2IEHA

Crystal structure of human kinesin eg5 in complex with (r)-mon97, a new monastrol-based inhibitor that binds as (r)-enantiomer
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
350
structure length
334
Chain Sequence
KGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Kinesin-like protein KIF11
publication title Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration.
pubmed doi rcsb
source organism Homo sapiens
total genus 106
structure length 334
sequence length 350
chains with identical sequence B
ec nomenclature ec 3.6.4.4: Transferred entry: 5.6.1.3.
pdb deposition date 2006-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2iehA00
4A50A 3DC4A 4ZHIA 4E7ZA 3T0QA 1LKXA 4PJJA 1I6IA 1D0XA 2FMEA 3ZCWA 1MMGA 3ZFDA 2XAEA 2Y65A 3LREA 5HLEA 1F9VA 2KINA 4Y05A 4LNUK 4FRZA 1D1AA 2OWMA 3B6UA 3CNZA 3B6VA 1SDMA 4H1GA 2XT3A 3WPNA 1D1BA 1Q0BA 4A14A 2GM1A 4PFPA 4PJNA 4BBGA 4A1ZA 1G8XA 1MMDA 4GKRA 3KARA 2NCDA 2MYSA 1II6A 2VASA 2UYIA 3K5EA 2FKYA 3HQDA 1MNEA 1GOJA 1D0ZA 2Q2YA 1RY6A 1BG2A 3PXNA 2Y5WA 4DBQA 3WRDA 5LT3A 1F9TA 4A51A 2Q2ZA 4PJMA 1BR4A 4ANJA 3H4SA 5LT0A 2VB6A 3K3BA 2ZFKA 5LT2A 1F9WA 2V26A 4DBRA 5LT1A 3COBA 1F9UA 3CJOA 1V8KA 2VVGA 3ZFCA 4B7BA 4PFOA 3NWNA 1FMVA 2G1QA 4A28A 4PK4A 2X2RA 1VFVA 3GBJA 1YRSA 1N6MA 3BFNA 1V8JA 2X51A 3X2TA 2UYMA 1CZ7A 4PJLA 1VOMA 2ZFMA 1VFZA 4BXNA 2X7CA 4AS7A 3KINA 4A5YA 3L1CA 2X7EA 4UBFA 2PG2A 2ZFJA 3L9HA 5GSZA 2ZFLA 2FL6A 2FL2A 1BR1A 4HNAK 4BN2A 2HEHA 3DCBA 1BR2A 2X7DA 1VFWA 1VFXA 1KK7A 1T5CA 1LVKA 1MMNA 4E7SA 2ZFIA 4ETPA 1MMAA 1I5SA 2WOGA 3KENA 1X88A 4ZCAA 5LT4A 1FMWA 2GRYA 3U06A 1MKJA 2IEHA 1D1CA 1D0YA 4AP0A
chains in the Genus database with same CATH superfamily
4A50A 3DC4A 4ZHIA 4E7ZA 3T0QA 1LKXA 4PJJA 1I6IA 1D0XA 2FMEA 3ZCWA 1MMGA 3ZFDA 2XAEA 2Y65A 3LREA 5HLEA 1F9VA 2KINA 4Y05A 4LNUK 4FRZA 1D1AA 2OWMA 3B6UA 3CNZA 3B6VA 1SDMA 4H1GA 2O0AA 2XT3A 3WPNA 1D1BA 1Q0BA 4A14A 2GM1A 4PFPA 4PJNA 4BBGA 4A1ZA 1G8XA 1MMDA 4GKQA 4GKRA 3KARA 2NCDA 2MYSA 1II6A 2VASA 2UYIA 3K5EA 2FKYA 3HQDA 1MNEA 1GOJA 1D0ZA 2Q2YA 1RY6A 1BG2A 3PXNA 2Y5WA 4DBQA 3WRDA 5LT3A 1F9TA 4A51A 2Q2ZA 4PJMA 1BR4A 4ANJA 3H4SA 5LT0A 2VB6A 3K3BA 2ZFKA 5LT2A 1F9WA 2V26A 4DBRA 5LT1A 3COBA 1F9UA 3CJOA 1V8KA 2VVGA 3ZFCA 4B7BA 4PFOA 3NWNA 1FMVA 2G1QA 4A28A 4PK4A 2X2RA 1VFVA 3GBJA 1YRSA 1N6MA 4GKPA 3BFNA 1V8JA 2X51A 3X2TA 2UYMA 1CZ7A 4PJLA 1VOMA 2ZFMA 1VFZA 4BXNA 2X7CA 4AS7A 3KINA 4A5YA 3L1CA 2X7EA 4UBFA 2PG2A 2ZFJA 3L9HA 5GSZA 2ZFLA 2FL6A 2FL2A 1BR1A 4HNAK 4BN2A 2HEHA 3DCBA 1BR2A 2X7DA 1VFWA 1VFXA 1KK7A 1T5CA 1LVKA 4ETPB 1MMNA 4E7SA 2ZFIA 4ETPA 1MMAA 1I5SA 2WOGA 3KENA 1X88A 4ZCAA 5LT4A 1FMWA 2GRYA 3U06A 1MKJA 2IEHA 1D1CA 1D0YA 4AP0A
chains in the Genus database with same CATH topology
4A50A 3DC4A 4ZHIA 4E7ZA 3T0QA 1LKXA 4PJJA 1I6IA 1D0XA 2FMEA 3ZCWA 1MMGA 3ZFDA 2XAEA 2Y65A 3LREA 5HLEA 1F9VA 2KINA 4Y05A 4LNUK 4FRZA 1D1AA 2OWMA 3B6UA 3CNZA 3B6VA 1SDMA 4H1GA 2XT3A 3WPNA 1D1BA 1Q0BA 4A14A 2GM1A 4PFPA 4PJNA 4BBGA 4A1ZA 1G8XA 1MMDA 4GKRA 3KARA 2NCDA 2MYSA 1II6A 2VASA 2UYIA 3K5EA 2FKYA 3HQDA 1MNEA 1GOJA 1D0ZA 2Q2YA 1RY6A 1BG2A 3PXNA 2Y5WA 4DBQA 3WRDA 5LT3A 1F9TA 4A51A 2Q2ZA 4PJMA 1BR4A 4ANJA 3H4SA 5LT0A 2VB6A 3K3BA 2ZFKA 5LT2A 1F9WA 2V26A 4DBRA 5LT1A 3COBA 1F9UA 3CJOA 1V8KA 2VVGA 3ZFCA 4B7BA 4PFOA 3NWNA 1FMVA 2G1QA 4A28A 4PK4A 2X2RA 1VFVA 3GBJA 1YRSA 1N6MA 3BFNA 1V8JA 2X51A 3X2TA 2UYMA 1CZ7A 4PJLA 1VOMA 2ZFMA 1VFZA 4BXNA 2X7CA 4AS7A 3KINA 4A5YA 3L1CA 2X7EA 4UBFA 2PG2A 2ZFJA 3L9HA 5GSZA 2ZFLA 2FL6A 2FL2A 1BR1A 4HNAK 4BN2A 2HEHA 3DCBA 1BR2A 2X7DA 1VFWA 1VFXA 1KK7A 1T5CA 1LVKA 1MMNA 4E7SA 2ZFIA 4ETPA 1MMAA 1I5SA 2WOGA 3KENA 1X88A 4ZCAA 5LT4A 1FMWA 2GRYA 3U06A 1MKJA 2IEHA 1D1CA 1D0YA 4AP0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A50 A;  3DC4 A;  4ZHI A;  4E7Z A;  3T0Q A;  1LKX A;  4PJJ A;  1I6I A;  1D0X A;  2FME A;  3ZCW A;  1MMG A;  3ZFD A;  2XAE A;  2Y65 A;  3LRE A;  5HLE A;  1F9V A;  2KIN A;  4Y05 A;  4LNU K;  4FRZ A;  1D1A A;  2OWM A;  3B6U A;  3CNZ A;  3B6V A;  1SDM A;  4H1G A;  2XT3 A;  3WPN A;  1D1B A;  1Q0B A;  4A14 A;  2GM1 A;  4PFP A;  4PJN A;  4BBG A;  4A1Z A;  1G8X A;  1MMD A;  4GKR A;  3KAR A;  2NCD A;  2MYS A;  1II6 A;  2VAS A;  2UYI A;  3K5E A;  2FKY A;  3HQD A;  1MNE A;  1GOJ A;  1D0Z A;  2Q2Y A;  1RY6 A;  1BG2 A;  3PXN A;  2Y5W A;  4DBQ A;  3WRD A;  5LT3 A;  1F9T A;  4A51 A;  2Q2Z A;  4PJM A;  1BR4 A;  4ANJ A;  3H4S A;  5LT0 A;  2VB6 A;  3K3B A;  2ZFK A;  5LT2 A;  1F9W A;  2V26 A;  4DBR A;  5LT1 A;  3COB A;  1F9U A;  3CJO A;  1V8K A;  2VVG A;  3ZFC A;  4B7B A;  4PFO A;  3NWN A;  1FMV A;  2G1Q A;  4A28 A;  4PK4 A;  2X2R A;  1VFV A;  3GBJ A;  1YRS A;  1N6M A;  3BFN A;  1V8J A;  2X51 A;  3X2T A;  2UYM A;  1CZ7 A;  4PJL A;  1VOM A;  2ZFM A;  1VFZ A;  4BXN A;  2X7C A;  4AS7 A;  3KIN A;  4A5Y A;  3L1C A;  2X7E A;  4UBF A;  2PG2 A;  2ZFJ A;  3L9H A;  5GSZ A;  2ZFL A;  2FL6 A;  2FL2 A;  1BR1 A;  4HNA K;  4BN2 A;  2HEH A;  3DCB A;  1BR2 A;  2X7D A;  1VFW A;  1VFX A;  1KK7 A;  1T5C A;  1LVK A;  1MMN A;  4E7S A;  2ZFI A;  4ETP A;  1MMA A;  1I5S A;  2WOG A;  3KEN A;  1X88 A;  4ZCA A;  5LT4 A;  1FMW A;  2GRY A;  3U06 A;  1MKJ A;  2IEH A;  1D1C A;  1D0Y A;  4AP0 A; 
#chains in the Genus database with same CATH topology
 4A50 A;  3DC4 A;  4ZHI A;  4E7Z A;  3T0Q A;  1LKX A;  4PJJ A;  1I6I A;  1D0X A;  2FME A;  3ZCW A;  1MMG A;  3ZFD A;  2XAE A;  2Y65 A;  3LRE A;  5HLE A;  1F9V A;  2KIN A;  4Y05 A;  4LNU K;  4FRZ A;  1D1A A;  2OWM A;  3B6U A;  3CNZ A;  3B6V A;  1SDM A;  4H1G A;  2O0A A;  2XT3 A;  3WPN A;  1D1B A;  1Q0B A;  4A14 A;  2GM1 A;  4PFP A;  4PJN A;  4BBG A;  4A1Z A;  1G8X A;  1MMD A;  4GKQ A;  4GKR A;  3KAR A;  2NCD A;  2MYS A;  1II6 A;  2VAS A;  2UYI A;  3K5E A;  2FKY A;  3HQD A;  1MNE A;  1GOJ A;  1D0Z A;  2Q2Y A;  1RY6 A;  1BG2 A;  3PXN A;  2Y5W A;  4DBQ A;  3WRD A;  5LT3 A;  1F9T A;  4A51 A;  2Q2Z A;  4PJM A;  1BR4 A;  4ANJ A;  3H4S A;  5LT0 A;  2VB6 A;  3K3B A;  2ZFK A;  5LT2 A;  1F9W A;  2V26 A;  4DBR A;  5LT1 A;  3COB A;  1F9U A;  3CJO A;  1V8K A;  2VVG A;  3ZFC A;  4B7B A;  4PFO A;  3NWN A;  1FMV A;  2G1Q A;  4A28 A;  4PK4 A;  2X2R A;  1VFV A;  3GBJ A;  1YRS A;  1N6M A;  4GKP A;  3BFN A;  1V8J A;  2X51 A;  3X2T A;  2UYM A;  1CZ7 A;  4PJL A;  1VOM A;  2ZFM A;  1VFZ A;  4BXN A;  2X7C A;  4AS7 A;  3KIN A;  4A5Y A;  3L1C A;  2X7E A;  4UBF A;  2PG2 A;  2ZFJ A;  3L9H A;  5GSZ A;  2ZFL A;  2FL6 A;  2FL2 A;  1BR1 A;  4HNA K;  4BN2 A;  2HEH A;  3DCB A;  1BR2 A;  2X7D A;  1VFW A;  1VFX A;  1KK7 A;  1T5C A;  1LVK A;  4ETP B;  1MMN A;  4E7S A;  2ZFI A;  4ETP A;  1MMA A;  1I5S A;  2WOG A;  3KEN A;  1X88 A;  4ZCA A;  5LT4 A;  1FMW A;  2GRY A;  3U06 A;  1MKJ A;  2IEH A;  1D1C A;  1D0Y A;  4AP0 A; 
#chains in the Genus database with same CATH homology
 4A50 A;  3DC4 A;  4ZHI A;  4E7Z A;  3T0Q A;  1LKX A;  4PJJ A;  1I6I A;  1D0X A;  2FME A;  3ZCW A;  1MMG A;  3ZFD A;  2XAE A;  2Y65 A;  3LRE A;  5HLE A;  1F9V A;  2KIN A;  4Y05 A;  4LNU K;  4FRZ A;  1D1A A;  2OWM A;  3B6U A;  3CNZ A;  3B6V A;  1SDM A;  4H1G A;  2XT3 A;  3WPN A;  1D1B A;  1Q0B A;  4A14 A;  2GM1 A;  4PFP A;  4PJN A;  4BBG A;  4A1Z A;  1G8X A;  1MMD A;  4GKR A;  3KAR A;  2NCD A;  2MYS A;  1II6 A;  2VAS A;  2UYI A;  3K5E A;  2FKY A;  3HQD A;  1MNE A;  1GOJ A;  1D0Z A;  2Q2Y A;  1RY6 A;  1BG2 A;  3PXN A;  2Y5W A;  4DBQ A;  3WRD A;  5LT3 A;  1F9T A;  4A51 A;  2Q2Z A;  4PJM A;  1BR4 A;  4ANJ A;  3H4S A;  5LT0 A;  2VB6 A;  3K3B A;  2ZFK A;  5LT2 A;  1F9W A;  2V26 A;  4DBR A;  5LT1 A;  3COB A;  1F9U A;  3CJO A;  1V8K A;  2VVG A;  3ZFC A;  4B7B A;  4PFO A;  3NWN A;  1FMV A;  2G1Q A;  4A28 A;  4PK4 A;  2X2R A;  1VFV A;  3GBJ A;  1YRS A;  1N6M A;  3BFN A;  1V8J A;  2X51 A;  3X2T A;  2UYM A;  1CZ7 A;  4PJL A;  1VOM A;  2ZFM A;  1VFZ A;  4BXN A;  2X7C A;  4AS7 A;  3KIN A;  4A5Y A;  3L1C A;  2X7E A;  4UBF A;  2PG2 A;  2ZFJ A;  3L9H A;  5GSZ A;  2ZFL A;  2FL6 A;  2FL2 A;  1BR1 A;  4HNA K;  4BN2 A;  2HEH A;  3DCB A;  1BR2 A;  2X7D A;  1VFW A;  1VFX A;  1KK7 A;  1T5C A;  1LVK A;  1MMN A;  4E7S A;  2ZFI A;  4ETP A;  1MMA A;  1I5S A;  2WOG A;  3KEN A;  1X88 A;  4ZCA A;  5LT4 A;  1FMW A;  2GRY A;  3U06 A;  1MKJ A;  2IEH A;  1D1C A;  1D0Y A;  4AP0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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