4BXNA

Eg5(wt) complex
Total Genus 66
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
66
sequence length
349
structure length
347
Chain Sequence
b'GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Motor protein
total genus 66
structure length 347
sequence length 349
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-07-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4bxnA00
3CNZA 2KINA 1D0ZA 2VASA 4A1ZA 4BBGA 2FMEA 1V8KA 3DC4A 2ZFIA 1FMVA 1YRSA 4A14A 1SDMA 1BR2A 3COBA 3H4SA 4PJMA 5GSZA 3ZFCA 2X7EA 2ZFKA 1D0XA 4E7ZA 4Y05A 3BFNA 4H1GA 3WPNA 4B7BA 1VFVA 1BR4A 4DBRA 4DBQA 1MMGA 1KK7A 1T5CA 1D1CA 3NWNA 4PFOA 1F9UA 4PK4A 1D1AA 1MKJA 4GKRA 3X2TA 4UBFA 4E7SA 5LT3A 2UYIA 3LREA 4AP0A 1LVKA 1VOMA 2HEHA 3GBJA 1X88A 2IEHA 4ZCAA 1GOJA 1F9TA 2GM1A 2ZFMA 1I6IA 3HQDA 2Q2YA 4PJJA 4HNAK 5LT2A 5LT1A 2NCDA 4LNUK 4ETPA 1N6MA 4ZHIA 2FL2A 2MYSA 3K3BA 4FRZA 2Y65A 5LT0A 1RY6A 2ZFLA 1VFZA 2X7CA 3U06A 4A5YA 3KARA 1MMDA 1F9VA 4A51A 1V8JA 4ANJA 4AS7A 3T0QA 4A28A 3L1CA 3ZFDA 1G8XA 1F9WA 2V26A 4BN2A 1BR1A 3L9HA 1BG2A 2XT3A 2FKYA 2X51A 2G1QA 2X2RA 5LT4A 3B6VA 2X7DA 3PXNA 2ZFJA 1Q0BA 4PJNA 1D0YA 1MMNA 1CZ7A 2OWMA 3KENA 1I5SA 4A50A 1MNEA 1VFXA 1VFWA 3ZCWA 2UYMA 2WOGA 3KINA 4BXNA 2Y5WA 2XAEA 5HLEA 1LKXA 1D1BA 2VVGA 1MMAA 3K5EA 4PJLA 1FMWA 3B6UA 3WRDA 2FL6A 3DCBA 2PG2A 3CJOA 2GRYA 1II6A 2Q2ZA 4PFPA 2VB6A
chains in the Genus database with same CATH superfamily
3CNZA 2KINA 1D0ZA 2VASA 4A1ZA 4BBGA 2FMEA 1V8KA 3DC4A 4ETPB 2ZFIA 1FMVA 1YRSA 4A14A 1SDMA 1BR2A 3COBA 3H4SA 4PJMA 5GSZA 3ZFCA 2X7EA 2ZFKA 1D0XA 4E7ZA 4Y05A 3BFNA 4H1GA 3WPNA 4B7BA 1VFVA 1BR4A 4DBRA 4DBQA 1MMGA 1KK7A 1T5CA 1D1CA 3NWNA 4PFOA 2O0AA 4GKPA 1F9UA 4PK4A 1D1AA 1MKJA 4GKRA 3X2TA 4UBFA 4E7SA 5LT3A 2UYIA 3LREA 4AP0A 1LVKA 1VOMA 2HEHA 3GBJA 1X88A 2IEHA 4ZCAA 1GOJA 1F9TA 2GM1A 2ZFMA 1I6IA 3HQDA 2Q2YA 4PJJA 4HNAK 5LT2A 5LT1A 2NCDA 4LNUK 4ETPA 1N6MA 4ZHIA 2FL2A 2MYSA 3K3BA 4FRZA 4GKQA 2Y65A 5LT0A 1RY6A 2ZFLA 1VFZA 2X7CA 3U06A 4A5YA 3KARA 1MMDA 1F9VA 4A51A 1V8JA 4ANJA 4AS7A 3T0QA 4A28A 3L1CA 3ZFDA 1G8XA 1F9WA 2V26A 4BN2A 1BR1A 3L9HA 1BG2A 2XT3A 2FKYA 2X51A 2G1QA 2X2RA 5LT4A 3B6VA 2X7DA 3PXNA 2ZFJA 1Q0BA 4PJNA 1D0YA 1MMNA 1CZ7A 2OWMA 3KENA 1I5SA 4A50A 1MNEA 1VFXA 1VFWA 3ZCWA 2UYMA 2WOGA 3KINA 4BXNA 2Y5WA 2XAEA 5HLEA 1LKXA 1D1BA 2VVGA 1MMAA 3K5EA 4PJLA 1FMWA 3B6UA 3WRDA 2FL6A 3DCBA 2PG2A 3CJOA 2GRYA 1II6A 2Q2ZA 4PFPA 2VB6A
chains in the Genus database with same CATH topology
3CNZA 2KINA 1D0ZA 2VASA 4A1ZA 4BBGA 2FMEA 1V8KA 3DC4A 2ZFIA 1FMVA 1YRSA 4A14A 1SDMA 1BR2A 3COBA 3H4SA 4PJMA 5GSZA 3ZFCA 2X7EA 2ZFKA 1D0XA 4E7ZA 4Y05A 3BFNA 4H1GA 3WPNA 4B7BA 1VFVA 1BR4A 4DBRA 4DBQA 1MMGA 1KK7A 1T5CA 1D1CA 3NWNA 4PFOA 1F9UA 4PK4A 1D1AA 1MKJA 4GKRA 3X2TA 4UBFA 4E7SA 5LT3A 2UYIA 3LREA 4AP0A 1LVKA 1VOMA 2HEHA 3GBJA 1X88A 2IEHA 4ZCAA 1GOJA 1F9TA 2GM1A 2ZFMA 1I6IA 3HQDA 2Q2YA 4PJJA 4HNAK 5LT2A 5LT1A 2NCDA 4LNUK 4ETPA 1N6MA 4ZHIA 2FL2A 2MYSA 3K3BA 4FRZA 2Y65A 5LT0A 1RY6A 2ZFLA 1VFZA 2X7CA 3U06A 4A5YA 3KARA 1MMDA 1F9VA 4A51A 1V8JA 4ANJA 4AS7A 3T0QA 4A28A 3L1CA 3ZFDA 1G8XA 1F9WA 2V26A 4BN2A 1BR1A 3L9HA 1BG2A 2XT3A 2FKYA 2X51A 2G1QA 2X2RA 5LT4A 3B6VA 2X7DA 3PXNA 2ZFJA 1Q0BA 4PJNA 1D0YA 1MMNA 1CZ7A 2OWMA 3KENA 1I5SA 4A50A 1MNEA 1VFXA 1VFWA 3ZCWA 2UYMA 2WOGA 3KINA 4BXNA 2Y5WA 2XAEA 5HLEA 1LKXA 1D1BA 2VVGA 1MMAA 3K5EA 4PJLA 1FMWA 3B6UA 3WRDA 2FL6A 3DCBA 2PG2A 3CJOA 2GRYA 1II6A 2Q2ZA 4PFPA 2VB6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CNZ A;  2KIN A;  1D0Z A;  2VAS A;  4A1Z A;  4BBG A;  2FME A;  1V8K A;  3DC4 A;  2ZFI A;  1FMV A;  1YRS A;  4A14 A;  1SDM A;  1BR2 A;  3COB A;  3H4S A;  4PJM A;  5GSZ A;  3ZFC A;  2X7E A;  2ZFK A;  1D0X A;  4E7Z A;  4Y05 A;  3BFN A;  4H1G A;  3WPN A;  4B7B A;  1VFV A;  1BR4 A;  4DBR A;  4DBQ A;  1MMG A;  1KK7 A;  1T5C A;  1D1C A;  3NWN A;  4PFO A;  1F9U A;  4PK4 A;  1D1A A;  1MKJ A;  4GKR A;  3X2T A;  4UBF A;  4E7S A;  5LT3 A;  2UYI A;  3LRE A;  4AP0 A;  1LVK A;  1VOM A;  2HEH A;  3GBJ A;  1X88 A;  2IEH A;  4ZCA A;  1GOJ A;  1F9T A;  2GM1 A;  2ZFM A;  1I6I A;  3HQD A;  2Q2Y A;  4PJJ A;  4HNA K;  5LT2 A;  5LT1 A;  2NCD A;  4LNU K;  4ETP A;  1N6M A;  4ZHI A;  2FL2 A;  2MYS A;  3K3B A;  4FRZ A;  2Y65 A;  5LT0 A;  1RY6 A;  2ZFL A;  1VFZ A;  2X7C A;  3U06 A;  4A5Y A;  3KAR A;  1MMD A;  1F9V A;  4A51 A;  1V8J A;  4ANJ A;  4AS7 A;  3T0Q A;  4A28 A;  3L1C A;  3ZFD A;  1G8X A;  1F9W A;  2V26 A;  4BN2 A;  1BR1 A;  3L9H A;  1BG2 A;  2XT3 A;  2FKY A;  2X51 A;  2G1Q A;  2X2R A;  5LT4 A;  3B6V A;  2X7D A;  3PXN A;  2ZFJ A;  1Q0B A;  4PJN A;  1D0Y A;  1MMN A;  1CZ7 A;  2OWM A;  3KEN A;  1I5S A;  4A50 A;  1MNE A;  1VFX A;  1VFW A;  3ZCW A;  2UYM A;  2WOG A;  3KIN A;  4BXN A;  2Y5W A;  2XAE A;  5HLE A;  1LKX A;  1D1B A;  2VVG A;  1MMA A;  3K5E A;  4PJL A;  1FMW A;  3B6U A;  3WRD A;  2FL6 A;  3DCB A;  2PG2 A;  3CJO A;  2GRY A;  1II6 A;  2Q2Z A;  4PFP A;  2VB6 A; 
#chains in the Genus database with same CATH topology
 3CNZ A;  2KIN A;  1D0Z A;  2VAS A;  4A1Z A;  4BBG A;  2FME A;  1V8K A;  3DC4 A;  4ETP B;  2ZFI A;  1FMV A;  1YRS A;  4A14 A;  1SDM A;  1BR2 A;  3COB A;  3H4S A;  4PJM A;  5GSZ A;  3ZFC A;  2X7E A;  2ZFK A;  1D0X A;  4E7Z A;  4Y05 A;  3BFN A;  4H1G A;  3WPN A;  4B7B A;  1VFV A;  1BR4 A;  4DBR A;  4DBQ A;  1MMG A;  1KK7 A;  1T5C A;  1D1C A;  3NWN A;  4PFO A;  2O0A A;  4GKP A;  1F9U A;  4PK4 A;  1D1A A;  1MKJ A;  4GKR A;  3X2T A;  4UBF A;  4E7S A;  5LT3 A;  2UYI A;  3LRE A;  4AP0 A;  1LVK A;  1VOM A;  2HEH A;  3GBJ A;  1X88 A;  2IEH A;  4ZCA A;  1GOJ A;  1F9T A;  2GM1 A;  2ZFM A;  1I6I A;  3HQD A;  2Q2Y A;  4PJJ A;  4HNA K;  5LT2 A;  5LT1 A;  2NCD A;  4LNU K;  4ETP A;  1N6M A;  4ZHI A;  2FL2 A;  2MYS A;  3K3B A;  4FRZ A;  4GKQ A;  2Y65 A;  5LT0 A;  1RY6 A;  2ZFL A;  1VFZ A;  2X7C A;  3U06 A;  4A5Y A;  3KAR A;  1MMD A;  1F9V A;  4A51 A;  1V8J A;  4ANJ A;  4AS7 A;  3T0Q A;  4A28 A;  3L1C A;  3ZFD A;  1G8X A;  1F9W A;  2V26 A;  4BN2 A;  1BR1 A;  3L9H A;  1BG2 A;  2XT3 A;  2FKY A;  2X51 A;  2G1Q A;  2X2R A;  5LT4 A;  3B6V A;  2X7D A;  3PXN A;  2ZFJ A;  1Q0B A;  4PJN A;  1D0Y A;  1MMN A;  1CZ7 A;  2OWM A;  3KEN A;  1I5S A;  4A50 A;  1MNE A;  1VFX A;  1VFW A;  3ZCW A;  2UYM A;  2WOG A;  3KIN A;  4BXN A;  2Y5W A;  2XAE A;  5HLE A;  1LKX A;  1D1B A;  2VVG A;  1MMA A;  3K5E A;  4PJL A;  1FMW A;  3B6U A;  3WRD A;  2FL6 A;  3DCB A;  2PG2 A;  3CJO A;  2GRY A;  1II6 A;  2Q2Z A;  4PFP A;  2VB6 A; 
#chains in the Genus database with same CATH homology
 3CNZ A;  2KIN A;  1D0Z A;  2VAS A;  4A1Z A;  4BBG A;  2FME A;  1V8K A;  3DC4 A;  2ZFI A;  1FMV A;  1YRS A;  4A14 A;  1SDM A;  1BR2 A;  3COB A;  3H4S A;  4PJM A;  5GSZ A;  3ZFC A;  2X7E A;  2ZFK A;  1D0X A;  4E7Z A;  4Y05 A;  3BFN A;  4H1G A;  3WPN A;  4B7B A;  1VFV A;  1BR4 A;  4DBR A;  4DBQ A;  1MMG A;  1KK7 A;  1T5C A;  1D1C A;  3NWN A;  4PFO A;  1F9U A;  4PK4 A;  1D1A A;  1MKJ A;  4GKR A;  3X2T A;  4UBF A;  4E7S A;  5LT3 A;  2UYI A;  3LRE A;  4AP0 A;  1LVK A;  1VOM A;  2HEH A;  3GBJ A;  1X88 A;  2IEH A;  4ZCA A;  1GOJ A;  1F9T A;  2GM1 A;  2ZFM A;  1I6I A;  3HQD A;  2Q2Y A;  4PJJ A;  4HNA K;  5LT2 A;  5LT1 A;  2NCD A;  4LNU K;  4ETP A;  1N6M A;  4ZHI A;  2FL2 A;  2MYS A;  3K3B A;  4FRZ A;  2Y65 A;  5LT0 A;  1RY6 A;  2ZFL A;  1VFZ A;  2X7C A;  3U06 A;  4A5Y A;  3KAR A;  1MMD A;  1F9V A;  4A51 A;  1V8J A;  4ANJ A;  4AS7 A;  3T0Q A;  4A28 A;  3L1C A;  3ZFD A;  1G8X A;  1F9W A;  2V26 A;  4BN2 A;  1BR1 A;  3L9H A;  1BG2 A;  2XT3 A;  2FKY A;  2X51 A;  2G1Q A;  2X2R A;  5LT4 A;  3B6V A;  2X7D A;  3PXN A;  2ZFJ A;  1Q0B A;  4PJN A;  1D0Y A;  1MMN A;  1CZ7 A;  2OWM A;  3KEN A;  1I5S A;  4A50 A;  1MNE A;  1VFX A;  1VFW A;  3ZCW A;  2UYM A;  2WOG A;  3KIN A;  4BXN A;  2Y5W A;  2XAE A;  5HLE A;  1LKX A;  1D1B A;  2VVG A;  1MMA A;  3K5E A;  4PJL A;  1FMW A;  3B6U A;  3WRD A;  2FL6 A;  3DCB A;  2PG2 A;  3CJO A;  2GRY A;  1II6 A;  2Q2Z A;  4PFP A;  2VB6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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