3CJOA

Crystal structure of ksp in complex with inhibitor 30
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
345
structure length
330
Chain Sequence
b'NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Kinesin-like protein KIF11
publication title Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Motor protein
total genus 91
structure length 330
sequence length 345
chains with identical sequence B
ec nomenclature
pdb deposition date 2008-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 3cjoA00
1BR1A 2UYIA 4PJMA 4H1GA 4AS7A 1D1AA 2GM1A 4GKRA 1MMNA 2G1QA 1GOJA 4A51A 1BG2A 1N6MA 4A5YA 5GSZA 1MKJA 3WRDA 1RY6A 3CNZA 4ZCAA 3BFNA 4PJJA 4A50A 5LT1A 3U06A 1KK7A 4BN2A 3LREA 2Y65A 3ZFCA 3NWNA 4PK4A 4ANJA 1X88A 3PXNA 4DBRA 4FRZA 1LKXA 2ZFLA 4UBFA 3K3BA 2FMEA 3KARA 4B7BA 2X7EA 3H4SA 4A1ZA 1VFZA 3KENA 2KINA 1LVKA 4ZHIA 4A14A 2HEHA 3KINA 2VASA 1MNEA 4ETPA 3L1CA 2IEHA 2ZFKA 4PJNA 3L9HA 1F9UA 4Y05A 1YRSA 2X7CA 2X51A 4BBGA 2ZFMA 1II6A 2ZFIA 1BR4A 3B6UA 2OWMA 2GRYA 3COBA 5LT0A 4AP0A 2FL2A 2Q2YA 1D1BA 3ZFDA 1SDMA 2ZFJA 1MMAA 5HLEA 4DBQA 1VFWA 4BXNA 3GBJA 4HNAK 2MYSA 2FL6A 2X2RA 3X2TA 1MMGA 3T0QA 1V8KA 2NCDA 1D0ZA 1G8XA 2XAEA 2Q2ZA 3DC4A 1I6IA 2UYMA 2PG2A 5LT4A 2VVGA 1V8JA 1VFVA 2FKYA 3WPNA 4A28A 1F9VA 1I5SA 1D0XA 1T5CA 4PFPA 4E7ZA 3CJOA 2WOGA 3HQDA 3K5EA 2XT3A 1VFXA 2X7DA 1FMVA 2Y5WA 1F9TA 1MMDA 1VOMA 3ZCWA 4PJLA 1BR2A 3DCBA 5LT2A 4E7SA 3B6VA 1CZ7A 2VB6A 2V26A 5LT3A 1Q0BA 4PFOA 1F9WA 1D1CA 1D0YA 4LNUK 1FMWA
chains in the Genus database with same CATH superfamily
1BR1A 2UYIA 4PJMA 4H1GA 4AS7A 1D1AA 2GM1A 4GKRA 2O0AA 1MMNA 2G1QA 1GOJA 4A51A 1BG2A 1N6MA 4A5YA 5GSZA 1MKJA 3WRDA 1RY6A 3CNZA 4ZCAA 3BFNA 4PJJA 4A50A 5LT1A 3U06A 1KK7A 4BN2A 3LREA 2Y65A 3ZFCA 3NWNA 4PK4A 4ANJA 1X88A 3PXNA 4DBRA 4FRZA 1LKXA 2ZFLA 4UBFA 3K3BA 2FMEA 3KARA 4B7BA 2X7EA 3H4SA 4A1ZA 1VFZA 3KENA 2KINA 1LVKA 4ZHIA 4A14A 2HEHA 3KINA 2VASA 1MNEA 4ETPA 3L1CA 2IEHA 2ZFKA 4PJNA 3L9HA 1F9UA 4Y05A 1YRSA 2X7CA 4GKPA 2X51A 4BBGA 2ZFMA 1II6A 4ETPB 2ZFIA 1BR4A 3B6UA 2OWMA 2GRYA 3COBA 5LT0A 4AP0A 2FL2A 2Q2YA 1D1BA 3ZFDA 1SDMA 2ZFJA 1MMAA 5HLEA 4DBQA 1VFWA 4BXNA 3GBJA 4HNAK 2MYSA 2FL6A 2X2RA 3X2TA 1MMGA 3T0QA 1V8KA 2NCDA 1D0ZA 1G8XA 2XAEA 2Q2ZA 3DC4A 1I6IA 2UYMA 2PG2A 5LT4A 2VVGA 1V8JA 4GKQA 1VFVA 2FKYA 3WPNA 4A28A 1F9VA 1I5SA 1D0XA 1T5CA 4PFPA 4E7ZA 3CJOA 2WOGA 3HQDA 3K5EA 2XT3A 1VFXA 2X7DA 1FMVA 2Y5WA 1F9TA 1MMDA 1VOMA 3ZCWA 4PJLA 1BR2A 3DCBA 5LT2A 4E7SA 3B6VA 1CZ7A 2VB6A 2V26A 5LT3A 1Q0BA 4PFOA 1F9WA 1D1CA 1D0YA 4LNUK 1FMWA
chains in the Genus database with same CATH topology
1BR1A 2UYIA 4PJMA 4H1GA 4AS7A 1D1AA 2GM1A 4GKRA 1MMNA 2G1QA 1GOJA 4A51A 1BG2A 1N6MA 4A5YA 5GSZA 1MKJA 3WRDA 1RY6A 3CNZA 4ZCAA 3BFNA 4PJJA 4A50A 5LT1A 3U06A 1KK7A 4BN2A 3LREA 2Y65A 3ZFCA 3NWNA 4PK4A 4ANJA 1X88A 3PXNA 4DBRA 4FRZA 1LKXA 2ZFLA 4UBFA 3K3BA 2FMEA 3KARA 4B7BA 2X7EA 3H4SA 4A1ZA 1VFZA 3KENA 2KINA 1LVKA 4ZHIA 4A14A 2HEHA 3KINA 2VASA 1MNEA 4ETPA 3L1CA 2IEHA 2ZFKA 4PJNA 3L9HA 1F9UA 4Y05A 1YRSA 2X7CA 2X51A 4BBGA 2ZFMA 1II6A 2ZFIA 1BR4A 3B6UA 2OWMA 2GRYA 3COBA 5LT0A 4AP0A 2FL2A 2Q2YA 1D1BA 3ZFDA 1SDMA 2ZFJA 1MMAA 5HLEA 4DBQA 1VFWA 4BXNA 3GBJA 4HNAK 2MYSA 2FL6A 2X2RA 3X2TA 1MMGA 3T0QA 1V8KA 2NCDA 1D0ZA 1G8XA 2XAEA 2Q2ZA 3DC4A 1I6IA 2UYMA 2PG2A 5LT4A 2VVGA 1V8JA 1VFVA 2FKYA 3WPNA 4A28A 1F9VA 1I5SA 1D0XA 1T5CA 4PFPA 4E7ZA 3CJOA 2WOGA 3HQDA 3K5EA 2XT3A 1VFXA 2X7DA 1FMVA 2Y5WA 1F9TA 1MMDA 1VOMA 3ZCWA 4PJLA 1BR2A 3DCBA 5LT2A 4E7SA 3B6VA 1CZ7A 2VB6A 2V26A 5LT3A 1Q0BA 4PFOA 1F9WA 1D1CA 1D0YA 4LNUK 1FMWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BR1 A;  2UYI A;  4PJM A;  4H1G A;  4AS7 A;  1D1A A;  2GM1 A;  4GKR A;  1MMN A;  2G1Q A;  1GOJ A;  4A51 A;  1BG2 A;  1N6M A;  4A5Y A;  5GSZ A;  1MKJ A;  3WRD A;  1RY6 A;  3CNZ A;  4ZCA A;  3BFN A;  4PJJ A;  4A50 A;  5LT1 A;  3U06 A;  1KK7 A;  4BN2 A;  3LRE A;  2Y65 A;  3ZFC A;  3NWN A;  4PK4 A;  4ANJ A;  1X88 A;  3PXN A;  4DBR A;  4FRZ A;  1LKX A;  2ZFL A;  4UBF A;  3K3B A;  2FME A;  3KAR A;  4B7B A;  2X7E A;  3H4S A;  4A1Z A;  1VFZ A;  3KEN A;  2KIN A;  1LVK A;  4ZHI A;  4A14 A;  2HEH A;  3KIN A;  2VAS A;  1MNE A;  4ETP A;  3L1C A;  2IEH A;  2ZFK A;  4PJN A;  3L9H A;  1F9U A;  4Y05 A;  1YRS A;  2X7C A;  2X51 A;  4BBG A;  2ZFM A;  1II6 A;  2ZFI A;  1BR4 A;  3B6U A;  2OWM A;  2GRY A;  3COB A;  5LT0 A;  4AP0 A;  2FL2 A;  2Q2Y A;  1D1B A;  3ZFD A;  1SDM A;  2ZFJ A;  1MMA A;  5HLE A;  4DBQ A;  1VFW A;  4BXN A;  3GBJ A;  4HNA K;  2MYS A;  2FL6 A;  2X2R A;  3X2T A;  1MMG A;  3T0Q A;  1V8K A;  2NCD A;  1D0Z A;  1G8X A;  2XAE A;  2Q2Z A;  3DC4 A;  1I6I A;  2UYM A;  2PG2 A;  5LT4 A;  2VVG A;  1V8J A;  1VFV A;  2FKY A;  3WPN A;  4A28 A;  1F9V A;  1I5S A;  1D0X A;  1T5C A;  4PFP A;  4E7Z A;  3CJO A;  2WOG A;  3HQD A;  3K5E A;  2XT3 A;  1VFX A;  2X7D A;  1FMV A;  2Y5W A;  1F9T A;  1MMD A;  1VOM A;  3ZCW A;  4PJL A;  1BR2 A;  3DCB A;  5LT2 A;  4E7S A;  3B6V A;  1CZ7 A;  2VB6 A;  2V26 A;  5LT3 A;  1Q0B A;  4PFO A;  1F9W A;  1D1C A;  1D0Y A;  4LNU K;  1FMW A; 
#chains in the Genus database with same CATH topology
 1BR1 A;  2UYI A;  4PJM A;  4H1G A;  4AS7 A;  1D1A A;  2GM1 A;  4GKR A;  2O0A A;  1MMN A;  2G1Q A;  1GOJ A;  4A51 A;  1BG2 A;  1N6M A;  4A5Y A;  5GSZ A;  1MKJ A;  3WRD A;  1RY6 A;  3CNZ A;  4ZCA A;  3BFN A;  4PJJ A;  4A50 A;  5LT1 A;  3U06 A;  1KK7 A;  4BN2 A;  3LRE A;  2Y65 A;  3ZFC A;  3NWN A;  4PK4 A;  4ANJ A;  1X88 A;  3PXN A;  4DBR A;  4FRZ A;  1LKX A;  2ZFL A;  4UBF A;  3K3B A;  2FME A;  3KAR A;  4B7B A;  2X7E A;  3H4S A;  4A1Z A;  1VFZ A;  3KEN A;  2KIN A;  1LVK A;  4ZHI A;  4A14 A;  2HEH A;  3KIN A;  2VAS A;  1MNE A;  4ETP A;  3L1C A;  2IEH A;  2ZFK A;  4PJN A;  3L9H A;  1F9U A;  4Y05 A;  1YRS A;  2X7C A;  4GKP A;  2X51 A;  4BBG A;  2ZFM A;  1II6 A;  4ETP B;  2ZFI A;  1BR4 A;  3B6U A;  2OWM A;  2GRY A;  3COB A;  5LT0 A;  4AP0 A;  2FL2 A;  2Q2Y A;  1D1B A;  3ZFD A;  1SDM A;  2ZFJ A;  1MMA A;  5HLE A;  4DBQ A;  1VFW A;  4BXN A;  3GBJ A;  4HNA K;  2MYS A;  2FL6 A;  2X2R A;  3X2T A;  1MMG A;  3T0Q A;  1V8K A;  2NCD A;  1D0Z A;  1G8X A;  2XAE A;  2Q2Z A;  3DC4 A;  1I6I A;  2UYM A;  2PG2 A;  5LT4 A;  2VVG A;  1V8J A;  4GKQ A;  1VFV A;  2FKY A;  3WPN A;  4A28 A;  1F9V A;  1I5S A;  1D0X A;  1T5C A;  4PFP A;  4E7Z A;  3CJO A;  2WOG A;  3HQD A;  3K5E A;  2XT3 A;  1VFX A;  2X7D A;  1FMV A;  2Y5W A;  1F9T A;  1MMD A;  1VOM A;  3ZCW A;  4PJL A;  1BR2 A;  3DCB A;  5LT2 A;  4E7S A;  3B6V A;  1CZ7 A;  2VB6 A;  2V26 A;  5LT3 A;  1Q0B A;  4PFO A;  1F9W A;  1D1C A;  1D0Y A;  4LNU K;  1FMW A; 
#chains in the Genus database with same CATH homology
 1BR1 A;  2UYI A;  4PJM A;  4H1G A;  4AS7 A;  1D1A A;  2GM1 A;  4GKR A;  1MMN A;  2G1Q A;  1GOJ A;  4A51 A;  1BG2 A;  1N6M A;  4A5Y A;  5GSZ A;  1MKJ A;  3WRD A;  1RY6 A;  3CNZ A;  4ZCA A;  3BFN A;  4PJJ A;  4A50 A;  5LT1 A;  3U06 A;  1KK7 A;  4BN2 A;  3LRE A;  2Y65 A;  3ZFC A;  3NWN A;  4PK4 A;  4ANJ A;  1X88 A;  3PXN A;  4DBR A;  4FRZ A;  1LKX A;  2ZFL A;  4UBF A;  3K3B A;  2FME A;  3KAR A;  4B7B A;  2X7E A;  3H4S A;  4A1Z A;  1VFZ A;  3KEN A;  2KIN A;  1LVK A;  4ZHI A;  4A14 A;  2HEH A;  3KIN A;  2VAS A;  1MNE A;  4ETP A;  3L1C A;  2IEH A;  2ZFK A;  4PJN A;  3L9H A;  1F9U A;  4Y05 A;  1YRS A;  2X7C A;  2X51 A;  4BBG A;  2ZFM A;  1II6 A;  2ZFI A;  1BR4 A;  3B6U A;  2OWM A;  2GRY A;  3COB A;  5LT0 A;  4AP0 A;  2FL2 A;  2Q2Y A;  1D1B A;  3ZFD A;  1SDM A;  2ZFJ A;  1MMA A;  5HLE A;  4DBQ A;  1VFW A;  4BXN A;  3GBJ A;  4HNA K;  2MYS A;  2FL6 A;  2X2R A;  3X2T A;  1MMG A;  3T0Q A;  1V8K A;  2NCD A;  1D0Z A;  1G8X A;  2XAE A;  2Q2Z A;  3DC4 A;  1I6I A;  2UYM A;  2PG2 A;  5LT4 A;  2VVG A;  1V8J A;  1VFV A;  2FKY A;  3WPN A;  4A28 A;  1F9V A;  1I5S A;  1D0X A;  1T5C A;  4PFP A;  4E7Z A;  3CJO A;  2WOG A;  3HQD A;  3K5E A;  2XT3 A;  1VFX A;  2X7D A;  1FMV A;  2Y5W A;  1F9T A;  1MMD A;  1VOM A;  3ZCW A;  4PJL A;  1BR2 A;  3DCB A;  5LT2 A;  4E7S A;  3B6V A;  1CZ7 A;  2VB6 A;  2V26 A;  5LT3 A;  1Q0B A;  4PFO A;  1F9W A;  1D1C A;  1D0Y A;  4LNU K;  1FMW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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