2X7DA

Crystal structure of human kinesin eg5 in complex with (s)-dimethylenastron
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
350
structure length
335
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 106
structure length 335
sequence length 350
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x7dA00
2Y65A 4PK4A 3CNZA 4AS7A 1BR1A 4GKRA 2ZFLA 3KENA 2OWMA 3BFNA 4PJLA 1G8XA 4H1GA 4PJMA 3WRDA 3PXNA 4DBQA 3HQDA 3CJOA 1I6IA 1VOMA 1BR4A 3ZFCA 3L9HA 1D0YA 3U06A 4A5YA 1MMAA 2ZFMA 2MYSA 1SDMA 1VFVA 2HEHA 4A28A 4A51A 2FL6A 2FMEA 3KINA 4BXNA 3GBJA 5HLEA 4ETPA 5LT3A 2GM1A 1CZ7A 3NWNA 1D1BA 1F9UA 4E7ZA 1KK7A 1D1CA 1X88A 1BR2A 1F9VA 2XAEA 3ZCWA 1F9TA 4PFOA 1D1AA 1RY6A 2Y5WA 2IEHA 1MMGA 1FMWA 2VASA 1FMVA 2ZFJA 1V8KA 1LKXA 5LT4A 3KARA 3B6UA 2V26A 2X2RA 2Q2YA 3DC4A 2G1QA 4ANJA 1VFXA 4BBGA 3DCBA 3H4SA 2KINA 3K5EA 3T0QA 2UYIA 5GSZA 4B7BA 1D0XA 1MKJA 1T5CA 1MMNA 1MMDA 3B6VA 4A1ZA 2WOGA 4A50A 4HNAK 3LREA 5LT1A 1V8JA 3X2TA 4UBFA 4FRZA 1II6A 2X51A 2ZFKA 2X7DA 1BG2A 4PFPA 1VFZA 4ZHIA 3K3BA 2UYMA 4Y05A 4AP0A 1N6MA 2FL2A 2X7EA 2X7CA 2Q2ZA 4E7SA 2GRYA 4DBRA 4A14A 5LT0A 3L1CA 3COBA 1YRSA 2VVGA 3WPNA 2PG2A 3ZFDA 4PJNA 1F9WA 2ZFIA 4LNUK 4BN2A 1VFWA 1GOJA 2FKYA 1MNEA 2XT3A 5LT2A 1Q0BA 2NCDA 1LVKA 4PJJA 2VB6A 4ZCAA 1I5SA 1D0ZA
chains in the Genus database with same CATH superfamily
2Y65A 4PK4A 3CNZA 4AS7A 1BR1A 4GKRA 2ZFLA 3KENA 2OWMA 3BFNA 4PJLA 1G8XA 4H1GA 4PJMA 3WRDA 3PXNA 4DBQA 3HQDA 3CJOA 2O0AA 1I6IA 1VOMA 1BR4A 3ZFCA 3L9HA 1D0YA 3U06A 4A5YA 1MMAA 2ZFMA 2MYSA 1SDMA 1VFVA 2HEHA 4A28A 4A51A 2FL6A 2FMEA 3KINA 4BXNA 3GBJA 5HLEA 4ETPA 5LT3A 2GM1A 1CZ7A 3NWNA 1D1BA 1F9UA 4E7ZA 1KK7A 1D1CA 1X88A 1BR2A 1F9VA 2XAEA 3ZCWA 1F9TA 4PFOA 1D1AA 1RY6A 2Y5WA 2IEHA 1MMGA 1FMWA 2VASA 1FMVA 2ZFJA 1V8KA 1LKXA 5LT4A 3KARA 3B6UA 2V26A 2X2RA 2Q2YA 4GKPA 3DC4A 2G1QA 4ANJA 1VFXA 4BBGA 3DCBA 3H4SA 2KINA 3K5EA 3T0QA 2UYIA 5GSZA 4B7BA 1D0XA 1MKJA 1T5CA 1MMNA 1MMDA 3B6VA 4A1ZA 2WOGA 4A50A 4HNAK 3LREA 5LT1A 1V8JA 3X2TA 4UBFA 4FRZA 1II6A 2X51A 2ZFKA 2X7DA 1BG2A 4PFPA 1VFZA 4ZHIA 3K3BA 2UYMA 4Y05A 4AP0A 1N6MA 2FL2A 2X7EA 2X7CA 2Q2ZA 4E7SA 2GRYA 4DBRA 4A14A 5LT0A 3L1CA 3COBA 1YRSA 2VVGA 3WPNA 2PG2A 3ZFDA 4PJNA 1F9WA 2ZFIA 4LNUK 4BN2A 1VFWA 4ETPB 1GOJA 2FKYA 1MNEA 2XT3A 5LT2A 4GKQA 1Q0BA 2NCDA 1LVKA 4PJJA 2VB6A 4ZCAA 1I5SA 1D0ZA
chains in the Genus database with same CATH topology
2Y65A 4PK4A 3CNZA 4AS7A 1BR1A 4GKRA 2ZFLA 3KENA 2OWMA 3BFNA 4PJLA 1G8XA 4H1GA 4PJMA 3WRDA 3PXNA 4DBQA 3HQDA 3CJOA 1I6IA 1VOMA 1BR4A 3ZFCA 3L9HA 1D0YA 3U06A 4A5YA 1MMAA 2ZFMA 2MYSA 1SDMA 1VFVA 2HEHA 4A28A 4A51A 2FL6A 2FMEA 3KINA 4BXNA 3GBJA 5HLEA 4ETPA 5LT3A 2GM1A 1CZ7A 3NWNA 1D1BA 1F9UA 4E7ZA 1KK7A 1D1CA 1X88A 1BR2A 1F9VA 2XAEA 3ZCWA 1F9TA 4PFOA 1D1AA 1RY6A 2Y5WA 2IEHA 1MMGA 1FMWA 2VASA 1FMVA 2ZFJA 1V8KA 1LKXA 5LT4A 3KARA 3B6UA 2V26A 2X2RA 2Q2YA 3DC4A 2G1QA 4ANJA 1VFXA 4BBGA 3DCBA 3H4SA 2KINA 3K5EA 3T0QA 2UYIA 5GSZA 4B7BA 1D0XA 1MKJA 1T5CA 1MMNA 1MMDA 3B6VA 4A1ZA 2WOGA 4A50A 4HNAK 3LREA 5LT1A 1V8JA 3X2TA 4UBFA 4FRZA 1II6A 2X51A 2ZFKA 2X7DA 1BG2A 4PFPA 1VFZA 4ZHIA 3K3BA 2UYMA 4Y05A 4AP0A 1N6MA 2FL2A 2X7EA 2X7CA 2Q2ZA 4E7SA 2GRYA 4DBRA 4A14A 5LT0A 3L1CA 3COBA 1YRSA 2VVGA 3WPNA 2PG2A 3ZFDA 4PJNA 1F9WA 2ZFIA 4LNUK 4BN2A 1VFWA 1GOJA 2FKYA 1MNEA 2XT3A 5LT2A 1Q0BA 2NCDA 1LVKA 4PJJA 2VB6A 4ZCAA 1I5SA 1D0ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Y65 A;  4PK4 A;  3CNZ A;  4AS7 A;  1BR1 A;  4GKR A;  2ZFL A;  3KEN A;  2OWM A;  3BFN A;  4PJL A;  1G8X A;  4H1G A;  4PJM A;  3WRD A;  3PXN A;  4DBQ A;  3HQD A;  3CJO A;  1I6I A;  1VOM A;  1BR4 A;  3ZFC A;  3L9H A;  1D0Y A;  3U06 A;  4A5Y A;  1MMA A;  2ZFM A;  2MYS A;  1SDM A;  1VFV A;  2HEH A;  4A28 A;  4A51 A;  2FL6 A;  2FME A;  3KIN A;  4BXN A;  3GBJ A;  5HLE A;  4ETP A;  5LT3 A;  2GM1 A;  1CZ7 A;  3NWN A;  1D1B A;  1F9U A;  4E7Z A;  1KK7 A;  1D1C A;  1X88 A;  1BR2 A;  1F9V A;  2XAE A;  3ZCW A;  1F9T A;  4PFO A;  1D1A A;  1RY6 A;  2Y5W A;  2IEH A;  1MMG A;  1FMW A;  2VAS A;  1FMV A;  2ZFJ A;  1V8K A;  1LKX A;  5LT4 A;  3KAR A;  3B6U A;  2V26 A;  2X2R A;  2Q2Y A;  3DC4 A;  2G1Q A;  4ANJ A;  1VFX A;  4BBG A;  3DCB A;  3H4S A;  2KIN A;  3K5E A;  3T0Q A;  2UYI A;  5GSZ A;  4B7B A;  1D0X A;  1MKJ A;  1T5C A;  1MMN A;  1MMD A;  3B6V A;  4A1Z A;  2WOG A;  4A50 A;  4HNA K;  3LRE A;  5LT1 A;  1V8J A;  3X2T A;  4UBF A;  4FRZ A;  1II6 A;  2X51 A;  2ZFK A;  2X7D A;  1BG2 A;  4PFP A;  1VFZ A;  4ZHI A;  3K3B A;  2UYM A;  4Y05 A;  4AP0 A;  1N6M A;  2FL2 A;  2X7E A;  2X7C A;  2Q2Z A;  4E7S A;  2GRY A;  4DBR A;  4A14 A;  5LT0 A;  3L1C A;  3COB A;  1YRS A;  2VVG A;  3WPN A;  2PG2 A;  3ZFD A;  4PJN A;  1F9W A;  2ZFI A;  4LNU K;  4BN2 A;  1VFW A;  1GOJ A;  2FKY A;  1MNE A;  2XT3 A;  5LT2 A;  1Q0B A;  2NCD A;  1LVK A;  4PJJ A;  2VB6 A;  4ZCA A;  1I5S A;  1D0Z A; 
#chains in the Genus database with same CATH topology
 2Y65 A;  4PK4 A;  3CNZ A;  4AS7 A;  1BR1 A;  4GKR A;  2ZFL A;  3KEN A;  2OWM A;  3BFN A;  4PJL A;  1G8X A;  4H1G A;  4PJM A;  3WRD A;  3PXN A;  4DBQ A;  3HQD A;  3CJO A;  2O0A A;  1I6I A;  1VOM A;  1BR4 A;  3ZFC A;  3L9H A;  1D0Y A;  3U06 A;  4A5Y A;  1MMA A;  2ZFM A;  2MYS A;  1SDM A;  1VFV A;  2HEH A;  4A28 A;  4A51 A;  2FL6 A;  2FME A;  3KIN A;  4BXN A;  3GBJ A;  5HLE A;  4ETP A;  5LT3 A;  2GM1 A;  1CZ7 A;  3NWN A;  1D1B A;  1F9U A;  4E7Z A;  1KK7 A;  1D1C A;  1X88 A;  1BR2 A;  1F9V A;  2XAE A;  3ZCW A;  1F9T A;  4PFO A;  1D1A A;  1RY6 A;  2Y5W A;  2IEH A;  1MMG A;  1FMW A;  2VAS A;  1FMV A;  2ZFJ A;  1V8K A;  1LKX A;  5LT4 A;  3KAR A;  3B6U A;  2V26 A;  2X2R A;  2Q2Y A;  4GKP A;  3DC4 A;  2G1Q A;  4ANJ A;  1VFX A;  4BBG A;  3DCB A;  3H4S A;  2KIN A;  3K5E A;  3T0Q A;  2UYI A;  5GSZ A;  4B7B A;  1D0X A;  1MKJ A;  1T5C A;  1MMN A;  1MMD A;  3B6V A;  4A1Z A;  2WOG A;  4A50 A;  4HNA K;  3LRE A;  5LT1 A;  1V8J A;  3X2T A;  4UBF A;  4FRZ A;  1II6 A;  2X51 A;  2ZFK A;  2X7D A;  1BG2 A;  4PFP A;  1VFZ A;  4ZHI A;  3K3B A;  2UYM A;  4Y05 A;  4AP0 A;  1N6M A;  2FL2 A;  2X7E A;  2X7C A;  2Q2Z A;  4E7S A;  2GRY A;  4DBR A;  4A14 A;  5LT0 A;  3L1C A;  3COB A;  1YRS A;  2VVG A;  3WPN A;  2PG2 A;  3ZFD A;  4PJN A;  1F9W A;  2ZFI A;  4LNU K;  4BN2 A;  1VFW A;  4ETP B;  1GOJ A;  2FKY A;  1MNE A;  2XT3 A;  5LT2 A;  4GKQ A;  1Q0B A;  2NCD A;  1LVK A;  4PJJ A;  2VB6 A;  4ZCA A;  1I5S A;  1D0Z A; 
#chains in the Genus database with same CATH homology
 2Y65 A;  4PK4 A;  3CNZ A;  4AS7 A;  1BR1 A;  4GKR A;  2ZFL A;  3KEN A;  2OWM A;  3BFN A;  4PJL A;  1G8X A;  4H1G A;  4PJM A;  3WRD A;  3PXN A;  4DBQ A;  3HQD A;  3CJO A;  1I6I A;  1VOM A;  1BR4 A;  3ZFC A;  3L9H A;  1D0Y A;  3U06 A;  4A5Y A;  1MMA A;  2ZFM A;  2MYS A;  1SDM A;  1VFV A;  2HEH A;  4A28 A;  4A51 A;  2FL6 A;  2FME A;  3KIN A;  4BXN A;  3GBJ A;  5HLE A;  4ETP A;  5LT3 A;  2GM1 A;  1CZ7 A;  3NWN A;  1D1B A;  1F9U A;  4E7Z A;  1KK7 A;  1D1C A;  1X88 A;  1BR2 A;  1F9V A;  2XAE A;  3ZCW A;  1F9T A;  4PFO A;  1D1A A;  1RY6 A;  2Y5W A;  2IEH A;  1MMG A;  1FMW A;  2VAS A;  1FMV A;  2ZFJ A;  1V8K A;  1LKX A;  5LT4 A;  3KAR A;  3B6U A;  2V26 A;  2X2R A;  2Q2Y A;  3DC4 A;  2G1Q A;  4ANJ A;  1VFX A;  4BBG A;  3DCB A;  3H4S A;  2KIN A;  3K5E A;  3T0Q A;  2UYI A;  5GSZ A;  4B7B A;  1D0X A;  1MKJ A;  1T5C A;  1MMN A;  1MMD A;  3B6V A;  4A1Z A;  2WOG A;  4A50 A;  4HNA K;  3LRE A;  5LT1 A;  1V8J A;  3X2T A;  4UBF A;  4FRZ A;  1II6 A;  2X51 A;  2ZFK A;  2X7D A;  1BG2 A;  4PFP A;  1VFZ A;  4ZHI A;  3K3B A;  2UYM A;  4Y05 A;  4AP0 A;  1N6M A;  2FL2 A;  2X7E A;  2X7C A;  2Q2Z A;  4E7S A;  2GRY A;  4DBR A;  4A14 A;  5LT0 A;  3L1C A;  3COB A;  1YRS A;  2VVG A;  3WPN A;  2PG2 A;  3ZFD A;  4PJN A;  1F9W A;  2ZFI A;  4LNU K;  4BN2 A;  1VFW A;  1GOJ A;  2FKY A;  1MNE A;  2XT3 A;  5LT2 A;  1Q0B A;  2NCD A;  1LVK A;  4PJJ A;  2VB6 A;  4ZCA A;  1I5S A;  1D0Z A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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