4AS7A

Eg5 complex 1
Total Genus 110
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
110
sequence length
349
structure length
349
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLDGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Motor protein
total genus 110
structure length 349
sequence length 349
ec nomenclature
pdb deposition date 2012-04-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4as7A00
2VVGA 4PFOA 2GRYA 2PG2A 1I6IA 1KK7A 1MNEA 1D0XA 1MMDA 4A50A 4BN2A 2UYMA 3ZFCA 3NWNA 1D1AA 3DCBA 4GKRA 3PXNA 4HNAK 2XAEA 2OWMA 3WRDA 1BG2A 2ZFKA 2FMEA 3COBA 4E7ZA 1D1BA 1D0ZA 3B6UA 4ZHIA 3ZCWA 3HQDA 1FMWA 4UBFA 3K3BA 4A14A 4AS7A 1CZ7A 2WOGA 3WPNA 4BBGA 4AP0A 1D1CA 2NCDA 3KENA 4ETPA 2GM1A 4E7SA 2ZFLA 4BXNA 4Y05A 1BR1A 1YRSA 2Q2YA 2ZFMA 1G8XA 2MYSA 3LREA 1SDMA 4DBRA 2X7CA 1T5CA 3CJOA 4H1GA 1D0YA 2VASA 4PJMA 2IEHA 2G1QA 4PFPA 2X7EA 1II6A 1F9TA 1MMAA 2Y65A 2FL2A 1X88A 1V8KA 1I5SA 1VFXA 2Y5WA 4PJJA 3T0QA 5GSZA 4A1ZA 3B6VA 1VOMA 3GBJA 1FMVA 1V8JA 4ANJA 2UYIA 3CNZA 5LT0A 2ZFIA 3DC4A 3ZFDA 4ZCAA 4PJNA 1VFWA 3KINA 1LVKA 2XT3A 1LKXA 5LT4A 4PJLA 4B7BA 5LT2A 2V26A 1MKJA 4PK4A 1BR4A 2KINA 5HLEA 2X7DA 1MMGA 1N6MA 1VFVA 2ZFJA 3L9HA 2Q2ZA 5LT1A 1MMNA 3H4SA 3X2TA 1VFZA 1BR2A 3KARA 1RY6A 3L1CA 4LNUK 4A5YA 1GOJA 1F9WA 1F9UA 4A28A 1Q0BA 3K5EA 3BFNA 4A51A 5LT3A 2X51A 2VB6A 2FKYA 4DBQA 3U06A 4FRZA 1F9VA 2X2RA 2FL6A 2HEHA
chains in the Genus database with same CATH superfamily
2VVGA 4PFOA 2GRYA 2PG2A 1I6IA 1KK7A 1MNEA 1D0XA 1MMDA 4A50A 4BN2A 2UYMA 3ZFCA 3NWNA 1D1AA 3DCBA 4GKRA 3PXNA 4HNAK 2XAEA 2OWMA 3WRDA 1BG2A 2ZFKA 2FMEA 4ETPB 3COBA 4E7ZA 1D1BA 1D0ZA 3B6UA 4ZHIA 3ZCWA 3HQDA 1FMWA 4UBFA 3K3BA 4A14A 4AS7A 1CZ7A 2WOGA 4GKPA 3WPNA 4BBGA 4AP0A 1D1CA 2NCDA 3KENA 4ETPA 2GM1A 4E7SA 2ZFLA 4BXNA 4Y05A 1BR1A 1YRSA 2Q2YA 2ZFMA 1G8XA 2MYSA 3LREA 4GKQA 1SDMA 4DBRA 2X7CA 1T5CA 3CJOA 4H1GA 1D0YA 2VASA 4PJMA 2IEHA 2G1QA 4PFPA 2X7EA 1II6A 1F9TA 1MMAA 2Y65A 2FL2A 1X88A 1V8KA 1I5SA 1VFXA 2Y5WA 4PJJA 3T0QA 5GSZA 4A1ZA 3B6VA 1VOMA 3GBJA 1FMVA 1V8JA 4ANJA 2UYIA 3CNZA 5LT0A 2ZFIA 3DC4A 3ZFDA 4ZCAA 4PJNA 1VFWA 3KINA 1LVKA 2XT3A 1LKXA 5LT4A 4PJLA 4B7BA 5LT2A 2V26A 1MKJA 4PK4A 1BR4A 2KINA 5HLEA 2X7DA 1MMGA 1N6MA 1VFVA 2ZFJA 3L9HA 2Q2ZA 5LT1A 1MMNA 3H4SA 3X2TA 1VFZA 1BR2A 3KARA 1RY6A 2O0AA 3L1CA 4LNUK 4A5YA 1GOJA 1F9WA 1F9UA 4A28A 1Q0BA 3K5EA 3BFNA 4A51A 5LT3A 2X51A 2VB6A 2FKYA 4DBQA 3U06A 4FRZA 1F9VA 2X2RA 2FL6A 2HEHA
chains in the Genus database with same CATH topology
2VVGA 4PFOA 2GRYA 2PG2A 1I6IA 1KK7A 1MNEA 1D0XA 1MMDA 4A50A 4BN2A 2UYMA 3ZFCA 3NWNA 1D1AA 3DCBA 4GKRA 3PXNA 4HNAK 2XAEA 2OWMA 3WRDA 1BG2A 2ZFKA 2FMEA 3COBA 4E7ZA 1D1BA 1D0ZA 3B6UA 4ZHIA 3ZCWA 3HQDA 1FMWA 4UBFA 3K3BA 4A14A 4AS7A 1CZ7A 2WOGA 3WPNA 4BBGA 4AP0A 1D1CA 2NCDA 3KENA 4ETPA 2GM1A 4E7SA 2ZFLA 4BXNA 4Y05A 1BR1A 1YRSA 2Q2YA 2ZFMA 1G8XA 2MYSA 3LREA 1SDMA 4DBRA 2X7CA 1T5CA 3CJOA 4H1GA 1D0YA 2VASA 4PJMA 2IEHA 2G1QA 4PFPA 2X7EA 1II6A 1F9TA 1MMAA 2Y65A 2FL2A 1X88A 1V8KA 1I5SA 1VFXA 2Y5WA 4PJJA 3T0QA 5GSZA 4A1ZA 3B6VA 1VOMA 3GBJA 1FMVA 1V8JA 4ANJA 2UYIA 3CNZA 5LT0A 2ZFIA 3DC4A 3ZFDA 4ZCAA 4PJNA 1VFWA 3KINA 1LVKA 2XT3A 1LKXA 5LT4A 4PJLA 4B7BA 5LT2A 2V26A 1MKJA 4PK4A 1BR4A 2KINA 5HLEA 2X7DA 1MMGA 1N6MA 1VFVA 2ZFJA 3L9HA 2Q2ZA 5LT1A 1MMNA 3H4SA 3X2TA 1VFZA 1BR2A 3KARA 1RY6A 3L1CA 4LNUK 4A5YA 1GOJA 1F9WA 1F9UA 4A28A 1Q0BA 3K5EA 3BFNA 4A51A 5LT3A 2X51A 2VB6A 2FKYA 4DBQA 3U06A 4FRZA 1F9VA 2X2RA 2FL6A 2HEHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VVG A;  4PFO A;  2GRY A;  2PG2 A;  1I6I A;  1KK7 A;  1MNE A;  1D0X A;  1MMD A;  4A50 A;  4BN2 A;  2UYM A;  3ZFC A;  3NWN A;  1D1A A;  3DCB A;  4GKR A;  3PXN A;  4HNA K;  2XAE A;  2OWM A;  3WRD A;  1BG2 A;  2ZFK A;  2FME A;  3COB A;  4E7Z A;  1D1B A;  1D0Z A;  3B6U A;  4ZHI A;  3ZCW A;  3HQD A;  1FMW A;  4UBF A;  3K3B A;  4A14 A;  4AS7 A;  1CZ7 A;  2WOG A;  3WPN A;  4BBG A;  4AP0 A;  1D1C A;  2NCD A;  3KEN A;  4ETP A;  2GM1 A;  4E7S A;  2ZFL A;  4BXN A;  4Y05 A;  1BR1 A;  1YRS A;  2Q2Y A;  2ZFM A;  1G8X A;  2MYS A;  3LRE A;  1SDM A;  4DBR A;  2X7C A;  1T5C A;  3CJO A;  4H1G A;  1D0Y A;  2VAS A;  4PJM A;  2IEH A;  2G1Q A;  4PFP A;  2X7E A;  1II6 A;  1F9T A;  1MMA A;  2Y65 A;  2FL2 A;  1X88 A;  1V8K A;  1I5S A;  1VFX A;  2Y5W A;  4PJJ A;  3T0Q A;  5GSZ A;  4A1Z A;  3B6V A;  1VOM A;  3GBJ A;  1FMV A;  1V8J A;  4ANJ A;  2UYI A;  3CNZ A;  5LT0 A;  2ZFI A;  3DC4 A;  3ZFD A;  4ZCA A;  4PJN A;  1VFW A;  3KIN A;  1LVK A;  2XT3 A;  1LKX A;  5LT4 A;  4PJL A;  4B7B A;  5LT2 A;  2V26 A;  1MKJ A;  4PK4 A;  1BR4 A;  2KIN A;  5HLE A;  2X7D A;  1MMG A;  1N6M A;  1VFV A;  2ZFJ A;  3L9H A;  2Q2Z A;  5LT1 A;  1MMN A;  3H4S A;  3X2T A;  1VFZ A;  1BR2 A;  3KAR A;  1RY6 A;  3L1C A;  4LNU K;  4A5Y A;  1GOJ A;  1F9W A;  1F9U A;  4A28 A;  1Q0B A;  3K5E A;  3BFN A;  4A51 A;  5LT3 A;  2X51 A;  2VB6 A;  2FKY A;  4DBQ A;  3U06 A;  4FRZ A;  1F9V A;  2X2R A;  2FL6 A;  2HEH A; 
#chains in the Genus database with same CATH topology
 2VVG A;  4PFO A;  2GRY A;  2PG2 A;  1I6I A;  1KK7 A;  1MNE A;  1D0X A;  1MMD A;  4A50 A;  4BN2 A;  2UYM A;  3ZFC A;  3NWN A;  1D1A A;  3DCB A;  4GKR A;  3PXN A;  4HNA K;  2XAE A;  2OWM A;  3WRD A;  1BG2 A;  2ZFK A;  2FME A;  4ETP B;  3COB A;  4E7Z A;  1D1B A;  1D0Z A;  3B6U A;  4ZHI A;  3ZCW A;  3HQD A;  1FMW A;  4UBF A;  3K3B A;  4A14 A;  4AS7 A;  1CZ7 A;  2WOG A;  4GKP A;  3WPN A;  4BBG A;  4AP0 A;  1D1C A;  2NCD A;  3KEN A;  4ETP A;  2GM1 A;  4E7S A;  2ZFL A;  4BXN A;  4Y05 A;  1BR1 A;  1YRS A;  2Q2Y A;  2ZFM A;  1G8X A;  2MYS A;  3LRE A;  4GKQ A;  1SDM A;  4DBR A;  2X7C A;  1T5C A;  3CJO A;  4H1G A;  1D0Y A;  2VAS A;  4PJM A;  2IEH A;  2G1Q A;  4PFP A;  2X7E A;  1II6 A;  1F9T A;  1MMA A;  2Y65 A;  2FL2 A;  1X88 A;  1V8K A;  1I5S A;  1VFX A;  2Y5W A;  4PJJ A;  3T0Q A;  5GSZ A;  4A1Z A;  3B6V A;  1VOM A;  3GBJ A;  1FMV A;  1V8J A;  4ANJ A;  2UYI A;  3CNZ A;  5LT0 A;  2ZFI A;  3DC4 A;  3ZFD A;  4ZCA A;  4PJN A;  1VFW A;  3KIN A;  1LVK A;  2XT3 A;  1LKX A;  5LT4 A;  4PJL A;  4B7B A;  5LT2 A;  2V26 A;  1MKJ A;  4PK4 A;  1BR4 A;  2KIN A;  5HLE A;  2X7D A;  1MMG A;  1N6M A;  1VFV A;  2ZFJ A;  3L9H A;  2Q2Z A;  5LT1 A;  1MMN A;  3H4S A;  3X2T A;  1VFZ A;  1BR2 A;  3KAR A;  1RY6 A;  2O0A A;  3L1C A;  4LNU K;  4A5Y A;  1GOJ A;  1F9W A;  1F9U A;  4A28 A;  1Q0B A;  3K5E A;  3BFN A;  4A51 A;  5LT3 A;  2X51 A;  2VB6 A;  2FKY A;  4DBQ A;  3U06 A;  4FRZ A;  1F9V A;  2X2R A;  2FL6 A;  2HEH A; 
#chains in the Genus database with same CATH homology
 2VVG A;  4PFO A;  2GRY A;  2PG2 A;  1I6I A;  1KK7 A;  1MNE A;  1D0X A;  1MMD A;  4A50 A;  4BN2 A;  2UYM A;  3ZFC A;  3NWN A;  1D1A A;  3DCB A;  4GKR A;  3PXN A;  4HNA K;  2XAE A;  2OWM A;  3WRD A;  1BG2 A;  2ZFK A;  2FME A;  3COB A;  4E7Z A;  1D1B A;  1D0Z A;  3B6U A;  4ZHI A;  3ZCW A;  3HQD A;  1FMW A;  4UBF A;  3K3B A;  4A14 A;  4AS7 A;  1CZ7 A;  2WOG A;  3WPN A;  4BBG A;  4AP0 A;  1D1C A;  2NCD A;  3KEN A;  4ETP A;  2GM1 A;  4E7S A;  2ZFL A;  4BXN A;  4Y05 A;  1BR1 A;  1YRS A;  2Q2Y A;  2ZFM A;  1G8X A;  2MYS A;  3LRE A;  1SDM A;  4DBR A;  2X7C A;  1T5C A;  3CJO A;  4H1G A;  1D0Y A;  2VAS A;  4PJM A;  2IEH A;  2G1Q A;  4PFP A;  2X7E A;  1II6 A;  1F9T A;  1MMA A;  2Y65 A;  2FL2 A;  1X88 A;  1V8K A;  1I5S A;  1VFX A;  2Y5W A;  4PJJ A;  3T0Q A;  5GSZ A;  4A1Z A;  3B6V A;  1VOM A;  3GBJ A;  1FMV A;  1V8J A;  4ANJ A;  2UYI A;  3CNZ A;  5LT0 A;  2ZFI A;  3DC4 A;  3ZFD A;  4ZCA A;  4PJN A;  1VFW A;  3KIN A;  1LVK A;  2XT3 A;  1LKX A;  5LT4 A;  4PJL A;  4B7B A;  5LT2 A;  2V26 A;  1MKJ A;  4PK4 A;  1BR4 A;  2KIN A;  5HLE A;  2X7D A;  1MMG A;  1N6M A;  1VFV A;  2ZFJ A;  3L9H A;  2Q2Z A;  5LT1 A;  1MMN A;  3H4S A;  3X2T A;  1VFZ A;  1BR2 A;  3KAR A;  1RY6 A;  3L1C A;  4LNU K;  4A5Y A;  1GOJ A;  1F9W A;  1F9U A;  4A28 A;  1Q0B A;  3K5E A;  3BFN A;  4A51 A;  5LT3 A;  2X51 A;  2VB6 A;  2FKY A;  4DBQ A;  3U06 A;  4FRZ A;  1F9V A;  2X2R A;  2FL6 A;  2HEH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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