4A51A

Crystal structure of human kinesin eg5 in complex with 1-(3-(((2-aminoethyl)thio)diphenylmethyl)phenyl)ethanone hydrochloride
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
346
structure length
322
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKLVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 100
structure length 322
sequence length 346
chains with identical sequence B, C, D, E, F, G
ec nomenclature
pdb deposition date 2011-10-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4a51A00
2Q2ZA 1GOJA 1FMVA 1SDMA 2UYIA 4PK4A 4BN2A 1X88A 3LREA 2Y5WA 2IEHA 3B6VA 1Q0BA 4E7ZA 1VFXA 4PJJA 4B7BA 1I5SA 4AP0A 3L9HA 3CJOA 1BR4A 1BR1A 2VB6A 2GRYA 4ZCAA 2ZFLA 5LT0A 3CNZA 1FMWA 2HEHA 3ZCWA 4UBFA 1F9VA 3COBA 4A5YA 5LT1A 2FL2A 1MMGA 1MNEA 1F9UA 2ZFIA 2WOGA 4PJMA 1D0ZA 1MMDA 3T0QA 4DBQA 4ANJA 3WRDA 1G8XA 1LVKA 2KINA 1MKJA 3PXNA 2XT3A 1BR2A 1RY6A 1VOMA 4A51A 2ZFJA 2Y65A 4A50A 1V8JA 2X7EA 3BFNA 2ZFKA 1V8KA 3GBJA 5LT3A 3DC4A 4HNAK 1VFVA 4BXNA 4GKRA 4FRZA 4PJLA 4ETPA 3NWNA 1I6IA 3KENA 2UYMA 1II6A 2X2RA 1D0XA 1KK7A 1LKXA 3ZFCA 4ZHIA 2GM1A 1N6MA 1F9WA 4PJNA 3B6UA 3WPNA 1D1BA 3KINA 5GSZA 2X51A 3HQDA 5LT4A 1VFWA 3DCBA 2FKYA 2XAEA 2VASA 1D1AA 2FMEA 4A14A 4A28A 2G1QA 3L1CA 3H4SA 4PFOA 2ZFMA 4H1GA 1MMNA 2NCDA 1D1CA 2Q2YA 4AS7A 2PG2A 1D0YA 1T5CA 2FL6A 3K5EA 4PFPA 2X7CA 1F9TA 4Y05A 3X2TA 4A1ZA 2V26A 1CZ7A 1VFZA 5LT2A 2X7DA 4DBRA 4LNUK 3K3BA 3KARA 4BBGA 2MYSA 3ZFDA 4E7SA 2VVGA 1MMAA 1BG2A 1YRSA 5HLEA 3U06A 2OWMA
chains in the Genus database with same CATH superfamily
2Q2ZA 1GOJA 1FMVA 1SDMA 2UYIA 4PK4A 4BN2A 1X88A 3LREA 2Y5WA 2IEHA 3B6VA 1Q0BA 4E7ZA 1VFXA 4PJJA 4B7BA 1I5SA 4AP0A 3L9HA 3CJOA 1BR4A 1BR1A 2VB6A 2GRYA 4ZCAA 2ZFLA 5LT0A 3CNZA 1FMWA 2HEHA 3ZCWA 4UBFA 1F9VA 3COBA 4A5YA 5LT1A 2FL2A 1MMGA 1MNEA 1F9UA 2ZFIA 2WOGA 4PJMA 1D0ZA 1MMDA 3T0QA 4DBQA 4ANJA 3WRDA 1G8XA 1LVKA 4GKPA 2KINA 1MKJA 3PXNA 2XT3A 1BR2A 1RY6A 1VOMA 4A51A 2ZFJA 2Y65A 4A50A 1V8JA 2X7EA 3BFNA 2ZFKA 1V8KA 3GBJA 5LT3A 3DC4A 4HNAK 1VFVA 4ETPB 4BXNA 4GKRA 4FRZA 4PJLA 4ETPA 3NWNA 1I6IA 3KENA 2UYMA 1II6A 2X2RA 1D0XA 1KK7A 1LKXA 3ZFCA 4ZHIA 2GM1A 1N6MA 1F9WA 4PJNA 3B6UA 3WPNA 1D1BA 3KINA 5GSZA 2X51A 3HQDA 5LT4A 4GKQA 1VFWA 3DCBA 2FKYA 2XAEA 2VASA 1D1AA 2FMEA 4A14A 4A28A 2G1QA 3L1CA 3H4SA 4PFOA 2O0AA 2ZFMA 4H1GA 1MMNA 2NCDA 1D1CA 2Q2YA 4AS7A 2PG2A 1D0YA 1T5CA 2FL6A 3K5EA 4PFPA 2X7CA 1F9TA 4Y05A 3X2TA 4A1ZA 2V26A 1CZ7A 1VFZA 5LT2A 2X7DA 4DBRA 4LNUK 3K3BA 3KARA 4BBGA 2MYSA 3ZFDA 4E7SA 2VVGA 1MMAA 1BG2A 1YRSA 5HLEA 3U06A 2OWMA
chains in the Genus database with same CATH topology
2Q2ZA 1GOJA 1FMVA 1SDMA 2UYIA 4PK4A 4BN2A 1X88A 3LREA 2Y5WA 2IEHA 3B6VA 1Q0BA 4E7ZA 1VFXA 4PJJA 4B7BA 1I5SA 4AP0A 3L9HA 3CJOA 1BR4A 1BR1A 2VB6A 2GRYA 4ZCAA 2ZFLA 5LT0A 3CNZA 1FMWA 2HEHA 3ZCWA 4UBFA 1F9VA 3COBA 4A5YA 5LT1A 2FL2A 1MMGA 1MNEA 1F9UA 2ZFIA 2WOGA 4PJMA 1D0ZA 1MMDA 3T0QA 4DBQA 4ANJA 3WRDA 1G8XA 1LVKA 2KINA 1MKJA 3PXNA 2XT3A 1BR2A 1RY6A 1VOMA 4A51A 2ZFJA 2Y65A 4A50A 1V8JA 2X7EA 3BFNA 2ZFKA 1V8KA 3GBJA 5LT3A 3DC4A 4HNAK 1VFVA 4BXNA 4GKRA 4FRZA 4PJLA 4ETPA 3NWNA 1I6IA 3KENA 2UYMA 1II6A 2X2RA 1D0XA 1KK7A 1LKXA 3ZFCA 4ZHIA 2GM1A 1N6MA 1F9WA 4PJNA 3B6UA 3WPNA 1D1BA 3KINA 5GSZA 2X51A 3HQDA 5LT4A 1VFWA 3DCBA 2FKYA 2XAEA 2VASA 1D1AA 2FMEA 4A14A 4A28A 2G1QA 3L1CA 3H4SA 4PFOA 2ZFMA 4H1GA 1MMNA 2NCDA 1D1CA 2Q2YA 4AS7A 2PG2A 1D0YA 1T5CA 2FL6A 3K5EA 4PFPA 2X7CA 1F9TA 4Y05A 3X2TA 4A1ZA 2V26A 1CZ7A 1VFZA 5LT2A 2X7DA 4DBRA 4LNUK 3K3BA 3KARA 4BBGA 2MYSA 3ZFDA 4E7SA 2VVGA 1MMAA 1BG2A 1YRSA 5HLEA 3U06A 2OWMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Q2Z A;  1GOJ A;  1FMV A;  1SDM A;  2UYI A;  4PK4 A;  4BN2 A;  1X88 A;  3LRE A;  2Y5W A;  2IEH A;  3B6V A;  1Q0B A;  4E7Z A;  1VFX A;  4PJJ A;  4B7B A;  1I5S A;  4AP0 A;  3L9H A;  3CJO A;  1BR4 A;  1BR1 A;  2VB6 A;  2GRY A;  4ZCA A;  2ZFL A;  5LT0 A;  3CNZ A;  1FMW A;  2HEH A;  3ZCW A;  4UBF A;  1F9V A;  3COB A;  4A5Y A;  5LT1 A;  2FL2 A;  1MMG A;  1MNE A;  1F9U A;  2ZFI A;  2WOG A;  4PJM A;  1D0Z A;  1MMD A;  3T0Q A;  4DBQ A;  4ANJ A;  3WRD A;  1G8X A;  1LVK A;  2KIN A;  1MKJ A;  3PXN A;  2XT3 A;  1BR2 A;  1RY6 A;  1VOM A;  4A51 A;  2ZFJ A;  2Y65 A;  4A50 A;  1V8J A;  2X7E A;  3BFN A;  2ZFK A;  1V8K A;  3GBJ A;  5LT3 A;  3DC4 A;  4HNA K;  1VFV A;  4BXN A;  4GKR A;  4FRZ A;  4PJL A;  4ETP A;  3NWN A;  1I6I A;  3KEN A;  2UYM A;  1II6 A;  2X2R A;  1D0X A;  1KK7 A;  1LKX A;  3ZFC A;  4ZHI A;  2GM1 A;  1N6M A;  1F9W A;  4PJN A;  3B6U A;  3WPN A;  1D1B A;  3KIN A;  5GSZ A;  2X51 A;  3HQD A;  5LT4 A;  1VFW A;  3DCB A;  2FKY A;  2XAE A;  2VAS A;  1D1A A;  2FME A;  4A14 A;  4A28 A;  2G1Q A;  3L1C A;  3H4S A;  4PFO A;  2ZFM A;  4H1G A;  1MMN A;  2NCD A;  1D1C A;  2Q2Y A;  4AS7 A;  2PG2 A;  1D0Y A;  1T5C A;  2FL6 A;  3K5E A;  4PFP A;  2X7C A;  1F9T A;  4Y05 A;  3X2T A;  4A1Z A;  2V26 A;  1CZ7 A;  1VFZ A;  5LT2 A;  2X7D A;  4DBR A;  4LNU K;  3K3B A;  3KAR A;  4BBG A;  2MYS A;  3ZFD A;  4E7S A;  2VVG A;  1MMA A;  1BG2 A;  1YRS A;  5HLE A;  3U06 A;  2OWM A; 
#chains in the Genus database with same CATH topology
 2Q2Z A;  1GOJ A;  1FMV A;  1SDM A;  2UYI A;  4PK4 A;  4BN2 A;  1X88 A;  3LRE A;  2Y5W A;  2IEH A;  3B6V A;  1Q0B A;  4E7Z A;  1VFX A;  4PJJ A;  4B7B A;  1I5S A;  4AP0 A;  3L9H A;  3CJO A;  1BR4 A;  1BR1 A;  2VB6 A;  2GRY A;  4ZCA A;  2ZFL A;  5LT0 A;  3CNZ A;  1FMW A;  2HEH A;  3ZCW A;  4UBF A;  1F9V A;  3COB A;  4A5Y A;  5LT1 A;  2FL2 A;  1MMG A;  1MNE A;  1F9U A;  2ZFI A;  2WOG A;  4PJM A;  1D0Z A;  1MMD A;  3T0Q A;  4DBQ A;  4ANJ A;  3WRD A;  1G8X A;  1LVK A;  4GKP A;  2KIN A;  1MKJ A;  3PXN A;  2XT3 A;  1BR2 A;  1RY6 A;  1VOM A;  4A51 A;  2ZFJ A;  2Y65 A;  4A50 A;  1V8J A;  2X7E A;  3BFN A;  2ZFK A;  1V8K A;  3GBJ A;  5LT3 A;  3DC4 A;  4HNA K;  1VFV A;  4ETP B;  4BXN A;  4GKR A;  4FRZ A;  4PJL A;  4ETP A;  3NWN A;  1I6I A;  3KEN A;  2UYM A;  1II6 A;  2X2R A;  1D0X A;  1KK7 A;  1LKX A;  3ZFC A;  4ZHI A;  2GM1 A;  1N6M A;  1F9W A;  4PJN A;  3B6U A;  3WPN A;  1D1B A;  3KIN A;  5GSZ A;  2X51 A;  3HQD A;  5LT4 A;  4GKQ A;  1VFW A;  3DCB A;  2FKY A;  2XAE A;  2VAS A;  1D1A A;  2FME A;  4A14 A;  4A28 A;  2G1Q A;  3L1C A;  3H4S A;  4PFO A;  2O0A A;  2ZFM A;  4H1G A;  1MMN A;  2NCD A;  1D1C A;  2Q2Y A;  4AS7 A;  2PG2 A;  1D0Y A;  1T5C A;  2FL6 A;  3K5E A;  4PFP A;  2X7C A;  1F9T A;  4Y05 A;  3X2T A;  4A1Z A;  2V26 A;  1CZ7 A;  1VFZ A;  5LT2 A;  2X7D A;  4DBR A;  4LNU K;  3K3B A;  3KAR A;  4BBG A;  2MYS A;  3ZFD A;  4E7S A;  2VVG A;  1MMA A;  1BG2 A;  1YRS A;  5HLE A;  3U06 A;  2OWM A; 
#chains in the Genus database with same CATH homology
 2Q2Z A;  1GOJ A;  1FMV A;  1SDM A;  2UYI A;  4PK4 A;  4BN2 A;  1X88 A;  3LRE A;  2Y5W A;  2IEH A;  3B6V A;  1Q0B A;  4E7Z A;  1VFX A;  4PJJ A;  4B7B A;  1I5S A;  4AP0 A;  3L9H A;  3CJO A;  1BR4 A;  1BR1 A;  2VB6 A;  2GRY A;  4ZCA A;  2ZFL A;  5LT0 A;  3CNZ A;  1FMW A;  2HEH A;  3ZCW A;  4UBF A;  1F9V A;  3COB A;  4A5Y A;  5LT1 A;  2FL2 A;  1MMG A;  1MNE A;  1F9U A;  2ZFI A;  2WOG A;  4PJM A;  1D0Z A;  1MMD A;  3T0Q A;  4DBQ A;  4ANJ A;  3WRD A;  1G8X A;  1LVK A;  2KIN A;  1MKJ A;  3PXN A;  2XT3 A;  1BR2 A;  1RY6 A;  1VOM A;  4A51 A;  2ZFJ A;  2Y65 A;  4A50 A;  1V8J A;  2X7E A;  3BFN A;  2ZFK A;  1V8K A;  3GBJ A;  5LT3 A;  3DC4 A;  4HNA K;  1VFV A;  4BXN A;  4GKR A;  4FRZ A;  4PJL A;  4ETP A;  3NWN A;  1I6I A;  3KEN A;  2UYM A;  1II6 A;  2X2R A;  1D0X A;  1KK7 A;  1LKX A;  3ZFC A;  4ZHI A;  2GM1 A;  1N6M A;  1F9W A;  4PJN A;  3B6U A;  3WPN A;  1D1B A;  3KIN A;  5GSZ A;  2X51 A;  3HQD A;  5LT4 A;  1VFW A;  3DCB A;  2FKY A;  2XAE A;  2VAS A;  1D1A A;  2FME A;  4A14 A;  4A28 A;  2G1Q A;  3L1C A;  3H4S A;  4PFO A;  2ZFM A;  4H1G A;  1MMN A;  2NCD A;  1D1C A;  2Q2Y A;  4AS7 A;  2PG2 A;  1D0Y A;  1T5C A;  2FL6 A;  3K5E A;  4PFP A;  2X7C A;  1F9T A;  4Y05 A;  3X2T A;  4A1Z A;  2V26 A;  1CZ7 A;  1VFZ A;  5LT2 A;  2X7D A;  4DBR A;  4LNU K;  3K3B A;  3KAR A;  4BBG A;  2MYS A;  3ZFD A;  4E7S A;  2VVG A;  1MMA A;  1BG2 A;  1YRS A;  5HLE A;  3U06 A;  2OWM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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