2X7DA

Crystal structure of human kinesin eg5 in complex with (s)-dimethylenastron
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
350
structure length
335
Chain Sequence
b'KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVN'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 106
structure length 335
sequence length 350
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x7dA00
1X88A 3ZFCA 2ZFIA 4PJLA 3B6VA 4BN2A 5LT4A 2IEHA 2X7CA 4FRZA 1BR4A 2FL2A 4ZCAA 2XT3A 3KENA 4PK4A 2X2RA 1F9WA 4PFOA 3COBA 4ANJA 1VFWA 3NWNA 4UBFA 2WOGA 1BR1A 1F9VA 1VFZA 3WRDA 4Y05A 1BR2A 2Y5WA 4HNAK 2HEHA 2Q2YA 2NCDA 1D1CA 2MYSA 1D1BA 1MKJA 4GKRA 3BFNA 1I6IA 1II6A 1VFVA 4A51A 1YRSA 1V8KA 1MNEA 2GM1A 1V8JA 1MMNA 3K5EA 5LT3A 1I5SA 4PFPA 1N6MA 2ZFJA 3H4SA 3CNZA 2UYIA 1LVKA 1KK7A 2OWMA 2G1QA 1D0ZA 1VFXA 2X7EA 1BG2A 1G8XA 3DCBA 4ZHIA 5LT1A 1Q0BA 4LNUK 4PJJA 4E7SA 2GRYA 4PJMA 1SDMA 4E7ZA 3ZCWA 3PXNA 4PJNA 3KINA 4AS7A 3WPNA 5HLEA 1RY6A 3L1CA 1F9UA 5LT2A 1D0YA 3HQDA 2UYMA 4H1GA 4ETPA 2XAEA 5GSZA 4B7BA 2PG2A 1F9TA 2Y65A 2VB6A 4A14A 4A5YA 1GOJA 3KARA 4AP0A 2VVGA 3B6UA 3T0QA 2X51A 3LREA 2ZFMA 4DBQA 2KINA 1FMWA 2V26A 4BBGA 4BXNA 4DBRA 1T5CA 2FL6A 1MMAA 3U06A 1LKXA 3X2TA 2FMEA 4A1ZA 2VASA 1FMVA 3ZFDA 1MMDA 1D0XA 2FKYA 4A50A 5LT0A 3L9HA 2Q2ZA 3K3BA 1MMGA 2ZFLA 4A28A 3GBJA 2ZFKA 3DC4A 3CJOA 1D1AA 2X7DA 1VOMA 1CZ7A
chains in the Genus database with same CATH superfamily
1X88A 3ZFCA 2ZFIA 4PJLA 3B6VA 4BN2A 5LT4A 2IEHA 2X7CA 4FRZA 1BR4A 2FL2A 4ZCAA 2XT3A 3KENA 4PK4A 2X2RA 1F9WA 2O0AA 4PFOA 3COBA 4ANJA 1VFWA 3NWNA 4UBFA 2WOGA 1BR1A 1F9VA 1VFZA 3WRDA 4Y05A 1BR2A 2Y5WA 4HNAK 2HEHA 2Q2YA 2NCDA 1D1CA 2MYSA 1D1BA 1MKJA 4GKRA 3BFNA 1I6IA 1II6A 1VFVA 4A51A 1YRSA 1V8KA 1MNEA 2GM1A 1V8JA 1MMNA 3K5EA 5LT3A 1I5SA 4PFPA 1N6MA 2ZFJA 3H4SA 3CNZA 2UYIA 1LVKA 1KK7A 2OWMA 2G1QA 1D0ZA 1VFXA 2X7EA 1BG2A 1G8XA 3DCBA 4ZHIA 5LT1A 1Q0BA 4LNUK 4PJJA 4E7SA 2GRYA 4PJMA 1SDMA 4E7ZA 3ZCWA 3PXNA 4PJNA 3KINA 4AS7A 3WPNA 5HLEA 1RY6A 3L1CA 1F9UA 5LT2A 4ETPB 1D0YA 3HQDA 2UYMA 4H1GA 4ETPA 2XAEA 5GSZA 4B7BA 2PG2A 1F9TA 2Y65A 2VB6A 4A14A 4A5YA 1GOJA 3KARA 4AP0A 2VVGA 3B6UA 4GKQA 3T0QA 2X51A 3LREA 4GKPA 2ZFMA 4DBQA 2KINA 1FMWA 2V26A 4BBGA 4BXNA 4DBRA 1T5CA 2FL6A 1MMAA 3U06A 1LKXA 3X2TA 2FMEA 4A1ZA 2VASA 1FMVA 3ZFDA 1MMDA 1D0XA 2FKYA 4A50A 5LT0A 3L9HA 2Q2ZA 3K3BA 1MMGA 2ZFLA 4A28A 3GBJA 2ZFKA 3DC4A 3CJOA 1D1AA 2X7DA 1VOMA 1CZ7A
chains in the Genus database with same CATH topology
1X88A 3ZFCA 2ZFIA 4PJLA 3B6VA 4BN2A 5LT4A 2IEHA 2X7CA 4FRZA 1BR4A 2FL2A 4ZCAA 2XT3A 3KENA 4PK4A 2X2RA 1F9WA 4PFOA 3COBA 4ANJA 1VFWA 3NWNA 4UBFA 2WOGA 1BR1A 1F9VA 1VFZA 3WRDA 4Y05A 1BR2A 2Y5WA 4HNAK 2HEHA 2Q2YA 2NCDA 1D1CA 2MYSA 1D1BA 1MKJA 4GKRA 3BFNA 1I6IA 1II6A 1VFVA 4A51A 1YRSA 1V8KA 1MNEA 2GM1A 1V8JA 1MMNA 3K5EA 5LT3A 1I5SA 4PFPA 1N6MA 2ZFJA 3H4SA 3CNZA 2UYIA 1LVKA 1KK7A 2OWMA 2G1QA 1D0ZA 1VFXA 2X7EA 1BG2A 1G8XA 3DCBA 4ZHIA 5LT1A 1Q0BA 4LNUK 4PJJA 4E7SA 2GRYA 4PJMA 1SDMA 4E7ZA 3ZCWA 3PXNA 4PJNA 3KINA 4AS7A 3WPNA 5HLEA 1RY6A 3L1CA 1F9UA 5LT2A 1D0YA 3HQDA 2UYMA 4H1GA 4ETPA 2XAEA 5GSZA 4B7BA 2PG2A 1F9TA 2Y65A 2VB6A 4A14A 4A5YA 1GOJA 3KARA 4AP0A 2VVGA 3B6UA 3T0QA 2X51A 3LREA 2ZFMA 4DBQA 2KINA 1FMWA 2V26A 4BBGA 4BXNA 4DBRA 1T5CA 2FL6A 1MMAA 3U06A 1LKXA 3X2TA 2FMEA 4A1ZA 2VASA 1FMVA 3ZFDA 1MMDA 1D0XA 2FKYA 4A50A 5LT0A 3L9HA 2Q2ZA 3K3BA 1MMGA 2ZFLA 4A28A 3GBJA 2ZFKA 3DC4A 3CJOA 1D1AA 2X7DA 1VOMA 1CZ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1X88 A;  3ZFC A;  2ZFI A;  4PJL A;  3B6V A;  4BN2 A;  5LT4 A;  2IEH A;  2X7C A;  4FRZ A;  1BR4 A;  2FL2 A;  4ZCA A;  2XT3 A;  3KEN A;  4PK4 A;  2X2R A;  1F9W A;  4PFO A;  3COB A;  4ANJ A;  1VFW A;  3NWN A;  4UBF A;  2WOG A;  1BR1 A;  1F9V A;  1VFZ A;  3WRD A;  4Y05 A;  1BR2 A;  2Y5W A;  4HNA K;  2HEH A;  2Q2Y A;  2NCD A;  1D1C A;  2MYS A;  1D1B A;  1MKJ A;  4GKR A;  3BFN A;  1I6I A;  1II6 A;  1VFV A;  4A51 A;  1YRS A;  1V8K A;  1MNE A;  2GM1 A;  1V8J A;  1MMN A;  3K5E A;  5LT3 A;  1I5S A;  4PFP A;  1N6M A;  2ZFJ A;  3H4S A;  3CNZ A;  2UYI A;  1LVK A;  1KK7 A;  2OWM A;  2G1Q A;  1D0Z A;  1VFX A;  2X7E A;  1BG2 A;  1G8X A;  3DCB A;  4ZHI A;  5LT1 A;  1Q0B A;  4LNU K;  4PJJ A;  4E7S A;  2GRY A;  4PJM A;  1SDM A;  4E7Z A;  3ZCW A;  3PXN A;  4PJN A;  3KIN A;  4AS7 A;  3WPN A;  5HLE A;  1RY6 A;  3L1C A;  1F9U A;  5LT2 A;  1D0Y A;  3HQD A;  2UYM A;  4H1G A;  4ETP A;  2XAE A;  5GSZ A;  4B7B A;  2PG2 A;  1F9T A;  2Y65 A;  2VB6 A;  4A14 A;  4A5Y A;  1GOJ A;  3KAR A;  4AP0 A;  2VVG A;  3B6U A;  3T0Q A;  2X51 A;  3LRE A;  2ZFM A;  4DBQ A;  2KIN A;  1FMW A;  2V26 A;  4BBG A;  4BXN A;  4DBR A;  1T5C A;  2FL6 A;  1MMA A;  3U06 A;  1LKX A;  3X2T A;  2FME A;  4A1Z A;  2VAS A;  1FMV A;  3ZFD A;  1MMD A;  1D0X A;  2FKY A;  4A50 A;  5LT0 A;  3L9H A;  2Q2Z A;  3K3B A;  1MMG A;  2ZFL A;  4A28 A;  3GBJ A;  2ZFK A;  3DC4 A;  3CJO A;  1D1A A;  2X7D A;  1VOM A;  1CZ7 A; 
#chains in the Genus database with same CATH topology
 1X88 A;  3ZFC A;  2ZFI A;  4PJL A;  3B6V A;  4BN2 A;  5LT4 A;  2IEH A;  2X7C A;  4FRZ A;  1BR4 A;  2FL2 A;  4ZCA A;  2XT3 A;  3KEN A;  4PK4 A;  2X2R A;  1F9W A;  2O0A A;  4PFO A;  3COB A;  4ANJ A;  1VFW A;  3NWN A;  4UBF A;  2WOG A;  1BR1 A;  1F9V A;  1VFZ A;  3WRD A;  4Y05 A;  1BR2 A;  2Y5W A;  4HNA K;  2HEH A;  2Q2Y A;  2NCD A;  1D1C A;  2MYS A;  1D1B A;  1MKJ A;  4GKR A;  3BFN A;  1I6I A;  1II6 A;  1VFV A;  4A51 A;  1YRS A;  1V8K A;  1MNE A;  2GM1 A;  1V8J A;  1MMN A;  3K5E A;  5LT3 A;  1I5S A;  4PFP A;  1N6M A;  2ZFJ A;  3H4S A;  3CNZ A;  2UYI A;  1LVK A;  1KK7 A;  2OWM A;  2G1Q A;  1D0Z A;  1VFX A;  2X7E A;  1BG2 A;  1G8X A;  3DCB A;  4ZHI A;  5LT1 A;  1Q0B A;  4LNU K;  4PJJ A;  4E7S A;  2GRY A;  4PJM A;  1SDM A;  4E7Z A;  3ZCW A;  3PXN A;  4PJN A;  3KIN A;  4AS7 A;  3WPN A;  5HLE A;  1RY6 A;  3L1C A;  1F9U A;  5LT2 A;  4ETP B;  1D0Y A;  3HQD A;  2UYM A;  4H1G A;  4ETP A;  2XAE A;  5GSZ A;  4B7B A;  2PG2 A;  1F9T A;  2Y65 A;  2VB6 A;  4A14 A;  4A5Y A;  1GOJ A;  3KAR A;  4AP0 A;  2VVG A;  3B6U A;  4GKQ A;  3T0Q A;  2X51 A;  3LRE A;  4GKP A;  2ZFM A;  4DBQ A;  2KIN A;  1FMW A;  2V26 A;  4BBG A;  4BXN A;  4DBR A;  1T5C A;  2FL6 A;  1MMA A;  3U06 A;  1LKX A;  3X2T A;  2FME A;  4A1Z A;  2VAS A;  1FMV A;  3ZFD A;  1MMD A;  1D0X A;  2FKY A;  4A50 A;  5LT0 A;  3L9H A;  2Q2Z A;  3K3B A;  1MMG A;  2ZFL A;  4A28 A;  3GBJ A;  2ZFK A;  3DC4 A;  3CJO A;  1D1A A;  2X7D A;  1VOM A;  1CZ7 A; 
#chains in the Genus database with same CATH homology
 1X88 A;  3ZFC A;  2ZFI A;  4PJL A;  3B6V A;  4BN2 A;  5LT4 A;  2IEH A;  2X7C A;  4FRZ A;  1BR4 A;  2FL2 A;  4ZCA A;  2XT3 A;  3KEN A;  4PK4 A;  2X2R A;  1F9W A;  4PFO A;  3COB A;  4ANJ A;  1VFW A;  3NWN A;  4UBF A;  2WOG A;  1BR1 A;  1F9V A;  1VFZ A;  3WRD A;  4Y05 A;  1BR2 A;  2Y5W A;  4HNA K;  2HEH A;  2Q2Y A;  2NCD A;  1D1C A;  2MYS A;  1D1B A;  1MKJ A;  4GKR A;  3BFN A;  1I6I A;  1II6 A;  1VFV A;  4A51 A;  1YRS A;  1V8K A;  1MNE A;  2GM1 A;  1V8J A;  1MMN A;  3K5E A;  5LT3 A;  1I5S A;  4PFP A;  1N6M A;  2ZFJ A;  3H4S A;  3CNZ A;  2UYI A;  1LVK A;  1KK7 A;  2OWM A;  2G1Q A;  1D0Z A;  1VFX A;  2X7E A;  1BG2 A;  1G8X A;  3DCB A;  4ZHI A;  5LT1 A;  1Q0B A;  4LNU K;  4PJJ A;  4E7S A;  2GRY A;  4PJM A;  1SDM A;  4E7Z A;  3ZCW A;  3PXN A;  4PJN A;  3KIN A;  4AS7 A;  3WPN A;  5HLE A;  1RY6 A;  3L1C A;  1F9U A;  5LT2 A;  1D0Y A;  3HQD A;  2UYM A;  4H1G A;  4ETP A;  2XAE A;  5GSZ A;  4B7B A;  2PG2 A;  1F9T A;  2Y65 A;  2VB6 A;  4A14 A;  4A5Y A;  1GOJ A;  3KAR A;  4AP0 A;  2VVG A;  3B6U A;  3T0Q A;  2X51 A;  3LRE A;  2ZFM A;  4DBQ A;  2KIN A;  1FMW A;  2V26 A;  4BBG A;  4BXN A;  4DBR A;  1T5C A;  2FL6 A;  1MMA A;  3U06 A;  1LKX A;  3X2T A;  2FME A;  4A1Z A;  2VAS A;  1FMV A;  3ZFD A;  1MMD A;  1D0X A;  2FKY A;  4A50 A;  5LT0 A;  3L9H A;  2Q2Z A;  3K3B A;  1MMG A;  2ZFL A;  4A28 A;  3GBJ A;  2ZFK A;  3DC4 A;  3CJO A;  1D1A A;  2X7D A;  1VOM A;  1CZ7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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