4AP0A

The mitotic kinesin eg5 in complex with mg-adp and ispinesib
Total Genus 92
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
92
sequence length
350
structure length
325
Chain Sequence
b'KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKEVKIGKLNLVDLAGSENIGRINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVN'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title The Structure of the Ternary Eg5-Adp-Ispinesib Complex
pubmed doi rcsb
source organism Homo sapiens
molecule tags Motor protein
total genus 92
structure length 325
sequence length 350
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4ap0A00
4PFOA 4UBFA 2ZFMA 3WPNA 1KK7A 1Q0BA 3WRDA 4LNUK 3DCBA 4BXNA 1F9TA 4ZCAA 4PJMA 1FMWA 3NWNA 4AP0A 4DBQA 2KINA 3L9HA 4DBRA 2Q2YA 2PG2A 2X7CA 2GRYA 4BBGA 1BR1A 1GOJA 1D0XA 3DC4A 4PJJA 2XT3A 4ETPA 5LT3A 2X51A 3K5EA 5HLEA 1V8KA 2ZFJA 1II6A 1MMAA 2GM1A 1MNEA 2OWMA 4A5YA 4PJNA 1LVKA 2VASA 5GSZA 1X88A 1VFWA 2FKYA 2UYIA 4E7ZA 2NCDA 2WOGA 2X7DA 3B6VA 3B6UA 2X2RA 1FMVA 3H4SA 3LREA 1MKJA 3KENA 1F9WA 2MYSA 3ZFDA 1G8XA 1F9UA 1VFXA 5LT4A 2XAEA 1D1AA 1BR4A 2G1QA 3HQDA 2FMEA 4Y05A 3ZCWA 4ANJA 2ZFIA 2V26A 2HEHA 4A28A 1I6IA 3ZFCA 1D0YA 1MMDA 5LT1A 1MMGA 4A50A 1VFZA 1YRSA 4H1GA 3BFNA 1VOMA 4A1ZA 1VFVA 4B7BA 1N6MA 1F9VA 4HNAK 1SDMA 4PJLA 3T0QA 1I5SA 2X7EA 1LKXA 3L1CA 1V8JA 2Y65A 2Y5WA 2Q2ZA 1D1BA 2ZFLA 2ZFKA 5LT0A 1BG2A 2IEHA 2VB6A 3KARA 3PXNA 4A51A 1CZ7A 4A14A 1D1CA 4ZHIA 3X2TA 3K3BA 2FL2A 4AS7A 3COBA 4E7SA 5LT2A 1T5CA 4FRZA 4PFPA 3CJOA 2FL6A 2VVGA 4BN2A 3CNZA 1D0ZA 1BR2A 4PK4A 3KINA 2UYMA 3GBJA 3U06A 1RY6A 1MMNA 4GKRA
chains in the Genus database with same CATH superfamily
4PFOA 4UBFA 2ZFMA 3WPNA 1KK7A 1Q0BA 3WRDA 4LNUK 3DCBA 4BXNA 1F9TA 4ZCAA 4PJMA 1FMWA 3NWNA 4AP0A 4DBQA 2KINA 3L9HA 4DBRA 2Q2YA 2PG2A 2X7CA 4GKPA 2GRYA 4BBGA 1BR1A 1GOJA 1D0XA 3DC4A 4PJJA 2XT3A 4ETPA 5LT3A 2X51A 3K5EA 5HLEA 1V8KA 2ZFJA 1II6A 1MMAA 2GM1A 1MNEA 2OWMA 4A5YA 4PJNA 1LVKA 2VASA 5GSZA 1X88A 1VFWA 2FKYA 2UYIA 4E7ZA 2NCDA 2WOGA 2X7DA 3B6VA 3B6UA 2X2RA 1FMVA 3H4SA 3LREA 1MKJA 3KENA 1F9WA 2MYSA 3ZFDA 1G8XA 1F9UA 1VFXA 4GKQA 2O0AA 5LT4A 2XAEA 1D1AA 1BR4A 2G1QA 3HQDA 4ETPB 2FMEA 4Y05A 3ZCWA 4ANJA 2ZFIA 2V26A 2HEHA 4A28A 1I6IA 3ZFCA 1D0YA 1MMDA 5LT1A 1MMGA 4A50A 1VFZA 1YRSA 4H1GA 3BFNA 1VOMA 4A1ZA 1VFVA 4B7BA 1N6MA 1F9VA 4HNAK 1SDMA 4PJLA 3T0QA 1I5SA 2X7EA 1LKXA 3L1CA 1V8JA 2Y65A 2Y5WA 2Q2ZA 1D1BA 2ZFLA 2ZFKA 5LT0A 1BG2A 2IEHA 2VB6A 3KARA 3PXNA 4A51A 1CZ7A 4A14A 1D1CA 4ZHIA 3X2TA 3K3BA 2FL2A 4AS7A 3COBA 4E7SA 5LT2A 1T5CA 4FRZA 4PFPA 3CJOA 2FL6A 2VVGA 4BN2A 3CNZA 1D0ZA 1BR2A 4PK4A 3KINA 2UYMA 3GBJA 3U06A 1RY6A 1MMNA 4GKRA
chains in the Genus database with same CATH topology
4PFOA 4UBFA 2ZFMA 3WPNA 1KK7A 1Q0BA 3WRDA 4LNUK 3DCBA 4BXNA 1F9TA 4ZCAA 4PJMA 1FMWA 3NWNA 4AP0A 4DBQA 2KINA 3L9HA 4DBRA 2Q2YA 2PG2A 2X7CA 2GRYA 4BBGA 1BR1A 1GOJA 1D0XA 3DC4A 4PJJA 2XT3A 4ETPA 5LT3A 2X51A 3K5EA 5HLEA 1V8KA 2ZFJA 1II6A 1MMAA 2GM1A 1MNEA 2OWMA 4A5YA 4PJNA 1LVKA 2VASA 5GSZA 1X88A 1VFWA 2FKYA 2UYIA 4E7ZA 2NCDA 2WOGA 2X7DA 3B6VA 3B6UA 2X2RA 1FMVA 3H4SA 3LREA 1MKJA 3KENA 1F9WA 2MYSA 3ZFDA 1G8XA 1F9UA 1VFXA 5LT4A 2XAEA 1D1AA 1BR4A 2G1QA 3HQDA 2FMEA 4Y05A 3ZCWA 4ANJA 2ZFIA 2V26A 2HEHA 4A28A 1I6IA 3ZFCA 1D0YA 1MMDA 5LT1A 1MMGA 4A50A 1VFZA 1YRSA 4H1GA 3BFNA 1VOMA 4A1ZA 1VFVA 4B7BA 1N6MA 1F9VA 4HNAK 1SDMA 4PJLA 3T0QA 1I5SA 2X7EA 1LKXA 3L1CA 1V8JA 2Y65A 2Y5WA 2Q2ZA 1D1BA 2ZFLA 2ZFKA 5LT0A 1BG2A 2IEHA 2VB6A 3KARA 3PXNA 4A51A 1CZ7A 4A14A 1D1CA 4ZHIA 3X2TA 3K3BA 2FL2A 4AS7A 3COBA 4E7SA 5LT2A 1T5CA 4FRZA 4PFPA 3CJOA 2FL6A 2VVGA 4BN2A 3CNZA 1D0ZA 1BR2A 4PK4A 3KINA 2UYMA 3GBJA 3U06A 1RY6A 1MMNA 4GKRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PFO A;  4UBF A;  2ZFM A;  3WPN A;  1KK7 A;  1Q0B A;  3WRD A;  4LNU K;  3DCB A;  4BXN A;  1F9T A;  4ZCA A;  4PJM A;  1FMW A;  3NWN A;  4AP0 A;  4DBQ A;  2KIN A;  3L9H A;  4DBR A;  2Q2Y A;  2PG2 A;  2X7C A;  2GRY A;  4BBG A;  1BR1 A;  1GOJ A;  1D0X A;  3DC4 A;  4PJJ A;  2XT3 A;  4ETP A;  5LT3 A;  2X51 A;  3K5E A;  5HLE A;  1V8K A;  2ZFJ A;  1II6 A;  1MMA A;  2GM1 A;  1MNE A;  2OWM A;  4A5Y A;  4PJN A;  1LVK A;  2VAS A;  5GSZ A;  1X88 A;  1VFW A;  2FKY A;  2UYI A;  4E7Z A;  2NCD A;  2WOG A;  2X7D A;  3B6V A;  3B6U A;  2X2R A;  1FMV A;  3H4S A;  3LRE A;  1MKJ A;  3KEN A;  1F9W A;  2MYS A;  3ZFD A;  1G8X A;  1F9U A;  1VFX A;  5LT4 A;  2XAE A;  1D1A A;  1BR4 A;  2G1Q A;  3HQD A;  2FME A;  4Y05 A;  3ZCW A;  4ANJ A;  2ZFI A;  2V26 A;  2HEH A;  4A28 A;  1I6I A;  3ZFC A;  1D0Y A;  1MMD A;  5LT1 A;  1MMG A;  4A50 A;  1VFZ A;  1YRS A;  4H1G A;  3BFN A;  1VOM A;  4A1Z A;  1VFV A;  4B7B A;  1N6M A;  1F9V A;  4HNA K;  1SDM A;  4PJL A;  3T0Q A;  1I5S A;  2X7E A;  1LKX A;  3L1C A;  1V8J A;  2Y65 A;  2Y5W A;  2Q2Z A;  1D1B A;  2ZFL A;  2ZFK A;  5LT0 A;  1BG2 A;  2IEH A;  2VB6 A;  3KAR A;  3PXN A;  4A51 A;  1CZ7 A;  4A14 A;  1D1C A;  4ZHI A;  3X2T A;  3K3B A;  2FL2 A;  4AS7 A;  3COB A;  4E7S A;  5LT2 A;  1T5C A;  4FRZ A;  4PFP A;  3CJO A;  2FL6 A;  2VVG A;  4BN2 A;  3CNZ A;  1D0Z A;  1BR2 A;  4PK4 A;  3KIN A;  2UYM A;  3GBJ A;  3U06 A;  1RY6 A;  1MMN A;  4GKR A; 
#chains in the Genus database with same CATH topology
 4PFO A;  4UBF A;  2ZFM A;  3WPN A;  1KK7 A;  1Q0B A;  3WRD A;  4LNU K;  3DCB A;  4BXN A;  1F9T A;  4ZCA A;  4PJM A;  1FMW A;  3NWN A;  4AP0 A;  4DBQ A;  2KIN A;  3L9H A;  4DBR A;  2Q2Y A;  2PG2 A;  2X7C A;  4GKP A;  2GRY A;  4BBG A;  1BR1 A;  1GOJ A;  1D0X A;  3DC4 A;  4PJJ A;  2XT3 A;  4ETP A;  5LT3 A;  2X51 A;  3K5E A;  5HLE A;  1V8K A;  2ZFJ A;  1II6 A;  1MMA A;  2GM1 A;  1MNE A;  2OWM A;  4A5Y A;  4PJN A;  1LVK A;  2VAS A;  5GSZ A;  1X88 A;  1VFW A;  2FKY A;  2UYI A;  4E7Z A;  2NCD A;  2WOG A;  2X7D A;  3B6V A;  3B6U A;  2X2R A;  1FMV A;  3H4S A;  3LRE A;  1MKJ A;  3KEN A;  1F9W A;  2MYS A;  3ZFD A;  1G8X A;  1F9U A;  1VFX A;  4GKQ A;  2O0A A;  5LT4 A;  2XAE A;  1D1A A;  1BR4 A;  2G1Q A;  3HQD A;  4ETP B;  2FME A;  4Y05 A;  3ZCW A;  4ANJ A;  2ZFI A;  2V26 A;  2HEH A;  4A28 A;  1I6I A;  3ZFC A;  1D0Y A;  1MMD A;  5LT1 A;  1MMG A;  4A50 A;  1VFZ A;  1YRS A;  4H1G A;  3BFN A;  1VOM A;  4A1Z A;  1VFV A;  4B7B A;  1N6M A;  1F9V A;  4HNA K;  1SDM A;  4PJL A;  3T0Q A;  1I5S A;  2X7E A;  1LKX A;  3L1C A;  1V8J A;  2Y65 A;  2Y5W A;  2Q2Z A;  1D1B A;  2ZFL A;  2ZFK A;  5LT0 A;  1BG2 A;  2IEH A;  2VB6 A;  3KAR A;  3PXN A;  4A51 A;  1CZ7 A;  4A14 A;  1D1C A;  4ZHI A;  3X2T A;  3K3B A;  2FL2 A;  4AS7 A;  3COB A;  4E7S A;  5LT2 A;  1T5C A;  4FRZ A;  4PFP A;  3CJO A;  2FL6 A;  2VVG A;  4BN2 A;  3CNZ A;  1D0Z A;  1BR2 A;  4PK4 A;  3KIN A;  2UYM A;  3GBJ A;  3U06 A;  1RY6 A;  1MMN A;  4GKR A; 
#chains in the Genus database with same CATH homology
 4PFO A;  4UBF A;  2ZFM A;  3WPN A;  1KK7 A;  1Q0B A;  3WRD A;  4LNU K;  3DCB A;  4BXN A;  1F9T A;  4ZCA A;  4PJM A;  1FMW A;  3NWN A;  4AP0 A;  4DBQ A;  2KIN A;  3L9H A;  4DBR A;  2Q2Y A;  2PG2 A;  2X7C A;  2GRY A;  4BBG A;  1BR1 A;  1GOJ A;  1D0X A;  3DC4 A;  4PJJ A;  2XT3 A;  4ETP A;  5LT3 A;  2X51 A;  3K5E A;  5HLE A;  1V8K A;  2ZFJ A;  1II6 A;  1MMA A;  2GM1 A;  1MNE A;  2OWM A;  4A5Y A;  4PJN A;  1LVK A;  2VAS A;  5GSZ A;  1X88 A;  1VFW A;  2FKY A;  2UYI A;  4E7Z A;  2NCD A;  2WOG A;  2X7D A;  3B6V A;  3B6U A;  2X2R A;  1FMV A;  3H4S A;  3LRE A;  1MKJ A;  3KEN A;  1F9W A;  2MYS A;  3ZFD A;  1G8X A;  1F9U A;  1VFX A;  5LT4 A;  2XAE A;  1D1A A;  1BR4 A;  2G1Q A;  3HQD A;  2FME A;  4Y05 A;  3ZCW A;  4ANJ A;  2ZFI A;  2V26 A;  2HEH A;  4A28 A;  1I6I A;  3ZFC A;  1D0Y A;  1MMD A;  5LT1 A;  1MMG A;  4A50 A;  1VFZ A;  1YRS A;  4H1G A;  3BFN A;  1VOM A;  4A1Z A;  1VFV A;  4B7B A;  1N6M A;  1F9V A;  4HNA K;  1SDM A;  4PJL A;  3T0Q A;  1I5S A;  2X7E A;  1LKX A;  3L1C A;  1V8J A;  2Y65 A;  2Y5W A;  2Q2Z A;  1D1B A;  2ZFL A;  2ZFK A;  5LT0 A;  1BG2 A;  2IEH A;  2VB6 A;  3KAR A;  3PXN A;  4A51 A;  1CZ7 A;  4A14 A;  1D1C A;  4ZHI A;  3X2T A;  3K3B A;  2FL2 A;  4AS7 A;  3COB A;  4E7S A;  5LT2 A;  1T5C A;  4FRZ A;  4PFP A;  3CJO A;  2FL6 A;  2VVG A;  4BN2 A;  3CNZ A;  1D0Z A;  1BR2 A;  4PK4 A;  3KIN A;  2UYM A;  3GBJ A;  3U06 A;  1RY6 A;  1MMN A;  4GKR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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