2PG2A

Crystal structure of ksp in complex with adp and thiophene containing inhibitor 15
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
347
structure length
331
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Motor protein,cell cycle
molecule keywords Kinesin-like protein KIF11
publication title Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors
pubmed doi rcsb
source organism Homo sapiens
total genus 106
structure length 331
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-04-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2pg2A00
4PJMA 3KARA 1SDMA 2Q2ZA 2WOGA 3LREA 1BR1A 5HLEA 2ZFJA 2KINA 2FL2A 4ETPA 1MMNA 2GM1A 1FMWA 2ZFLA 1X88A 1D1BA 1VOMA 1VFWA 2X7EA 4BXNA 2OWMA 4PK4A 2XT3A 3KINA 2ZFKA 4BBGA 3L1CA 3PXNA 1BG2A 1D0XA 1MMGA 4A50A 1II6A 3KENA 5LT2A 2FL6A 2VB6A 1FMVA 1MMDA 2X7CA 2Q2YA 1LKXA 3WPNA 1LVKA 4HNAK 4UBFA 4H1GA 2HEHA 5GSZA 3H4SA 3NWNA 2NCDA 1VFZA 1RY6A 5LT0A 2UYIA 1D1AA 2X2RA 1BR4A 1I6IA 4A51A 2X51A 1VFXA 1F9VA 3BFNA 1KK7A 3U06A 2GRYA 3B6UA 4FRZA 4A1ZA 2IEHA 1I5SA 2VASA 4PFPA 2VVGA 5LT1A 3DCBA 1GOJA 2ZFIA 3ZFCA 4A5YA 2PG2A 1CZ7A 2Y65A 1N6MA 1MMAA 2V26A 1BR2A 4AP0A 3L9HA 2ZFMA 1D0ZA 3HQDA 1VFVA 2XAEA 4GKRA 4PJJA 1MKJA 4A28A 2G1QA 4PJNA 2Y5WA 1F9UA 3CNZA 2X7DA 2UYMA 4PJLA 3CJOA 4ANJA 3WRDA 4DBRA 4ZHIA 1YRSA 4B7BA 2FKYA 3DC4A 3K5EA 5LT4A 4DBQA 3ZCWA 4A14A 4PFOA 1D1CA 1V8KA 4E7SA 3COBA 4Y05A 2MYSA 1V8JA 1MNEA 4ZCAA 3X2TA 1G8XA 3K3BA 4BN2A 5LT3A 4LNUK 3ZFDA 2FMEA 1F9TA 3T0QA 4AS7A 3B6VA 1T5CA 3GBJA 1Q0BA 4E7ZA 1D0YA 1F9WA
chains in the Genus database with same CATH superfamily
4PJMA 3KARA 1SDMA 2Q2ZA 2WOGA 3LREA 1BR1A 5HLEA 2ZFJA 2KINA 2FL2A 4ETPB 4ETPA 1MMNA 2GM1A 1FMWA 2ZFLA 1X88A 1D1BA 1VOMA 1VFWA 2X7EA 4BXNA 2OWMA 4PK4A 2XT3A 3KINA 2ZFKA 4BBGA 3L1CA 3PXNA 1BG2A 1D0XA 1MMGA 4A50A 1II6A 3KENA 5LT2A 2FL6A 2VB6A 1FMVA 1MMDA 2X7CA 2Q2YA 1LKXA 3WPNA 1LVKA 4HNAK 4UBFA 4H1GA 2HEHA 5GSZA 3H4SA 3NWNA 2NCDA 1VFZA 1RY6A 5LT0A 2UYIA 1D1AA 2O0AA 2X2RA 1BR4A 1I6IA 4A51A 2X51A 1VFXA 1F9VA 3BFNA 1KK7A 3U06A 2GRYA 4GKPA 3B6UA 4FRZA 4A1ZA 2IEHA 1I5SA 2VASA 4PFPA 2VVGA 5LT1A 3DCBA 1GOJA 2ZFIA 3ZFCA 4A5YA 2PG2A 1CZ7A 2Y65A 1N6MA 1MMAA 2V26A 1BR2A 4AP0A 3L9HA 2ZFMA 1D0ZA 3HQDA 1VFVA 2XAEA 4GKRA 4PJJA 1MKJA 4A28A 2G1QA 4PJNA 2Y5WA 1F9UA 3CNZA 2X7DA 2UYMA 4PJLA 3CJOA 4ANJA 3WRDA 4DBRA 4ZHIA 1YRSA 4B7BA 2FKYA 3DC4A 3K5EA 5LT4A 4DBQA 3ZCWA 4A14A 4PFOA 1D1CA 1V8KA 4E7SA 3COBA 4Y05A 4GKQA 2MYSA 1V8JA 1MNEA 4ZCAA 3X2TA 1G8XA 3K3BA 4BN2A 5LT3A 4LNUK 3ZFDA 2FMEA 1F9TA 3T0QA 4AS7A 3B6VA 1T5CA 3GBJA 1Q0BA 4E7ZA 1D0YA 1F9WA
chains in the Genus database with same CATH topology
4PJMA 3KARA 1SDMA 2Q2ZA 2WOGA 3LREA 1BR1A 5HLEA 2ZFJA 2KINA 2FL2A 4ETPA 1MMNA 2GM1A 1FMWA 2ZFLA 1X88A 1D1BA 1VOMA 1VFWA 2X7EA 4BXNA 2OWMA 4PK4A 2XT3A 3KINA 2ZFKA 4BBGA 3L1CA 3PXNA 1BG2A 1D0XA 1MMGA 4A50A 1II6A 3KENA 5LT2A 2FL6A 2VB6A 1FMVA 1MMDA 2X7CA 2Q2YA 1LKXA 3WPNA 1LVKA 4HNAK 4UBFA 4H1GA 2HEHA 5GSZA 3H4SA 3NWNA 2NCDA 1VFZA 1RY6A 5LT0A 2UYIA 1D1AA 2X2RA 1BR4A 1I6IA 4A51A 2X51A 1VFXA 1F9VA 3BFNA 1KK7A 3U06A 2GRYA 3B6UA 4FRZA 4A1ZA 2IEHA 1I5SA 2VASA 4PFPA 2VVGA 5LT1A 3DCBA 1GOJA 2ZFIA 3ZFCA 4A5YA 2PG2A 1CZ7A 2Y65A 1N6MA 1MMAA 2V26A 1BR2A 4AP0A 3L9HA 2ZFMA 1D0ZA 3HQDA 1VFVA 2XAEA 4GKRA 4PJJA 1MKJA 4A28A 2G1QA 4PJNA 2Y5WA 1F9UA 3CNZA 2X7DA 2UYMA 4PJLA 3CJOA 4ANJA 3WRDA 4DBRA 4ZHIA 1YRSA 4B7BA 2FKYA 3DC4A 3K5EA 5LT4A 4DBQA 3ZCWA 4A14A 4PFOA 1D1CA 1V8KA 4E7SA 3COBA 4Y05A 2MYSA 1V8JA 1MNEA 4ZCAA 3X2TA 1G8XA 3K3BA 4BN2A 5LT3A 4LNUK 3ZFDA 2FMEA 1F9TA 3T0QA 4AS7A 3B6VA 1T5CA 3GBJA 1Q0BA 4E7ZA 1D0YA 1F9WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PJM A;  3KAR A;  1SDM A;  2Q2Z A;  2WOG A;  3LRE A;  1BR1 A;  5HLE A;  2ZFJ A;  2KIN A;  2FL2 A;  4ETP A;  1MMN A;  2GM1 A;  1FMW A;  2ZFL A;  1X88 A;  1D1B A;  1VOM A;  1VFW A;  2X7E A;  4BXN A;  2OWM A;  4PK4 A;  2XT3 A;  3KIN A;  2ZFK A;  4BBG A;  3L1C A;  3PXN A;  1BG2 A;  1D0X A;  1MMG A;  4A50 A;  1II6 A;  3KEN A;  5LT2 A;  2FL6 A;  2VB6 A;  1FMV A;  1MMD A;  2X7C A;  2Q2Y A;  1LKX A;  3WPN A;  1LVK A;  4HNA K;  4UBF A;  4H1G A;  2HEH A;  5GSZ A;  3H4S A;  3NWN A;  2NCD A;  1VFZ A;  1RY6 A;  5LT0 A;  2UYI A;  1D1A A;  2X2R A;  1BR4 A;  1I6I A;  4A51 A;  2X51 A;  1VFX A;  1F9V A;  3BFN A;  1KK7 A;  3U06 A;  2GRY A;  3B6U A;  4FRZ A;  4A1Z A;  2IEH A;  1I5S A;  2VAS A;  4PFP A;  2VVG A;  5LT1 A;  3DCB A;  1GOJ A;  2ZFI A;  3ZFC A;  4A5Y A;  2PG2 A;  1CZ7 A;  2Y65 A;  1N6M A;  1MMA A;  2V26 A;  1BR2 A;  4AP0 A;  3L9H A;  2ZFM A;  1D0Z A;  3HQD A;  1VFV A;  2XAE A;  4GKR A;  4PJJ A;  1MKJ A;  4A28 A;  2G1Q A;  4PJN A;  2Y5W A;  1F9U A;  3CNZ A;  2X7D A;  2UYM A;  4PJL A;  3CJO A;  4ANJ A;  3WRD A;  4DBR A;  4ZHI A;  1YRS A;  4B7B A;  2FKY A;  3DC4 A;  3K5E A;  5LT4 A;  4DBQ A;  3ZCW A;  4A14 A;  4PFO A;  1D1C A;  1V8K A;  4E7S A;  3COB A;  4Y05 A;  2MYS A;  1V8J A;  1MNE A;  4ZCA A;  3X2T A;  1G8X A;  3K3B A;  4BN2 A;  5LT3 A;  4LNU K;  3ZFD A;  2FME A;  1F9T A;  3T0Q A;  4AS7 A;  3B6V A;  1T5C A;  3GBJ A;  1Q0B A;  4E7Z A;  1D0Y A;  1F9W A; 
#chains in the Genus database with same CATH topology
 4PJM A;  3KAR A;  1SDM A;  2Q2Z A;  2WOG A;  3LRE A;  1BR1 A;  5HLE A;  2ZFJ A;  2KIN A;  2FL2 A;  4ETP B;  4ETP A;  1MMN A;  2GM1 A;  1FMW A;  2ZFL A;  1X88 A;  1D1B A;  1VOM A;  1VFW A;  2X7E A;  4BXN A;  2OWM A;  4PK4 A;  2XT3 A;  3KIN A;  2ZFK A;  4BBG A;  3L1C A;  3PXN A;  1BG2 A;  1D0X A;  1MMG A;  4A50 A;  1II6 A;  3KEN A;  5LT2 A;  2FL6 A;  2VB6 A;  1FMV A;  1MMD A;  2X7C A;  2Q2Y A;  1LKX A;  3WPN A;  1LVK A;  4HNA K;  4UBF A;  4H1G A;  2HEH A;  5GSZ A;  3H4S A;  3NWN A;  2NCD A;  1VFZ A;  1RY6 A;  5LT0 A;  2UYI A;  1D1A A;  2O0A A;  2X2R A;  1BR4 A;  1I6I A;  4A51 A;  2X51 A;  1VFX A;  1F9V A;  3BFN A;  1KK7 A;  3U06 A;  2GRY A;  4GKP A;  3B6U A;  4FRZ A;  4A1Z A;  2IEH A;  1I5S A;  2VAS A;  4PFP A;  2VVG A;  5LT1 A;  3DCB A;  1GOJ A;  2ZFI A;  3ZFC A;  4A5Y A;  2PG2 A;  1CZ7 A;  2Y65 A;  1N6M A;  1MMA A;  2V26 A;  1BR2 A;  4AP0 A;  3L9H A;  2ZFM A;  1D0Z A;  3HQD A;  1VFV A;  2XAE A;  4GKR A;  4PJJ A;  1MKJ A;  4A28 A;  2G1Q A;  4PJN A;  2Y5W A;  1F9U A;  3CNZ A;  2X7D A;  2UYM A;  4PJL A;  3CJO A;  4ANJ A;  3WRD A;  4DBR A;  4ZHI A;  1YRS A;  4B7B A;  2FKY A;  3DC4 A;  3K5E A;  5LT4 A;  4DBQ A;  3ZCW A;  4A14 A;  4PFO A;  1D1C A;  1V8K A;  4E7S A;  3COB A;  4Y05 A;  4GKQ A;  2MYS A;  1V8J A;  1MNE A;  4ZCA A;  3X2T A;  1G8X A;  3K3B A;  4BN2 A;  5LT3 A;  4LNU K;  3ZFD A;  2FME A;  1F9T A;  3T0Q A;  4AS7 A;  3B6V A;  1T5C A;  3GBJ A;  1Q0B A;  4E7Z A;  1D0Y A;  1F9W A; 
#chains in the Genus database with same CATH homology
 4PJM A;  3KAR A;  1SDM A;  2Q2Z A;  2WOG A;  3LRE A;  1BR1 A;  5HLE A;  2ZFJ A;  2KIN A;  2FL2 A;  4ETP A;  1MMN A;  2GM1 A;  1FMW A;  2ZFL A;  1X88 A;  1D1B A;  1VOM A;  1VFW A;  2X7E A;  4BXN A;  2OWM A;  4PK4 A;  2XT3 A;  3KIN A;  2ZFK A;  4BBG A;  3L1C A;  3PXN A;  1BG2 A;  1D0X A;  1MMG A;  4A50 A;  1II6 A;  3KEN A;  5LT2 A;  2FL6 A;  2VB6 A;  1FMV A;  1MMD A;  2X7C A;  2Q2Y A;  1LKX A;  3WPN A;  1LVK A;  4HNA K;  4UBF A;  4H1G A;  2HEH A;  5GSZ A;  3H4S A;  3NWN A;  2NCD A;  1VFZ A;  1RY6 A;  5LT0 A;  2UYI A;  1D1A A;  2X2R A;  1BR4 A;  1I6I A;  4A51 A;  2X51 A;  1VFX A;  1F9V A;  3BFN A;  1KK7 A;  3U06 A;  2GRY A;  3B6U A;  4FRZ A;  4A1Z A;  2IEH A;  1I5S A;  2VAS A;  4PFP A;  2VVG A;  5LT1 A;  3DCB A;  1GOJ A;  2ZFI A;  3ZFC A;  4A5Y A;  2PG2 A;  1CZ7 A;  2Y65 A;  1N6M A;  1MMA A;  2V26 A;  1BR2 A;  4AP0 A;  3L9H A;  2ZFM A;  1D0Z A;  3HQD A;  1VFV A;  2XAE A;  4GKR A;  4PJJ A;  1MKJ A;  4A28 A;  2G1Q A;  4PJN A;  2Y5W A;  1F9U A;  3CNZ A;  2X7D A;  2UYM A;  4PJL A;  3CJO A;  4ANJ A;  3WRD A;  4DBR A;  4ZHI A;  1YRS A;  4B7B A;  2FKY A;  3DC4 A;  3K5E A;  5LT4 A;  4DBQ A;  3ZCW A;  4A14 A;  4PFO A;  1D1C A;  1V8K A;  4E7S A;  3COB A;  4Y05 A;  2MYS A;  1V8J A;  1MNE A;  4ZCA A;  3X2T A;  1G8X A;  3K3B A;  4BN2 A;  5LT3 A;  4LNU K;  3ZFD A;  2FME A;  1F9T A;  3T0Q A;  4AS7 A;  3B6V A;  1T5C A;  3GBJ A;  1Q0B A;  4E7Z A;  1D0Y A;  1F9W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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