3WPNA

Kinesin spindle protein eg5 in complex with atp-competitive inhibitor pvzb1194
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
355
structure length
309
Chain Sequence
b'KGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGDKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTASSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Kinesin-like protein KIF11
publication title Structural basis of new allosteric inhibition in Kinesin spindle protein eg5
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 88
structure length 309
sequence length 355
ec nomenclature
pdb deposition date 2014-01-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 3wpnA00
5LT4A 2FKYA 4A51A 1II6A 3DCBA 2FMEA 2HEHA 4PJNA 3DC4A 2UYMA 1I5SA 1KK7A 5GSZA 3KINA 4PJLA 3GBJA 2ZFJA 4A1ZA 1D1CA 4ZHIA 1T5CA 2ZFMA 4LNUK 2Q2ZA 2X7DA 4ZCAA 1BR4A 3WRDA 1D0ZA 4A14A 2XT3A 1YRSA 2KINA 5LT2A 2ZFLA 3WPNA 1VFVA 4HNAK 4E7SA 4H1GA 1MMAA 1CZ7A 2Y65A 4DBRA 2G1QA 1F9VA 1MMDA 3KENA 2FL6A 2Q2YA 2X51A 1VFWA 4PFPA 1N6MA 1I6IA 2VASA 3HQDA 3NWNA 5LT0A 2VVGA 4UBFA 3KARA 2OWMA 3L1CA 2FL2A 3K5EA 3ZFCA 4PJMA 4B7BA 1X88A 1V8KA 3ZFDA 1GOJA 1G8XA 5HLEA 2ZFIA 1Q0BA 2MYSA 3H4SA 5LT1A 2UYIA 3PXNA 5LT3A 1LKXA 1VFXA 4Y05A 4BN2A 1D1AA 1VFZA 2NCDA 1BR2A 1MMGA 4A5YA 1F9UA 1MMNA 4FRZA 3L9HA 2GRYA 2VB6A 4A28A 4PK4A 3X2TA 1MNEA 1SDMA 4GKRA 3U06A 2X2RA 1MKJA 2PG2A 4AS7A 1D0XA 4BXNA 4ANJA 2IEHA 4AP0A 1D0YA 2Y5WA 3CJOA 3CNZA 1FMVA 4PFOA 1FMWA 1BR1A 1F9WA 2X7CA 1VOMA 3T0QA 1F9TA 1BG2A 1LVKA 4DBQA 4E7ZA 2V26A 4ETPA 4A50A 1D1BA 2WOGA 2X7EA 3BFNA 2GM1A 1V8JA 2ZFKA 3B6VA 3COBA 2XAEA 4BBGA 3K3BA 1RY6A 4PJJA 3LREA 3B6UA 3ZCWA
chains in the Genus database with same CATH superfamily
5LT4A 2FKYA 4A51A 1II6A 3DCBA 2FMEA 2HEHA 4PJNA 3DC4A 2UYMA 1I5SA 1KK7A 5GSZA 3KINA 4PJLA 3GBJA 2ZFJA 4A1ZA 1D1CA 4ZHIA 1T5CA 4ETPB 2ZFMA 4LNUK 2Q2ZA 2X7DA 4ZCAA 1BR4A 3WRDA 1D0ZA 4A14A 2XT3A 1YRSA 2KINA 5LT2A 2ZFLA 3WPNA 1VFVA 4HNAK 4E7SA 4H1GA 1MMAA 1CZ7A 2Y65A 4DBRA 2G1QA 1F9VA 1MMDA 3KENA 2FL6A 2Q2YA 2X51A 1VFWA 4PFPA 1N6MA 1I6IA 2VASA 3HQDA 3NWNA 5LT0A 2VVGA 4UBFA 3KARA 2OWMA 3L1CA 2FL2A 3K5EA 4GKQA 3ZFCA 4PJMA 4B7BA 1X88A 1V8KA 2O0AA 1GOJA 1G8XA 3ZFDA 5HLEA 2ZFIA 1Q0BA 2MYSA 3H4SA 5LT1A 2UYIA 3PXNA 5LT3A 1LKXA 1VFXA 4Y05A 4BN2A 1D1AA 1VFZA 2NCDA 1BR2A 1MMGA 4A5YA 1F9UA 1MMNA 4FRZA 4GKPA 3L9HA 2GRYA 2VB6A 4A28A 4PK4A 3X2TA 1MNEA 1SDMA 4GKRA 3U06A 2X2RA 1MKJA 2PG2A 4AS7A 1D0XA 4BXNA 4ANJA 2IEHA 4AP0A 1D0YA 2Y5WA 3CJOA 3CNZA 1FMVA 4PFOA 1FMWA 1BR1A 1F9WA 2X7CA 1VOMA 3T0QA 1F9TA 1BG2A 1LVKA 4DBQA 4E7ZA 2V26A 4ETPA 4A50A 1D1BA 2WOGA 2X7EA 3BFNA 2GM1A 1V8JA 2ZFKA 3B6VA 3COBA 2XAEA 4BBGA 3K3BA 1RY6A 4PJJA 3LREA 3B6UA 3ZCWA
chains in the Genus database with same CATH topology
5LT4A 2FKYA 4A51A 1II6A 3DCBA 2FMEA 2HEHA 4PJNA 3DC4A 2UYMA 1I5SA 1KK7A 5GSZA 3KINA 4PJLA 3GBJA 2ZFJA 4A1ZA 1D1CA 4ZHIA 1T5CA 2ZFMA 4LNUK 2Q2ZA 2X7DA 4ZCAA 1BR4A 3WRDA 1D0ZA 4A14A 2XT3A 1YRSA 2KINA 5LT2A 2ZFLA 3WPNA 1VFVA 4HNAK 4E7SA 4H1GA 1MMAA 1CZ7A 2Y65A 4DBRA 2G1QA 1F9VA 1MMDA 3KENA 2FL6A 2Q2YA 2X51A 1VFWA 4PFPA 1N6MA 1I6IA 2VASA 3HQDA 3NWNA 5LT0A 2VVGA 4UBFA 3KARA 2OWMA 3L1CA 2FL2A 3K5EA 3ZFCA 4PJMA 4B7BA 1X88A 1V8KA 3ZFDA 1GOJA 1G8XA 5HLEA 2ZFIA 1Q0BA 2MYSA 3H4SA 5LT1A 2UYIA 3PXNA 5LT3A 1LKXA 1VFXA 4Y05A 4BN2A 1D1AA 1VFZA 2NCDA 1BR2A 1MMGA 4A5YA 1F9UA 1MMNA 4FRZA 3L9HA 2GRYA 2VB6A 4A28A 4PK4A 3X2TA 1MNEA 1SDMA 4GKRA 3U06A 2X2RA 1MKJA 2PG2A 4AS7A 1D0XA 4BXNA 4ANJA 2IEHA 4AP0A 1D0YA 2Y5WA 3CJOA 3CNZA 1FMVA 4PFOA 1FMWA 1BR1A 1F9WA 2X7CA 1VOMA 3T0QA 1F9TA 1BG2A 1LVKA 4DBQA 4E7ZA 2V26A 4ETPA 4A50A 1D1BA 2WOGA 2X7EA 3BFNA 2GM1A 1V8JA 2ZFKA 3B6VA 3COBA 2XAEA 4BBGA 3K3BA 1RY6A 4PJJA 3LREA 3B6UA 3ZCWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LT4 A;  2FKY A;  4A51 A;  1II6 A;  3DCB A;  2FME A;  2HEH A;  4PJN A;  3DC4 A;  2UYM A;  1I5S A;  1KK7 A;  5GSZ A;  3KIN A;  4PJL A;  3GBJ A;  2ZFJ A;  4A1Z A;  1D1C A;  4ZHI A;  1T5C A;  2ZFM A;  4LNU K;  2Q2Z A;  2X7D A;  4ZCA A;  1BR4 A;  3WRD A;  1D0Z A;  4A14 A;  2XT3 A;  1YRS A;  2KIN A;  5LT2 A;  2ZFL A;  3WPN A;  1VFV A;  4HNA K;  4E7S A;  4H1G A;  1MMA A;  1CZ7 A;  2Y65 A;  4DBR A;  2G1Q A;  1F9V A;  1MMD A;  3KEN A;  2FL6 A;  2Q2Y A;  2X51 A;  1VFW A;  4PFP A;  1N6M A;  1I6I A;  2VAS A;  3HQD A;  3NWN A;  5LT0 A;  2VVG A;  4UBF A;  3KAR A;  2OWM A;  3L1C A;  2FL2 A;  3K5E A;  3ZFC A;  4PJM A;  4B7B A;  1X88 A;  1V8K A;  3ZFD A;  1GOJ A;  1G8X A;  5HLE A;  2ZFI A;  1Q0B A;  2MYS A;  3H4S A;  5LT1 A;  2UYI A;  3PXN A;  5LT3 A;  1LKX A;  1VFX A;  4Y05 A;  4BN2 A;  1D1A A;  1VFZ A;  2NCD A;  1BR2 A;  1MMG A;  4A5Y A;  1F9U A;  1MMN A;  4FRZ A;  3L9H A;  2GRY A;  2VB6 A;  4A28 A;  4PK4 A;  3X2T A;  1MNE A;  1SDM A;  4GKR A;  3U06 A;  2X2R A;  1MKJ A;  2PG2 A;  4AS7 A;  1D0X A;  4BXN A;  4ANJ A;  2IEH A;  4AP0 A;  1D0Y A;  2Y5W A;  3CJO A;  3CNZ A;  1FMV A;  4PFO A;  1FMW A;  1BR1 A;  1F9W A;  2X7C A;  1VOM A;  3T0Q A;  1F9T A;  1BG2 A;  1LVK A;  4DBQ A;  4E7Z A;  2V26 A;  4ETP A;  4A50 A;  1D1B A;  2WOG A;  2X7E A;  3BFN A;  2GM1 A;  1V8J A;  2ZFK A;  3B6V A;  3COB A;  2XAE A;  4BBG A;  3K3B A;  1RY6 A;  4PJJ A;  3LRE A;  3B6U A;  3ZCW A; 
#chains in the Genus database with same CATH topology
 5LT4 A;  2FKY A;  4A51 A;  1II6 A;  3DCB A;  2FME A;  2HEH A;  4PJN A;  3DC4 A;  2UYM A;  1I5S A;  1KK7 A;  5GSZ A;  3KIN A;  4PJL A;  3GBJ A;  2ZFJ A;  4A1Z A;  1D1C A;  4ZHI A;  1T5C A;  4ETP B;  2ZFM A;  4LNU K;  2Q2Z A;  2X7D A;  4ZCA A;  1BR4 A;  3WRD A;  1D0Z A;  4A14 A;  2XT3 A;  1YRS A;  2KIN A;  5LT2 A;  2ZFL A;  3WPN A;  1VFV A;  4HNA K;  4E7S A;  4H1G A;  1MMA A;  1CZ7 A;  2Y65 A;  4DBR A;  2G1Q A;  1F9V A;  1MMD A;  3KEN A;  2FL6 A;  2Q2Y A;  2X51 A;  1VFW A;  4PFP A;  1N6M A;  1I6I A;  2VAS A;  3HQD A;  3NWN A;  5LT0 A;  2VVG A;  4UBF A;  3KAR A;  2OWM A;  3L1C A;  2FL2 A;  3K5E A;  4GKQ A;  3ZFC A;  4PJM A;  4B7B A;  1X88 A;  1V8K A;  2O0A A;  1GOJ A;  1G8X A;  3ZFD A;  5HLE A;  2ZFI A;  1Q0B A;  2MYS A;  3H4S A;  5LT1 A;  2UYI A;  3PXN A;  5LT3 A;  1LKX A;  1VFX A;  4Y05 A;  4BN2 A;  1D1A A;  1VFZ A;  2NCD A;  1BR2 A;  1MMG A;  4A5Y A;  1F9U A;  1MMN A;  4FRZ A;  4GKP A;  3L9H A;  2GRY A;  2VB6 A;  4A28 A;  4PK4 A;  3X2T A;  1MNE A;  1SDM A;  4GKR A;  3U06 A;  2X2R A;  1MKJ A;  2PG2 A;  4AS7 A;  1D0X A;  4BXN A;  4ANJ A;  2IEH A;  4AP0 A;  1D0Y A;  2Y5W A;  3CJO A;  3CNZ A;  1FMV A;  4PFO A;  1FMW A;  1BR1 A;  1F9W A;  2X7C A;  1VOM A;  3T0Q A;  1F9T A;  1BG2 A;  1LVK A;  4DBQ A;  4E7Z A;  2V26 A;  4ETP A;  4A50 A;  1D1B A;  2WOG A;  2X7E A;  3BFN A;  2GM1 A;  1V8J A;  2ZFK A;  3B6V A;  3COB A;  2XAE A;  4BBG A;  3K3B A;  1RY6 A;  4PJJ A;  3LRE A;  3B6U A;  3ZCW A; 
#chains in the Genus database with same CATH homology
 5LT4 A;  2FKY A;  4A51 A;  1II6 A;  3DCB A;  2FME A;  2HEH A;  4PJN A;  3DC4 A;  2UYM A;  1I5S A;  1KK7 A;  5GSZ A;  3KIN A;  4PJL A;  3GBJ A;  2ZFJ A;  4A1Z A;  1D1C A;  4ZHI A;  1T5C A;  2ZFM A;  4LNU K;  2Q2Z A;  2X7D A;  4ZCA A;  1BR4 A;  3WRD A;  1D0Z A;  4A14 A;  2XT3 A;  1YRS A;  2KIN A;  5LT2 A;  2ZFL A;  3WPN A;  1VFV A;  4HNA K;  4E7S A;  4H1G A;  1MMA A;  1CZ7 A;  2Y65 A;  4DBR A;  2G1Q A;  1F9V A;  1MMD A;  3KEN A;  2FL6 A;  2Q2Y A;  2X51 A;  1VFW A;  4PFP A;  1N6M A;  1I6I A;  2VAS A;  3HQD A;  3NWN A;  5LT0 A;  2VVG A;  4UBF A;  3KAR A;  2OWM A;  3L1C A;  2FL2 A;  3K5E A;  3ZFC A;  4PJM A;  4B7B A;  1X88 A;  1V8K A;  3ZFD A;  1GOJ A;  1G8X A;  5HLE A;  2ZFI A;  1Q0B A;  2MYS A;  3H4S A;  5LT1 A;  2UYI A;  3PXN A;  5LT3 A;  1LKX A;  1VFX A;  4Y05 A;  4BN2 A;  1D1A A;  1VFZ A;  2NCD A;  1BR2 A;  1MMG A;  4A5Y A;  1F9U A;  1MMN A;  4FRZ A;  3L9H A;  2GRY A;  2VB6 A;  4A28 A;  4PK4 A;  3X2T A;  1MNE A;  1SDM A;  4GKR A;  3U06 A;  2X2R A;  1MKJ A;  2PG2 A;  4AS7 A;  1D0X A;  4BXN A;  4ANJ A;  2IEH A;  4AP0 A;  1D0Y A;  2Y5W A;  3CJO A;  3CNZ A;  1FMV A;  4PFO A;  1FMW A;  1BR1 A;  1F9W A;  2X7C A;  1VOM A;  3T0Q A;  1F9T A;  1BG2 A;  1LVK A;  4DBQ A;  4E7Z A;  2V26 A;  4ETP A;  4A50 A;  1D1B A;  2WOG A;  2X7E A;  3BFN A;  2GM1 A;  1V8J A;  2ZFK A;  3B6V A;  3COB A;  2XAE A;  4BBG A;  3K3B A;  1RY6 A;  4PJJ A;  3LRE A;  3B6U A;  3ZCW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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