2X7DA

Crystal structure of human kinesin eg5 in complex with (s)-dimethylenastron
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
350
structure length
335
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cell cycle
molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
pubmed doi rcsb
source organism Homo sapiens
total genus 106
structure length 335
sequence length 350
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x7dA00
2HEHA 3KARA 4ANJA 2G1QA 1VFVA 3B6VA 1I6IA 2ZFMA 1V8KA 3U06A 2FKYA 1F9VA 1VOMA 3WRDA 2Y65A 1D1CA 1F9UA 4DBQA 2IEHA 2Y5WA 4GKRA 5HLEA 1II6A 4B7BA 3B6UA 3BFNA 5LT1A 4E7ZA 3GBJA 1V8JA 3K3BA 1MMNA 4A50A 4UBFA 4H1GA 4A28A 4BXNA 5LT4A 1D0ZA 4PJJA 3ZCWA 3LREA 4A51A 1X88A 2X7CA 2Q2YA 4LNUK 4FRZA 4PJMA 5LT3A 1T5CA 4Y05A 4AS7A 4ETPA 2ZFKA 2VASA 2VB6A 1VFZA 4PFOA 3ZFDA 2UYIA 3H4SA 2FL6A 1YRSA 2FL2A 4PJNA 1MMDA 3X2TA 2FMEA 3HQDA 4HNAK 1Q0BA 3T0QA 1D1AA 2MYSA 2GM1A 2ZFJA 2X7EA 3KENA 5LT2A 2WOGA 1BR1A 4DBRA 1FMWA 4A5YA 2Q2ZA 1MMAA 1LVKA 2PG2A 3NWNA 4E7SA 3COBA 2KINA 3CJOA 1VFWA 2X2RA 1D1BA 4AP0A 1VFXA 1FMVA 1MKJA 3DCBA 1CZ7A 1BG2A 1I5SA 2ZFLA 3KINA 1F9TA 1D0XA 2X51A 4PJLA 3L9HA 2NCDA 2OWMA 1RY6A 1MMGA 2ZFIA 2V26A 1BR4A 3L1CA 3ZFCA 4PFPA 3WPNA 1BR2A 3K5EA 2XAEA 3DC4A 4BBGA 1F9WA 5GSZA 2UYMA 1N6MA 4A14A 1GOJA 4BN2A 5LT0A 4ZCAA 1G8XA 1D0YA 1SDMA 2GRYA 2XT3A 1LKXA 1MNEA 2VVGA 2X7DA 3PXNA 4PK4A 1KK7A 4A1ZA 4ZHIA 3CNZA
chains in the Genus database with same CATH superfamily
2HEHA 3KARA 4ANJA 4GKPA 2G1QA 1VFVA 3B6VA 1I6IA 2ZFMA 1V8KA 3U06A 2FKYA 1F9VA 1VOMA 3WRDA 2Y65A 1D1CA 1F9UA 4DBQA 2IEHA 2Y5WA 4GKRA 5HLEA 1II6A 4B7BA 3B6UA 3BFNA 5LT1A 4GKQA 3GBJA 1V8JA 3K3BA 4ETPB 4E7ZA 1MMNA 4A50A 4UBFA 4H1GA 4A28A 4BXNA 5LT4A 1D0ZA 4PJJA 3ZCWA 3LREA 4A51A 1X88A 2X7CA 2Q2YA 4LNUK 4FRZA 4PJMA 5LT3A 1T5CA 4Y05A 4AS7A 4ETPA 2ZFKA 2VASA 2VB6A 1VFZA 4PFOA 3ZFDA 2UYIA 3H4SA 2FL6A 1YRSA 2FL2A 4PJNA 1MMDA 3X2TA 2FMEA 3HQDA 4HNAK 1Q0BA 3T0QA 1D1AA 2MYSA 2GM1A 2ZFJA 2X7EA 3KENA 5LT2A 2WOGA 1BR1A 4DBRA 1FMWA 4A5YA 2Q2ZA 1MMAA 1LVKA 2PG2A 3NWNA 4E7SA 3COBA 2KINA 3CJOA 1VFWA 2X2RA 1D1BA 4AP0A 1VFXA 1FMVA 1MKJA 3DCBA 1CZ7A 1BG2A 1I5SA 2ZFLA 3KINA 1F9TA 1D0XA 2X51A 4PJLA 3L9HA 2NCDA 2OWMA 1RY6A 1MMGA 2ZFIA 2V26A 1BR4A 3L1CA 3ZFCA 4PFPA 3WPNA 1BR2A 3K5EA 2XAEA 3DC4A 4BBGA 1F9WA 5GSZA 2UYMA 1N6MA 2O0AA 1GOJA 4A14A 4BN2A 5LT0A 4ZCAA 1G8XA 1D0YA 1SDMA 2GRYA 2XT3A 1LKXA 1MNEA 2VVGA 2X7DA 3PXNA 4PK4A 1KK7A 4A1ZA 4ZHIA 3CNZA
chains in the Genus database with same CATH topology
2HEHA 3KARA 4ANJA 2G1QA 1VFVA 3B6VA 1I6IA 2ZFMA 1V8KA 3U06A 2FKYA 1F9VA 1VOMA 3WRDA 2Y65A 1D1CA 1F9UA 4DBQA 2IEHA 2Y5WA 4GKRA 5HLEA 1II6A 4B7BA 3B6UA 3BFNA 5LT1A 4E7ZA 3GBJA 1V8JA 3K3BA 1MMNA 4A50A 4UBFA 4H1GA 4A28A 4BXNA 5LT4A 1D0ZA 4PJJA 3ZCWA 3LREA 4A51A 1X88A 2X7CA 2Q2YA 4LNUK 4FRZA 4PJMA 5LT3A 1T5CA 4Y05A 4AS7A 4ETPA 2ZFKA 2VASA 2VB6A 1VFZA 4PFOA 3ZFDA 2UYIA 3H4SA 2FL6A 1YRSA 2FL2A 4PJNA 1MMDA 3X2TA 2FMEA 3HQDA 4HNAK 1Q0BA 3T0QA 1D1AA 2MYSA 2GM1A 2ZFJA 2X7EA 3KENA 5LT2A 2WOGA 1BR1A 4DBRA 1FMWA 4A5YA 2Q2ZA 1MMAA 1LVKA 2PG2A 3NWNA 4E7SA 3COBA 2KINA 3CJOA 1VFWA 2X2RA 1D1BA 4AP0A 1VFXA 1FMVA 1MKJA 3DCBA 1CZ7A 1BG2A 1I5SA 2ZFLA 3KINA 1F9TA 1D0XA 2X51A 4PJLA 3L9HA 2NCDA 2OWMA 1RY6A 1MMGA 2ZFIA 2V26A 1BR4A 3L1CA 3ZFCA 4PFPA 3WPNA 1BR2A 3K5EA 2XAEA 3DC4A 4BBGA 1F9WA 5GSZA 2UYMA 1N6MA 4A14A 1GOJA 4BN2A 5LT0A 4ZCAA 1G8XA 1D0YA 1SDMA 2GRYA 2XT3A 1LKXA 1MNEA 2VVGA 2X7DA 3PXNA 4PK4A 1KK7A 4A1ZA 4ZHIA 3CNZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HEH A;  3KAR A;  4ANJ A;  2G1Q A;  1VFV A;  3B6V A;  1I6I A;  2ZFM A;  1V8K A;  3U06 A;  2FKY A;  1F9V A;  1VOM A;  3WRD A;  2Y65 A;  1D1C A;  1F9U A;  4DBQ A;  2IEH A;  2Y5W A;  4GKR A;  5HLE A;  1II6 A;  4B7B A;  3B6U A;  3BFN A;  5LT1 A;  4E7Z A;  3GBJ A;  1V8J A;  3K3B A;  1MMN A;  4A50 A;  4UBF A;  4H1G A;  4A28 A;  4BXN A;  5LT4 A;  1D0Z A;  4PJJ A;  3ZCW A;  3LRE A;  4A51 A;  1X88 A;  2X7C A;  2Q2Y A;  4LNU K;  4FRZ A;  4PJM A;  5LT3 A;  1T5C A;  4Y05 A;  4AS7 A;  4ETP A;  2ZFK A;  2VAS A;  2VB6 A;  1VFZ A;  4PFO A;  3ZFD A;  2UYI A;  3H4S A;  2FL6 A;  1YRS A;  2FL2 A;  4PJN A;  1MMD A;  3X2T A;  2FME A;  3HQD A;  4HNA K;  1Q0B A;  3T0Q A;  1D1A A;  2MYS A;  2GM1 A;  2ZFJ A;  2X7E A;  3KEN A;  5LT2 A;  2WOG A;  1BR1 A;  4DBR A;  1FMW A;  4A5Y A;  2Q2Z A;  1MMA A;  1LVK A;  2PG2 A;  3NWN A;  4E7S A;  3COB A;  2KIN A;  3CJO A;  1VFW A;  2X2R A;  1D1B A;  4AP0 A;  1VFX A;  1FMV A;  1MKJ A;  3DCB A;  1CZ7 A;  1BG2 A;  1I5S A;  2ZFL A;  3KIN A;  1F9T A;  1D0X A;  2X51 A;  4PJL A;  3L9H A;  2NCD A;  2OWM A;  1RY6 A;  1MMG A;  2ZFI A;  2V26 A;  1BR4 A;  3L1C A;  3ZFC A;  4PFP A;  3WPN A;  1BR2 A;  3K5E A;  2XAE A;  3DC4 A;  4BBG A;  1F9W A;  5GSZ A;  2UYM A;  1N6M A;  4A14 A;  1GOJ A;  4BN2 A;  5LT0 A;  4ZCA A;  1G8X A;  1D0Y A;  1SDM A;  2GRY A;  2XT3 A;  1LKX A;  1MNE A;  2VVG A;  2X7D A;  3PXN A;  4PK4 A;  1KK7 A;  4A1Z A;  4ZHI A;  3CNZ A; 
#chains in the Genus database with same CATH topology
 2HEH A;  3KAR A;  4ANJ A;  4GKP A;  2G1Q A;  1VFV A;  3B6V A;  1I6I A;  2ZFM A;  1V8K A;  3U06 A;  2FKY A;  1F9V A;  1VOM A;  3WRD A;  2Y65 A;  1D1C A;  1F9U A;  4DBQ A;  2IEH A;  2Y5W A;  4GKR A;  5HLE A;  1II6 A;  4B7B A;  3B6U A;  3BFN A;  5LT1 A;  4GKQ A;  3GBJ A;  1V8J A;  3K3B A;  4ETP B;  4E7Z A;  1MMN A;  4A50 A;  4UBF A;  4H1G A;  4A28 A;  4BXN A;  5LT4 A;  1D0Z A;  4PJJ A;  3ZCW A;  3LRE A;  4A51 A;  1X88 A;  2X7C A;  2Q2Y A;  4LNU K;  4FRZ A;  4PJM A;  5LT3 A;  1T5C A;  4Y05 A;  4AS7 A;  4ETP A;  2ZFK A;  2VAS A;  2VB6 A;  1VFZ A;  4PFO A;  3ZFD A;  2UYI A;  3H4S A;  2FL6 A;  1YRS A;  2FL2 A;  4PJN A;  1MMD A;  3X2T A;  2FME A;  3HQD A;  4HNA K;  1Q0B A;  3T0Q A;  1D1A A;  2MYS A;  2GM1 A;  2ZFJ A;  2X7E A;  3KEN A;  5LT2 A;  2WOG A;  1BR1 A;  4DBR A;  1FMW A;  4A5Y A;  2Q2Z A;  1MMA A;  1LVK A;  2PG2 A;  3NWN A;  4E7S A;  3COB A;  2KIN A;  3CJO A;  1VFW A;  2X2R A;  1D1B A;  4AP0 A;  1VFX A;  1FMV A;  1MKJ A;  3DCB A;  1CZ7 A;  1BG2 A;  1I5S A;  2ZFL A;  3KIN A;  1F9T A;  1D0X A;  2X51 A;  4PJL A;  3L9H A;  2NCD A;  2OWM A;  1RY6 A;  1MMG A;  2ZFI A;  2V26 A;  1BR4 A;  3L1C A;  3ZFC A;  4PFP A;  3WPN A;  1BR2 A;  3K5E A;  2XAE A;  3DC4 A;  4BBG A;  1F9W A;  5GSZ A;  2UYM A;  1N6M A;  2O0A A;  1GOJ A;  4A14 A;  4BN2 A;  5LT0 A;  4ZCA A;  1G8X A;  1D0Y A;  1SDM A;  2GRY A;  2XT3 A;  1LKX A;  1MNE A;  2VVG A;  2X7D A;  3PXN A;  4PK4 A;  1KK7 A;  4A1Z A;  4ZHI A;  3CNZ A; 
#chains in the Genus database with same CATH homology
 2HEH A;  3KAR A;  4ANJ A;  2G1Q A;  1VFV A;  3B6V A;  1I6I A;  2ZFM A;  1V8K A;  3U06 A;  2FKY A;  1F9V A;  1VOM A;  3WRD A;  2Y65 A;  1D1C A;  1F9U A;  4DBQ A;  2IEH A;  2Y5W A;  4GKR A;  5HLE A;  1II6 A;  4B7B A;  3B6U A;  3BFN A;  5LT1 A;  4E7Z A;  3GBJ A;  1V8J A;  3K3B A;  1MMN A;  4A50 A;  4UBF A;  4H1G A;  4A28 A;  4BXN A;  5LT4 A;  1D0Z A;  4PJJ A;  3ZCW A;  3LRE A;  4A51 A;  1X88 A;  2X7C A;  2Q2Y A;  4LNU K;  4FRZ A;  4PJM A;  5LT3 A;  1T5C A;  4Y05 A;  4AS7 A;  4ETP A;  2ZFK A;  2VAS A;  2VB6 A;  1VFZ A;  4PFO A;  3ZFD A;  2UYI A;  3H4S A;  2FL6 A;  1YRS A;  2FL2 A;  4PJN A;  1MMD A;  3X2T A;  2FME A;  3HQD A;  4HNA K;  1Q0B A;  3T0Q A;  1D1A A;  2MYS A;  2GM1 A;  2ZFJ A;  2X7E A;  3KEN A;  5LT2 A;  2WOG A;  1BR1 A;  4DBR A;  1FMW A;  4A5Y A;  2Q2Z A;  1MMA A;  1LVK A;  2PG2 A;  3NWN A;  4E7S A;  3COB A;  2KIN A;  3CJO A;  1VFW A;  2X2R A;  1D1B A;  4AP0 A;  1VFX A;  1FMV A;  1MKJ A;  3DCB A;  1CZ7 A;  1BG2 A;  1I5S A;  2ZFL A;  3KIN A;  1F9T A;  1D0X A;  2X51 A;  4PJL A;  3L9H A;  2NCD A;  2OWM A;  1RY6 A;  1MMG A;  2ZFI A;  2V26 A;  1BR4 A;  3L1C A;  3ZFC A;  4PFP A;  3WPN A;  1BR2 A;  3K5E A;  2XAE A;  3DC4 A;  4BBG A;  1F9W A;  5GSZ A;  2UYM A;  1N6M A;  4A14 A;  1GOJ A;  4BN2 A;  5LT0 A;  4ZCA A;  1G8X A;  1D0Y A;  1SDM A;  2GRY A;  2XT3 A;  1LKX A;  1MNE A;  2VVG A;  2X7D A;  3PXN A;  4PK4 A;  1KK7 A;  4A1Z A;  4ZHI A;  3CNZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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