4BXNA

Eg5(wt) complex
Total Genus 66
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
66
sequence length
349
structure length
347
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Motor protein
total genus 66
structure length 347
sequence length 349
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-07-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4bxnA00
2WOGA 2X2RA 4A28A 1D1AA 4BN2A 4PFPA 1MMDA 4Y05A 4B7BA 1BR2A 1MMGA 3H4SA 1F9UA 1Q0BA 2X7DA 1BG2A 1KK7A 5LT0A 3ZFDA 3GBJA 3K5EA 3B6UA 2FL2A 3LREA 4PK4A 3DCBA 3U06A 4DBRA 2UYMA 1V8KA 1VFVA 1MNEA 3KINA 1VFWA 2PG2A 4A50A 3PXNA 4PJNA 2X51A 1F9WA 4HNAK 4A5YA 2Y5WA 2MYSA 1D1BA 2G1QA 1V8JA 1D0YA 2X7EA 2ZFJA 1VOMA 1X88A 5HLEA 1YRSA 3COBA 1D0XA 4FRZA 4AS7A 2UYIA 3L1CA 1VFZA 2ZFIA 2VB6A 4UBFA 3NWNA 3BFNA 3WRDA 2IEHA 2HEHA 2GM1A 4E7SA 3X2TA 1I5SA 2X7CA 2GRYA 4A51A 1F9VA 5LT2A 3ZCWA 1II6A 1FMVA 5LT3A 1D0ZA 2Y65A 4ZHIA 1GOJA 2ZFMA 4PJLA 1I6IA 4ETPA 4H1GA 2ZFKA 2NCDA 2XAEA 4PFOA 1CZ7A 3KENA 1T5CA 1MMNA 2XT3A 1BR4A 3K3BA 4GKRA 1SDMA 2KINA 1MMAA 3L9HA 1D1CA 4BBGA 3B6VA 4E7ZA 4BXNA 5LT1A 2VASA 3WPNA 2Q2YA 1RY6A 4ANJA 4PJMA 2ZFLA 1BR1A 4PJJA 3CNZA 1MKJA 4A14A 1LKXA 3ZFCA 5GSZA 3KARA 2OWMA 4LNUK 1G8XA 2Q2ZA 2V26A 2FL6A 4A1ZA 1F9TA 2FKYA 2VVGA 4ZCAA 5LT4A 4AP0A 1N6MA 2FMEA 1FMWA 1VFXA 3DC4A 3CJOA 3T0QA 1LVKA 4DBQA 3HQDA
chains in the Genus database with same CATH superfamily
2WOGA 2X2RA 4A28A 1D1AA 4BN2A 4PFPA 1MMDA 4Y05A 4B7BA 4GKQA 1BR2A 1MMGA 3H4SA 1F9UA 1Q0BA 2X7DA 1BG2A 1KK7A 5LT0A 3ZFDA 3GBJA 3K5EA 3B6UA 2FL2A 3LREA 4PK4A 3DCBA 3U06A 4DBRA 2UYMA 1V8KA 1VFVA 1MNEA 3KINA 1VFWA 2PG2A 4A50A 3PXNA 4PJNA 2X51A 1F9WA 4HNAK 4A5YA 2Y5WA 2MYSA 1D1BA 2G1QA 1V8JA 1D0YA 2X7EA 2ZFJA 1VOMA 1X88A 5HLEA 1YRSA 3COBA 1D0XA 4FRZA 4AS7A 2UYIA 3L1CA 1VFZA 2ZFIA 2VB6A 4UBFA 3NWNA 3BFNA 3WRDA 2IEHA 2HEHA 2GM1A 4E7SA 3X2TA 1I5SA 2X7CA 2GRYA 4GKPA 1F9VA 5LT2A 4A51A 3ZCWA 1II6A 1FMVA 5LT3A 1D0ZA 2Y65A 4ZHIA 2O0AA 1GOJA 2ZFMA 4PJLA 1I6IA 4ETPA 4H1GA 2ZFKA 2NCDA 2XAEA 4PFOA 1CZ7A 3KENA 1T5CA 1MMNA 2XT3A 1BR4A 3K3BA 4GKRA 1SDMA 2KINA 1MMAA 3L9HA 1D1CA 4BBGA 3B6VA 4E7ZA 4BXNA 5LT1A 2VASA 3WPNA 4ETPB 2Q2YA 1RY6A 4ANJA 4PJMA 2ZFLA 1BR1A 4PJJA 3CNZA 1MKJA 4A14A 1LKXA 3ZFCA 5GSZA 3KARA 2OWMA 4LNUK 1G8XA 2Q2ZA 2V26A 2FL6A 4A1ZA 1F9TA 2FKYA 2VVGA 4ZCAA 5LT4A 4AP0A 1N6MA 2FMEA 1FMWA 1VFXA 3DC4A 3CJOA 3T0QA 1LVKA 4DBQA 3HQDA
chains in the Genus database with same CATH topology
2WOGA 2X2RA 4A28A 1D1AA 4BN2A 4PFPA 1MMDA 4Y05A 4B7BA 1BR2A 1MMGA 3H4SA 1F9UA 1Q0BA 2X7DA 1BG2A 1KK7A 5LT0A 3ZFDA 3GBJA 3K5EA 3B6UA 2FL2A 3LREA 4PK4A 3DCBA 3U06A 4DBRA 2UYMA 1V8KA 1VFVA 1MNEA 3KINA 1VFWA 2PG2A 4A50A 3PXNA 4PJNA 2X51A 1F9WA 4HNAK 4A5YA 2Y5WA 2MYSA 1D1BA 2G1QA 1V8JA 1D0YA 2X7EA 2ZFJA 1VOMA 1X88A 5HLEA 1YRSA 3COBA 1D0XA 4FRZA 4AS7A 2UYIA 3L1CA 1VFZA 2ZFIA 2VB6A 4UBFA 3NWNA 3BFNA 3WRDA 2IEHA 2HEHA 2GM1A 4E7SA 3X2TA 1I5SA 2X7CA 2GRYA 4A51A 1F9VA 5LT2A 3ZCWA 1II6A 1FMVA 5LT3A 1D0ZA 2Y65A 4ZHIA 1GOJA 2ZFMA 4PJLA 1I6IA 4ETPA 4H1GA 2ZFKA 2NCDA 2XAEA 4PFOA 1CZ7A 3KENA 1T5CA 1MMNA 2XT3A 1BR4A 3K3BA 4GKRA 1SDMA 2KINA 1MMAA 3L9HA 1D1CA 4BBGA 3B6VA 4E7ZA 4BXNA 5LT1A 2VASA 3WPNA 2Q2YA 1RY6A 4ANJA 4PJMA 2ZFLA 1BR1A 4PJJA 3CNZA 1MKJA 4A14A 1LKXA 3ZFCA 5GSZA 3KARA 2OWMA 4LNUK 1G8XA 2Q2ZA 2V26A 2FL6A 4A1ZA 1F9TA 2FKYA 2VVGA 4ZCAA 5LT4A 4AP0A 1N6MA 2FMEA 1FMWA 1VFXA 3DC4A 3CJOA 3T0QA 1LVKA 4DBQA 3HQDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WOG A;  2X2R A;  4A28 A;  1D1A A;  4BN2 A;  4PFP A;  1MMD A;  4Y05 A;  4B7B A;  1BR2 A;  1MMG A;  3H4S A;  1F9U A;  1Q0B A;  2X7D A;  1BG2 A;  1KK7 A;  5LT0 A;  3ZFD A;  3GBJ A;  3K5E A;  3B6U A;  2FL2 A;  3LRE A;  4PK4 A;  3DCB A;  3U06 A;  4DBR A;  2UYM A;  1V8K A;  1VFV A;  1MNE A;  3KIN A;  1VFW A;  2PG2 A;  4A50 A;  3PXN A;  4PJN A;  2X51 A;  1F9W A;  4HNA K;  4A5Y A;  2Y5W A;  2MYS A;  1D1B A;  2G1Q A;  1V8J A;  1D0Y A;  2X7E A;  2ZFJ A;  1VOM A;  1X88 A;  5HLE A;  1YRS A;  3COB A;  1D0X A;  4FRZ A;  4AS7 A;  2UYI A;  3L1C A;  1VFZ A;  2ZFI A;  2VB6 A;  4UBF A;  3NWN A;  3BFN A;  3WRD A;  2IEH A;  2HEH A;  2GM1 A;  4E7S A;  3X2T A;  1I5S A;  2X7C A;  2GRY A;  4A51 A;  1F9V A;  5LT2 A;  3ZCW A;  1II6 A;  1FMV A;  5LT3 A;  1D0Z A;  2Y65 A;  4ZHI A;  1GOJ A;  2ZFM A;  4PJL A;  1I6I A;  4ETP A;  4H1G A;  2ZFK A;  2NCD A;  2XAE A;  4PFO A;  1CZ7 A;  3KEN A;  1T5C A;  1MMN A;  2XT3 A;  1BR4 A;  3K3B A;  4GKR A;  1SDM A;  2KIN A;  1MMA A;  3L9H A;  1D1C A;  4BBG A;  3B6V A;  4E7Z A;  4BXN A;  5LT1 A;  2VAS A;  3WPN A;  2Q2Y A;  1RY6 A;  4ANJ A;  4PJM A;  2ZFL A;  1BR1 A;  4PJJ A;  3CNZ A;  1MKJ A;  4A14 A;  1LKX A;  3ZFC A;  5GSZ A;  3KAR A;  2OWM A;  4LNU K;  1G8X A;  2Q2Z A;  2V26 A;  2FL6 A;  4A1Z A;  1F9T A;  2FKY A;  2VVG A;  4ZCA A;  5LT4 A;  4AP0 A;  1N6M A;  2FME A;  1FMW A;  1VFX A;  3DC4 A;  3CJO A;  3T0Q A;  1LVK A;  4DBQ A;  3HQD A; 
#chains in the Genus database with same CATH topology
 2WOG A;  2X2R A;  4A28 A;  1D1A A;  4BN2 A;  4PFP A;  1MMD A;  4Y05 A;  4B7B A;  4GKQ A;  1BR2 A;  1MMG A;  3H4S A;  1F9U A;  1Q0B A;  2X7D A;  1BG2 A;  1KK7 A;  5LT0 A;  3ZFD A;  3GBJ A;  3K5E A;  3B6U A;  2FL2 A;  3LRE A;  4PK4 A;  3DCB A;  3U06 A;  4DBR A;  2UYM A;  1V8K A;  1VFV A;  1MNE A;  3KIN A;  1VFW A;  2PG2 A;  4A50 A;  3PXN A;  4PJN A;  2X51 A;  1F9W A;  4HNA K;  4A5Y A;  2Y5W A;  2MYS A;  1D1B A;  2G1Q A;  1V8J A;  1D0Y A;  2X7E A;  2ZFJ A;  1VOM A;  1X88 A;  5HLE A;  1YRS A;  3COB A;  1D0X A;  4FRZ A;  4AS7 A;  2UYI A;  3L1C A;  1VFZ A;  2ZFI A;  2VB6 A;  4UBF A;  3NWN A;  3BFN A;  3WRD A;  2IEH A;  2HEH A;  2GM1 A;  4E7S A;  3X2T A;  1I5S A;  2X7C A;  2GRY A;  4GKP A;  1F9V A;  5LT2 A;  4A51 A;  3ZCW A;  1II6 A;  1FMV A;  5LT3 A;  1D0Z A;  2Y65 A;  4ZHI A;  2O0A A;  1GOJ A;  2ZFM A;  4PJL A;  1I6I A;  4ETP A;  4H1G A;  2ZFK A;  2NCD A;  2XAE A;  4PFO A;  1CZ7 A;  3KEN A;  1T5C A;  1MMN A;  2XT3 A;  1BR4 A;  3K3B A;  4GKR A;  1SDM A;  2KIN A;  1MMA A;  3L9H A;  1D1C A;  4BBG A;  3B6V A;  4E7Z A;  4BXN A;  5LT1 A;  2VAS A;  3WPN A;  4ETP B;  2Q2Y A;  1RY6 A;  4ANJ A;  4PJM A;  2ZFL A;  1BR1 A;  4PJJ A;  3CNZ A;  1MKJ A;  4A14 A;  1LKX A;  3ZFC A;  5GSZ A;  3KAR A;  2OWM A;  4LNU K;  1G8X A;  2Q2Z A;  2V26 A;  2FL6 A;  4A1Z A;  1F9T A;  2FKY A;  2VVG A;  4ZCA A;  5LT4 A;  4AP0 A;  1N6M A;  2FME A;  1FMW A;  1VFX A;  3DC4 A;  3CJO A;  3T0Q A;  1LVK A;  4DBQ A;  3HQD A; 
#chains in the Genus database with same CATH homology
 2WOG A;  2X2R A;  4A28 A;  1D1A A;  4BN2 A;  4PFP A;  1MMD A;  4Y05 A;  4B7B A;  1BR2 A;  1MMG A;  3H4S A;  1F9U A;  1Q0B A;  2X7D A;  1BG2 A;  1KK7 A;  5LT0 A;  3ZFD A;  3GBJ A;  3K5E A;  3B6U A;  2FL2 A;  3LRE A;  4PK4 A;  3DCB A;  3U06 A;  4DBR A;  2UYM A;  1V8K A;  1VFV A;  1MNE A;  3KIN A;  1VFW A;  2PG2 A;  4A50 A;  3PXN A;  4PJN A;  2X51 A;  1F9W A;  4HNA K;  4A5Y A;  2Y5W A;  2MYS A;  1D1B A;  2G1Q A;  1V8J A;  1D0Y A;  2X7E A;  2ZFJ A;  1VOM A;  1X88 A;  5HLE A;  1YRS A;  3COB A;  1D0X A;  4FRZ A;  4AS7 A;  2UYI A;  3L1C A;  1VFZ A;  2ZFI A;  2VB6 A;  4UBF A;  3NWN A;  3BFN A;  3WRD A;  2IEH A;  2HEH A;  2GM1 A;  4E7S A;  3X2T A;  1I5S A;  2X7C A;  2GRY A;  4A51 A;  1F9V A;  5LT2 A;  3ZCW A;  1II6 A;  1FMV A;  5LT3 A;  1D0Z A;  2Y65 A;  4ZHI A;  1GOJ A;  2ZFM A;  4PJL A;  1I6I A;  4ETP A;  4H1G A;  2ZFK A;  2NCD A;  2XAE A;  4PFO A;  1CZ7 A;  3KEN A;  1T5C A;  1MMN A;  2XT3 A;  1BR4 A;  3K3B A;  4GKR A;  1SDM A;  2KIN A;  1MMA A;  3L9H A;  1D1C A;  4BBG A;  3B6V A;  4E7Z A;  4BXN A;  5LT1 A;  2VAS A;  3WPN A;  2Q2Y A;  1RY6 A;  4ANJ A;  4PJM A;  2ZFL A;  1BR1 A;  4PJJ A;  3CNZ A;  1MKJ A;  4A14 A;  1LKX A;  3ZFC A;  5GSZ A;  3KAR A;  2OWM A;  4LNU K;  1G8X A;  2Q2Z A;  2V26 A;  2FL6 A;  4A1Z A;  1F9T A;  2FKY A;  2VVG A;  4ZCA A;  5LT4 A;  4AP0 A;  1N6M A;  2FME A;  1FMW A;  1VFX A;  3DC4 A;  3CJO A;  3T0Q A;  1LVK A;  4DBQ A;  3HQD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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