4AS7A

Eg5 complex 1
Total Genus 110
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
110
sequence length
349
structure length
349
Chain Sequence
b'GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLDGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Motor protein
total genus 110
structure length 349
sequence length 349
ec nomenclature
pdb deposition date 2012-04-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4as7A00
4GKRA 2UYMA 4ETPA 4HNAK 2OWMA 3B6UA 1D1BA 2V26A 2VASA 1VFVA 5GSZA 1BR4A 1MKJA 4A14A 1D1AA 4B7BA 2ZFLA 1KK7A 2G1QA 2UYIA 4PFPA 1D0XA 2X51A 1MMGA 2MYSA 3WRDA 4PJMA 4Y05A 3KENA 1CZ7A 4BXNA 4A50A 2FMEA 1MMAA 1II6A 2ZFJA 2FL2A 1G8XA 2KINA 1I5SA 1D1CA 4PJJA 4AP0A 1LVKA 3B6VA 1Q0BA 1D0YA 2PG2A 3KARA 4DBQA 3L9HA 5LT0A 3X2TA 1SDMA 3K3BA 4ZCAA 3COBA 1V8JA 5LT1A 3DCBA 3K5EA 5LT3A 4AS7A 4ANJA 3U06A 3H4SA 3BFNA 1BG2A 2HEHA 3DC4A 2VVGA 1VOMA 1VFZA 2NCDA 3HQDA 1F9VA 1X88A 1MMNA 2VB6A 4A51A 4DBRA 3WPNA 2Q2YA 3ZCWA 3GBJA 2ZFIA 4PK4A 1MNEA 1LKXA 1VFXA 2Y65A 4A28A 3PXNA 2GM1A 1N6MA 1YRSA 1FMVA 5LT2A 4BN2A 2ZFKA 2XT3A 3CNZA 4PFOA 1V8KA 4E7SA 2WOGA 3L1CA 1D0ZA 2Y5WA 1RY6A 3ZFCA 1F9UA 4A5YA 2FL6A 1VFWA 4LNUK 2X2RA 2Q2ZA 1T5CA 2GRYA 1MMDA 2FKYA 3LREA 2ZFMA 1BR2A 1FMWA 4PJLA 3T0QA 4ZHIA 2X7DA 4BBGA 1I6IA 2XAEA 4A1ZA 2IEHA 5LT4A 3CJOA 3ZFDA 4UBFA 4E7ZA 3NWNA 5HLEA 2X7CA 2X7EA 4FRZA 1GOJA 1BR1A 4H1GA 4PJNA 3KINA 1F9TA 1F9WA
chains in the Genus database with same CATH superfamily
4GKRA 2UYMA 4ETPA 4HNAK 2OWMA 3B6UA 1D1BA 2V26A 2VASA 1VFVA 5GSZA 1BR4A 1MKJA 4A14A 1D1AA 4B7BA 2ZFLA 1KK7A 2G1QA 2UYIA 4PFPA 1D0XA 2X51A 1MMGA 2MYSA 3WRDA 4PJMA 4Y05A 3KENA 1CZ7A 4BXNA 4A50A 2FMEA 1MMAA 1II6A 2ZFJA 2FL2A 1G8XA 2KINA 1I5SA 1D1CA 4PJJA 4AP0A 1LVKA 3B6VA 1Q0BA 1D0YA 4GKQA 2PG2A 3KARA 4DBQA 3L9HA 5LT0A 3X2TA 1SDMA 3K3BA 4ZCAA 4ETPB 3COBA 1V8JA 5LT1A 3DCBA 3K5EA 5LT3A 4AS7A 4ANJA 3U06A 3H4SA 3BFNA 1BG2A 2HEHA 3DC4A 2VVGA 1VOMA 1VFZA 2NCDA 3HQDA 1F9VA 1X88A 1MMNA 2VB6A 4A51A 4DBRA 3WPNA 2Q2YA 3ZCWA 3GBJA 2ZFIA 4PK4A 1MNEA 1LKXA 1VFXA 2Y65A 4A28A 3PXNA 2GM1A 1N6MA 1YRSA 1FMVA 5LT2A 4BN2A 2ZFKA 2XT3A 3CNZA 4PFOA 4GKPA 1V8KA 4E7SA 2WOGA 3L1CA 1D0ZA 2Y5WA 1RY6A 3ZFCA 1F9UA 4A5YA 2FL6A 1VFWA 4LNUK 2X2RA 2Q2ZA 1T5CA 2GRYA 1MMDA 2FKYA 3LREA 2ZFMA 1BR2A 1FMWA 4PJLA 3T0QA 4ZHIA 2X7DA 4BBGA 1I6IA 2XAEA 4A1ZA 2IEHA 5LT4A 3CJOA 3ZFDA 4UBFA 4E7ZA 3NWNA 5HLEA 2X7CA 2X7EA 4FRZA 1GOJA 1BR1A 4H1GA 4PJNA 3KINA 1F9TA 1F9WA 2O0AA
chains in the Genus database with same CATH topology
4GKRA 2UYMA 4ETPA 4HNAK 2OWMA 3B6UA 1D1BA 2V26A 2VASA 1VFVA 5GSZA 1BR4A 1MKJA 4A14A 1D1AA 4B7BA 2ZFLA 1KK7A 2G1QA 2UYIA 4PFPA 1D0XA 2X51A 1MMGA 2MYSA 3WRDA 4PJMA 4Y05A 3KENA 1CZ7A 4BXNA 4A50A 2FMEA 1MMAA 1II6A 2ZFJA 2FL2A 1G8XA 2KINA 1I5SA 1D1CA 4PJJA 4AP0A 1LVKA 3B6VA 1Q0BA 1D0YA 2PG2A 3KARA 4DBQA 3L9HA 5LT0A 3X2TA 1SDMA 3K3BA 4ZCAA 3COBA 1V8JA 5LT1A 3DCBA 3K5EA 5LT3A 4AS7A 4ANJA 3U06A 3H4SA 3BFNA 1BG2A 2HEHA 3DC4A 2VVGA 1VOMA 1VFZA 2NCDA 3HQDA 1F9VA 1X88A 1MMNA 2VB6A 4A51A 4DBRA 3WPNA 2Q2YA 3ZCWA 3GBJA 2ZFIA 4PK4A 1MNEA 1LKXA 1VFXA 2Y65A 4A28A 3PXNA 2GM1A 1N6MA 1YRSA 1FMVA 5LT2A 4BN2A 2ZFKA 2XT3A 3CNZA 4PFOA 1V8KA 4E7SA 2WOGA 3L1CA 1D0ZA 2Y5WA 1RY6A 3ZFCA 1F9UA 4A5YA 2FL6A 1VFWA 4LNUK 2X2RA 2Q2ZA 1T5CA 2GRYA 1MMDA 2FKYA 3LREA 2ZFMA 1BR2A 1FMWA 4PJLA 3T0QA 4ZHIA 2X7DA 4BBGA 1I6IA 2XAEA 4A1ZA 2IEHA 5LT4A 3CJOA 3ZFDA 4UBFA 4E7ZA 3NWNA 5HLEA 2X7CA 2X7EA 4FRZA 1GOJA 1BR1A 4H1GA 4PJNA 3KINA 1F9TA 1F9WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GKR A;  2UYM A;  4ETP A;  4HNA K;  2OWM A;  3B6U A;  1D1B A;  2V26 A;  2VAS A;  1VFV A;  5GSZ A;  1BR4 A;  1MKJ A;  4A14 A;  1D1A A;  4B7B A;  2ZFL A;  1KK7 A;  2G1Q A;  2UYI A;  4PFP A;  1D0X A;  2X51 A;  1MMG A;  2MYS A;  3WRD A;  4PJM A;  4Y05 A;  3KEN A;  1CZ7 A;  4BXN A;  4A50 A;  2FME A;  1MMA A;  1II6 A;  2ZFJ A;  2FL2 A;  1G8X A;  2KIN A;  1I5S A;  1D1C A;  4PJJ A;  4AP0 A;  1LVK A;  3B6V A;  1Q0B A;  1D0Y A;  2PG2 A;  3KAR A;  4DBQ A;  3L9H A;  5LT0 A;  3X2T A;  1SDM A;  3K3B A;  4ZCA A;  3COB A;  1V8J A;  5LT1 A;  3DCB A;  3K5E A;  5LT3 A;  4AS7 A;  4ANJ A;  3U06 A;  3H4S A;  3BFN A;  1BG2 A;  2HEH A;  3DC4 A;  2VVG A;  1VOM A;  1VFZ A;  2NCD A;  3HQD A;  1F9V A;  1X88 A;  1MMN A;  2VB6 A;  4A51 A;  4DBR A;  3WPN A;  2Q2Y A;  3ZCW A;  3GBJ A;  2ZFI A;  4PK4 A;  1MNE A;  1LKX A;  1VFX A;  2Y65 A;  4A28 A;  3PXN A;  2GM1 A;  1N6M A;  1YRS A;  1FMV A;  5LT2 A;  4BN2 A;  2ZFK A;  2XT3 A;  3CNZ A;  4PFO A;  1V8K A;  4E7S A;  2WOG A;  3L1C A;  1D0Z A;  2Y5W A;  1RY6 A;  3ZFC A;  1F9U A;  4A5Y A;  2FL6 A;  1VFW A;  4LNU K;  2X2R A;  2Q2Z A;  1T5C A;  2GRY A;  1MMD A;  2FKY A;  3LRE A;  2ZFM A;  1BR2 A;  1FMW A;  4PJL A;  3T0Q A;  4ZHI A;  2X7D A;  4BBG A;  1I6I A;  2XAE A;  4A1Z A;  2IEH A;  5LT4 A;  3CJO A;  3ZFD A;  4UBF A;  4E7Z A;  3NWN A;  5HLE A;  2X7C A;  2X7E A;  4FRZ A;  1GOJ A;  1BR1 A;  4H1G A;  4PJN A;  3KIN A;  1F9T A;  1F9W A; 
#chains in the Genus database with same CATH topology
 4GKR A;  2UYM A;  4ETP A;  4HNA K;  2OWM A;  3B6U A;  1D1B A;  2V26 A;  2VAS A;  1VFV A;  5GSZ A;  1BR4 A;  1MKJ A;  4A14 A;  1D1A A;  4B7B A;  2ZFL A;  1KK7 A;  2G1Q A;  2UYI A;  4PFP A;  1D0X A;  2X51 A;  1MMG A;  2MYS A;  3WRD A;  4PJM A;  4Y05 A;  3KEN A;  1CZ7 A;  4BXN A;  4A50 A;  2FME A;  1MMA A;  1II6 A;  2ZFJ A;  2FL2 A;  1G8X A;  2KIN A;  1I5S A;  1D1C A;  4PJJ A;  4AP0 A;  1LVK A;  3B6V A;  1Q0B A;  1D0Y A;  4GKQ A;  2PG2 A;  3KAR A;  4DBQ A;  3L9H A;  5LT0 A;  3X2T A;  1SDM A;  3K3B A;  4ZCA A;  4ETP B;  3COB A;  1V8J A;  5LT1 A;  3DCB A;  3K5E A;  5LT3 A;  4AS7 A;  4ANJ A;  3U06 A;  3H4S A;  3BFN A;  1BG2 A;  2HEH A;  3DC4 A;  2VVG A;  1VOM A;  1VFZ A;  2NCD A;  3HQD A;  1F9V A;  1X88 A;  1MMN A;  2VB6 A;  4A51 A;  4DBR A;  3WPN A;  2Q2Y A;  3ZCW A;  3GBJ A;  2ZFI A;  4PK4 A;  1MNE A;  1LKX A;  1VFX A;  2Y65 A;  4A28 A;  3PXN A;  2GM1 A;  1N6M A;  1YRS A;  1FMV A;  5LT2 A;  4BN2 A;  2ZFK A;  2XT3 A;  3CNZ A;  4PFO A;  4GKP A;  1V8K A;  4E7S A;  2WOG A;  3L1C A;  1D0Z A;  2Y5W A;  1RY6 A;  3ZFC A;  1F9U A;  4A5Y A;  2FL6 A;  1VFW A;  4LNU K;  2X2R A;  2Q2Z A;  1T5C A;  2GRY A;  1MMD A;  2FKY A;  3LRE A;  2ZFM A;  1BR2 A;  1FMW A;  4PJL A;  3T0Q A;  4ZHI A;  2X7D A;  4BBG A;  1I6I A;  2XAE A;  4A1Z A;  2IEH A;  5LT4 A;  3CJO A;  3ZFD A;  4UBF A;  4E7Z A;  3NWN A;  5HLE A;  2X7C A;  2X7E A;  4FRZ A;  1GOJ A;  1BR1 A;  4H1G A;  4PJN A;  3KIN A;  1F9T A;  1F9W A;  2O0A A; 
#chains in the Genus database with same CATH homology
 4GKR A;  2UYM A;  4ETP A;  4HNA K;  2OWM A;  3B6U A;  1D1B A;  2V26 A;  2VAS A;  1VFV A;  5GSZ A;  1BR4 A;  1MKJ A;  4A14 A;  1D1A A;  4B7B A;  2ZFL A;  1KK7 A;  2G1Q A;  2UYI A;  4PFP A;  1D0X A;  2X51 A;  1MMG A;  2MYS A;  3WRD A;  4PJM A;  4Y05 A;  3KEN A;  1CZ7 A;  4BXN A;  4A50 A;  2FME A;  1MMA A;  1II6 A;  2ZFJ A;  2FL2 A;  1G8X A;  2KIN A;  1I5S A;  1D1C A;  4PJJ A;  4AP0 A;  1LVK A;  3B6V A;  1Q0B A;  1D0Y A;  2PG2 A;  3KAR A;  4DBQ A;  3L9H A;  5LT0 A;  3X2T A;  1SDM A;  3K3B A;  4ZCA A;  3COB A;  1V8J A;  5LT1 A;  3DCB A;  3K5E A;  5LT3 A;  4AS7 A;  4ANJ A;  3U06 A;  3H4S A;  3BFN A;  1BG2 A;  2HEH A;  3DC4 A;  2VVG A;  1VOM A;  1VFZ A;  2NCD A;  3HQD A;  1F9V A;  1X88 A;  1MMN A;  2VB6 A;  4A51 A;  4DBR A;  3WPN A;  2Q2Y A;  3ZCW A;  3GBJ A;  2ZFI A;  4PK4 A;  1MNE A;  1LKX A;  1VFX A;  2Y65 A;  4A28 A;  3PXN A;  2GM1 A;  1N6M A;  1YRS A;  1FMV A;  5LT2 A;  4BN2 A;  2ZFK A;  2XT3 A;  3CNZ A;  4PFO A;  1V8K A;  4E7S A;  2WOG A;  3L1C A;  1D0Z A;  2Y5W A;  1RY6 A;  3ZFC A;  1F9U A;  4A5Y A;  2FL6 A;  1VFW A;  4LNU K;  2X2R A;  2Q2Z A;  1T5C A;  2GRY A;  1MMD A;  2FKY A;  3LRE A;  2ZFM A;  1BR2 A;  1FMW A;  4PJL A;  3T0Q A;  4ZHI A;  2X7D A;  4BBG A;  1I6I A;  2XAE A;  4A1Z A;  2IEH A;  5LT4 A;  3CJO A;  3ZFD A;  4UBF A;  4E7Z A;  3NWN A;  5HLE A;  2X7C A;  2X7E A;  4FRZ A;  1GOJ A;  1BR1 A;  4H1G A;  4PJN A;  3KIN A;  1F9T A;  1F9W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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