3L9HA

X-ray structure of mitotic kinesin-5 (ksp, kif11, eg5)in complex with the hexahydro-2h-pyrano[3,2-c]quinoline emd 534085
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
347
structure length
331
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Kinesin-like protein KIF11
publication title The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Motor protein
total genus 106
structure length 331
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-01-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 3l9hA00
3KENA 2UYIA 4PJNA 1VFWA 2VB6A 2Y5WA 1GOJA 1VFVA 2Q2ZA 2MYSA 2X51A 3PXNA 5LT2A 1CZ7A 2X7DA 4GKRA 1MKJA 1D0XA 2ZFJA 1VFXA 4PFPA 3ZFDA 4H1GA 4BBGA 1KK7A 3T0QA 4A14A 3L1CA 1BR2A 2OWMA 3CNZA 2ZFIA 1MMNA 4UBFA 3ZFCA 5LT0A 1MMGA 3KARA 1LKXA 3WRDA 2FL2A 4FRZA 2X7EA 1G8XA 5GSZA 2Y65A 4ZHIA 3L9HA 1F9UA 2GM1A 1D1AA 3ZCWA 4E7SA 1RY6A 2FKYA 2KINA 3LREA 1MNEA 4B7BA 3DC4A 4A1ZA 1II6A 5LT4A 1FMWA 4E7ZA 2ZFKA 3B6UA 4AS7A 1F9VA 4BN2A 1YRSA 4AP0A 2VVGA 2PG2A 2XAEA 2XT3A 4ANJA 5LT3A 1F9TA 1V8JA 2GRYA 1VFZA 1X88A 1VOMA 4PFOA 2ZFLA 4DBQA 4A50A 4LNUK 3WPNA 3DCBA 5HLEA 1SDMA 2UYMA 3BFNA 1LVKA 3U06A 3B6VA 3GBJA 2IEHA 1I6IA 2V26A 2ZFMA 2X7CA 2X2RA 5LT1A 2NCDA 3HQDA 1FMVA 3COBA 3CJOA 3X2TA 2HEHA 4HNAK 1MMAA 1Q0BA 1D0ZA 2FMEA 1V8KA 1D1CA 4PJLA 4A28A 1I5SA 4Y05A 1BR1A 4DBRA 4A51A 2VASA 3K5EA 2FL6A 1BG2A 4A5YA 1N6MA 4PJJA 4ZCAA 3KINA 3NWNA 1MMDA 1D1BA 4PJMA 2G1QA 3H4SA 3K3BA 4BXNA 1BR4A 1T5CA 2WOGA 4ETPA 1D0YA 4PK4A 1F9WA 2Q2YA
chains in the Genus database with same CATH superfamily
3KENA 2UYIA 4PJNA 1VFWA 2VB6A 2Y5WA 1GOJA 1VFVA 2Q2ZA 2MYSA 2X51A 3PXNA 5LT2A 1CZ7A 2X7DA 4GKRA 1MKJA 1D0XA 2ZFJA 1VFXA 4PFPA 3ZFDA 4H1GA 4BBGA 1KK7A 3T0QA 4A14A 3L1CA 1BR2A 2OWMA 3CNZA 2ZFIA 1MMNA 4UBFA 3ZFCA 5LT0A 1MMGA 3KARA 1LKXA 3WRDA 2FL2A 4FRZA 2X7EA 1G8XA 5GSZA 2Y65A 4ZHIA 3L9HA 1F9UA 2GM1A 1D1AA 3ZCWA 4E7SA 1RY6A 2FKYA 2KINA 3LREA 1MNEA 4B7BA 3DC4A 4A1ZA 1II6A 5LT4A 1FMWA 4E7ZA 2ZFKA 3B6UA 4AS7A 1F9VA 4ETPB 4BN2A 1YRSA 4AP0A 2VVGA 2PG2A 2XAEA 2XT3A 4ANJA 5LT3A 1F9TA 1V8JA 4GKPA 2GRYA 1VFZA 1X88A 1VOMA 4PFOA 2ZFLA 4DBQA 4A50A 4LNUK 3WPNA 3DCBA 5HLEA 1SDMA 2UYMA 3BFNA 1LVKA 3U06A 3B6VA 3GBJA 2IEHA 1I6IA 2V26A 2ZFMA 2X7CA 2X2RA 5LT1A 2NCDA 3HQDA 1FMVA 3COBA 3CJOA 3X2TA 2HEHA 4HNAK 1MMAA 1Q0BA 1D0ZA 2FMEA 1V8KA 1D1CA 4PJLA 4A28A 1I5SA 4Y05A 1BR1A 4GKQA 4DBRA 4A51A 2VASA 2O0AA 3K5EA 2FL6A 1BG2A 4A5YA 1N6MA 4PJJA 4ZCAA 3KINA 3NWNA 1MMDA 1D1BA 4PJMA 2G1QA 3H4SA 3K3BA 4BXNA 1BR4A 1T5CA 2WOGA 4ETPA 1D0YA 4PK4A 1F9WA 2Q2YA
chains in the Genus database with same CATH topology
3KENA 2UYIA 4PJNA 1VFWA 2VB6A 2Y5WA 1GOJA 1VFVA 2Q2ZA 2MYSA 2X51A 3PXNA 5LT2A 1CZ7A 2X7DA 4GKRA 1MKJA 1D0XA 2ZFJA 1VFXA 4PFPA 3ZFDA 4H1GA 4BBGA 1KK7A 3T0QA 4A14A 3L1CA 1BR2A 2OWMA 3CNZA 2ZFIA 1MMNA 4UBFA 3ZFCA 5LT0A 1MMGA 3KARA 1LKXA 3WRDA 2FL2A 4FRZA 2X7EA 1G8XA 5GSZA 2Y65A 4ZHIA 3L9HA 1F9UA 2GM1A 1D1AA 3ZCWA 4E7SA 1RY6A 2FKYA 2KINA 3LREA 1MNEA 4B7BA 3DC4A 4A1ZA 1II6A 5LT4A 1FMWA 4E7ZA 2ZFKA 3B6UA 4AS7A 1F9VA 4BN2A 1YRSA 4AP0A 2VVGA 2PG2A 2XAEA 2XT3A 4ANJA 5LT3A 1F9TA 1V8JA 2GRYA 1VFZA 1X88A 1VOMA 4PFOA 2ZFLA 4DBQA 4A50A 4LNUK 3WPNA 3DCBA 5HLEA 1SDMA 2UYMA 3BFNA 1LVKA 3U06A 3B6VA 3GBJA 2IEHA 1I6IA 2V26A 2ZFMA 2X7CA 2X2RA 5LT1A 2NCDA 3HQDA 1FMVA 3COBA 3CJOA 3X2TA 2HEHA 4HNAK 1MMAA 1Q0BA 1D0ZA 2FMEA 1V8KA 1D1CA 4PJLA 4A28A 1I5SA 4Y05A 1BR1A 4DBRA 4A51A 2VASA 3K5EA 2FL6A 1BG2A 4A5YA 1N6MA 4PJJA 4ZCAA 3KINA 3NWNA 1MMDA 1D1BA 4PJMA 2G1QA 3H4SA 3K3BA 4BXNA 1BR4A 1T5CA 2WOGA 4ETPA 1D0YA 4PK4A 1F9WA 2Q2YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KEN A;  2UYI A;  4PJN A;  1VFW A;  2VB6 A;  2Y5W A;  1GOJ A;  1VFV A;  2Q2Z A;  2MYS A;  2X51 A;  3PXN A;  5LT2 A;  1CZ7 A;  2X7D A;  4GKR A;  1MKJ A;  1D0X A;  2ZFJ A;  1VFX A;  4PFP A;  3ZFD A;  4H1G A;  4BBG A;  1KK7 A;  3T0Q A;  4A14 A;  3L1C A;  1BR2 A;  2OWM A;  3CNZ A;  2ZFI A;  1MMN A;  4UBF A;  3ZFC A;  5LT0 A;  1MMG A;  3KAR A;  1LKX A;  3WRD A;  2FL2 A;  4FRZ A;  2X7E A;  1G8X A;  5GSZ A;  2Y65 A;  4ZHI A;  3L9H A;  1F9U A;  2GM1 A;  1D1A A;  3ZCW A;  4E7S A;  1RY6 A;  2FKY A;  2KIN A;  3LRE A;  1MNE A;  4B7B A;  3DC4 A;  4A1Z A;  1II6 A;  5LT4 A;  1FMW A;  4E7Z A;  2ZFK A;  3B6U A;  4AS7 A;  1F9V A;  4BN2 A;  1YRS A;  4AP0 A;  2VVG A;  2PG2 A;  2XAE A;  2XT3 A;  4ANJ A;  5LT3 A;  1F9T A;  1V8J A;  2GRY A;  1VFZ A;  1X88 A;  1VOM A;  4PFO A;  2ZFL A;  4DBQ A;  4A50 A;  4LNU K;  3WPN A;  3DCB A;  5HLE A;  1SDM A;  2UYM A;  3BFN A;  1LVK A;  3U06 A;  3B6V A;  3GBJ A;  2IEH A;  1I6I A;  2V26 A;  2ZFM A;  2X7C A;  2X2R A;  5LT1 A;  2NCD A;  3HQD A;  1FMV A;  3COB A;  3CJO A;  3X2T A;  2HEH A;  4HNA K;  1MMA A;  1Q0B A;  1D0Z A;  2FME A;  1V8K A;  1D1C A;  4PJL A;  4A28 A;  1I5S A;  4Y05 A;  1BR1 A;  4DBR A;  4A51 A;  2VAS A;  3K5E A;  2FL6 A;  1BG2 A;  4A5Y A;  1N6M A;  4PJJ A;  4ZCA A;  3KIN A;  3NWN A;  1MMD A;  1D1B A;  4PJM A;  2G1Q A;  3H4S A;  3K3B A;  4BXN A;  1BR4 A;  1T5C A;  2WOG A;  4ETP A;  1D0Y A;  4PK4 A;  1F9W A;  2Q2Y A; 
#chains in the Genus database with same CATH topology
 3KEN A;  2UYI A;  4PJN A;  1VFW A;  2VB6 A;  2Y5W A;  1GOJ A;  1VFV A;  2Q2Z A;  2MYS A;  2X51 A;  3PXN A;  5LT2 A;  1CZ7 A;  2X7D A;  4GKR A;  1MKJ A;  1D0X A;  2ZFJ A;  1VFX A;  4PFP A;  3ZFD A;  4H1G A;  4BBG A;  1KK7 A;  3T0Q A;  4A14 A;  3L1C A;  1BR2 A;  2OWM A;  3CNZ A;  2ZFI A;  1MMN A;  4UBF A;  3ZFC A;  5LT0 A;  1MMG A;  3KAR A;  1LKX A;  3WRD A;  2FL2 A;  4FRZ A;  2X7E A;  1G8X A;  5GSZ A;  2Y65 A;  4ZHI A;  3L9H A;  1F9U A;  2GM1 A;  1D1A A;  3ZCW A;  4E7S A;  1RY6 A;  2FKY A;  2KIN A;  3LRE A;  1MNE A;  4B7B A;  3DC4 A;  4A1Z A;  1II6 A;  5LT4 A;  1FMW A;  4E7Z A;  2ZFK A;  3B6U A;  4AS7 A;  1F9V A;  4ETP B;  4BN2 A;  1YRS A;  4AP0 A;  2VVG A;  2PG2 A;  2XAE A;  2XT3 A;  4ANJ A;  5LT3 A;  1F9T A;  1V8J A;  4GKP A;  2GRY A;  1VFZ A;  1X88 A;  1VOM A;  4PFO A;  2ZFL A;  4DBQ A;  4A50 A;  4LNU K;  3WPN A;  3DCB A;  5HLE A;  1SDM A;  2UYM A;  3BFN A;  1LVK A;  3U06 A;  3B6V A;  3GBJ A;  2IEH A;  1I6I A;  2V26 A;  2ZFM A;  2X7C A;  2X2R A;  5LT1 A;  2NCD A;  3HQD A;  1FMV A;  3COB A;  3CJO A;  3X2T A;  2HEH A;  4HNA K;  1MMA A;  1Q0B A;  1D0Z A;  2FME A;  1V8K A;  1D1C A;  4PJL A;  4A28 A;  1I5S A;  4Y05 A;  1BR1 A;  4GKQ A;  4DBR A;  4A51 A;  2VAS A;  2O0A A;  3K5E A;  2FL6 A;  1BG2 A;  4A5Y A;  1N6M A;  4PJJ A;  4ZCA A;  3KIN A;  3NWN A;  1MMD A;  1D1B A;  4PJM A;  2G1Q A;  3H4S A;  3K3B A;  4BXN A;  1BR4 A;  1T5C A;  2WOG A;  4ETP A;  1D0Y A;  4PK4 A;  1F9W A;  2Q2Y A; 
#chains in the Genus database with same CATH homology
 3KEN A;  2UYI A;  4PJN A;  1VFW A;  2VB6 A;  2Y5W A;  1GOJ A;  1VFV A;  2Q2Z A;  2MYS A;  2X51 A;  3PXN A;  5LT2 A;  1CZ7 A;  2X7D A;  4GKR A;  1MKJ A;  1D0X A;  2ZFJ A;  1VFX A;  4PFP A;  3ZFD A;  4H1G A;  4BBG A;  1KK7 A;  3T0Q A;  4A14 A;  3L1C A;  1BR2 A;  2OWM A;  3CNZ A;  2ZFI A;  1MMN A;  4UBF A;  3ZFC A;  5LT0 A;  1MMG A;  3KAR A;  1LKX A;  3WRD A;  2FL2 A;  4FRZ A;  2X7E A;  1G8X A;  5GSZ A;  2Y65 A;  4ZHI A;  3L9H A;  1F9U A;  2GM1 A;  1D1A A;  3ZCW A;  4E7S A;  1RY6 A;  2FKY A;  2KIN A;  3LRE A;  1MNE A;  4B7B A;  3DC4 A;  4A1Z A;  1II6 A;  5LT4 A;  1FMW A;  4E7Z A;  2ZFK A;  3B6U A;  4AS7 A;  1F9V A;  4BN2 A;  1YRS A;  4AP0 A;  2VVG A;  2PG2 A;  2XAE A;  2XT3 A;  4ANJ A;  5LT3 A;  1F9T A;  1V8J A;  2GRY A;  1VFZ A;  1X88 A;  1VOM A;  4PFO A;  2ZFL A;  4DBQ A;  4A50 A;  4LNU K;  3WPN A;  3DCB A;  5HLE A;  1SDM A;  2UYM A;  3BFN A;  1LVK A;  3U06 A;  3B6V A;  3GBJ A;  2IEH A;  1I6I A;  2V26 A;  2ZFM A;  2X7C A;  2X2R A;  5LT1 A;  2NCD A;  3HQD A;  1FMV A;  3COB A;  3CJO A;  3X2T A;  2HEH A;  4HNA K;  1MMA A;  1Q0B A;  1D0Z A;  2FME A;  1V8K A;  1D1C A;  4PJL A;  4A28 A;  1I5S A;  4Y05 A;  1BR1 A;  4DBR A;  4A51 A;  2VAS A;  3K5E A;  2FL6 A;  1BG2 A;  4A5Y A;  1N6M A;  4PJJ A;  4ZCA A;  3KIN A;  3NWN A;  1MMD A;  1D1B A;  4PJM A;  2G1Q A;  3H4S A;  3K3B A;  4BXN A;  1BR4 A;  1T5C A;  2WOG A;  4ETP A;  1D0Y A;  4PK4 A;  1F9W A;  2Q2Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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