2PG2A

Crystal structure of ksp in complex with adp and thiophene containing inhibitor 15
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
347
structure length
331
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Kinesin-like protein KIF11
publication title Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors
pubmed doi rcsb
source organism Homo sapiens
molecule tags Motor protein,cell cycle
total genus 106
structure length 331
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-04-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2pg2A00
1D0ZA 3X2TA 1LVKA 4UBFA 1D1AA 1YRSA 4BN2A 4AP0A 1F9VA 3ZFDA 1MMDA 4E7SA 1V8JA 1X88A 4ETPA 2UYMA 3KINA 1MNEA 4BXNA 1II6A 3K3BA 2ZFLA 2MYSA 2FL2A 1VFVA 2ZFJA 4FRZA 4AS7A 1BR2A 2Q2ZA 4PK4A 3B6VA 1SDMA 2VVGA 2VB6A 3DCBA 2UYIA 2VASA 4LNUK 3LREA 4GKRA 3L1CA 2G1QA 2IEHA 4BBGA 2FMEA 2ZFKA 2X7CA 4B7BA 2OWMA 3CJOA 3U06A 3H4SA 1RY6A 4HNAK 3K5EA 4PFOA 4A14A 1I6IA 1I5SA 3L9HA 5LT3A 1VFWA 3NWNA 4PJJA 3DC4A 3PXNA 5GSZA 1MMGA 1MKJA 2PG2A 1CZ7A 2Y65A 1D1BA 2FKYA 3B6UA 4PJMA 4E7ZA 2ZFIA 2Q2YA 3CNZA 1FMVA 3WPNA 1MMAA 4PFPA 3HQDA 5LT4A 4ZHIA 2Y5WA 1D1CA 3WRDA 1D0XA 3ZCWA 3KARA 2ZFMA 3KENA 1VOMA 2X51A 1VFXA 2WOGA 2KINA 4A51A 1N6MA 2GM1A 4Y05A 4ZCAA 3T0QA 4A50A 4H1GA 1BG2A 4PJLA 4A1ZA 3COBA 1GOJA 5HLEA 4A28A 2XT3A 5LT1A 1F9WA 4ANJA 4A5YA 2HEHA 4DBQA 2GRYA 2XAEA 1LKXA 2X7DA 4PJNA 1F9UA 4DBRA 1D0YA 1VFZA 3GBJA 5LT2A 1FMWA 3BFNA 1V8KA 1KK7A 1G8XA 1T5CA 2X7EA 3ZFCA 2V26A 1F9TA 1BR1A 2FL6A 5LT0A 1MMNA 2NCDA 2X2RA 1BR4A 1Q0BA
chains in the Genus database with same CATH superfamily
1D0ZA 3X2TA 1LVKA 4UBFA 1D1AA 1YRSA 4BN2A 4AP0A 1F9VA 3ZFDA 1MMDA 4E7SA 1V8JA 1X88A 4ETPA 2UYMA 3KINA 1MNEA 4BXNA 1II6A 3K3BA 4GKQA 2ZFLA 2MYSA 2FL2A 1VFVA 2ZFJA 4FRZA 4AS7A 1BR2A 2Q2ZA 4PK4A 3B6VA 1SDMA 2VVGA 2VB6A 3DCBA 2UYIA 2VASA 4LNUK 3LREA 4GKRA 4GKPA 3L1CA 2G1QA 2IEHA 4BBGA 2FMEA 2ZFKA 2X7CA 4B7BA 2OWMA 3CJOA 3U06A 3H4SA 1RY6A 4HNAK 3K5EA 4PFOA 4A14A 1I6IA 1I5SA 3L9HA 5LT3A 1VFWA 3NWNA 4PJJA 3DC4A 3PXNA 5GSZA 1MMGA 1MKJA 2PG2A 1CZ7A 2Y65A 1D1BA 2FKYA 3B6UA 4PJMA 4E7ZA 2ZFIA 2Q2YA 3CNZA 1FMVA 3WPNA 1MMAA 4PFPA 3HQDA 5LT4A 4ZHIA 2Y5WA 1D1CA 3WRDA 1D0XA 3ZCWA 3KARA 2ZFMA 3KENA 1VOMA 2X51A 1VFXA 1Q0BA 2WOGA 2KINA 4A51A 1N6MA 2GM1A 4Y05A 4ZCAA 3T0QA 4A50A 4H1GA 1BG2A 4PJLA 4A1ZA 3COBA 1GOJA 5HLEA 4A28A 4ETPB 2XT3A 5LT1A 1F9WA 4ANJA 4A5YA 2HEHA 4DBQA 2GRYA 2XAEA 1LKXA 2X7DA 4PJNA 1F9UA 4DBRA 1D0YA 1VFZA 3GBJA 5LT2A 1FMWA 3BFNA 1V8KA 1KK7A 1G8XA 1T5CA 2X7EA 3ZFCA 2V26A 1F9TA 1BR1A 2FL6A 5LT0A 1MMNA 2NCDA 2X2RA 1BR4A 2O0AA
chains in the Genus database with same CATH topology
1D0ZA 3X2TA 1LVKA 4UBFA 1D1AA 1YRSA 4BN2A 4AP0A 1F9VA 3ZFDA 1MMDA 4E7SA 1V8JA 1X88A 4ETPA 2UYMA 3KINA 1MNEA 4BXNA 1II6A 3K3BA 2ZFLA 2MYSA 2FL2A 1VFVA 2ZFJA 4FRZA 4AS7A 1BR2A 2Q2ZA 4PK4A 3B6VA 1SDMA 2VVGA 2VB6A 3DCBA 2UYIA 2VASA 4LNUK 3LREA 4GKRA 3L1CA 2G1QA 2IEHA 4BBGA 2FMEA 2ZFKA 2X7CA 4B7BA 2OWMA 3CJOA 3U06A 3H4SA 1RY6A 4HNAK 3K5EA 4PFOA 4A14A 1I6IA 1I5SA 3L9HA 5LT3A 1VFWA 3NWNA 4PJJA 3DC4A 3PXNA 5GSZA 1MMGA 1MKJA 2PG2A 1CZ7A 2Y65A 1D1BA 2FKYA 3B6UA 4PJMA 4E7ZA 2ZFIA 2Q2YA 3CNZA 1FMVA 3WPNA 1MMAA 4PFPA 3HQDA 5LT4A 4ZHIA 2Y5WA 1D1CA 3WRDA 1D0XA 3ZCWA 3KARA 2ZFMA 3KENA 1VOMA 2X51A 1VFXA 2WOGA 2KINA 4A51A 1N6MA 2GM1A 4Y05A 4ZCAA 3T0QA 4A50A 4H1GA 1BG2A 4PJLA 4A1ZA 3COBA 1GOJA 5HLEA 4A28A 2XT3A 5LT1A 1F9WA 4ANJA 4A5YA 2HEHA 4DBQA 2GRYA 2XAEA 1LKXA 2X7DA 4PJNA 1F9UA 4DBRA 1D0YA 1VFZA 3GBJA 5LT2A 1FMWA 3BFNA 1V8KA 1KK7A 1G8XA 1T5CA 2X7EA 3ZFCA 2V26A 1F9TA 1BR1A 2FL6A 5LT0A 1MMNA 2NCDA 2X2RA 1BR4A 1Q0BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1D0Z A;  3X2T A;  1LVK A;  4UBF A;  1D1A A;  1YRS A;  4BN2 A;  4AP0 A;  1F9V A;  3ZFD A;  1MMD A;  4E7S A;  1V8J A;  1X88 A;  4ETP A;  2UYM A;  3KIN A;  1MNE A;  4BXN A;  1II6 A;  3K3B A;  2ZFL A;  2MYS A;  2FL2 A;  1VFV A;  2ZFJ A;  4FRZ A;  4AS7 A;  1BR2 A;  2Q2Z A;  4PK4 A;  3B6V A;  1SDM A;  2VVG A;  2VB6 A;  3DCB A;  2UYI A;  2VAS A;  4LNU K;  3LRE A;  4GKR A;  3L1C A;  2G1Q A;  2IEH A;  4BBG A;  2FME A;  2ZFK A;  2X7C A;  4B7B A;  2OWM A;  3CJO A;  3U06 A;  3H4S A;  1RY6 A;  4HNA K;  3K5E A;  4PFO A;  4A14 A;  1I6I A;  1I5S A;  3L9H A;  5LT3 A;  1VFW A;  3NWN A;  4PJJ A;  3DC4 A;  3PXN A;  5GSZ A;  1MMG A;  1MKJ A;  2PG2 A;  1CZ7 A;  2Y65 A;  1D1B A;  2FKY A;  3B6U A;  4PJM A;  4E7Z A;  2ZFI A;  2Q2Y A;  3CNZ A;  1FMV A;  3WPN A;  1MMA A;  4PFP A;  3HQD A;  5LT4 A;  4ZHI A;  2Y5W A;  1D1C A;  3WRD A;  1D0X A;  3ZCW A;  3KAR A;  2ZFM A;  3KEN A;  1VOM A;  2X51 A;  1VFX A;  2WOG A;  2KIN A;  4A51 A;  1N6M A;  2GM1 A;  4Y05 A;  4ZCA A;  3T0Q A;  4A50 A;  4H1G A;  1BG2 A;  4PJL A;  4A1Z A;  3COB A;  1GOJ A;  5HLE A;  4A28 A;  2XT3 A;  5LT1 A;  1F9W A;  4ANJ A;  4A5Y A;  2HEH A;  4DBQ A;  2GRY A;  2XAE A;  1LKX A;  2X7D A;  4PJN A;  1F9U A;  4DBR A;  1D0Y A;  1VFZ A;  3GBJ A;  5LT2 A;  1FMW A;  3BFN A;  1V8K A;  1KK7 A;  1G8X A;  1T5C A;  2X7E A;  3ZFC A;  2V26 A;  1F9T A;  1BR1 A;  2FL6 A;  5LT0 A;  1MMN A;  2NCD A;  2X2R A;  1BR4 A;  1Q0B A; 
#chains in the Genus database with same CATH topology
 1D0Z A;  3X2T A;  1LVK A;  4UBF A;  1D1A A;  1YRS A;  4BN2 A;  4AP0 A;  1F9V A;  3ZFD A;  1MMD A;  4E7S A;  1V8J A;  1X88 A;  4ETP A;  2UYM A;  3KIN A;  1MNE A;  4BXN A;  1II6 A;  3K3B A;  4GKQ A;  2ZFL A;  2MYS A;  2FL2 A;  1VFV A;  2ZFJ A;  4FRZ A;  4AS7 A;  1BR2 A;  2Q2Z A;  4PK4 A;  3B6V A;  1SDM A;  2VVG A;  2VB6 A;  3DCB A;  2UYI A;  2VAS A;  4LNU K;  3LRE A;  4GKR A;  4GKP A;  3L1C A;  2G1Q A;  2IEH A;  4BBG A;  2FME A;  2ZFK A;  2X7C A;  4B7B A;  2OWM A;  3CJO A;  3U06 A;  3H4S A;  1RY6 A;  4HNA K;  3K5E A;  4PFO A;  4A14 A;  1I6I A;  1I5S A;  3L9H A;  5LT3 A;  1VFW A;  3NWN A;  4PJJ A;  3DC4 A;  3PXN A;  5GSZ A;  1MMG A;  1MKJ A;  2PG2 A;  1CZ7 A;  2Y65 A;  1D1B A;  2FKY A;  3B6U A;  4PJM A;  4E7Z A;  2ZFI A;  2Q2Y A;  3CNZ A;  1FMV A;  3WPN A;  1MMA A;  4PFP A;  3HQD A;  5LT4 A;  4ZHI A;  2Y5W A;  1D1C A;  3WRD A;  1D0X A;  3ZCW A;  3KAR A;  2ZFM A;  3KEN A;  1VOM A;  2X51 A;  1VFX A;  1Q0B A;  2WOG A;  2KIN A;  4A51 A;  1N6M A;  2GM1 A;  4Y05 A;  4ZCA A;  3T0Q A;  4A50 A;  4H1G A;  1BG2 A;  4PJL A;  4A1Z A;  3COB A;  1GOJ A;  5HLE A;  4A28 A;  4ETP B;  2XT3 A;  5LT1 A;  1F9W A;  4ANJ A;  4A5Y A;  2HEH A;  4DBQ A;  2GRY A;  2XAE A;  1LKX A;  2X7D A;  4PJN A;  1F9U A;  4DBR A;  1D0Y A;  1VFZ A;  3GBJ A;  5LT2 A;  1FMW A;  3BFN A;  1V8K A;  1KK7 A;  1G8X A;  1T5C A;  2X7E A;  3ZFC A;  2V26 A;  1F9T A;  1BR1 A;  2FL6 A;  5LT0 A;  1MMN A;  2NCD A;  2X2R A;  1BR4 A;  2O0A A; 
#chains in the Genus database with same CATH homology
 1D0Z A;  3X2T A;  1LVK A;  4UBF A;  1D1A A;  1YRS A;  4BN2 A;  4AP0 A;  1F9V A;  3ZFD A;  1MMD A;  4E7S A;  1V8J A;  1X88 A;  4ETP A;  2UYM A;  3KIN A;  1MNE A;  4BXN A;  1II6 A;  3K3B A;  2ZFL A;  2MYS A;  2FL2 A;  1VFV A;  2ZFJ A;  4FRZ A;  4AS7 A;  1BR2 A;  2Q2Z A;  4PK4 A;  3B6V A;  1SDM A;  2VVG A;  2VB6 A;  3DCB A;  2UYI A;  2VAS A;  4LNU K;  3LRE A;  4GKR A;  3L1C A;  2G1Q A;  2IEH A;  4BBG A;  2FME A;  2ZFK A;  2X7C A;  4B7B A;  2OWM A;  3CJO A;  3U06 A;  3H4S A;  1RY6 A;  4HNA K;  3K5E A;  4PFO A;  4A14 A;  1I6I A;  1I5S A;  3L9H A;  5LT3 A;  1VFW A;  3NWN A;  4PJJ A;  3DC4 A;  3PXN A;  5GSZ A;  1MMG A;  1MKJ A;  2PG2 A;  1CZ7 A;  2Y65 A;  1D1B A;  2FKY A;  3B6U A;  4PJM A;  4E7Z A;  2ZFI A;  2Q2Y A;  3CNZ A;  1FMV A;  3WPN A;  1MMA A;  4PFP A;  3HQD A;  5LT4 A;  4ZHI A;  2Y5W A;  1D1C A;  3WRD A;  1D0X A;  3ZCW A;  3KAR A;  2ZFM A;  3KEN A;  1VOM A;  2X51 A;  1VFX A;  2WOG A;  2KIN A;  4A51 A;  1N6M A;  2GM1 A;  4Y05 A;  4ZCA A;  3T0Q A;  4A50 A;  4H1G A;  1BG2 A;  4PJL A;  4A1Z A;  3COB A;  1GOJ A;  5HLE A;  4A28 A;  2XT3 A;  5LT1 A;  1F9W A;  4ANJ A;  4A5Y A;  2HEH A;  4DBQ A;  2GRY A;  2XAE A;  1LKX A;  2X7D A;  4PJN A;  1F9U A;  4DBR A;  1D0Y A;  1VFZ A;  3GBJ A;  5LT2 A;  1FMW A;  3BFN A;  1V8K A;  1KK7 A;  1G8X A;  1T5C A;  2X7E A;  3ZFC A;  2V26 A;  1F9T A;  1BR1 A;  2FL6 A;  5LT0 A;  1MMN A;  2NCD A;  2X2R A;  1BR4 A;  1Q0B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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