA 3H4SA 4B7BA 2ZFIA 3B6VA 1I6IA 3X2TA 1I5SA 3U06A 1BR2A 2XAEA 2X7EA 4ZCAA 4PJNA 1F9UA 4LNUK 4ETPA 4E7ZA 2VASA 2MYSA 2XT3A 4ETPB 1LKXA 1VFWA 2V26A 1YRSA 2KINA 3DCBA 4A5YA 2UYIA 4PJJA 1MMAA 4PFPA 4A14A 5LT0A 2X2RA 3LREA 2WOGA 3WPNA 1F9TA 2FL2A 4GKRA 5LT2A 2X7DA 4PJLA 3T0QA 3NWNA 3DC4A 4Y05A 4A51A 1BR1A 4A28A 1Q0BA 1V8KA 3ZFDA 1FMWA 4A1ZA 4DBQA 1CZ7A 5LT3A 1D0ZA 1D1BA 2ZFLA 3KARA 1SDMA 1MMDA 3WRDA 4PJMA 5GSZA 2UYMA 2VVGA 2FMEA 2FL6A 5HLEA 1D0XA 4E7SA 1GOJA 4H1GA 2O0AA 3B6UA 1MNEA 2GRYA 2G1QA 2VB6A 4ANJA 2X51A 1FMVA 3KINA 1BR4A 1VOMA 4AS7A 3CNZA 2X7CA 1MKJA 1X88A 2Y65A 4AP0A 1D1AA 1BG2A 2ZFJA 1VFXA 1VFZA 4UBFA 3COBA 1G8XA 2FKYA 3HQDA 2PG2A 2Q2ZA 3CJOA 2Q2YA 4ZHIA 1V8JA 1F9VA 2GM1A 4GKQA 4PFOA 1LVKA 5LT1A 1MMNA 2NCDA 3KENA 1KK7A 1D0YA 1MMGA 2ZFKA 3BFNA 3L9HA 1II6A 2OWMA 2HEHA 4DBRA 2IEHA 2Y5WA 1VFVA 1N6MA 1T5CA 3K5EA 4PK4A 3GBJA 4A50A 4BBGA 4BN2A 4BXNA 3K3BA 3L1CA 4HNAK 5LT4A 3PXNA 1F9WA 2ZFMA 1D1CA 4FRZA 4GKPA 3ZFCA
chains in the Genus database with same CATH topology
1RY6A 3ZCWA 3H4SA 4B7BA 2ZFIA 3B6VA 1I6IA 3X2TA 1I5SA 3U06A 1BR2A 2XAEA 2X7EA 4ZCAA 4PJNA 1F9UA 4LNUK 4ETPA 4E7ZA 2VASA 2MYSA 2XT3A 1LKXA 1VFWA 2V26A 1YRSA 2KINA 3DCBA 4A5YA 2UYIA 4PJJA 1MMAA 4PFPA 4A14A 5LT0A 2X2RA 3LREA 2WOGA 3WPNA 1F9TA 2FL2A 4GKRA 5LT2A 2X7DA 4PJLA 3T0QA 3NWNA 3DC4A 4Y05A 4A51A 1BR1A 4A28A 1Q0BA 1V8KA 3ZFDA 1FMWA 4A1ZA 4DBQA 1CZ7A 5LT3A 1D0ZA 1D1BA 2ZFLA 3KARA 1SDMA 1MMDA 3WRDA 4PJMA 5GSZA 2UYMA 2VVGA 2FMEA 2FL6A 5HLEA 1D0XA 4E7SA 1GOJA 4H1GA 3B6UA 1MNEA 2GRYA 2G1QA 2VB6A 4ANJA 2X51A 1FMVA 3KINA 1BR4A 1VOMA 4AS7A 3CNZA 2X7CA 1MKJA 1X88A 2Y65A 4AP0A 1D1AA 1BG2A 2ZFJA 1VFXA 1VFZA 4UBFA 3COBA 1G8XA 2FKYA 3HQDA 2PG2A 2Q2ZA 3CJOA 2Q2YA 4ZHIA 1V8JA 1F9VA 2GM1A 4PFOA 1LVKA 5LT1A 1MMNA 2NCDA 3KENA 1KK7A 1D0YA 1MMGA 2ZFKA 3BFNA 3L9HA 1II6A 2OWMA 2HEHA 4DBRA 2IEHA 2Y5WA 1VFVA 1N6MA 1T5CA 3K5EA 4PK4A 3GBJA 4A50A 4BBGA 4BN2A 4BXNA 3K3BA 3L1CA 4HNAK 5LT4A 3PXNA 1F9WA 2ZFMA 1D1CA 4FRZA 3ZFCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RY6 A;  3ZCW A;  3H4S A;  4B7B A;  2ZFI A;  3B6V A;  1I6I A;  3X2T A;  1I5S A;  3U06 A;  1BR2 A;  2XAE A;  2X7E A;  4ZCA A;  4PJN A;  1F9U A;  4LNU K;  4ETP A;  4E7Z A;  2VAS A;  2MYS A;  2XT3 A;  1LKX A;  1VFW A;  2V26 A;  1YRS A;  2KIN A;  3DCB A;  4A5Y A;  2UYI A;  4PJJ A;  1MMA A;  4PFP A;  4A14 A;  5LT0 A;  2X2R A;  3LRE A;  2WOG A;  3WPN A;  1F9T A;  2FL2 A;  4GKR A;  5LT2 A;  2X7D A;  4PJL A;  3T0Q A;  3NWN A;  3DC4 A;  4Y05 A;  4A51 A;  1BR1 A;  4A28 A;  1Q0B A;  1V8K A;  3ZFD A;  1FMW A;  4A1Z A;  4DBQ A;  1CZ7 A;  5LT3 A;  1D0Z A;  1D1B A;  2ZFL A;  3KAR A;  1SDM A;  1MMD A;  3WRD A;  4PJM A;  5GSZ A;  2UYM A;  2VVG A;  2FME A;  2FL6 A;  5HLE A;  1D0X A;  4E7S A;  1GOJ A;  4H1G A;  3B6U A;  1MNE A;  2GRY A;  2G1Q A;  2VB6 A;  4ANJ A;  2X51 A;  1FMV A;  3KIN A;  1BR4 A;  1VOM A;  4AS7 A;  3CNZ A;  2X7C A;  1MKJ A;  1X88 A;  2Y65 A;  4AP0 A;  1D1A A;  1BG2 A;  2ZFJ A;  1VFX A;  1VFZ A;  4UBF A;  3COB A;  1G8X A;  2FKY A;  3HQD A;  2PG2 A;  2Q2Z A;  3CJO A;  2Q2Y A;  4ZHI A;  1V8J A;  1F9V A;  2GM1 A;  4PFO A;  1LVK A;  5LT1 A;  1MMN A;  2NCD A;  3KEN A;  1KK7 A;  1D0Y A;  1MMG A;  2ZFK A;  3BFN A;  3L9H A;  1II6 A;  2OWM A;  2HEH A;  4DBR A;  2IEH A;  2Y5W A;  1VFV A;  1N6M A;  1T5C A;  3K5E A;  4PK4 A;  3GBJ A;  4A50 A;  4BBG A;  4BN2 A;  4BXN A;  3K3B A;  3L1C A;  4HNA K;  5LT4 A;  3PXN A;  1F9W A;  2ZFM A;  1D1C A;  4FRZ A;  3ZFC A; 
#chains in the Genus database with same CATH topology
 1RY6 A;  3ZCW A;  3H4S A;  4B7B A;  2ZFI A;  3B6V A;  1I6I A;  3X2T A;  1I5S A;  3U06 A;  1BR2 A;  2XAE A;  2X7E A;  4ZCA A;  4PJN A;  1F9U A;  4LNU K;  4ETP A;  4E7Z A;  2VAS A;  2MYS A;  2XT3 A;  4ETP B;  1LKX A;  1VFW A;  2V26 A;  1YRS A;  2KIN A;  3DCB A;  4A5Y A;  2UYI A;  4PJJ A;  1MMA A;  4PFP A;  4A14 A;  5LT0 A;  2X2R A;  3LRE A;  2WOG A;  3WPN A;  1F9T A;  2FL2 A;  4GKR A;  5LT2 A;  2X7D A;  4PJL A;  3T0Q A;  3NWN A;  3DC4 A;  4Y05 A;  4A51 A;  1BR1 A;  4A28 A;  1Q0B A;  1V8K A;  3ZFD A;  1FMW A;  4A1Z A;  4DBQ A;  1CZ7 A;  5LT3 A;  1D0Z A;  1D1B A;  2ZFL A;  3KAR A;  1SDM A;  1MMD A;  3WRD A;  4PJM A;  5GSZ A;  2UYM A;  2VVG A;  2FME A;  2FL6 A;  5HLE A;  1D0X A;  4E7S A;  1GOJ A;  4H1G A;  2O0A A;  3B6U A;  1MNE A;  2GRY A;  2G1Q A;  2VB6 A;  4ANJ A;  2X51 A;  1FMV A;  3KIN A;  1BR4 A;  1VOM A;  4AS7 A;  3CNZ A;  2X7C A;  1MKJ A;  1X88 A;  2Y65 A;  4AP0 A;  1D1A A;  1BG2 A;  2ZFJ A;  1VFX A;  1VFZ A;  4UBF A;  3COB A;  1G8X A;  2FKY A;  3HQD A;  2PG2 A;  2Q2Z A;  3CJO A;  2Q2Y A;  4ZHI A;  1V8J A;  1F9V A;  2GM1 A;  4GKQ A;  4PFO A;  1LVK A;  5LT1 A;  1MMN A;  2NCD A;  3KEN A;  1KK7 A;  1D0Y A;  1MMG A;  2ZFK A;  3BFN A;  3L9H A;  1II6 A;  2OWM A;  2HEH A;  4DBR A;  2IEH A;  2Y5W A;  1VFV A;  1N6M A;  1T5C A;  3K5E A;  4PK4 A;  3GBJ A;  4A50 A;  4BBG A;  4BN2 A;  4BXN A;  3K3B A;  3L1C A;  4HNA K;  5LT4 A;  3PXN A;  1F9W A;  2ZFM A;  1D1C A;  4FRZ A;  4GKP A;  3ZFC A; 
#chains in the Genus database with same CATH homology
 1RY6 A;  3ZCW A;  3H4S A;  4B7B A;  2ZFI A;  3B6V A;  1I6I A;  3X2T A;  1I5S A;  3U06 A;  1BR2 A;  2XAE A;  2X7E A;  4ZCA A;  4PJN A;  1F9U A;  4LNU K;  4ETP A;  4E7Z A;  2VAS A;  2MYS A;  2XT3 A;  1LKX A;  1VFW A;  2V26 A;  1YRS A;  2KIN A;  3DCB A;  4A5Y A;  2UYI A;  4PJJ A;  1MMA A;  4PFP A;  4A14 A;  5LT0 A;  2X2R A;  3LRE A;  2WOG A;  3WPN A;  1F9T A;  2FL2 A;  4GKR A;  5LT2 A;  2X7D A;  4PJL A;  3T0Q A;  3NWN A;  3DC4 A;  4Y05 A;  4A51 A;  1BR1 A;  4A28 A;  1Q0B A;  1V8K A;  3ZFD A;  1FMW A;  4A1Z A;  4DBQ A;  1CZ7 A;  5LT3 A;  1D0Z A;  1D1B A;  2ZFL A;  3KAR A;  1SDM A;  1MMD A;  3WRD A;  4PJM A;  5GSZ A;  2UYM A;  2VVG A;  2FME A;  2FL6 A;  5HLE A;  1D0X A;  4E7S A;  1GOJ A;  4H1G A;  3B6U A;  1MNE A;  2GRY A;  2G1Q A;  2VB6 A;  4ANJ A;  2X51 A;  1FMV A;  3KIN A;  1BR4 A;  1VOM A;  4AS7 A;  3CNZ A;  2X7C A;  1MKJ A;  1X88 A;  2Y65 A;  4AP0 A;  1D1A A;  1BG2 A;  2ZFJ A;  1VFX A;  1VFZ A;  4UBF A;  3COB A;  1G8X A;  2FKY A;  3HQD A;  2PG2 A;  2Q2Z A;  3CJO A;  2Q2Y A;  4ZHI A;  1V8J A;  1F9V A;  2GM1 A;  4PFO A;  1LVK A;  5LT1 A;  1MMN A;  2NCD A;  3KEN A;  1KK7 A;  1D0Y A;  1MMG A;  2ZFK A;  3BFN A;  3L9H A;  1II6 A;  2OWM A;  2HEH A;  4DBR A;  2IEH A;  2Y5W A;  1VFV A;  1N6M A;  1T5C A;  3K5E A;  4PK4 A;  3GBJ A;  4A50 A;  4BBG A;  4BN2 A;  4BXN A;  3K3B A;  3L1C A;  4HNA K;  5LT4 A;  3PXN A;  1F9W A;  2ZFM A;  1D1C A;  4FRZ A;  3ZFC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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