1X88A

Human eg5 motor domain bound to mg-adp and monastrol
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
347
structure length
332
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Kinesin-like protein KIF11
publication title Structural Basis of Eg5 Inhibition by Monastrol
rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 109
structure length 332
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2004-08-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 1x88A00
1BR2A 4Y05A 1T5CA 2ZFJA 1MMDA 4E7SA 3B6UA 1II6A 4UBFA 1BG2A 1BR4A 2GRYA 1V8JA 3WPNA 3CJOA 2NCDA 4A5YA 1VFZA 1D1CA 3ZFDA 5LT2A 2Q2YA 2V26A 3WRDA 5LT0A 2X7CA 1FMWA 3KINA 3L1CA 1I5SA 2PG2A 3DC4A 2FKYA 1VFXA 1CZ7A 3K5EA 1D1BA 3L9HA 4AS7A 4HNAK 3B6VA 4A1ZA 1D0YA 2G1QA 4ZHIA 5LT4A 1RY6A 2X7DA 1G8XA 3HQDA 4FRZA 1MMNA 1I6IA 4PJLA 1VFVA 3U06A 1F9UA 1BR1A 3H4SA 2HEHA 1V8KA 1X88A 4PK4A 1F9WA 4BBGA 1D1AA 2Q2ZA 2Y5WA 4BXNA 4PJMA 4B7BA 1Q0BA 2FL6A 4PFPA 5LT3A 3CNZA 4DBRA 4ETPA 2Y65A 4LNUK 4A51A 3ZFCA 1MNEA 2X2RA 2IEHA 4H1GA 1MMAA 2FL2A 3K3BA 2X51A 2VASA 1MKJA 3BFNA 4A14A 3KENA 1SDMA 2ZFIA 1FMVA 2ZFKA 1MMGA 1N6MA 2UYMA 4ZCAA 3X2TA 3COBA 3LREA 1VOMA 2WOGA 2XT3A 2ZFLA 1LVKA 4AP0A 1VFWA 1YRSA 3PXNA 5HLEA 2OWMA 3T0QA 1GOJA 4PFOA 2X7EA 3DCBA 4PJNA 3NWNA 1F9VA 2ZFMA 4BN2A 5GSZA 4ANJA 1D0ZA 1F9TA 5LT1A 3GBJA 3ZCWA 1KK7A 3KARA 2FMEA 2XAEA 4DBQA 2UYIA 2VB6A 4GKRA 4E7ZA 2KINA 2GM1A 2VVGA 2MYSA 1D0XA 4A50A 1LKXA 4PJJA 4A28A
chains in the Genus database with same CATH superfamily
1BR2A 4Y05A 1T5CA 2ZFJA 1MMDA 4E7SA 3B6UA 1II6A 4UBFA 1BG2A 1BR4A 2GRYA 1V8JA 3WPNA 3CJOA 2NCDA 4A5YA 1VFZA 4GKQA 1D1CA 3ZFDA 5LT2A 2Q2YA 2V26A 3WRDA 5LT0A 2X7CA 1FMWA 3KINA 3L1CA 4GKPA 1I5SA 2PG2A 3DC4A 2FKYA 1VFXA 1CZ7A 3K5EA 1D1BA 3L9HA 4AS7A 4HNAK 3B6VA 4A1ZA 1D0YA 2G1QA 4ZHIA 5LT4A 1RY6A 4ETPB 2X7DA 1G8XA 3HQDA 4FRZA 1MMNA 1I6IA 4PJLA 1VFVA 3U06A 1F9UA 1BR1A 3H4SA 2HEHA 1V8KA 1X88A 4PK4A 1F9WA 4BBGA 1D1AA 2Q2ZA 2Y5WA 4BXNA 4PJMA 4B7BA 1Q0BA 2FL6A 4PFPA 5LT3A 3CNZA 4DBRA 4ETPA 2Y65A 4LNUK 4A51A 3ZFCA 1MNEA 2X2RA 2IEHA 4H1GA 1MMAA 2FL2A 3K3BA 2X51A 2O0AA 2VASA 1MKJA 3BFNA 4A14A 3KENA 1SDMA 2ZFIA 1FMVA 2ZFKA 1MMGA 1N6MA 2UYMA 4ZCAA 3X2TA 3COBA 3LREA 1VOMA 2WOGA 2XT3A 2ZFLA 1LVKA 4AP0A 1VFWA 1YRSA 3PXNA 5HLEA 2OWMA 3T0QA 1GOJA 4PFOA 2X7EA 3DCBA 4PJNA 3NWNA 1F9VA 2ZFMA 4BN2A 5GSZA 4ANJA 1D0ZA 1F9TA 5LT1A 3GBJA 3ZCWA 1KK7A 3KARA 2FMEA 2XAEA 4DBQA 2UYIA 2VB6A 4GKRA 4E7ZA 2KINA 2GM1A 2VVGA 2MYSA 1D0XA 4A50A 1LKXA 4PJJA 4A28A
chains in the Genus database with same CATH topology
1BR2A 4Y05A 1T5CA 2ZFJA 1MMDA 4E7SA 3B6UA 1II6A 4UBFA 1BG2A 1BR4A 2GRYA 1V8JA 3WPNA 3CJOA 2NCDA 4A5YA 1VFZA 1D1CA 3ZFDA 5LT2A 2Q2YA 2V26A 3WRDA 5LT0A 2X7CA 1FMWA 3KINA 3L1CA 1I5SA 2PG2A 3DC4A 2FKYA 1VFXA 1CZ7A 3K5EA 1D1BA 3L9HA 4AS7A 4HNAK 3B6VA 4A1ZA 1D0YA 2G1QA 4ZHIA 5LT4A 1RY6A 2X7DA 1G8XA 3HQDA 4FRZA 1MMNA 1I6IA 4PJLA 1VFVA 3U06A 1F9UA 1BR1A 3H4SA 2HEHA 1V8KA 1X88A 4PK4A 1F9WA 4BBGA 1D1AA 2Q2ZA 2Y5WA 4BXNA 4PJMA 4B7BA 1Q0BA 2FL6A 4PFPA 5LT3A 3CNZA 4DBRA 4ETPA 2Y65A 4LNUK 4A51A 3ZFCA 1MNEA 2X2RA 2IEHA 4H1GA 1MMAA 2FL2A 3K3BA 2X51A 2VASA 1MKJA 3BFNA 4A14A 3KENA 1SDMA 2ZFIA 1FMVA 2ZFKA 1MMGA 1N6MA 2UYMA 4ZCAA 3X2TA 3COBA 3LREA 1VOMA 2WOGA 2XT3A 2ZFLA 1LVKA 4AP0A 1VFWA 1YRSA 3PXNA 5HLEA 2OWMA 3T0QA 1GOJA 4PFOA 2X7EA 3DCBA 4PJNA 3NWNA 1F9VA 2ZFMA 4BN2A 5GSZA 4ANJA 1D0ZA 1F9TA 5LT1A 3GBJA 3ZCWA 1KK7A 3KARA 2FMEA 2XAEA 4DBQA 2UYIA 2VB6A 4GKRA 4E7ZA 2KINA 2GM1A 2VVGA 2MYSA 1D0XA 4A50A 1LKXA 4PJJA 4A28A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BR2 A;  4Y05 A;  1T5C A;  2ZFJ A;  1MMD A;  4E7S A;  3B6U A;  1II6 A;  4UBF A;  1BG2 A;  1BR4 A;  2GRY A;  1V8J A;  3WPN A;  3CJO A;  2NCD A;  4A5Y A;  1VFZ A;  1D1C A;  3ZFD A;  5LT2 A;  2Q2Y A;  2V26 A;  3WRD A;  5LT0 A;  2X7C A;  1FMW A;  3KIN A;  3L1C A;  1I5S A;  2PG2 A;  3DC4 A;  2FKY A;  1VFX A;  1CZ7 A;  3K5E A;  1D1B A;  3L9H A;  4AS7 A;  4HNA K;  3B6V A;  4A1Z A;  1D0Y A;  2G1Q A;  4ZHI A;  5LT4 A;  1RY6 A;  2X7D A;  1G8X A;  3HQD A;  4FRZ A;  1MMN A;  1I6I A;  4PJL A;  1VFV A;  3U06 A;  1F9U A;  1BR1 A;  3H4S A;  2HEH A;  1V8K A;  1X88 A;  4PK4 A;  1F9W A;  4BBG A;  1D1A A;  2Q2Z A;  2Y5W A;  4BXN A;  4PJM A;  4B7B A;  1Q0B A;  2FL6 A;  4PFP A;  5LT3 A;  3CNZ A;  4DBR A;  4ETP A;  2Y65 A;  4LNU K;  4A51 A;  3ZFC A;  1MNE A;  2X2R A;  2IEH A;  4H1G A;  1MMA A;  2FL2 A;  3K3B A;  2X51 A;  2VAS A;  1MKJ A;  3BFN A;  4A14 A;  3KEN A;  1SDM A;  2ZFI A;  1FMV A;  2ZFK A;  1MMG A;  1N6M A;  2UYM A;  4ZCA A;  3X2T A;  3COB A;  3LRE A;  1VOM A;  2WOG A;  2XT3 A;  2ZFL A;  1LVK A;  4AP0 A;  1VFW A;  1YRS A;  3PXN A;  5HLE A;  2OWM A;  3T0Q A;  1GOJ A;  4PFO A;  2X7E A;  3DCB A;  4PJN A;  3NWN A;  1F9V A;  2ZFM A;  4BN2 A;  5GSZ A;  4ANJ A;  1D0Z A;  1F9T A;  5LT1 A;  3GBJ A;  3ZCW A;  1KK7 A;  3KAR A;  2FME A;  2XAE A;  4DBQ A;  2UYI A;  2VB6 A;  4GKR A;  4E7Z A;  2KIN A;  2GM1 A;  2VVG A;  2MYS A;  1D0X A;  4A50 A;  1LKX A;  4PJJ A;  4A28 A; 
#chains in the Genus database with same CATH topology
 1BR2 A;  4Y05 A;  1T5C A;  2ZFJ A;  1MMD A;  4E7S A;  3B6U A;  1II6 A;  4UBF A;  1BG2 A;  1BR4 A;  2GRY A;  1V8J A;  3WPN A;  3CJO A;  2NCD A;  4A5Y A;  1VFZ A;  4GKQ A;  1D1C A;  3ZFD A;  5LT2 A;  2Q2Y A;  2V26 A;  3WRD A;  5LT0 A;  2X7C A;  1FMW A;  3KIN A;  3L1C A;  4GKP A;  1I5S A;  2PG2 A;  3DC4 A;  2FKY A;  1VFX A;  1CZ7 A;  3K5E A;  1D1B A;  3L9H A;  4AS7 A;  4HNA K;  3B6V A;  4A1Z A;  1D0Y A;  2G1Q A;  4ZHI A;  5LT4 A;  1RY6 A;  4ETP B;  2X7D A;  1G8X A;  3HQD A;  4FRZ A;  1MMN A;  1I6I A;  4PJL A;  1VFV A;  3U06 A;  1F9U A;  1BR1 A;  3H4S A;  2HEH A;  1V8K A;  1X88 A;  4PK4 A;  1F9W A;  4BBG A;  1D1A A;  2Q2Z A;  2Y5W A;  4BXN A;  4PJM A;  4B7B A;  1Q0B A;  2FL6 A;  4PFP A;  5LT3 A;  3CNZ A;  4DBR A;  4ETP A;  2Y65 A;  4LNU K;  4A51 A;  3ZFC A;  1MNE A;  2X2R A;  2IEH A;  4H1G A;  1MMA A;  2FL2 A;  3K3B A;  2X51 A;  2O0A A;  2VAS A;  1MKJ A;  3BFN A;  4A14 A;  3KEN A;  1SDM A;  2ZFI A;  1FMV A;  2ZFK A;  1MMG A;  1N6M A;  2UYM A;  4ZCA A;  3X2T A;  3COB A;  3LRE A;  1VOM A;  2WOG A;  2XT3 A;  2ZFL A;  1LVK A;  4AP0 A;  1VFW A;  1YRS A;  3PXN A;  5HLE A;  2OWM A;  3T0Q A;  1GOJ A;  4PFO A;  2X7E A;  3DCB A;  4PJN A;  3NWN A;  1F9V A;  2ZFM A;  4BN2 A;  5GSZ A;  4ANJ A;  1D0Z A;  1F9T A;  5LT1 A;  3GBJ A;  3ZCW A;  1KK7 A;  3KAR A;  2FME A;  2XAE A;  4DBQ A;  2UYI A;  2VB6 A;  4GKR A;  4E7Z A;  2KIN A;  2GM1 A;  2VVG A;  2MYS A;  1D0X A;  4A50 A;  1LKX A;  4PJJ A;  4A28 A; 
#chains in the Genus database with same CATH homology
 1BR2 A;  4Y05 A;  1T5C A;  2ZFJ A;  1MMD A;  4E7S A;  3B6U A;  1II6 A;  4UBF A;  1BG2 A;  1BR4 A;  2GRY A;  1V8J A;  3WPN A;  3CJO A;  2NCD A;  4A5Y A;  1VFZ A;  1D1C A;  3ZFD A;  5LT2 A;  2Q2Y A;  2V26 A;  3WRD A;  5LT0 A;  2X7C A;  1FMW A;  3KIN A;  3L1C A;  1I5S A;  2PG2 A;  3DC4 A;  2FKY A;  1VFX A;  1CZ7 A;  3K5E A;  1D1B A;  3L9H A;  4AS7 A;  4HNA K;  3B6V A;  4A1Z A;  1D0Y A;  2G1Q A;  4ZHI A;  5LT4 A;  1RY6 A;  2X7D A;  1G8X A;  3HQD A;  4FRZ A;  1MMN A;  1I6I A;  4PJL A;  1VFV A;  3U06 A;  1F9U A;  1BR1 A;  3H4S A;  2HEH A;  1V8K A;  1X88 A;  4PK4 A;  1F9W A;  4BBG A;  1D1A A;  2Q2Z A;  2Y5W A;  4BXN A;  4PJM A;  4B7B A;  1Q0B A;  2FL6 A;  4PFP A;  5LT3 A;  3CNZ A;  4DBR A;  4ETP A;  2Y65 A;  4LNU K;  4A51 A;  3ZFC A;  1MNE A;  2X2R A;  2IEH A;  4H1G A;  1MMA A;  2FL2 A;  3K3B A;  2X51 A;  2VAS A;  1MKJ A;  3BFN A;  4A14 A;  3KEN A;  1SDM A;  2ZFI A;  1FMV A;  2ZFK A;  1MMG A;  1N6M A;  2UYM A;  4ZCA A;  3X2T A;  3COB A;  3LRE A;  1VOM A;  2WOG A;  2XT3 A;  2ZFL A;  1LVK A;  4AP0 A;  1VFW A;  1YRS A;  3PXN A;  5HLE A;  2OWM A;  3T0Q A;  1GOJ A;  4PFO A;  2X7E A;  3DCB A;  4PJN A;  3NWN A;  1F9V A;  2ZFM A;  4BN2 A;  5GSZ A;  4ANJ A;  1D0Z A;  1F9T A;  5LT1 A;  3GBJ A;  3ZCW A;  1KK7 A;  3KAR A;  2FME A;  2XAE A;  4DBQ A;  2UYI A;  2VB6 A;  4GKR A;  4E7Z A;  2KIN A;  2GM1 A;  2VVG A;  2MYS A;  1D0X A;  4A50 A;  1LKX A;  4PJJ A;  4A28 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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