1X88A

Human eg5 motor domain bound to mg-adp and monastrol
Total Genus 109
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
347
structure length
332
Chain Sequence
b'NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule keywords Kinesin-like protein KIF11
publication title Structural Basis of Eg5 Inhibition by Monastrol
rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 109
structure length 332
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2004-08-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 1x88A00
3H4SA 4E7ZA 5LT3A 2FKYA 2GM1A 2KINA 4ANJA 3COBA 2X7EA 2VVGA 2Y65A 3PXNA 1LKXA 3L1CA 4PFOA 2UYMA 3B6UA 1G8XA 1MMAA 1X88A 4H1GA 2WOGA 4PFPA 1VFVA 2VASA 5HLEA 2G1QA 4UBFA 3DCBA 3KENA 1D1BA 2HEHA 1FMWA 1LVKA 3BFNA 3NWNA 4E7SA 2X7DA 1BR4A 1D0ZA 3B6VA 3ZCWA 1V8JA 3WRDA 4BXNA 4PJJA 1D0XA 1F9WA 2X51A 3CJOA 1F9VA 1VFXA 4A1ZA 4A5YA 1V8KA 5LT4A 1VFZA 2V26A 1MMGA 3K3BA 4AP0A 1MKJA 4Y05A 3CNZA 2NCDA 3ZFDA 3T0QA 3L9HA 4DBQA 2ZFJA 1F9TA 3K5EA 4ETPA 4GKRA 4AS7A 3DC4A 4A28A 2PG2A 3KINA 2XAEA 1GOJA 1D0YA 2UYIA 4PJMA 2X2RA 1CZ7A 4PJLA 2XT3A 1I6IA 4A14A 2FL2A 1N6MA 3X2TA 1Q0BA 5LT2A 4PJNA 4PK4A 4ZHIA 2GRYA 3LREA 2Q2YA 1VOMA 1I5SA 2X7CA 3KARA 4LNUK 2Q2ZA 1MMDA 4HNAK 3HQDA 4B7BA 1SDMA 5LT0A 4ZCAA 1T5CA 1MMNA 2Y5WA 1FMVA 2OWMA 1VFWA 2ZFKA 1YRSA 1II6A 1D1CA 1BR2A 2ZFIA 5GSZA 2MYSA 5LT1A 1BG2A 4A50A 1F9UA 2FMEA 2ZFMA 4BBGA 2FL6A 4DBRA 3U06A 4BN2A 4A51A 1KK7A 3GBJA 4FRZA 1BR1A 1MNEA 2VB6A 3ZFCA 2ZFLA 1RY6A 3WPNA 1D1AA 2IEHA
chains in the Genus database with same CATH superfamily
3H4SA 4E7ZA 5LT3A 2FKYA 2GM1A 2KINA 4ANJA 3COBA 2X7EA 2VVGA 2Y65A 3PXNA 1LKXA 3L1CA 4PFOA 2UYMA 3B6UA 1G8XA 1MMAA 1X88A 4H1GA 2WOGA 4PFPA 1VFVA 2VASA 5HLEA 2G1QA 4UBFA 3DCBA 3KENA 1D1BA 2HEHA 1FMWA 1LVKA 3BFNA 3NWNA 4E7SA 2X7DA 1BR4A 1D0ZA 3B6VA 3ZCWA 1V8JA 3WRDA 4BXNA 4PJJA 1D0XA 1F9WA 2X51A 3CJOA 1F9VA 1VFXA 4A1ZA 4A5YA 1V8KA 5LT4A 1VFZA 2V26A 1MMGA 3K3BA 4AP0A 1MKJA 4Y05A 3CNZA 2NCDA 4GKPA 3ZFDA 3T0QA 3L9HA 4DBQA 2ZFJA 1F9TA 3K5EA 4ETPA 4GKRA 4AS7A 3DC4A 4A28A 2PG2A 3KINA 2XAEA 1GOJA 1D0YA 4GKQA 2UYIA 4PJMA 2X2RA 1CZ7A 4PJLA 2XT3A 1I6IA 4A14A 2FL2A 1N6MA 3X2TA 1Q0BA 5LT2A 4PJNA 4PK4A 4ZHIA 2GRYA 3LREA 2Q2YA 1VOMA 1I5SA 2X7CA 3KARA 4LNUK 2Q2ZA 1MMDA 4HNAK 3HQDA 4B7BA 1SDMA 5LT0A 4ZCAA 2O0AA 1T5CA 1MMNA 2Y5WA 1FMVA 2OWMA 1VFWA 2ZFKA 1YRSA 1II6A 1D1CA 1BR2A 2ZFIA 5GSZA 2MYSA 5LT1A 1BG2A 4A50A 1F9UA 2FMEA 2ZFMA 4BBGA 2FL6A 4DBRA 3U06A 4BN2A 4A51A 1KK7A 3GBJA 4ETPB 4FRZA 1BR1A 1MNEA 2VB6A 3ZFCA 2ZFLA 1RY6A 3WPNA 1D1AA 2IEHA
chains in the Genus database with same CATH topology
3H4SA 4E7ZA 5LT3A 2FKYA 2GM1A 2KINA 4ANJA 3COBA 2X7EA 2VVGA 2Y65A 3PXNA 1LKXA 3L1CA 4PFOA 2UYMA 3B6UA 1G8XA 1MMAA 1X88A 4H1GA 2WOGA 4PFPA 1VFVA 2VASA 5HLEA 2G1QA 4UBFA 3DCBA 3KENA 1D1BA 2HEHA 1FMWA 1LVKA 3BFNA 3NWNA 4E7SA 2X7DA 1BR4A 1D0ZA 3B6VA 3ZCWA 1V8JA 3WRDA 4BXNA 4PJJA 1D0XA 1F9WA 2X51A 3CJOA 1F9VA 1VFXA 4A1ZA 4A5YA 1V8KA 5LT4A 1VFZA 2V26A 1MMGA 3K3BA 4AP0A 1MKJA 4Y05A 3CNZA 2NCDA 3ZFDA 3T0QA 3L9HA 4DBQA 2ZFJA 1F9TA 3K5EA 4ETPA 4GKRA 4AS7A 3DC4A 4A28A 2PG2A 3KINA 2XAEA 1GOJA 1D0YA 2UYIA 4PJMA 2X2RA 1CZ7A 4PJLA 2XT3A 1I6IA 4A14A 2FL2A 1N6MA 3X2TA 1Q0BA 5LT2A 4PJNA 4PK4A 4ZHIA 2GRYA 3LREA 2Q2YA 1VOMA 1I5SA 2X7CA 3KARA 4LNUK 2Q2ZA 1MMDA 4HNAK 3HQDA 4B7BA 1SDMA 5LT0A 4ZCAA 1T5CA 1MMNA 2Y5WA 1FMVA 2OWMA 1VFWA 2ZFKA 1YRSA 1II6A 1D1CA 1BR2A 2ZFIA 5GSZA 2MYSA 5LT1A 1BG2A 4A50A 1F9UA 2FMEA 2ZFMA 4BBGA 2FL6A 4DBRA 3U06A 4BN2A 4A51A 1KK7A 3GBJA 4FRZA 1BR1A 1MNEA 2VB6A 3ZFCA 2ZFLA 1RY6A 3WPNA 1D1AA 2IEHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3H4S A;  4E7Z A;  5LT3 A;  2FKY A;  2GM1 A;  2KIN A;  4ANJ A;  3COB A;  2X7E A;  2VVG A;  2Y65 A;  3PXN A;  1LKX A;  3L1C A;  4PFO A;  2UYM A;  3B6U A;  1G8X A;  1MMA A;  1X88 A;  4H1G A;  2WOG A;  4PFP A;  1VFV A;  2VAS A;  5HLE A;  2G1Q A;  4UBF A;  3DCB A;  3KEN A;  1D1B A;  2HEH A;  1FMW A;  1LVK A;  3BFN A;  3NWN A;  4E7S A;  2X7D A;  1BR4 A;  1D0Z A;  3B6V A;  3ZCW A;  1V8J A;  3WRD A;  4BXN A;  4PJJ A;  1D0X A;  1F9W A;  2X51 A;  3CJO A;  1F9V A;  1VFX A;  4A1Z A;  4A5Y A;  1V8K A;  5LT4 A;  1VFZ A;  2V26 A;  1MMG A;  3K3B A;  4AP0 A;  1MKJ A;  4Y05 A;  3CNZ A;  2NCD A;  3ZFD A;  3T0Q A;  3L9H A;  4DBQ A;  2ZFJ A;  1F9T A;  3K5E A;  4ETP A;  4GKR A;  4AS7 A;  3DC4 A;  4A28 A;  2PG2 A;  3KIN A;  2XAE A;  1GOJ A;  1D0Y A;  2UYI A;  4PJM A;  2X2R A;  1CZ7 A;  4PJL A;  2XT3 A;  1I6I A;  4A14 A;  2FL2 A;  1N6M A;  3X2T A;  1Q0B A;  5LT2 A;  4PJN A;  4PK4 A;  4ZHI A;  2GRY A;  3LRE A;  2Q2Y A;  1VOM A;  1I5S A;  2X7C A;  3KAR A;  4LNU K;  2Q2Z A;  1MMD A;  4HNA K;  3HQD A;  4B7B A;  1SDM A;  5LT0 A;  4ZCA A;  1T5C A;  1MMN A;  2Y5W A;  1FMV A;  2OWM A;  1VFW A;  2ZFK A;  1YRS A;  1II6 A;  1D1C A;  1BR2 A;  2ZFI A;  5GSZ A;  2MYS A;  5LT1 A;  1BG2 A;  4A50 A;  1F9U A;  2FME A;  2ZFM A;  4BBG A;  2FL6 A;  4DBR A;  3U06 A;  4BN2 A;  4A51 A;  1KK7 A;  3GBJ A;  4FRZ A;  1BR1 A;  1MNE A;  2VB6 A;  3ZFC A;  2ZFL A;  1RY6 A;  3WPN A;  1D1A A;  2IEH A; 
#chains in the Genus database with same CATH topology
 3H4S A;  4E7Z A;  5LT3 A;  2FKY A;  2GM1 A;  2KIN A;  4ANJ A;  3COB A;  2X7E A;  2VVG A;  2Y65 A;  3PXN A;  1LKX A;  3L1C A;  4PFO A;  2UYM A;  3B6U A;  1G8X A;  1MMA A;  1X88 A;  4H1G A;  2WOG A;  4PFP A;  1VFV A;  2VAS A;  5HLE A;  2G1Q A;  4UBF A;  3DCB A;  3KEN A;  1D1B A;  2HEH A;  1FMW A;  1LVK A;  3BFN A;  3NWN A;  4E7S A;  2X7D A;  1BR4 A;  1D0Z A;  3B6V A;  3ZCW A;  1V8J A;  3WRD A;  4BXN A;  4PJJ A;  1D0X A;  1F9W A;  2X51 A;  3CJO A;  1F9V A;  1VFX A;  4A1Z A;  4A5Y A;  1V8K A;  5LT4 A;  1VFZ A;  2V26 A;  1MMG A;  3K3B A;  4AP0 A;  1MKJ A;  4Y05 A;  3CNZ A;  2NCD A;  4GKP A;  3ZFD A;  3T0Q A;  3L9H A;  4DBQ A;  2ZFJ A;  1F9T A;  3K5E A;  4ETP A;  4GKR A;  4AS7 A;  3DC4 A;  4A28 A;  2PG2 A;  3KIN A;  2XAE A;  1GOJ A;  1D0Y A;  4GKQ A;  2UYI A;  4PJM A;  2X2R A;  1CZ7 A;  4PJL A;  2XT3 A;  1I6I A;  4A14 A;  2FL2 A;  1N6M A;  3X2T A;  1Q0B A;  5LT2 A;  4PJN A;  4PK4 A;  4ZHI A;  2GRY A;  3LRE A;  2Q2Y A;  1VOM A;  1I5S A;  2X7C A;  3KAR A;  4LNU K;  2Q2Z A;  1MMD A;  4HNA K;  3HQD A;  4B7B A;  1SDM A;  5LT0 A;  4ZCA A;  2O0A A;  1T5C A;  1MMN A;  2Y5W A;  1FMV A;  2OWM A;  1VFW A;  2ZFK A;  1YRS A;  1II6 A;  1D1C A;  1BR2 A;  2ZFI A;  5GSZ A;  2MYS A;  5LT1 A;  1BG2 A;  4A50 A;  1F9U A;  2FME A;  2ZFM A;  4BBG A;  2FL6 A;  4DBR A;  3U06 A;  4BN2 A;  4A51 A;  1KK7 A;  3GBJ A;  4ETP B;  4FRZ A;  1BR1 A;  1MNE A;  2VB6 A;  3ZFC A;  2ZFL A;  1RY6 A;  3WPN A;  1D1A A;  2IEH A; 
#chains in the Genus database with same CATH homology
 3H4S A;  4E7Z A;  5LT3 A;  2FKY A;  2GM1 A;  2KIN A;  4ANJ A;  3COB A;  2X7E A;  2VVG A;  2Y65 A;  3PXN A;  1LKX A;  3L1C A;  4PFO A;  2UYM A;  3B6U A;  1G8X A;  1MMA A;  1X88 A;  4H1G A;  2WOG A;  4PFP A;  1VFV A;  2VAS A;  5HLE A;  2G1Q A;  4UBF A;  3DCB A;  3KEN A;  1D1B A;  2HEH A;  1FMW A;  1LVK A;  3BFN A;  3NWN A;  4E7S A;  2X7D A;  1BR4 A;  1D0Z A;  3B6V A;  3ZCW A;  1V8J A;  3WRD A;  4BXN A;  4PJJ A;  1D0X A;  1F9W A;  2X51 A;  3CJO A;  1F9V A;  1VFX A;  4A1Z A;  4A5Y A;  1V8K A;  5LT4 A;  1VFZ A;  2V26 A;  1MMG A;  3K3B A;  4AP0 A;  1MKJ A;  4Y05 A;  3CNZ A;  2NCD A;  3ZFD A;  3T0Q A;  3L9H A;  4DBQ A;  2ZFJ A;  1F9T A;  3K5E A;  4ETP A;  4GKR A;  4AS7 A;  3DC4 A;  4A28 A;  2PG2 A;  3KIN A;  2XAE A;  1GOJ A;  1D0Y A;  2UYI A;  4PJM A;  2X2R A;  1CZ7 A;  4PJL A;  2XT3 A;  1I6I A;  4A14 A;  2FL2 A;  1N6M A;  3X2T A;  1Q0B A;  5LT2 A;  4PJN A;  4PK4 A;  4ZHI A;  2GRY A;  3LRE A;  2Q2Y A;  1VOM A;  1I5S A;  2X7C A;  3KAR A;  4LNU K;  2Q2Z A;  1MMD A;  4HNA K;  3HQD A;  4B7B A;  1SDM A;  5LT0 A;  4ZCA A;  1T5C A;  1MMN A;  2Y5W A;  1FMV A;  2OWM A;  1VFW A;  2ZFK A;  1YRS A;  1II6 A;  1D1C A;  1BR2 A;  2ZFI A;  5GSZ A;  2MYS A;  5LT1 A;  1BG2 A;  4A50 A;  1F9U A;  2FME A;  2ZFM A;  4BBG A;  2FL6 A;  4DBR A;  3U06 A;  4BN2 A;  4A51 A;  1KK7 A;  3GBJ A;  4FRZ A;  1BR1 A;  1MNE A;  2VB6 A;  3ZFC A;  2ZFL A;  1RY6 A;  3WPN A;  1D1A A;  2IEH A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...