2PG2A

Crystal structure of ksp in complex with adp and thiophene containing inhibitor 15
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
347
structure length
331
Chain Sequence
b'GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Kinesin-like protein KIF11
publication title Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors
pubmed doi rcsb
source organism Homo sapiens
molecule tags Motor protein,cell cycle
total genus 106
structure length 331
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-04-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2pg2A00
1VOMA 2PG2A 3KARA 2ZFKA 2IEHA 1D1AA 1KK7A 1LVKA 1VFZA 1X88A 2X7EA 3CJOA 2ZFMA 1D1BA 3ZFCA 5LT2A 4A50A 2FMEA 3ZFDA 1F9WA 1LKXA 3B6VA 1SDMA 4DBRA 4PJJA 1MKJA 5GSZA 3CNZA 2V26A 4AS7A 1GOJA 4PJNA 4ZHIA 2FKYA 4Y05A 4A51A 4DBQA 1N6MA 1F9VA 1BR4A 4FRZA 4E7ZA 2XAEA 1MNEA 4ETPA 2UYMA 5LT1A 3NWNA 2MYSA 1RY6A 3H4SA 4ZCAA 4PK4A 2ZFLA 3L1CA 3HQDA 2X51A 4GKRA 4A14A 4PJMA 1G8XA 1V8JA 1CZ7A 4PJLA 2HEHA 3T0QA 1FMWA 1FMVA 2VASA 2GM1A 4PFPA 2Y5WA 4E7SA 2WOGA 1F9UA 3BFNA 2NCDA 3COBA 3LREA 4A28A 4BXNA 1T5CA 1MMDA 4LNUK 3U06A 2VB6A 1BG2A 1VFWA 2ZFIA 3K3BA 1I5SA 3WPNA 1D0YA 4BBGA 5LT3A 1MMAA 3DCBA 1D0XA 3X2TA 4H1GA 1MMGA 2VVGA 3WRDA 3DC4A 1F9TA 2GRYA 3PXNA 1BR2A 2KINA 4UBFA 5LT4A 3GBJA 1D0ZA 4B7BA 3ZCWA 2X7DA 1MMNA 2ZFJA 3B6UA 1D1CA 1I6IA 2XT3A 4BN2A 2FL6A 3KINA 4AP0A 2UYIA 2X2RA 4ANJA 4PFOA 5LT0A 1YRSA 3L9HA 2G1QA 3KENA 3K5EA 2OWMA 4HNAK 2X7CA 2Y65A 4A1ZA 4A5YA 1VFXA 1VFVA 1BR1A 2Q2ZA 1V8KA 5HLEA 2FL2A 2Q2YA 1II6A 1Q0BA
chains in the Genus database with same CATH superfamily
1VOMA 2PG2A 3KARA 2ZFKA 2IEHA 1D1AA 1KK7A 1LVKA 1VFZA 1X88A 2X7EA 3CJOA 2ZFMA 1D1BA 3ZFCA 5LT2A 4A50A 2FMEA 2O0AA 3ZFDA 1F9WA 1LKXA 3B6VA 1SDMA 4DBRA 4PJJA 1MKJA 5GSZA 3CNZA 2V26A 4AS7A 1GOJA 4PJNA 4ZHIA 2FKYA 4Y05A 4A51A 4DBQA 1N6MA 1F9VA 1BR4A 4FRZA 4E7ZA 2XAEA 1MNEA 4ETPA 2UYMA 5LT1A 3NWNA 2MYSA 1RY6A 3H4SA 4ZCAA 4PK4A 2ZFLA 3L1CA 3HQDA 2X51A 4GKRA 4A14A 4PJMA 1G8XA 1V8JA 1CZ7A 4PJLA 4ETPB 2HEHA 3T0QA 1FMWA 1FMVA 2VASA 2GM1A 4PFPA 2Y5WA 4E7SA 2WOGA 1F9UA 3BFNA 2NCDA 3COBA 3LREA 4A28A 4BXNA 1T5CA 1MMDA 4LNUK 3U06A 2VB6A 1BG2A 1VFWA 2ZFIA 3K3BA 1I5SA 3WPNA 1D0YA 4BBGA 5LT3A 1MMAA 3DCBA 1D0XA 3X2TA 4H1GA 1MMGA 2VVGA 3WRDA 3DC4A 1F9TA 2GRYA 3PXNA 1BR2A 2KINA 4UBFA 5LT4A 3GBJA 1D0ZA 4B7BA 3ZCWA 4GKPA 4GKQA 2X7DA 1MMNA 2ZFJA 3B6UA 1D1CA 1I6IA 2XT3A 4BN2A 2FL6A 3KINA 4AP0A 2UYIA 2X2RA 4ANJA 4PFOA 5LT0A 1YRSA 3L9HA 2G1QA 3KENA 3K5EA 2OWMA 4HNAK 2X7CA 2Y65A 4A1ZA 4A5YA 1VFXA 1VFVA 1BR1A 2Q2ZA 1V8KA 5HLEA 2FL2A 2Q2YA 1II6A 1Q0BA
chains in the Genus database with same CATH topology
1VOMA 2PG2A 3KARA 2ZFKA 2IEHA 1D1AA 1KK7A 1LVKA 1VFZA 1X88A 2X7EA 3CJOA 2ZFMA 1D1BA 3ZFCA 5LT2A 4A50A 2FMEA 3ZFDA 1F9WA 1LKXA 3B6VA 1SDMA 4DBRA 4PJJA 1MKJA 5GSZA 3CNZA 2V26A 4AS7A 1GOJA 4PJNA 4ZHIA 2FKYA 4Y05A 4A51A 4DBQA 1N6MA 1F9VA 1BR4A 4FRZA 4E7ZA 2XAEA 1MNEA 4ETPA 2UYMA 5LT1A 3NWNA 2MYSA 1RY6A 3H4SA 4ZCAA 4PK4A 2ZFLA 3L1CA 3HQDA 2X51A 4GKRA 4A14A 4PJMA 1G8XA 1V8JA 1CZ7A 4PJLA 2HEHA 3T0QA 1FMWA 1FMVA 2VASA 2GM1A 4PFPA 2Y5WA 4E7SA 2WOGA 1F9UA 3BFNA 2NCDA 3COBA 3LREA 4A28A 4BXNA 1T5CA 1MMDA 4LNUK 3U06A 2VB6A 1BG2A 1VFWA 2ZFIA 3K3BA 1I5SA 3WPNA 1D0YA 4BBGA 5LT3A 1MMAA 3DCBA 1D0XA 3X2TA 4H1GA 1MMGA 2VVGA 3WRDA 3DC4A 1F9TA 2GRYA 3PXNA 1BR2A 2KINA 4UBFA 5LT4A 3GBJA 1D0ZA 4B7BA 3ZCWA 2X7DA 1MMNA 2ZFJA 3B6UA 1D1CA 1I6IA 2XT3A 4BN2A 2FL6A 3KINA 4AP0A 2UYIA 2X2RA 4ANJA 4PFOA 5LT0A 1YRSA 3L9HA 2G1QA 3KENA 3K5EA 2OWMA 4HNAK 2X7CA 2Y65A 4A1ZA 4A5YA 1VFXA 1VFVA 1BR1A 2Q2ZA 1V8KA 5HLEA 2FL2A 2Q2YA 1II6A 1Q0BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1VOM A;  2PG2 A;  3KAR A;  2ZFK A;  2IEH A;  1D1A A;  1KK7 A;  1LVK A;  1VFZ A;  1X88 A;  2X7E A;  3CJO A;  2ZFM A;  1D1B A;  3ZFC A;  5LT2 A;  4A50 A;  2FME A;  3ZFD A;  1F9W A;  1LKX A;  3B6V A;  1SDM A;  4DBR A;  4PJJ A;  1MKJ A;  5GSZ A;  3CNZ A;  2V26 A;  4AS7 A;  1GOJ A;  4PJN A;  4ZHI A;  2FKY A;  4Y05 A;  4A51 A;  4DBQ A;  1N6M A;  1F9V A;  1BR4 A;  4FRZ A;  4E7Z A;  2XAE A;  1MNE A;  4ETP A;  2UYM A;  5LT1 A;  3NWN A;  2MYS A;  1RY6 A;  3H4S A;  4ZCA A;  4PK4 A;  2ZFL A;  3L1C A;  3HQD A;  2X51 A;  4GKR A;  4A14 A;  4PJM A;  1G8X A;  1V8J A;  1CZ7 A;  4PJL A;  2HEH A;  3T0Q A;  1FMW A;  1FMV A;  2VAS A;  2GM1 A;  4PFP A;  2Y5W A;  4E7S A;  2WOG A;  1F9U A;  3BFN A;  2NCD A;  3COB A;  3LRE A;  4A28 A;  4BXN A;  1T5C A;  1MMD A;  4LNU K;  3U06 A;  2VB6 A;  1BG2 A;  1VFW A;  2ZFI A;  3K3B A;  1I5S A;  3WPN A;  1D0Y A;  4BBG A;  5LT3 A;  1MMA A;  3DCB A;  1D0X A;  3X2T A;  4H1G A;  1MMG A;  2VVG A;  3WRD A;  3DC4 A;  1F9T A;  2GRY A;  3PXN A;  1BR2 A;  2KIN A;  4UBF A;  5LT4 A;  3GBJ A;  1D0Z A;  4B7B A;  3ZCW A;  2X7D A;  1MMN A;  2ZFJ A;  3B6U A;  1D1C A;  1I6I A;  2XT3 A;  4BN2 A;  2FL6 A;  3KIN A;  4AP0 A;  2UYI A;  2X2R A;  4ANJ A;  4PFO A;  5LT0 A;  1YRS A;  3L9H A;  2G1Q A;  3KEN A;  3K5E A;  2OWM A;  4HNA K;  2X7C A;  2Y65 A;  4A1Z A;  4A5Y A;  1VFX A;  1VFV A;  1BR1 A;  2Q2Z A;  1V8K A;  5HLE A;  2FL2 A;  2Q2Y A;  1II6 A;  1Q0B A; 
#chains in the Genus database with same CATH topology
 1VOM A;  2PG2 A;  3KAR A;  2ZFK A;  2IEH A;  1D1A A;  1KK7 A;  1LVK A;  1VFZ A;  1X88 A;  2X7E A;  3CJO A;  2ZFM A;  1D1B A;  3ZFC A;  5LT2 A;  4A50 A;  2FME A;  2O0A A;  3ZFD A;  1F9W A;  1LKX A;  3B6V A;  1SDM A;  4DBR A;  4PJJ A;  1MKJ A;  5GSZ A;  3CNZ A;  2V26 A;  4AS7 A;  1GOJ A;  4PJN A;  4ZHI A;  2FKY A;  4Y05 A;  4A51 A;  4DBQ A;  1N6M A;  1F9V A;  1BR4 A;  4FRZ A;  4E7Z A;  2XAE A;  1MNE A;  4ETP A;  2UYM A;  5LT1 A;  3NWN A;  2MYS A;  1RY6 A;  3H4S A;  4ZCA A;  4PK4 A;  2ZFL A;  3L1C A;  3HQD A;  2X51 A;  4GKR A;  4A14 A;  4PJM A;  1G8X A;  1V8J A;  1CZ7 A;  4PJL A;  4ETP B;  2HEH A;  3T0Q A;  1FMW A;  1FMV A;  2VAS A;  2GM1 A;  4PFP A;  2Y5W A;  4E7S A;  2WOG A;  1F9U A;  3BFN A;  2NCD A;  3COB A;  3LRE A;  4A28 A;  4BXN A;  1T5C A;  1MMD A;  4LNU K;  3U06 A;  2VB6 A;  1BG2 A;  1VFW A;  2ZFI A;  3K3B A;  1I5S A;  3WPN A;  1D0Y A;  4BBG A;  5LT3 A;  1MMA A;  3DCB A;  1D0X A;  3X2T A;  4H1G A;  1MMG A;  2VVG A;  3WRD A;  3DC4 A;  1F9T A;  2GRY A;  3PXN A;  1BR2 A;  2KIN A;  4UBF A;  5LT4 A;  3GBJ A;  1D0Z A;  4B7B A;  3ZCW A;  4GKP A;  4GKQ A;  2X7D A;  1MMN A;  2ZFJ A;  3B6U A;  1D1C A;  1I6I A;  2XT3 A;  4BN2 A;  2FL6 A;  3KIN A;  4AP0 A;  2UYI A;  2X2R A;  4ANJ A;  4PFO A;  5LT0 A;  1YRS A;  3L9H A;  2G1Q A;  3KEN A;  3K5E A;  2OWM A;  4HNA K;  2X7C A;  2Y65 A;  4A1Z A;  4A5Y A;  1VFX A;  1VFV A;  1BR1 A;  2Q2Z A;  1V8K A;  5HLE A;  2FL2 A;  2Q2Y A;  1II6 A;  1Q0B A; 
#chains in the Genus database with same CATH homology
 1VOM A;  2PG2 A;  3KAR A;  2ZFK A;  2IEH A;  1D1A A;  1KK7 A;  1LVK A;  1VFZ A;  1X88 A;  2X7E A;  3CJO A;  2ZFM A;  1D1B A;  3ZFC A;  5LT2 A;  4A50 A;  2FME A;  3ZFD A;  1F9W A;  1LKX A;  3B6V A;  1SDM A;  4DBR A;  4PJJ A;  1MKJ A;  5GSZ A;  3CNZ A;  2V26 A;  4AS7 A;  1GOJ A;  4PJN A;  4ZHI A;  2FKY A;  4Y05 A;  4A51 A;  4DBQ A;  1N6M A;  1F9V A;  1BR4 A;  4FRZ A;  4E7Z A;  2XAE A;  1MNE A;  4ETP A;  2UYM A;  5LT1 A;  3NWN A;  2MYS A;  1RY6 A;  3H4S A;  4ZCA A;  4PK4 A;  2ZFL A;  3L1C A;  3HQD A;  2X51 A;  4GKR A;  4A14 A;  4PJM A;  1G8X A;  1V8J A;  1CZ7 A;  4PJL A;  2HEH A;  3T0Q A;  1FMW A;  1FMV A;  2VAS A;  2GM1 A;  4PFP A;  2Y5W A;  4E7S A;  2WOG A;  1F9U A;  3BFN A;  2NCD A;  3COB A;  3LRE A;  4A28 A;  4BXN A;  1T5C A;  1MMD A;  4LNU K;  3U06 A;  2VB6 A;  1BG2 A;  1VFW A;  2ZFI A;  3K3B A;  1I5S A;  3WPN A;  1D0Y A;  4BBG A;  5LT3 A;  1MMA A;  3DCB A;  1D0X A;  3X2T A;  4H1G A;  1MMG A;  2VVG A;  3WRD A;  3DC4 A;  1F9T A;  2GRY A;  3PXN A;  1BR2 A;  2KIN A;  4UBF A;  5LT4 A;  3GBJ A;  1D0Z A;  4B7B A;  3ZCW A;  2X7D A;  1MMN A;  2ZFJ A;  3B6U A;  1D1C A;  1I6I A;  2XT3 A;  4BN2 A;  2FL6 A;  3KIN A;  4AP0 A;  2UYI A;  2X2R A;  4ANJ A;  4PFO A;  5LT0 A;  1YRS A;  3L9H A;  2G1Q A;  3KEN A;  3K5E A;  2OWM A;  4HNA K;  2X7C A;  2Y65 A;  4A1Z A;  4A5Y A;  1VFX A;  1VFV A;  1BR1 A;  2Q2Z A;  1V8K A;  5HLE A;  2FL2 A;  2Q2Y A;  1II6 A;  1Q0B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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