2FL6A

Crystal structure of ksp in complex with inhibitor 6
Total Genus 103
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
103
sequence length
345
structure length
330
Chain Sequence
b'NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Kinesin-like protein KIF11
publication title Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 103
structure length 330
sequence length 345
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-01-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2fl6A00
1D0YA 1VFWA 5LT2A 4E7SA 5LT0A 4PJJA 1F9VA 1F9UA 3LREA 1V8KA 4AS7A 2VASA 1BR4A 4Y05A 4PK4A 5LT4A 4PJNA 1D1AA 5GSZA 2ZFJA 2Y5WA 4B7BA 2ZFKA 1I6IA 5HLEA 2X7EA 1FMWA 3WRDA 4BBGA 4A5YA 1MMNA 4PJMA 3ZFCA 1II6A 3B6UA 4FRZA 4GKRA 1V8JA 3GBJA 4A50A 2GRYA 3K3BA 2X51A 1I5SA 4PFPA 3WPNA 3HQDA 1YRSA 1VFZA 1BG2A 2ZFLA 4DBQA 1BR2A 4PJLA 2Q2ZA 3CJOA 2XAEA 4A51A 2X2RA 3T0QA 5LT3A 1FMVA 1VOMA 4A28A 1F9WA 4E7ZA 1N6MA 4LNUK 1D0ZA 2FMEA 2HEHA 1RY6A 2UYIA 2UYMA 4ANJA 4ZHIA 1VFVA 4BN2A 1F9TA 3L1CA 4A14A 2KINA 3BFNA 1MKJA 2Q2YA 5LT1A 3PXNA 1G8XA 2X7CA 1MMAA 1Q0BA 4AP0A 3X2TA 1SDMA 3CNZA 2OWMA 3ZCWA 1MMGA 3COBA 3H4SA 3L9HA 3ZFDA 1MNEA 1BR1A 1KK7A 1GOJA 2FL6A 4UBFA 1D1CA 2V26A 2VVGA 3DC4A 3DCBA 4HNAK 1T5CA 1LVKA 2GM1A 4ZCAA 3B6VA 3NWNA 2ZFMA 2WOGA 2FL2A 2IEHA 3KARA 3U06A 1LKXA 3K5EA 4ETPA 3KINA 1MMDA 4PFOA 1CZ7A 2XT3A 3KENA 2ZFIA 1D0XA 2FKYA 2PG2A 1D1BA 2NCDA 2Y65A 2X7DA 4A1ZA 1VFXA 2MYSA 4H1GA 4DBRA 4BXNA 1X88A 2VB6A 2G1QA
chains in the Genus database with same CATH superfamily
1D0YA 1VFWA 5LT2A 4E7SA 5LT0A 4PJJA 1F9VA 1F9UA 3LREA 1V8KA 4AS7A 2VASA 1BR4A 4Y05A 4PK4A 5LT4A 4PJNA 1D1AA 5GSZA 2ZFJA 2Y5WA 4B7BA 2ZFKA 1I6IA 5HLEA 2X7EA 1FMWA 3WRDA 4BBGA 4A5YA 1MMNA 4PJMA 3ZFCA 1II6A 3B6UA 4FRZA 4GKRA 1V8JA 3GBJA 4A50A 2GRYA 3K3BA 2X51A 1I5SA 4PFPA 3WPNA 3HQDA 1YRSA 1VFZA 1BG2A 2ZFLA 4DBQA 1BR2A 2O0AA 4PJLA 2Q2ZA 3CJOA 2XAEA 4A51A 2X2RA 3T0QA 5LT3A 1FMVA 1VOMA 4A28A 1F9WA 4E7ZA 1N6MA 4LNUK 1D0ZA 2FMEA 2HEHA 1RY6A 2UYIA 2UYMA 4ANJA 4ZHIA 1VFVA 4BN2A 4GKPA 1F9TA 3L1CA 4A14A 2KINA 3BFNA 1MKJA 2Q2YA 5LT1A 3PXNA 1G8XA 2X7CA 1MMAA 1Q0BA 4AP0A 4ETPB 3X2TA 1SDMA 3CNZA 2OWMA 3ZCWA 1MMGA 3COBA 3H4SA 3L9HA 3ZFDA 1MNEA 1BR1A 1KK7A 1GOJA 4GKQA 2FL6A 4UBFA 1D1CA 2V26A 2VVGA 3DC4A 3DCBA 4HNAK 1T5CA 1LVKA 2GM1A 4ZCAA 3B6VA 3NWNA 2ZFMA 2WOGA 2FL2A 2IEHA 3KARA 3U06A 1LKXA 3K5EA 4ETPA 3KINA 1MMDA 4PFOA 1CZ7A 2XT3A 3KENA 2ZFIA 1D0XA 2FKYA 2PG2A 1D1BA 2NCDA 2Y65A 2X7DA 4A1ZA 1VFXA 2MYSA 4H1GA 4DBRA 4BXNA 1X88A 2VB6A 2G1QA
chains in the Genus database with same CATH topology
1D0YA 1VFWA 5LT2A 4E7SA 5LT0A 4PJJA 1F9VA 1F9UA 3LREA 1V8KA 4AS7A 2VASA 1BR4A 4Y05A 4PK4A 5LT4A 4PJNA 1D1AA 5GSZA 2ZFJA 2Y5WA 4B7BA 2ZFKA 1I6IA 5HLEA 2X7EA 1FMWA 3WRDA 4BBGA 4A5YA 1MMNA 4PJMA 3ZFCA 1II6A 3B6UA 4FRZA 4GKRA 1V8JA 3GBJA 4A50A 2GRYA 3K3BA 2X51A 1I5SA 4PFPA 3WPNA 3HQDA 1YRSA 1VFZA 1BG2A 2ZFLA 4DBQA 1BR2A 4PJLA 2Q2ZA 3CJOA 2XAEA 4A51A 2X2RA 3T0QA 5LT3A 1FMVA 1VOMA 4A28A 1F9WA 4E7ZA 1N6MA 4LNUK 1D0ZA 2FMEA 2HEHA 1RY6A 2UYIA 2UYMA 4ANJA 4ZHIA 1VFVA 4BN2A 1F9TA 3L1CA 4A14A 2KINA 3BFNA 1MKJA 2Q2YA 5LT1A 3PXNA 1G8XA 2X7CA 1MMAA 1Q0BA 4AP0A 3X2TA 1SDMA 3CNZA 2OWMA 3ZCWA 1MMGA 3COBA 3H4SA 3L9HA 3ZFDA 1MNEA 1BR1A 1KK7A 1GOJA 2FL6A 4UBFA 1D1CA 2V26A 2VVGA 3DC4A 3DCBA 4HNAK 1T5CA 1LVKA 2GM1A 4ZCAA 3B6VA 3NWNA 2ZFMA 2WOGA 2FL2A 2IEHA 3KARA 3U06A 1LKXA 3K5EA 4ETPA 3KINA 1MMDA 4PFOA 1CZ7A 2XT3A 3KENA 2ZFIA 1D0XA 2FKYA 2PG2A 1D1BA 2NCDA 2Y65A 2X7DA 4A1ZA 1VFXA 2MYSA 4H1GA 4DBRA 4BXNA 1X88A 2VB6A 2G1QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1D0Y A;  1VFW A;  5LT2 A;  4E7S A;  5LT0 A;  4PJJ A;  1F9V A;  1F9U A;  3LRE A;  1V8K A;  4AS7 A;  2VAS A;  1BR4 A;  4Y05 A;  4PK4 A;  5LT4 A;  4PJN A;  1D1A A;  5GSZ A;  2ZFJ A;  2Y5W A;  4B7B A;  2ZFK A;  1I6I A;  5HLE A;  2X7E A;  1FMW A;  3WRD A;  4BBG A;  4A5Y A;  1MMN A;  4PJM A;  3ZFC A;  1II6 A;  3B6U A;  4FRZ A;  4GKR A;  1V8J A;  3GBJ A;  4A50 A;  2GRY A;  3K3B A;  2X51 A;  1I5S A;  4PFP A;  3WPN A;  3HQD A;  1YRS A;  1VFZ A;  1BG2 A;  2ZFL A;  4DBQ A;  1BR2 A;  4PJL A;  2Q2Z A;  3CJO A;  2XAE A;  4A51 A;  2X2R A;  3T0Q A;  5LT3 A;  1FMV A;  1VOM A;  4A28 A;  1F9W A;  4E7Z A;  1N6M A;  4LNU K;  1D0Z A;  2FME A;  2HEH A;  1RY6 A;  2UYI A;  2UYM A;  4ANJ A;  4ZHI A;  1VFV A;  4BN2 A;  1F9T A;  3L1C A;  4A14 A;  2KIN A;  3BFN A;  1MKJ A;  2Q2Y A;  5LT1 A;  3PXN A;  1G8X A;  2X7C A;  1MMA A;  1Q0B A;  4AP0 A;  3X2T A;  1SDM A;  3CNZ A;  2OWM A;  3ZCW A;  1MMG A;  3COB A;  3H4S A;  3L9H A;  3ZFD A;  1MNE A;  1BR1 A;  1KK7 A;  1GOJ A;  2FL6 A;  4UBF A;  1D1C A;  2V26 A;  2VVG A;  3DC4 A;  3DCB A;  4HNA K;  1T5C A;  1LVK A;  2GM1 A;  4ZCA A;  3B6V A;  3NWN A;  2ZFM A;  2WOG A;  2FL2 A;  2IEH A;  3KAR A;  3U06 A;  1LKX A;  3K5E A;  4ETP A;  3KIN A;  1MMD A;  4PFO A;  1CZ7 A;  2XT3 A;  3KEN A;  2ZFI A;  1D0X A;  2FKY A;  2PG2 A;  1D1B A;  2NCD A;  2Y65 A;  2X7D A;  4A1Z A;  1VFX A;  2MYS A;  4H1G A;  4DBR A;  4BXN A;  1X88 A;  2VB6 A;  2G1Q A; 
#chains in the Genus database with same CATH topology
 1D0Y A;  1VFW A;  5LT2 A;  4E7S A;  5LT0 A;  4PJJ A;  1F9V A;  1F9U A;  3LRE A;  1V8K A;  4AS7 A;  2VAS A;  1BR4 A;  4Y05 A;  4PK4 A;  5LT4 A;  4PJN A;  1D1A A;  5GSZ A;  2ZFJ A;  2Y5W A;  4B7B A;  2ZFK A;  1I6I A;  5HLE A;  2X7E A;  1FMW A;  3WRD A;  4BBG A;  4A5Y A;  1MMN A;  4PJM A;  3ZFC A;  1II6 A;  3B6U A;  4FRZ A;  4GKR A;  1V8J A;  3GBJ A;  4A50 A;  2GRY A;  3K3B A;  2X51 A;  1I5S A;  4PFP A;  3WPN A;  3HQD A;  1YRS A;  1VFZ A;  1BG2 A;  2ZFL A;  4DBQ A;  1BR2 A;  2O0A A;  4PJL A;  2Q2Z A;  3CJO A;  2XAE A;  4A51 A;  2X2R A;  3T0Q A;  5LT3 A;  1FMV A;  1VOM A;  4A28 A;  1F9W A;  4E7Z A;  1N6M A;  4LNU K;  1D0Z A;  2FME A;  2HEH A;  1RY6 A;  2UYI A;  2UYM A;  4ANJ A;  4ZHI A;  1VFV A;  4BN2 A;  4GKP A;  1F9T A;  3L1C A;  4A14 A;  2KIN A;  3BFN A;  1MKJ A;  2Q2Y A;  5LT1 A;  3PXN A;  1G8X A;  2X7C A;  1MMA A;  1Q0B A;  4AP0 A;  4ETP B;  3X2T A;  1SDM A;  3CNZ A;  2OWM A;  3ZCW A;  1MMG A;  3COB A;  3H4S A;  3L9H A;  3ZFD A;  1MNE A;  1BR1 A;  1KK7 A;  1GOJ A;  4GKQ A;  2FL6 A;  4UBF A;  1D1C A;  2V26 A;  2VVG A;  3DC4 A;  3DCB A;  4HNA K;  1T5C A;  1LVK A;  2GM1 A;  4ZCA A;  3B6V A;  3NWN A;  2ZFM A;  2WOG A;  2FL2 A;  2IEH A;  3KAR A;  3U06 A;  1LKX A;  3K5E A;  4ETP A;  3KIN A;  1MMD A;  4PFO A;  1CZ7 A;  2XT3 A;  3KEN A;  2ZFI A;  1D0X A;  2FKY A;  2PG2 A;  1D1B A;  2NCD A;  2Y65 A;  2X7D A;  4A1Z A;  1VFX A;  2MYS A;  4H1G A;  4DBR A;  4BXN A;  1X88 A;  2VB6 A;  2G1Q A; 
#chains in the Genus database with same CATH homology
 1D0Y A;  1VFW A;  5LT2 A;  4E7S A;  5LT0 A;  4PJJ A;  1F9V A;  1F9U A;  3LRE A;  1V8K A;  4AS7 A;  2VAS A;  1BR4 A;  4Y05 A;  4PK4 A;  5LT4 A;  4PJN A;  1D1A A;  5GSZ A;  2ZFJ A;  2Y5W A;  4B7B A;  2ZFK A;  1I6I A;  5HLE A;  2X7E A;  1FMW A;  3WRD A;  4BBG A;  4A5Y A;  1MMN A;  4PJM A;  3ZFC A;  1II6 A;  3B6U A;  4FRZ A;  4GKR A;  1V8J A;  3GBJ A;  4A50 A;  2GRY A;  3K3B A;  2X51 A;  1I5S A;  4PFP A;  3WPN A;  3HQD A;  1YRS A;  1VFZ A;  1BG2 A;  2ZFL A;  4DBQ A;  1BR2 A;  4PJL A;  2Q2Z A;  3CJO A;  2XAE A;  4A51 A;  2X2R A;  3T0Q A;  5LT3 A;  1FMV A;  1VOM A;  4A28 A;  1F9W A;  4E7Z A;  1N6M A;  4LNU K;  1D0Z A;  2FME A;  2HEH A;  1RY6 A;  2UYI A;  2UYM A;  4ANJ A;  4ZHI A;  1VFV A;  4BN2 A;  1F9T A;  3L1C A;  4A14 A;  2KIN A;  3BFN A;  1MKJ A;  2Q2Y A;  5LT1 A;  3PXN A;  1G8X A;  2X7C A;  1MMA A;  1Q0B A;  4AP0 A;  3X2T A;  1SDM A;  3CNZ A;  2OWM A;  3ZCW A;  1MMG A;  3COB A;  3H4S A;  3L9H A;  3ZFD A;  1MNE A;  1BR1 A;  1KK7 A;  1GOJ A;  2FL6 A;  4UBF A;  1D1C A;  2V26 A;  2VVG A;  3DC4 A;  3DCB A;  4HNA K;  1T5C A;  1LVK A;  2GM1 A;  4ZCA A;  3B6V A;  3NWN A;  2ZFM A;  2WOG A;  2FL2 A;  2IEH A;  3KAR A;  3U06 A;  1LKX A;  3K5E A;  4ETP A;  3KIN A;  1MMD A;  4PFO A;  1CZ7 A;  2XT3 A;  3KEN A;  2ZFI A;  1D0X A;  2FKY A;  2PG2 A;  1D1B A;  2NCD A;  2Y65 A;  2X7D A;  4A1Z A;  1VFX A;  2MYS A;  4H1G A;  4DBR A;  4BXN A;  1X88 A;  2VB6 A;  2G1Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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