3L9HA

X-ray structure of mitotic kinesin-5 (ksp, kif11, eg5)in complex with the hexahydro-2h-pyrano[3,2-c]quinoline emd 534085
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
347
structure length
331
Chain Sequence
b'GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Kinesin-like protein KIF11
publication title The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Motor protein
total genus 106
structure length 331
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-01-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 3l9hA00
2VB6A 3L1CA 4DBRA 1VOMA 1VFZA 1VFXA 2UYIA 5GSZA 3T0QA 3DC4A 2Q2YA 4A5YA 3CJOA 3B6VA 3KENA 2IEHA 5LT1A 3HQDA 4Y05A 3KARA 4E7SA 4AS7A 1MMAA 2UYMA 2XT3A 1VFWA 4A28A 2WOGA 3H4SA 1F9TA 1BR2A 4ANJA 4A50A 1G8XA 2X7EA 1BG2A 4FRZA 1RY6A 1D0YA 3PXNA 1LVKA 2ZFJA 4BBGA 5LT2A 2NCDA 4BN2A 4PFPA 2VVGA 1F9UA 1BR1A 5HLEA 1II6A 3DCBA 4GKRA 4PK4A 1KK7A 4A1ZA 3COBA 5LT0A 1T5CA 2Y5WA 1VFVA 1D0ZA 2VASA 4E7ZA 3K3BA 2Q2ZA 2V26A 3ZCWA 3KINA 4ETPA 1YRSA 1SDMA 1F9VA 2HEHA 2XAEA 1N6MA 1CZ7A 2FKYA 1F9WA 4PJLA 1V8JA 5LT3A 3U06A 3L9HA 2MYSA 5LT4A 2PG2A 1X88A 1MNEA 2GRYA 1V8KA 3K5EA 4PJNA 4PFOA 2ZFLA 2G1QA 3NWNA 4UBFA 4ZCAA 1I5SA 3BFNA 1D0XA 2X7CA 1I6IA 3WRDA 3ZFCA 4A14A 2ZFIA 2ZFMA 4PJJA 3CNZA 4H1GA 4A51A 3ZFDA 3B6UA 4AP0A 1D1AA 4BXNA 2KINA 4LNUK 1MMGA 2GM1A 2ZFKA 1FMVA 1MMNA 1LKXA 3X2TA 4PJMA 2Y65A 1GOJA 2FL2A 1BR4A 2FL6A 4B7BA 4ZHIA 2X51A 2OWMA 3WPNA 1D1BA 1D1CA 1Q0BA 3LREA 2X7DA 3GBJA 4HNAK 4DBQA 1MKJA 2FMEA 2X2RA 1FMWA 1MMDA
chains in the Genus database with same CATH superfamily
2VB6A 3L1CA 4DBRA 1VOMA 1VFZA 1VFXA 2UYIA 5GSZA 3T0QA 3DC4A 2Q2YA 4A5YA 3CJOA 3B6VA 3KENA 2IEHA 5LT1A 3HQDA 4Y05A 3KARA 4E7SA 4AS7A 1MMAA 2UYMA 2XT3A 1VFWA 4A28A 2WOGA 3H4SA 1F9TA 1BR2A 4ANJA 2O0AA 4GKQA 4A50A 1G8XA 2X7EA 1BG2A 4FRZA 1RY6A 1D0YA 3PXNA 1LVKA 2ZFJA 4BBGA 5LT2A 2NCDA 4BN2A 4PFPA 2VVGA 4GKPA 1F9UA 1BR1A 5HLEA 1II6A 3DCBA 4GKRA 4PK4A 1KK7A 4A1ZA 3COBA 5LT0A 1T5CA 2Y5WA 1VFVA 1D0ZA 2VASA 4E7ZA 3K3BA 2Q2ZA 2V26A 3ZCWA 3KINA 4ETPA 1YRSA 1SDMA 1F9VA 2HEHA 2XAEA 1N6MA 1CZ7A 2FKYA 1F9WA 4PJLA 1V8JA 5LT3A 3U06A 3L9HA 2MYSA 5LT4A 2PG2A 1X88A 1MNEA 2GRYA 1V8KA 3K5EA 4PJNA 4PFOA 2ZFLA 2G1QA 3NWNA 4UBFA 4ZCAA 1I5SA 3BFNA 1D0XA 2X7CA 1I6IA 3WRDA 3ZFCA 4A14A 2ZFIA 2ZFMA 4PJJA 3CNZA 4H1GA 4A51A 3ZFDA 3B6UA 4AP0A 1D1AA 4BXNA 2KINA 4LNUK 1MMGA 2GM1A 2ZFKA 1FMVA 1MMNA 1LKXA 3X2TA 4PJMA 2Y65A 1GOJA 4ETPB 2FL2A 1BR4A 2FL6A 4B7BA 4ZHIA 2X51A 2OWMA 3WPNA 1D1BA 1D1CA 1Q0BA 3LREA 2X7DA 3GBJA 4HNAK 4DBQA 1MKJA 2FMEA 2X2RA 1FMWA 1MMDA
chains in the Genus database with same CATH topology
2VB6A 3L1CA 4DBRA 1VOMA 1VFZA 1VFXA 2UYIA 5GSZA 3T0QA 3DC4A 2Q2YA 4A5YA 3CJOA 3B6VA 3KENA 2IEHA 5LT1A 3HQDA 4Y05A 3KARA 4E7SA 4AS7A 1MMAA 2UYMA 2XT3A 1VFWA 4A28A 2WOGA 3H4SA 1F9TA 1BR2A 4ANJA 4A50A 1G8XA 2X7EA 1BG2A 4FRZA 1RY6A 1D0YA 3PXNA 1LVKA 2ZFJA 4BBGA 5LT2A 2NCDA 4BN2A 4PFPA 2VVGA 1F9UA 1BR1A 5HLEA 1II6A 3DCBA 4GKRA 4PK4A 1KK7A 4A1ZA 3COBA 5LT0A 1T5CA 2Y5WA 1VFVA 1D0ZA 2VASA 4E7ZA 3K3BA 2Q2ZA 2V26A 3ZCWA 3KINA 4ETPA 1YRSA 1SDMA 1F9VA 2HEHA 2XAEA 1N6MA 1CZ7A 2FKYA 1F9WA 4PJLA 1V8JA 5LT3A 3U06A 3L9HA 2MYSA 5LT4A 2PG2A 1X88A 1MNEA 2GRYA 1V8KA 3K5EA 4PJNA 4PFOA 2ZFLA 2G1QA 3NWNA 4UBFA 4ZCAA 1I5SA 3BFNA 1D0XA 2X7CA 1I6IA 3WRDA 3ZFCA 4A14A 2ZFIA 2ZFMA 4PJJA 3CNZA 4H1GA 4A51A 3ZFDA 3B6UA 4AP0A 1D1AA 4BXNA 2KINA 4LNUK 1MMGA 2GM1A 2ZFKA 1FMVA 1MMNA 1LKXA 3X2TA 4PJMA 2Y65A 1GOJA 2FL2A 1BR4A 2FL6A 4B7BA 4ZHIA 2X51A 2OWMA 3WPNA 1D1BA 1D1CA 1Q0BA 3LREA 2X7DA 3GBJA 4HNAK 4DBQA 1MKJA 2FMEA 2X2RA 1FMWA 1MMDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VB6 A;  3L1C A;  4DBR A;  1VOM A;  1VFZ A;  1VFX A;  2UYI A;  5GSZ A;  3T0Q A;  3DC4 A;  2Q2Y A;  4A5Y A;  3CJO A;  3B6V A;  3KEN A;  2IEH A;  5LT1 A;  3HQD A;  4Y05 A;  3KAR A;  4E7S A;  4AS7 A;  1MMA A;  2UYM A;  2XT3 A;  1VFW A;  4A28 A;  2WOG A;  3H4S A;  1F9T A;  1BR2 A;  4ANJ A;  4A50 A;  1G8X A;  2X7E A;  1BG2 A;  4FRZ A;  1RY6 A;  1D0Y A;  3PXN A;  1LVK A;  2ZFJ A;  4BBG A;  5LT2 A;  2NCD A;  4BN2 A;  4PFP A;  2VVG A;  1F9U A;  1BR1 A;  5HLE A;  1II6 A;  3DCB A;  4GKR A;  4PK4 A;  1KK7 A;  4A1Z A;  3COB A;  5LT0 A;  1T5C A;  2Y5W A;  1VFV A;  1D0Z A;  2VAS A;  4E7Z A;  3K3B A;  2Q2Z A;  2V26 A;  3ZCW A;  3KIN A;  4ETP A;  1YRS A;  1SDM A;  1F9V A;  2HEH A;  2XAE A;  1N6M A;  1CZ7 A;  2FKY A;  1F9W A;  4PJL A;  1V8J A;  5LT3 A;  3U06 A;  3L9H A;  2MYS A;  5LT4 A;  2PG2 A;  1X88 A;  1MNE A;  2GRY A;  1V8K A;  3K5E A;  4PJN A;  4PFO A;  2ZFL A;  2G1Q A;  3NWN A;  4UBF A;  4ZCA A;  1I5S A;  3BFN A;  1D0X A;  2X7C A;  1I6I A;  3WRD A;  3ZFC A;  4A14 A;  2ZFI A;  2ZFM A;  4PJJ A;  3CNZ A;  4H1G A;  4A51 A;  3ZFD A;  3B6U A;  4AP0 A;  1D1A A;  4BXN A;  2KIN A;  4LNU K;  1MMG A;  2GM1 A;  2ZFK A;  1FMV A;  1MMN A;  1LKX A;  3X2T A;  4PJM A;  2Y65 A;  1GOJ A;  2FL2 A;  1BR4 A;  2FL6 A;  4B7B A;  4ZHI A;  2X51 A;  2OWM A;  3WPN A;  1D1B A;  1D1C A;  1Q0B A;  3LRE A;  2X7D A;  3GBJ A;  4HNA K;  4DBQ A;  1MKJ A;  2FME A;  2X2R A;  1FMW A;  1MMD A; 
#chains in the Genus database with same CATH topology
 2VB6 A;  3L1C A;  4DBR A;  1VOM A;  1VFZ A;  1VFX A;  2UYI A;  5GSZ A;  3T0Q A;  3DC4 A;  2Q2Y A;  4A5Y A;  3CJO A;  3B6V A;  3KEN A;  2IEH A;  5LT1 A;  3HQD A;  4Y05 A;  3KAR A;  4E7S A;  4AS7 A;  1MMA A;  2UYM A;  2XT3 A;  1VFW A;  4A28 A;  2WOG A;  3H4S A;  1F9T A;  1BR2 A;  4ANJ A;  2O0A A;  4GKQ A;  4A50 A;  1G8X A;  2X7E A;  1BG2 A;  4FRZ A;  1RY6 A;  1D0Y A;  3PXN A;  1LVK A;  2ZFJ A;  4BBG A;  5LT2 A;  2NCD A;  4BN2 A;  4PFP A;  2VVG A;  4GKP A;  1F9U A;  1BR1 A;  5HLE A;  1II6 A;  3DCB A;  4GKR A;  4PK4 A;  1KK7 A;  4A1Z A;  3COB A;  5LT0 A;  1T5C A;  2Y5W A;  1VFV A;  1D0Z A;  2VAS A;  4E7Z A;  3K3B A;  2Q2Z A;  2V26 A;  3ZCW A;  3KIN A;  4ETP A;  1YRS A;  1SDM A;  1F9V A;  2HEH A;  2XAE A;  1N6M A;  1CZ7 A;  2FKY A;  1F9W A;  4PJL A;  1V8J A;  5LT3 A;  3U06 A;  3L9H A;  2MYS A;  5LT4 A;  2PG2 A;  1X88 A;  1MNE A;  2GRY A;  1V8K A;  3K5E A;  4PJN A;  4PFO A;  2ZFL A;  2G1Q A;  3NWN A;  4UBF A;  4ZCA A;  1I5S A;  3BFN A;  1D0X A;  2X7C A;  1I6I A;  3WRD A;  3ZFC A;  4A14 A;  2ZFI A;  2ZFM A;  4PJJ A;  3CNZ A;  4H1G A;  4A51 A;  3ZFD A;  3B6U A;  4AP0 A;  1D1A A;  4BXN A;  2KIN A;  4LNU K;  1MMG A;  2GM1 A;  2ZFK A;  1FMV A;  1MMN A;  1LKX A;  3X2T A;  4PJM A;  2Y65 A;  1GOJ A;  4ETP B;  2FL2 A;  1BR4 A;  2FL6 A;  4B7B A;  4ZHI A;  2X51 A;  2OWM A;  3WPN A;  1D1B A;  1D1C A;  1Q0B A;  3LRE A;  2X7D A;  3GBJ A;  4HNA K;  4DBQ A;  1MKJ A;  2FME A;  2X2R A;  1FMW A;  1MMD A; 
#chains in the Genus database with same CATH homology
 2VB6 A;  3L1C A;  4DBR A;  1VOM A;  1VFZ A;  1VFX A;  2UYI A;  5GSZ A;  3T0Q A;  3DC4 A;  2Q2Y A;  4A5Y A;  3CJO A;  3B6V A;  3KEN A;  2IEH A;  5LT1 A;  3HQD A;  4Y05 A;  3KAR A;  4E7S A;  4AS7 A;  1MMA A;  2UYM A;  2XT3 A;  1VFW A;  4A28 A;  2WOG A;  3H4S A;  1F9T A;  1BR2 A;  4ANJ A;  4A50 A;  1G8X A;  2X7E A;  1BG2 A;  4FRZ A;  1RY6 A;  1D0Y A;  3PXN A;  1LVK A;  2ZFJ A;  4BBG A;  5LT2 A;  2NCD A;  4BN2 A;  4PFP A;  2VVG A;  1F9U A;  1BR1 A;  5HLE A;  1II6 A;  3DCB A;  4GKR A;  4PK4 A;  1KK7 A;  4A1Z A;  3COB A;  5LT0 A;  1T5C A;  2Y5W A;  1VFV A;  1D0Z A;  2VAS A;  4E7Z A;  3K3B A;  2Q2Z A;  2V26 A;  3ZCW A;  3KIN A;  4ETP A;  1YRS A;  1SDM A;  1F9V A;  2HEH A;  2XAE A;  1N6M A;  1CZ7 A;  2FKY A;  1F9W A;  4PJL A;  1V8J A;  5LT3 A;  3U06 A;  3L9H A;  2MYS A;  5LT4 A;  2PG2 A;  1X88 A;  1MNE A;  2GRY A;  1V8K A;  3K5E A;  4PJN A;  4PFO A;  2ZFL A;  2G1Q A;  3NWN A;  4UBF A;  4ZCA A;  1I5S A;  3BFN A;  1D0X A;  2X7C A;  1I6I A;  3WRD A;  3ZFC A;  4A14 A;  2ZFI A;  2ZFM A;  4PJJ A;  3CNZ A;  4H1G A;  4A51 A;  3ZFD A;  3B6U A;  4AP0 A;  1D1A A;  4BXN A;  2KIN A;  4LNU K;  1MMG A;  2GM1 A;  2ZFK A;  1FMV A;  1MMN A;  1LKX A;  3X2T A;  4PJM A;  2Y65 A;  1GOJ A;  2FL2 A;  1BR4 A;  2FL6 A;  4B7B A;  4ZHI A;  2X51 A;  2OWM A;  3WPN A;  1D1B A;  1D1C A;  1Q0B A;  3LRE A;  2X7D A;  3GBJ A;  4HNA K;  4DBQ A;  1MKJ A;  2FME A;  2X2R A;  1FMW A;  1MMD A; 
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similar chains in the Genus database (?% sequence similarity)
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