2IEHA

Crystal structure of human kinesin eg5 in complex with (r)-mon97, a new monastrol-based inhibitor that binds as (r)-enantiomer
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
350
structure length
334
Chain Sequence
KGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Kinesin-like protein KIF11
total genus 106
structure length 334
sequence length 350
chains with identical sequence B
ec nomenclature ec 3.6.4.4: Transferred entry: 5.6.1.3.
pdb deposition date 2006-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2iehA00
1MNEA 1I6IA 5LT4A 3WPNA 1MKJA 2XAEA 4ANJA 5LT0A 1YRSA 4DBQA 3DCBA 2FKYA 3WRDA 4UBFA 4A14A 3KENA 1F9UA 3LREA 2Y65A 3PXNA 4PJMA 4HNAK 2VB6A 1CZ7A 1LKXA 2Q2YA 1BR4A 3COBA 3CNZA 2X2RA 3HQDA 4A50A 2X7EA 4A5YA 1VFVA 2ZFIA 3KARA 4AS7A 1T5CA 2MYSA 1D0YA 1X88A 4E7ZA 1MMGA 2OWMA 4Y05A 1V8JA 1D1AA 4PJLA 3ZCWA 4BBGA 4PFOA 4BXNA 2ZFJA 4BN2A 2G1QA 3L9HA 3K5EA 3T0QA 1VFWA 3NWNA 4A51A 5LT1A 4PFPA 4ETPA 1MMDA 1D1CA 3H4SA 2UYMA 2PG2A 2HEHA 2Y5WA 2GRYA 2X7DA 1MMAA 1F9TA 2FL2A 5LT2A 4PK4A 3L1CA 1RY6A 4DBRA 1N6MA 3X2TA 3BFNA 2XT3A 1MMNA 2ZFLA 1D0XA 4ZCAA 5GSZA 1V8KA 1BR1A 3DC4A 2V26A 1I5SA 2VASA 1D1BA 3B6VA 4FRZA 3GBJA 3U06A 1FMWA 1GOJA 2UYIA 1II6A 4E7SA 3KINA 1Q0BA 4H1GA 2IEHA 2FL6A 4PJNA 1LVKA 1FMVA 4LNUK 1SDMA 2X7CA 1BG2A 1D0ZA 1VOMA 4ZHIA 4B7BA 5LT3A 3B6UA 1BR2A 3CJOA 4A1ZA 2NCDA 3ZFDA 2ZFMA 1KK7A 2ZFKA 2GM1A 2VVGA 1VFZA 4GKRA 3ZFCA 3K3BA 4AP0A 4A28A 4PJJA 2WOGA 1F9WA 1G8XA 2FMEA 1VFXA 2Q2ZA 2X51A 5HLEA 1F9VA 2KINA
chains in the Genus database with same CATH superfamily
1MNEA 1I6IA 5LT4A 3WPNA 1MKJA 2XAEA 4GKQA 4ANJA 5LT0A 1YRSA 4DBQA 3DCBA 2FKYA 3WRDA 4UBFA 4A14A 3KENA 1F9UA 3LREA 2Y65A 3PXNA 4PJMA 4HNAK 2VB6A 1CZ7A 1LKXA 2Q2YA 1BR4A 3COBA 3CNZA 2X2RA 3HQDA 4A50A 2X7EA 4A5YA 1VFVA 2ZFIA 3KARA 4AS7A 1T5CA 2MYSA 1D0YA 1X88A 4E7ZA 1MMGA 2OWMA 4Y05A 1V8JA 1D1AA 4PJLA 3ZCWA 4BBGA 4PFOA 4BXNA 2ZFJA 4BN2A 2G1QA 3L9HA 3K5EA 3T0QA 1VFWA 3NWNA 4A51A 5LT1A 4PFPA 4ETPA 1MMDA 1D1CA 3H4SA 2UYMA 2PG2A 2HEHA 2Y5WA 2GRYA 2X7DA 1MMAA 1F9TA 2FL2A 5LT2A 4PK4A 3L1CA 1RY6A 4DBRA 1N6MA 3X2TA 3BFNA 4ETPB 2XT3A 1MMNA 2ZFLA 1D0XA 4ZCAA 5GSZA 1V8KA 1BR1A 3DC4A 2V26A 1I5SA 2VASA 1D1BA 3B6VA 4FRZA 4GKPA 3GBJA 3U06A 1FMWA 1GOJA 2UYIA 1II6A 4E7SA 3KINA 1Q0BA 4H1GA 2IEHA 2FL6A 4PJNA 1LVKA 1FMVA 4LNUK 1SDMA 2X7CA 1BG2A 1D0ZA 1VOMA 4ZHIA 4B7BA 5LT3A 3B6UA 1BR2A 3CJOA 4A1ZA 2NCDA 3ZFDA 2ZFMA 1KK7A 2ZFKA 2GM1A 2VVGA 1VFZA 2O0AA 4GKRA 3ZFCA 3K3BA 4AP0A 4A28A 4PJJA 2WOGA 1F9WA 1G8XA 2FMEA 1VFXA 2Q2ZA 2X51A 5HLEA 1F9VA 2KINA
chains in the Genus database with same CATH topology
1MNEA 1I6IA 5LT4A 3WPNA 1MKJA 2XAEA 4ANJA 5LT0A 1YRSA 4DBQA 3DCBA 2FKYA 3WRDA 4UBFA 4A14A 3KENA 1F9UA 3LREA 2Y65A 3PXNA 4PJMA 4HNAK 2VB6A 1CZ7A 1LKXA 2Q2YA 1BR4A 3COBA 3CNZA 2X2RA 3HQDA 4A50A 2X7EA 4A5YA 1VFVA 2ZFIA 3KARA 4AS7A 1T5CA 2MYSA 1D0YA 1X88A 4E7ZA 1MMGA 2OWMA 4Y05A 1V8JA 1D1AA 4PJLA 3ZCWA 4BBGA 4PFOA 4BXNA 2ZFJA 4BN2A 2G1QA 3L9HA 3K5EA 3T0QA 1VFWA 3NWNA 4A51A 5LT1A 4PFPA 4ETPA 1MMDA 1D1CA 3H4SA 2UYMA 2PG2A 2HEHA 2Y5WA 2GRYA 2X7DA 1MMAA 1F9TA 2FL2A 5LT2A 4PK4A 3L1CA 1RY6A 4DBRA 1N6MA 3X2TA 3BFNA 2XT3A 1MMNA 2ZFLA 1D0XA 4ZCAA 5GSZA 1V8KA 1BR1A 3DC4A 2V26A 1I5SA 2VASA 1D1BA 3B6VA 4FRZA 3GBJA 3U06A 1FMWA 1GOJA 2UYIA 1II6A 4E7SA 3KINA 1Q0BA 4H1GA 2IEHA 2FL6A 4PJNA 1LVKA 1FMVA 4LNUK 1SDMA 2X7CA 1BG2A 1D0ZA 1VOMA 4ZHIA 4B7BA 5LT3A 3B6UA 1BR2A 3CJOA 4A1ZA 2NCDA 3ZFDA 2ZFMA 1KK7A 2ZFKA 2GM1A 2VVGA 1VFZA 4GKRA 3ZFCA 3K3BA 4AP0A 4A28A 4PJJA 2WOGA 1F9WA 1G8XA 2FMEA 1VFXA 2Q2ZA 2X51A 5HLEA 1F9VA 2KINA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MNE A;  1I6I A;  5LT4 A;  3WPN A;  1MKJ A;  2XAE A;  4ANJ A;  5LT0 A;  1YRS A;  4DBQ A;  3DCB A;  2FKY A;  3WRD A;  4UBF A;  4A14 A;  3KEN A;  1F9U A;  3LRE A;  2Y65 A;  3PXN A;  4PJM A;  4HNA K;  2VB6 A;  1CZ7 A;  1LKX A;  2Q2Y A;  1BR4 A;  3COB A;  3CNZ A;  2X2R A;  3HQD A;  4A50 A;  2X7E A;  4A5Y A;  1VFV A;  2ZFI A;  3KAR A;  4AS7 A;  1T5C A;  2MYS A;  1D0Y A;  1X88 A;  4E7Z A;  1MMG A;  2OWM A;  4Y05 A;  1V8J A;  1D1A A;  4PJL A;  3ZCW A;  4BBG A;  4PFO A;  4BXN A;  2ZFJ A;  4BN2 A;  2G1Q A;  3L9H A;  3K5E A;  3T0Q A;  1VFW A;  3NWN A;  4A51 A;  5LT1 A;  4PFP A;  4ETP A;  1MMD A;  1D1C A;  3H4S A;  2UYM A;  2PG2 A;  2HEH A;  2Y5W A;  2GRY A;  2X7D A;  1MMA A;  1F9T A;  2FL2 A;  5LT2 A;  4PK4 A;  3L1C A;  1RY6 A;  4DBR A;  1N6M A;  3X2T A;  3BFN A;  2XT3 A;  1MMN A;  2ZFL A;  1D0X A;  4ZCA A;  5GSZ A;  1V8K A;  1BR1 A;  3DC4 A;  2V26 A;  1I5S A;  2VAS A;  1D1B A;  3B6V A;  4FRZ A;  3GBJ A;  3U06 A;  1FMW A;  1GOJ A;  2UYI A;  1II6 A;  4E7S A;  3KIN A;  1Q0B A;  4H1G A;  2IEH A;  2FL6 A;  4PJN A;  1LVK A;  1FMV A;  4LNU K;  1SDM A;  2X7C A;  1BG2 A;  1D0Z A;  1VOM A;  4ZHI A;  4B7B A;  5LT3 A;  3B6U A;  1BR2 A;  3CJO A;  4A1Z A;  2NCD A;  3ZFD A;  2ZFM A;  1KK7 A;  2ZFK A;  2GM1 A;  2VVG A;  1VFZ A;  4GKR A;  3ZFC A;  3K3B A;  4AP0 A;  4A28 A;  4PJJ A;  2WOG A;  1F9W A;  1G8X A;  2FME A;  1VFX A;  2Q2Z A;  2X51 A;  5HLE A;  1F9V A;  2KIN A; 
#chains in the Genus database with same CATH topology
 1MNE A;  1I6I A;  5LT4 A;  3WPN A;  1MKJ A;  2XAE A;  4GKQ A;  4ANJ A;  5LT0 A;  1YRS A;  4DBQ A;  3DCB A;  2FKY A;  3WRD A;  4UBF A;  4A14 A;  3KEN A;  1F9U A;  3LRE A;  2Y65 A;  3PXN A;  4PJM A;  4HNA K;  2VB6 A;  1CZ7 A;  1LKX A;  2Q2Y A;  1BR4 A;  3COB A;  3CNZ A;  2X2R A;  3HQD A;  4A50 A;  2X7E A;  4A5Y A;  1VFV A;  2ZFI A;  3KAR A;  4AS7 A;  1T5C A;  2MYS A;  1D0Y A;  1X88 A;  4E7Z A;  1MMG A;  2OWM A;  4Y05 A;  1V8J A;  1D1A A;  4PJL A;  3ZCW A;  4BBG A;  4PFO A;  4BXN A;  2ZFJ A;  4BN2 A;  2G1Q A;  3L9H A;  3K5E A;  3T0Q A;  1VFW A;  3NWN A;  4A51 A;  5LT1 A;  4PFP A;  4ETP A;  1MMD A;  1D1C A;  3H4S A;  2UYM A;  2PG2 A;  2HEH A;  2Y5W A;  2GRY A;  2X7D A;  1MMA A;  1F9T A;  2FL2 A;  5LT2 A;  4PK4 A;  3L1C A;  1RY6 A;  4DBR A;  1N6M A;  3X2T A;  3BFN A;  4ETP B;  2XT3 A;  1MMN A;  2ZFL A;  1D0X A;  4ZCA A;  5GSZ A;  1V8K A;  1BR1 A;  3DC4 A;  2V26 A;  1I5S A;  2VAS A;  1D1B A;  3B6V A;  4FRZ A;  4GKP A;  3GBJ A;  3U06 A;  1FMW A;  1GOJ A;  2UYI A;  1II6 A;  4E7S A;  3KIN A;  1Q0B A;  4H1G A;  2IEH A;  2FL6 A;  4PJN A;  1LVK A;  1FMV A;  4LNU K;  1SDM A;  2X7C A;  1BG2 A;  1D0Z A;  1VOM A;  4ZHI A;  4B7B A;  5LT3 A;  3B6U A;  1BR2 A;  3CJO A;  4A1Z A;  2NCD A;  3ZFD A;  2ZFM A;  1KK7 A;  2ZFK A;  2GM1 A;  2VVG A;  1VFZ A;  2O0A A;  4GKR A;  3ZFC A;  3K3B A;  4AP0 A;  4A28 A;  4PJJ A;  2WOG A;  1F9W A;  1G8X A;  2FME A;  1VFX A;  2Q2Z A;  2X51 A;  5HLE A;  1F9V A;  2KIN A; 
#chains in the Genus database with same CATH homology
 1MNE A;  1I6I A;  5LT4 A;  3WPN A;  1MKJ A;  2XAE A;  4ANJ A;  5LT0 A;  1YRS A;  4DBQ A;  3DCB A;  2FKY A;  3WRD A;  4UBF A;  4A14 A;  3KEN A;  1F9U A;  3LRE A;  2Y65 A;  3PXN A;  4PJM A;  4HNA K;  2VB6 A;  1CZ7 A;  1LKX A;  2Q2Y A;  1BR4 A;  3COB A;  3CNZ A;  2X2R A;  3HQD A;  4A50 A;  2X7E A;  4A5Y A;  1VFV A;  2ZFI A;  3KAR A;  4AS7 A;  1T5C A;  2MYS A;  1D0Y A;  1X88 A;  4E7Z A;  1MMG A;  2OWM A;  4Y05 A;  1V8J A;  1D1A A;  4PJL A;  3ZCW A;  4BBG A;  4PFO A;  4BXN A;  2ZFJ A;  4BN2 A;  2G1Q A;  3L9H A;  3K5E A;  3T0Q A;  1VFW A;  3NWN A;  4A51 A;  5LT1 A;  4PFP A;  4ETP A;  1MMD A;  1D1C A;  3H4S A;  2UYM A;  2PG2 A;  2HEH A;  2Y5W A;  2GRY A;  2X7D A;  1MMA A;  1F9T A;  2FL2 A;  5LT2 A;  4PK4 A;  3L1C A;  1RY6 A;  4DBR A;  1N6M A;  3X2T A;  3BFN A;  2XT3 A;  1MMN A;  2ZFL A;  1D0X A;  4ZCA A;  5GSZ A;  1V8K A;  1BR1 A;  3DC4 A;  2V26 A;  1I5S A;  2VAS A;  1D1B A;  3B6V A;  4FRZ A;  3GBJ A;  3U06 A;  1FMW A;  1GOJ A;  2UYI A;  1II6 A;  4E7S A;  3KIN A;  1Q0B A;  4H1G A;  2IEH A;  2FL6 A;  4PJN A;  1LVK A;  1FMV A;  4LNU K;  1SDM A;  2X7C A;  1BG2 A;  1D0Z A;  1VOM A;  4ZHI A;  4B7B A;  5LT3 A;  3B6U A;  1BR2 A;  3CJO A;  4A1Z A;  2NCD A;  3ZFD A;  2ZFM A;  1KK7 A;  2ZFK A;  2GM1 A;  2VVG A;  1VFZ A;  4GKR A;  3ZFC A;  3K3B A;  4AP0 A;  4A28 A;  4PJJ A;  2WOG A;  1F9W A;  1G8X A;  2FME A;  1VFX A;  2Q2Z A;  2X51 A;  5HLE A;  1F9V A;  2KIN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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