2Q2YA

Crystal structure of ksp in complex with inhibitor 1
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
345
structure length
330
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Kinesin-like protein KIF11
publication title Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 98
structure length 330
sequence length 345
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-05-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2q2yA00
3COBA 2ZFMA 4LNUK 4E7ZA 5LT0A 1MMAA 3BFNA 2ZFIA 2XAEA 4ZHIA 1SDMA 4BBGA 4PFOA 4PJJA 3WRDA 3B6UA 2UYIA 1T5CA 1GOJA 4AS7A 3ZFCA 5GSZA 2Q2YA 4A50A 2FL6A 1Q0BA 1MMGA 3L1CA 2V26A 5LT4A 1MKJA 1D0ZA 1G8XA 1F9TA 2VVGA 2X51A 2X7CA 1YRSA 4B7BA 1KK7A 3H4SA 1LKXA 1FMWA 2VASA 2X7DA 5HLEA 2FL2A 4PFPA 3CNZA 2NCDA 2FMEA 2ZFLA 3NWNA 1MMNA 2Q2ZA 3X2TA 1BR4A 3KARA 3HQDA 2PG2A 4UBFA 2XT3A 1V8KA 4DBRA 1BR1A 3T0QA 1F9WA 1X88A 5LT3A 1D1AA 1CZ7A 4FRZA 2FKYA 4PK4A 4BXNA 1VFZA 3LREA 1BR2A 1FMVA 1LVKA 3PXNA 4Y05A 3ZCWA 1MMDA 4ETPA 1N6MA 1VFXA 2G1QA 2WOGA 3DC4A 4A28A 2ZFKA 1RY6A 2OWMA 1BG2A 4H1GA 4PJMA 4PJLA 4ANJA 3DCBA 2VB6A 3B6VA 4AP0A 5LT1A 1II6A 2X2RA 1F9UA 4GKRA 4A5YA 3K5EA 2GRYA 1I5SA 4A14A 2ZFJA 3U06A 2X7EA 1D1CA 4A1ZA 3CJOA 2MYSA 3WPNA 2KINA 3KINA 2GM1A 1D1BA 1VFVA 2Y65A 1I6IA 1VOMA 4DBQA 3KENA 4BN2A 2IEHA 2Y5WA 3ZFDA 1VFWA 1MNEA 3L9HA 1V8JA 4E7SA 4HNAK 4PJNA 1F9VA 2UYMA 4ZCAA 3GBJA 5LT2A 3K3BA 1D0XA 1D0YA 4A51A 2HEHA
chains in the Genus database with same CATH superfamily
3COBA 2O0AA 2ZFMA 4LNUK 4E7ZA 5LT0A 1MMAA 3BFNA 2ZFIA 2XAEA 4ZHIA 1SDMA 4BBGA 4PFOA 4PJJA 3WRDA 3B6UA 4GKQA 2UYIA 1T5CA 1GOJA 4AS7A 3ZFCA 5GSZA 2Q2YA 4A50A 2FL6A 1Q0BA 1MMGA 3L1CA 2V26A 5LT4A 1MKJA 1D0ZA 1G8XA 1F9TA 2VVGA 2X51A 2X7CA 1YRSA 4B7BA 1KK7A 3H4SA 1LKXA 1FMWA 2VASA 2X7DA 5HLEA 2FL2A 4PFPA 3CNZA 2NCDA 2FMEA 2ZFLA 3NWNA 1MMNA 2Q2ZA 3X2TA 1BR4A 3KARA 3HQDA 2PG2A 4UBFA 2XT3A 1V8KA 4DBRA 1BR1A 3T0QA 1F9WA 1X88A 5LT3A 1D1AA 1CZ7A 4FRZA 2FKYA 4PK4A 4BXNA 1VFZA 3LREA 1BR2A 1FMVA 1LVKA 3PXNA 4Y05A 3ZCWA 1MMDA 4ETPA 1N6MA 1VFXA 2G1QA 2WOGA 3DC4A 4A28A 2ZFKA 1RY6A 4GKPA 2OWMA 1BG2A 4H1GA 4PJMA 4PJLA 4ANJA 4ETPB 3DCBA 2VB6A 3B6VA 4AP0A 5LT1A 1II6A 2X2RA 1F9UA 4GKRA 4A5YA 3K5EA 2GRYA 1I5SA 4A14A 2ZFJA 3U06A 2X7EA 1D1CA 4A1ZA 3CJOA 2MYSA 3WPNA 2KINA 3KINA 2GM1A 1D1BA 1VFVA 2Y65A 1I6IA 1VOMA 4DBQA 3KENA 4BN2A 2IEHA 2Y5WA 3ZFDA 1VFWA 1MNEA 3L9HA 1V8JA 4E7SA 4HNAK 4PJNA 1F9VA 2UYMA 4ZCAA 3GBJA 5LT2A 3K3BA 1D0XA 1D0YA 4A51A 2HEHA
chains in the Genus database with same CATH topology
3COBA 2ZFMA 4LNUK 4E7ZA 5LT0A 1MMAA 3BFNA 2ZFIA 2XAEA 4ZHIA 1SDMA 4BBGA 4PFOA 4PJJA 3WRDA 3B6UA 2UYIA 1T5CA 1GOJA 4AS7A 3ZFCA 5GSZA 2Q2YA 4A50A 2FL6A 1Q0BA 1MMGA 3L1CA 2V26A 5LT4A 1MKJA 1D0ZA 1G8XA 1F9TA 2VVGA 2X51A 2X7CA 1YRSA 4B7BA 1KK7A 3H4SA 1LKXA 1FMWA 2VASA 2X7DA 5HLEA 2FL2A 4PFPA 3CNZA 2NCDA 2FMEA 2ZFLA 3NWNA 1MMNA 2Q2ZA 3X2TA 1BR4A 3KARA 3HQDA 2PG2A 4UBFA 2XT3A 1V8KA 4DBRA 1BR1A 3T0QA 1F9WA 1X88A 5LT3A 1D1AA 1CZ7A 4FRZA 2FKYA 4PK4A 4BXNA 1VFZA 3LREA 1BR2A 1FMVA 1LVKA 3PXNA 4Y05A 3ZCWA 1MMDA 4ETPA 1N6MA 1VFXA 2G1QA 2WOGA 3DC4A 4A28A 2ZFKA 1RY6A 2OWMA 1BG2A 4H1GA 4PJMA 4PJLA 4ANJA 3DCBA 2VB6A 3B6VA 4AP0A 5LT1A 1II6A 2X2RA 1F9UA 4GKRA 4A5YA 3K5EA 2GRYA 1I5SA 4A14A 2ZFJA 3U06A 2X7EA 1D1CA 4A1ZA 3CJOA 2MYSA 3WPNA 2KINA 3KINA 2GM1A 1D1BA 1VFVA 2Y65A 1I6IA 1VOMA 4DBQA 3KENA 4BN2A 2IEHA 2Y5WA 3ZFDA 1VFWA 1MNEA 3L9HA 1V8JA 4E7SA 4HNAK 4PJNA 1F9VA 2UYMA 4ZCAA 3GBJA 5LT2A 3K3BA 1D0XA 1D0YA 4A51A 2HEHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3COB A;  2ZFM A;  4LNU K;  4E7Z A;  5LT0 A;  1MMA A;  3BFN A;  2ZFI A;  2XAE A;  4ZHI A;  1SDM A;  4BBG A;  4PFO A;  4PJJ A;  3WRD A;  3B6U A;  2UYI A;  1T5C A;  1GOJ A;  4AS7 A;  3ZFC A;  5GSZ A;  2Q2Y A;  4A50 A;  2FL6 A;  1Q0B A;  1MMG A;  3L1C A;  2V26 A;  5LT4 A;  1MKJ A;  1D0Z A;  1G8X A;  1F9T A;  2VVG A;  2X51 A;  2X7C A;  1YRS A;  4B7B A;  1KK7 A;  3H4S A;  1LKX A;  1FMW A;  2VAS A;  2X7D A;  5HLE A;  2FL2 A;  4PFP A;  3CNZ A;  2NCD A;  2FME A;  2ZFL A;  3NWN A;  1MMN A;  2Q2Z A;  3X2T A;  1BR4 A;  3KAR A;  3HQD A;  2PG2 A;  4UBF A;  2XT3 A;  1V8K A;  4DBR A;  1BR1 A;  3T0Q A;  1F9W A;  1X88 A;  5LT3 A;  1D1A A;  1CZ7 A;  4FRZ A;  2FKY A;  4PK4 A;  4BXN A;  1VFZ A;  3LRE A;  1BR2 A;  1FMV A;  1LVK A;  3PXN A;  4Y05 A;  3ZCW A;  1MMD A;  4ETP A;  1N6M A;  1VFX A;  2G1Q A;  2WOG A;  3DC4 A;  4A28 A;  2ZFK A;  1RY6 A;  2OWM A;  1BG2 A;  4H1G A;  4PJM A;  4PJL A;  4ANJ A;  3DCB A;  2VB6 A;  3B6V A;  4AP0 A;  5LT1 A;  1II6 A;  2X2R A;  1F9U A;  4GKR A;  4A5Y A;  3K5E A;  2GRY A;  1I5S A;  4A14 A;  2ZFJ A;  3U06 A;  2X7E A;  1D1C A;  4A1Z A;  3CJO A;  2MYS A;  3WPN A;  2KIN A;  3KIN A;  2GM1 A;  1D1B A;  1VFV A;  2Y65 A;  1I6I A;  1VOM A;  4DBQ A;  3KEN A;  4BN2 A;  2IEH A;  2Y5W A;  3ZFD A;  1VFW A;  1MNE A;  3L9H A;  1V8J A;  4E7S A;  4HNA K;  4PJN A;  1F9V A;  2UYM A;  4ZCA A;  3GBJ A;  5LT2 A;  3K3B A;  1D0X A;  1D0Y A;  4A51 A;  2HEH A; 
#chains in the Genus database with same CATH topology
 3COB A;  2O0A A;  2ZFM A;  4LNU K;  4E7Z A;  5LT0 A;  1MMA A;  3BFN A;  2ZFI A;  2XAE A;  4ZHI A;  1SDM A;  4BBG A;  4PFO A;  4PJJ A;  3WRD A;  3B6U A;  4GKQ A;  2UYI A;  1T5C A;  1GOJ A;  4AS7 A;  3ZFC A;  5GSZ A;  2Q2Y A;  4A50 A;  2FL6 A;  1Q0B A;  1MMG A;  3L1C A;  2V26 A;  5LT4 A;  1MKJ A;  1D0Z A;  1G8X A;  1F9T A;  2VVG A;  2X51 A;  2X7C A;  1YRS A;  4B7B A;  1KK7 A;  3H4S A;  1LKX A;  1FMW A;  2VAS A;  2X7D A;  5HLE A;  2FL2 A;  4PFP A;  3CNZ A;  2NCD A;  2FME A;  2ZFL A;  3NWN A;  1MMN A;  2Q2Z A;  3X2T A;  1BR4 A;  3KAR A;  3HQD A;  2PG2 A;  4UBF A;  2XT3 A;  1V8K A;  4DBR A;  1BR1 A;  3T0Q A;  1F9W A;  1X88 A;  5LT3 A;  1D1A A;  1CZ7 A;  4FRZ A;  2FKY A;  4PK4 A;  4BXN A;  1VFZ A;  3LRE A;  1BR2 A;  1FMV A;  1LVK A;  3PXN A;  4Y05 A;  3ZCW A;  1MMD A;  4ETP A;  1N6M A;  1VFX A;  2G1Q A;  2WOG A;  3DC4 A;  4A28 A;  2ZFK A;  1RY6 A;  4GKP A;  2OWM A;  1BG2 A;  4H1G A;  4PJM A;  4PJL A;  4ANJ A;  4ETP B;  3DCB A;  2VB6 A;  3B6V A;  4AP0 A;  5LT1 A;  1II6 A;  2X2R A;  1F9U A;  4GKR A;  4A5Y A;  3K5E A;  2GRY A;  1I5S A;  4A14 A;  2ZFJ A;  3U06 A;  2X7E A;  1D1C A;  4A1Z A;  3CJO A;  2MYS A;  3WPN A;  2KIN A;  3KIN A;  2GM1 A;  1D1B A;  1VFV A;  2Y65 A;  1I6I A;  1VOM A;  4DBQ A;  3KEN A;  4BN2 A;  2IEH A;  2Y5W A;  3ZFD A;  1VFW A;  1MNE A;  3L9H A;  1V8J A;  4E7S A;  4HNA K;  4PJN A;  1F9V A;  2UYM A;  4ZCA A;  3GBJ A;  5LT2 A;  3K3B A;  1D0X A;  1D0Y A;  4A51 A;  2HEH A; 
#chains in the Genus database with same CATH homology
 3COB A;  2ZFM A;  4LNU K;  4E7Z A;  5LT0 A;  1MMA A;  3BFN A;  2ZFI A;  2XAE A;  4ZHI A;  1SDM A;  4BBG A;  4PFO A;  4PJJ A;  3WRD A;  3B6U A;  2UYI A;  1T5C A;  1GOJ A;  4AS7 A;  3ZFC A;  5GSZ A;  2Q2Y A;  4A50 A;  2FL6 A;  1Q0B A;  1MMG A;  3L1C A;  2V26 A;  5LT4 A;  1MKJ A;  1D0Z A;  1G8X A;  1F9T A;  2VVG A;  2X51 A;  2X7C A;  1YRS A;  4B7B A;  1KK7 A;  3H4S A;  1LKX A;  1FMW A;  2VAS A;  2X7D A;  5HLE A;  2FL2 A;  4PFP A;  3CNZ A;  2NCD A;  2FME A;  2ZFL A;  3NWN A;  1MMN A;  2Q2Z A;  3X2T A;  1BR4 A;  3KAR A;  3HQD A;  2PG2 A;  4UBF A;  2XT3 A;  1V8K A;  4DBR A;  1BR1 A;  3T0Q A;  1F9W A;  1X88 A;  5LT3 A;  1D1A A;  1CZ7 A;  4FRZ A;  2FKY A;  4PK4 A;  4BXN A;  1VFZ A;  3LRE A;  1BR2 A;  1FMV A;  1LVK A;  3PXN A;  4Y05 A;  3ZCW A;  1MMD A;  4ETP A;  1N6M A;  1VFX A;  2G1Q A;  2WOG A;  3DC4 A;  4A28 A;  2ZFK A;  1RY6 A;  2OWM A;  1BG2 A;  4H1G A;  4PJM A;  4PJL A;  4ANJ A;  3DCB A;  2VB6 A;  3B6V A;  4AP0 A;  5LT1 A;  1II6 A;  2X2R A;  1F9U A;  4GKR A;  4A5Y A;  3K5E A;  2GRY A;  1I5S A;  4A14 A;  2ZFJ A;  3U06 A;  2X7E A;  1D1C A;  4A1Z A;  3CJO A;  2MYS A;  3WPN A;  2KIN A;  3KIN A;  2GM1 A;  1D1B A;  1VFV A;  2Y65 A;  1I6I A;  1VOM A;  4DBQ A;  3KEN A;  4BN2 A;  2IEH A;  2Y5W A;  3ZFD A;  1VFW A;  1MNE A;  3L9H A;  1V8J A;  4E7S A;  4HNA K;  4PJN A;  1F9V A;  2UYM A;  4ZCA A;  3GBJ A;  5LT2 A;  3K3B A;  1D0X A;  1D0Y A;  4A51 A;  2HEH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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