4AP0A

The mitotic kinesin eg5 in complex with mg-adp and ispinesib
Total Genus 92
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
92
sequence length
350
structure length
325
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKEVKIGKLNLVDLAGSENIGRINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title The Structure of the Ternary Eg5-Adp-Ispinesib Complex
pubmed doi rcsb
source organism Homo sapiens
molecule tags Motor protein
total genus 92
structure length 325
sequence length 350
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4ap0A00
1MMGA 3X2TA 2FL2A 2UYMA 2ZFMA 1I6IA 1BR1A 5LT2A 1F9WA 1LKXA 4ZHIA 4PJNA 1VFZA 2FL6A 2X2RA 1V8JA 3CNZA 3GBJA 3DCBA 4PJJA 4A51A 1VFXA 1G8XA 2Y65A 1MKJA 4E7SA 2GRYA 4PJMA 2Q2YA 1D0XA 1II6A 4GKRA 2ZFJA 1BR4A 1MMAA 3COBA 2OWMA 4FRZA 1VFVA 3ZFCA 4A14A 3T0QA 4HNAK 2KINA 4PFOA 1N6MA 4PFPA 4UBFA 1LVKA 1F9TA 1D1BA 3K3BA 1MNEA 3LREA 4ANJA 3WPNA 4BXNA 1BG2A 4DBRA 1D1AA 5LT0A 5LT1A 3U06A 1Q0BA 2X7CA 3H4SA 5GSZA 1F9UA 2ZFIA 3KENA 3ZCWA 3K5EA 5LT3A 1F9VA 2G1QA 1V8KA 2Q2ZA 1YRSA 4H1GA 2ZFLA 2FKYA 3NWNA 1X88A 4ZCAA 4B7BA 2PG2A 1T5CA 1RY6A 2FMEA 2GM1A 4A1ZA 1I5SA 3BFNA 1MMNA 2VVGA 2VB6A 3HQDA 3KARA 3L9HA 1GOJA 1VFWA 2Y5WA 1D1CA 4A5YA 3CJOA 4BN2A 4PK4A 4E7ZA 4AS7A 2WOGA 2VASA 3KINA 1KK7A 4BBGA 5HLEA 3B6VA 1D0ZA 1FMVA 2XAEA 2V26A 2X7DA 3PXNA 1MMDA 3ZFDA 2X7EA 1VOMA 4LNUK 2MYSA 2ZFKA 2X51A 1SDMA 3L1CA 3B6UA 4Y05A 4A28A 1D0YA 2NCDA 5LT4A 3WRDA 4PJLA 4AP0A 1CZ7A 4DBQA 4ETPA 4A50A 2UYIA 1FMWA 3DC4A 2IEHA 2XT3A 1BR2A 2HEHA
chains in the Genus database with same CATH superfamily
1MMGA 3X2TA 2FL2A 2UYMA 2ZFMA 1I6IA 1BR1A 5LT2A 1F9WA 1LKXA 4ZHIA 4PJNA 1VFZA 2FL6A 2X2RA 1V8JA 3CNZA 3GBJA 3DCBA 4PJJA 4A51A 1VFXA 1G8XA 2Y65A 1MKJA 4E7SA 2GRYA 4PJMA 2Q2YA 4ETPB 1D0XA 1II6A 4GKRA 2ZFJA 4GKPA 1BR4A 1MMAA 3COBA 2OWMA 4FRZA 1VFVA 4GKQA 3ZFCA 4A14A 3T0QA 4HNAK 2KINA 4PFOA 1N6MA 4PFPA 4UBFA 1LVKA 1F9TA 1D1BA 3K3BA 1MNEA 3LREA 4ANJA 3WPNA 4BXNA 1BG2A 4DBRA 1D1AA 5LT0A 5LT1A 3U06A 1Q0BA 2X7CA 3H4SA 5GSZA 1F9UA 2ZFIA 3KENA 3ZCWA 3K5EA 5LT3A 1F9VA 2G1QA 1V8KA 2Q2ZA 1YRSA 4H1GA 2ZFLA 2FKYA 3NWNA 1X88A 4ZCAA 4B7BA 2PG2A 1T5CA 1RY6A 2FMEA 2GM1A 4A1ZA 1I5SA 3BFNA 1MMNA 2VVGA 2VB6A 3HQDA 3KARA 3L9HA 1GOJA 1VFWA 2Y5WA 1D1CA 4A5YA 3CJOA 4BN2A 4PK4A 4E7ZA 4AS7A 2WOGA 2VASA 3KINA 1KK7A 4BBGA 5HLEA 3B6VA 1D0ZA 1FMVA 2XAEA 2V26A 2X7DA 3PXNA 1MMDA 3ZFDA 2X7EA 1VOMA 4LNUK 2MYSA 2ZFKA 2X51A 1SDMA 3L1CA 3B6UA 4Y05A 4A28A 1D0YA 2NCDA 5LT4A 3WRDA 4PJLA 4AP0A 1CZ7A 4DBQA 4ETPA 4A50A 2UYIA 1FMWA 3DC4A 2O0AA 2IEHA 2XT3A 1BR2A 2HEHA
chains in the Genus database with same CATH topology
1MMGA 3X2TA 2FL2A 2UYMA 2ZFMA 1I6IA 1BR1A 5LT2A 1F9WA 1LKXA 4ZHIA 4PJNA 1VFZA 2FL6A 2X2RA 1V8JA 3CNZA 3GBJA 3DCBA 4PJJA 4A51A 1VFXA 1G8XA 2Y65A 1MKJA 4E7SA 2GRYA 4PJMA 2Q2YA 1D0XA 1II6A 4GKRA 2ZFJA 1BR4A 1MMAA 3COBA 2OWMA 4FRZA 1VFVA 3ZFCA 4A14A 3T0QA 4HNAK 2KINA 4PFOA 1N6MA 4PFPA 4UBFA 1LVKA 1F9TA 1D1BA 3K3BA 1MNEA 3LREA 4ANJA 3WPNA 4BXNA 1BG2A 4DBRA 1D1AA 5LT0A 5LT1A 3U06A 1Q0BA 2X7CA 3H4SA 5GSZA 1F9UA 2ZFIA 3KENA 3ZCWA 3K5EA 5LT3A 1F9VA 2G1QA 1V8KA 2Q2ZA 1YRSA 4H1GA 2ZFLA 2FKYA 3NWNA 1X88A 4ZCAA 4B7BA 2PG2A 1T5CA 1RY6A 2FMEA 2GM1A 4A1ZA 1I5SA 3BFNA 1MMNA 2VVGA 2VB6A 3HQDA 3KARA 3L9HA 1GOJA 1VFWA 2Y5WA 1D1CA 4A5YA 3CJOA 4BN2A 4PK4A 4E7ZA 4AS7A 2WOGA 2VASA 3KINA 1KK7A 4BBGA 5HLEA 3B6VA 1D0ZA 1FMVA 2XAEA 2V26A 2X7DA 3PXNA 1MMDA 3ZFDA 2X7EA 1VOMA 4LNUK 2MYSA 2ZFKA 2X51A 1SDMA 3L1CA 3B6UA 4Y05A 4A28A 1D0YA 2NCDA 5LT4A 3WRDA 4PJLA 4AP0A 1CZ7A 4DBQA 4ETPA 4A50A 2UYIA 1FMWA 3DC4A 2IEHA 2XT3A 1BR2A 2HEHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MMG A;  3X2T A;  2FL2 A;  2UYM A;  2ZFM A;  1I6I A;  1BR1 A;  5LT2 A;  1F9W A;  1LKX A;  4ZHI A;  4PJN A;  1VFZ A;  2FL6 A;  2X2R A;  1V8J A;  3CNZ A;  3GBJ A;  3DCB A;  4PJJ A;  4A51 A;  1VFX A;  1G8X A;  2Y65 A;  1MKJ A;  4E7S A;  2GRY A;  4PJM A;  2Q2Y A;  1D0X A;  1II6 A;  4GKR A;  2ZFJ A;  1BR4 A;  1MMA A;  3COB A;  2OWM A;  4FRZ A;  1VFV A;  3ZFC A;  4A14 A;  3T0Q A;  4HNA K;  2KIN A;  4PFO A;  1N6M A;  4PFP A;  4UBF A;  1LVK A;  1F9T A;  1D1B A;  3K3B A;  1MNE A;  3LRE A;  4ANJ A;  3WPN A;  4BXN A;  1BG2 A;  4DBR A;  1D1A A;  5LT0 A;  5LT1 A;  3U06 A;  1Q0B A;  2X7C A;  3H4S A;  5GSZ A;  1F9U A;  2ZFI A;  3KEN A;  3ZCW A;  3K5E A;  5LT3 A;  1F9V A;  2G1Q A;  1V8K A;  2Q2Z A;  1YRS A;  4H1G A;  2ZFL A;  2FKY A;  3NWN A;  1X88 A;  4ZCA A;  4B7B A;  2PG2 A;  1T5C A;  1RY6 A;  2FME A;  2GM1 A;  4A1Z A;  1I5S A;  3BFN A;  1MMN A;  2VVG A;  2VB6 A;  3HQD A;  3KAR A;  3L9H A;  1GOJ A;  1VFW A;  2Y5W A;  1D1C A;  4A5Y A;  3CJO A;  4BN2 A;  4PK4 A;  4E7Z A;  4AS7 A;  2WOG A;  2VAS A;  3KIN A;  1KK7 A;  4BBG A;  5HLE A;  3B6V A;  1D0Z A;  1FMV A;  2XAE A;  2V26 A;  2X7D A;  3PXN A;  1MMD A;  3ZFD A;  2X7E A;  1VOM A;  4LNU K;  2MYS A;  2ZFK A;  2X51 A;  1SDM A;  3L1C A;  3B6U A;  4Y05 A;  4A28 A;  1D0Y A;  2NCD A;  5LT4 A;  3WRD A;  4PJL A;  4AP0 A;  1CZ7 A;  4DBQ A;  4ETP A;  4A50 A;  2UYI A;  1FMW A;  3DC4 A;  2IEH A;  2XT3 A;  1BR2 A;  2HEH A; 
#chains in the Genus database with same CATH topology
 1MMG A;  3X2T A;  2FL2 A;  2UYM A;  2ZFM A;  1I6I A;  1BR1 A;  5LT2 A;  1F9W A;  1LKX A;  4ZHI A;  4PJN A;  1VFZ A;  2FL6 A;  2X2R A;  1V8J A;  3CNZ A;  3GBJ A;  3DCB A;  4PJJ A;  4A51 A;  1VFX A;  1G8X A;  2Y65 A;  1MKJ A;  4E7S A;  2GRY A;  4PJM A;  2Q2Y A;  4ETP B;  1D0X A;  1II6 A;  4GKR A;  2ZFJ A;  4GKP A;  1BR4 A;  1MMA A;  3COB A;  2OWM A;  4FRZ A;  1VFV A;  4GKQ A;  3ZFC A;  4A14 A;  3T0Q A;  4HNA K;  2KIN A;  4PFO A;  1N6M A;  4PFP A;  4UBF A;  1LVK A;  1F9T A;  1D1B A;  3K3B A;  1MNE A;  3LRE A;  4ANJ A;  3WPN A;  4BXN A;  1BG2 A;  4DBR A;  1D1A A;  5LT0 A;  5LT1 A;  3U06 A;  1Q0B A;  2X7C A;  3H4S A;  5GSZ A;  1F9U A;  2ZFI A;  3KEN A;  3ZCW A;  3K5E A;  5LT3 A;  1F9V A;  2G1Q A;  1V8K A;  2Q2Z A;  1YRS A;  4H1G A;  2ZFL A;  2FKY A;  3NWN A;  1X88 A;  4ZCA A;  4B7B A;  2PG2 A;  1T5C A;  1RY6 A;  2FME A;  2GM1 A;  4A1Z A;  1I5S A;  3BFN A;  1MMN A;  2VVG A;  2VB6 A;  3HQD A;  3KAR A;  3L9H A;  1GOJ A;  1VFW A;  2Y5W A;  1D1C A;  4A5Y A;  3CJO A;  4BN2 A;  4PK4 A;  4E7Z A;  4AS7 A;  2WOG A;  2VAS A;  3KIN A;  1KK7 A;  4BBG A;  5HLE A;  3B6V A;  1D0Z A;  1FMV A;  2XAE A;  2V26 A;  2X7D A;  3PXN A;  1MMD A;  3ZFD A;  2X7E A;  1VOM A;  4LNU K;  2MYS A;  2ZFK A;  2X51 A;  1SDM A;  3L1C A;  3B6U A;  4Y05 A;  4A28 A;  1D0Y A;  2NCD A;  5LT4 A;  3WRD A;  4PJL A;  4AP0 A;  1CZ7 A;  4DBQ A;  4ETP A;  4A50 A;  2UYI A;  1FMW A;  3DC4 A;  2O0A A;  2IEH A;  2XT3 A;  1BR2 A;  2HEH A; 
#chains in the Genus database with same CATH homology
 1MMG A;  3X2T A;  2FL2 A;  2UYM A;  2ZFM A;  1I6I A;  1BR1 A;  5LT2 A;  1F9W A;  1LKX A;  4ZHI A;  4PJN A;  1VFZ A;  2FL6 A;  2X2R A;  1V8J A;  3CNZ A;  3GBJ A;  3DCB A;  4PJJ A;  4A51 A;  1VFX A;  1G8X A;  2Y65 A;  1MKJ A;  4E7S A;  2GRY A;  4PJM A;  2Q2Y A;  1D0X A;  1II6 A;  4GKR A;  2ZFJ A;  1BR4 A;  1MMA A;  3COB A;  2OWM A;  4FRZ A;  1VFV A;  3ZFC A;  4A14 A;  3T0Q A;  4HNA K;  2KIN A;  4PFO A;  1N6M A;  4PFP A;  4UBF A;  1LVK A;  1F9T A;  1D1B A;  3K3B A;  1MNE A;  3LRE A;  4ANJ A;  3WPN A;  4BXN A;  1BG2 A;  4DBR A;  1D1A A;  5LT0 A;  5LT1 A;  3U06 A;  1Q0B A;  2X7C A;  3H4S A;  5GSZ A;  1F9U A;  2ZFI A;  3KEN A;  3ZCW A;  3K5E A;  5LT3 A;  1F9V A;  2G1Q A;  1V8K A;  2Q2Z A;  1YRS A;  4H1G A;  2ZFL A;  2FKY A;  3NWN A;  1X88 A;  4ZCA A;  4B7B A;  2PG2 A;  1T5C A;  1RY6 A;  2FME A;  2GM1 A;  4A1Z A;  1I5S A;  3BFN A;  1MMN A;  2VVG A;  2VB6 A;  3HQD A;  3KAR A;  3L9H A;  1GOJ A;  1VFW A;  2Y5W A;  1D1C A;  4A5Y A;  3CJO A;  4BN2 A;  4PK4 A;  4E7Z A;  4AS7 A;  2WOG A;  2VAS A;  3KIN A;  1KK7 A;  4BBG A;  5HLE A;  3B6V A;  1D0Z A;  1FMV A;  2XAE A;  2V26 A;  2X7D A;  3PXN A;  1MMD A;  3ZFD A;  2X7E A;  1VOM A;  4LNU K;  2MYS A;  2ZFK A;  2X51 A;  1SDM A;  3L1C A;  3B6U A;  4Y05 A;  4A28 A;  1D0Y A;  2NCD A;  5LT4 A;  3WRD A;  4PJL A;  4AP0 A;  1CZ7 A;  4DBQ A;  4ETP A;  4A50 A;  2UYI A;  1FMW A;  3DC4 A;  2IEH A;  2XT3 A;  1BR2 A;  2HEH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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