2X2RA

Crystal structure of human kinesin eg5 in complex with (r)-2-amino-3-((4-chlorophenyl)diphenylmethylthio)propanoic acid
Total Genus 111
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
111
sequence length
349
structure length
331
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cell cycle
molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
pubmed doi rcsb
source organism Homo sapiens
total genus 111
structure length 331
sequence length 349
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2010-01-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x2rA00
2ZFJA 4PK4A 4Y05A 2GM1A 4DBQA 3PXNA 2ZFKA 3DC4A 4PFOA 2UYMA 1MMAA 4HNAK 1KK7A 2Q2ZA 3GBJA 2FL2A 3K3BA 2VVGA 2Y5WA 1II6A 2X7EA 4AS7A 3L9HA 3LREA 2FMEA 3U06A 3COBA 1F9UA 4PJLA 3K5EA 1FMWA 1MMNA 1VFXA 4E7SA 1D1AA 3ZCWA 1F9VA 4H1GA 1SDMA 4A28A 2X7CA 4PFPA 2XT3A 1Q0BA 2G1QA 3KARA 3H4SA 4ZHIA 4PJMA 3ZFDA 1VFVA 4A5YA 2PG2A 1F9WA 2ZFMA 4E7ZA 2ZFLA 1MKJA 4A51A 2ZFIA 1RY6A 3CJOA 1I6IA 2VASA 2WOGA 3BFNA 4PJNA 1BR1A 1MNEA 4ETPA 1D1BA 1LVKA 2X7DA 2HEHA 4AP0A 1D1CA 1VFWA 1GOJA 2XAEA 3WPNA 4FRZA 3ZFCA 1D0YA 1FMVA 3NWNA 1LKXA 5GSZA 1T5CA 2MYSA 1VFZA 3WRDA 1BR2A 2NCDA 4PJJA 1VOMA 5LT0A 2VB6A 1N6MA 2V26A 4A14A 4ANJA 1G8XA 1V8JA 3DCBA 4GKRA 2Q2YA 3HQDA 1V8KA 5LT1A 2GRYA 2OWMA 5LT2A 1D0XA 4B7BA 3KENA 1F9TA 3L1CA 4UBFA 1YRSA 3B6UA 4BBGA 1X88A 1BR4A 4A50A 1CZ7A 1BG2A 4LNUK 1D0ZA 5LT3A 2KINA 2X51A 1MMGA 3B6VA 4ZCAA 4A1ZA 2Y65A 4BXNA 5LT4A 3T0QA 3X2TA 2FL6A 2UYIA 1I5SA 1MMDA 2IEHA 2X2RA 4BN2A 3KINA 2FKYA 5HLEA 3CNZA 4DBRA
chains in the Genus database with same CATH superfamily
2ZFJA 4PK4A 4Y05A 2GM1A 4DBQA 3PXNA 2ZFKA 3DC4A 4PFOA 2UYMA 1MMAA 4HNAK 1KK7A 2Q2ZA 3GBJA 2FL2A 3K3BA 2VVGA 2Y5WA 2O0AA 1II6A 2X7EA 4AS7A 3L9HA 3LREA 2FMEA 3U06A 3COBA 1F9UA 4PJLA 3K5EA 1FMWA 1MMNA 1VFXA 4E7SA 1D1AA 3ZCWA 1F9VA 4H1GA 1SDMA 4A28A 2X7CA 4PFPA 2XT3A 1Q0BA 2G1QA 3KARA 3H4SA 4ZHIA 4PJMA 3ZFDA 1VFVA 4A5YA 2PG2A 1F9WA 2ZFMA 4E7ZA 2ZFLA 1MKJA 4A51A 2ZFIA 1RY6A 3CJOA 1I6IA 2VASA 2WOGA 3BFNA 4PJNA 1BR1A 1MNEA 4ETPA 1D1BA 1LVKA 2X7DA 4GKQA 2HEHA 4GKPA 4AP0A 1D1CA 1VFWA 1GOJA 2XAEA 3WPNA 4ETPB 4FRZA 3ZFCA 1D0YA 1FMVA 3NWNA 1LKXA 5GSZA 1T5CA 2MYSA 1VFZA 3WRDA 1BR2A 2NCDA 4PJJA 1VOMA 5LT0A 2VB6A 1N6MA 2V26A 4A14A 4ANJA 1G8XA 1V8JA 3DCBA 4GKRA 2Q2YA 3HQDA 1V8KA 5LT1A 2GRYA 2OWMA 5LT2A 1D0XA 4B7BA 3KENA 1F9TA 3L1CA 4UBFA 1YRSA 3B6UA 4BBGA 1X88A 1BR4A 4A50A 1CZ7A 1BG2A 4LNUK 1D0ZA 5LT3A 2KINA 2X51A 1MMGA 3B6VA 4ZCAA 4A1ZA 2Y65A 4BXNA 5LT4A 3T0QA 3X2TA 2FL6A 2UYIA 1I5SA 1MMDA 2IEHA 2X2RA 4BN2A 3KINA 2FKYA 5HLEA 3CNZA 4DBRA
chains in the Genus database with same CATH topology
2ZFJA 4PK4A 4Y05A 2GM1A 4DBQA 3PXNA 2ZFKA 3DC4A 4PFOA 2UYMA 1MMAA 4HNAK 1KK7A 2Q2ZA 3GBJA 2FL2A 3K3BA 2VVGA 2Y5WA 1II6A 2X7EA 4AS7A 3L9HA 3LREA 2FMEA 3U06A 3COBA 1F9UA 4PJLA 3K5EA 1FMWA 1MMNA 1VFXA 4E7SA 1D1AA 3ZCWA 1F9VA 4H1GA 1SDMA 4A28A 2X7CA 4PFPA 2XT3A 1Q0BA 2G1QA 3KARA 3H4SA 4ZHIA 4PJMA 3ZFDA 1VFVA 4A5YA 2PG2A 1F9WA 2ZFMA 4E7ZA 2ZFLA 1MKJA 4A51A 2ZFIA 1RY6A 3CJOA 1I6IA 2VASA 2WOGA 3BFNA 4PJNA 1BR1A 1MNEA 4ETPA 1D1BA 1LVKA 2X7DA 2HEHA 4AP0A 1D1CA 1VFWA 1GOJA 2XAEA 3WPNA 4FRZA 3ZFCA 1D0YA 1FMVA 3NWNA 1LKXA 5GSZA 1T5CA 2MYSA 1VFZA 3WRDA 1BR2A 2NCDA 4PJJA 1VOMA 5LT0A 2VB6A 1N6MA 2V26A 4A14A 4ANJA 1G8XA 1V8JA 3DCBA 4GKRA 2Q2YA 3HQDA 1V8KA 5LT1A 2GRYA 2OWMA 5LT2A 1D0XA 4B7BA 3KENA 1F9TA 3L1CA 4UBFA 1YRSA 3B6UA 4BBGA 1X88A 1BR4A 4A50A 1CZ7A 1BG2A 4LNUK 1D0ZA 5LT3A 2KINA 2X51A 1MMGA 3B6VA 4ZCAA 4A1ZA 2Y65A 4BXNA 5LT4A 3T0QA 3X2TA 2FL6A 2UYIA 1I5SA 1MMDA 2IEHA 2X2RA 4BN2A 3KINA 2FKYA 5HLEA 3CNZA 4DBRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZFJ A;  4PK4 A;  4Y05 A;  2GM1 A;  4DBQ A;  3PXN A;  2ZFK A;  3DC4 A;  4PFO A;  2UYM A;  1MMA A;  4HNA K;  1KK7 A;  2Q2Z A;  3GBJ A;  2FL2 A;  3K3B A;  2VVG A;  2Y5W A;  1II6 A;  2X7E A;  4AS7 A;  3L9H A;  3LRE A;  2FME A;  3U06 A;  3COB A;  1F9U A;  4PJL A;  3K5E A;  1FMW A;  1MMN A;  1VFX A;  4E7S A;  1D1A A;  3ZCW A;  1F9V A;  4H1G A;  1SDM A;  4A28 A;  2X7C A;  4PFP A;  2XT3 A;  1Q0B A;  2G1Q A;  3KAR A;  3H4S A;  4ZHI A;  4PJM A;  3ZFD A;  1VFV A;  4A5Y A;  2PG2 A;  1F9W A;  2ZFM A;  4E7Z A;  2ZFL A;  1MKJ A;  4A51 A;  2ZFI A;  1RY6 A;  3CJO A;  1I6I A;  2VAS A;  2WOG A;  3BFN A;  4PJN A;  1BR1 A;  1MNE A;  4ETP A;  1D1B A;  1LVK A;  2X7D A;  2HEH A;  4AP0 A;  1D1C A;  1VFW A;  1GOJ A;  2XAE A;  3WPN A;  4FRZ A;  3ZFC A;  1D0Y A;  1FMV A;  3NWN A;  1LKX A;  5GSZ A;  1T5C A;  2MYS A;  1VFZ A;  3WRD A;  1BR2 A;  2NCD A;  4PJJ A;  1VOM A;  5LT0 A;  2VB6 A;  1N6M A;  2V26 A;  4A14 A;  4ANJ A;  1G8X A;  1V8J A;  3DCB A;  4GKR A;  2Q2Y A;  3HQD A;  1V8K A;  5LT1 A;  2GRY A;  2OWM A;  5LT2 A;  1D0X A;  4B7B A;  3KEN A;  1F9T A;  3L1C A;  4UBF A;  1YRS A;  3B6U A;  4BBG A;  1X88 A;  1BR4 A;  4A50 A;  1CZ7 A;  1BG2 A;  4LNU K;  1D0Z A;  5LT3 A;  2KIN A;  2X51 A;  1MMG A;  3B6V A;  4ZCA A;  4A1Z A;  2Y65 A;  4BXN A;  5LT4 A;  3T0Q A;  3X2T A;  2FL6 A;  2UYI A;  1I5S A;  1MMD A;  2IEH A;  2X2R A;  4BN2 A;  3KIN A;  2FKY A;  5HLE A;  3CNZ A;  4DBR A; 
#chains in the Genus database with same CATH topology
 2ZFJ A;  4PK4 A;  4Y05 A;  2GM1 A;  4DBQ A;  3PXN A;  2ZFK A;  3DC4 A;  4PFO A;  2UYM A;  1MMA A;  4HNA K;  1KK7 A;  2Q2Z A;  3GBJ A;  2FL2 A;  3K3B A;  2VVG A;  2Y5W A;  2O0A A;  1II6 A;  2X7E A;  4AS7 A;  3L9H A;  3LRE A;  2FME A;  3U06 A;  3COB A;  1F9U A;  4PJL A;  3K5E A;  1FMW A;  1MMN A;  1VFX A;  4E7S A;  1D1A A;  3ZCW A;  1F9V A;  4H1G A;  1SDM A;  4A28 A;  2X7C A;  4PFP A;  2XT3 A;  1Q0B A;  2G1Q A;  3KAR A;  3H4S A;  4ZHI A;  4PJM A;  3ZFD A;  1VFV A;  4A5Y A;  2PG2 A;  1F9W A;  2ZFM A;  4E7Z A;  2ZFL A;  1MKJ A;  4A51 A;  2ZFI A;  1RY6 A;  3CJO A;  1I6I A;  2VAS A;  2WOG A;  3BFN A;  4PJN A;  1BR1 A;  1MNE A;  4ETP A;  1D1B A;  1LVK A;  2X7D A;  4GKQ A;  2HEH A;  4GKP A;  4AP0 A;  1D1C A;  1VFW A;  1GOJ A;  2XAE A;  3WPN A;  4ETP B;  4FRZ A;  3ZFC A;  1D0Y A;  1FMV A;  3NWN A;  1LKX A;  5GSZ A;  1T5C A;  2MYS A;  1VFZ A;  3WRD A;  1BR2 A;  2NCD A;  4PJJ A;  1VOM A;  5LT0 A;  2VB6 A;  1N6M A;  2V26 A;  4A14 A;  4ANJ A;  1G8X A;  1V8J A;  3DCB A;  4GKR A;  2Q2Y A;  3HQD A;  1V8K A;  5LT1 A;  2GRY A;  2OWM A;  5LT2 A;  1D0X A;  4B7B A;  3KEN A;  1F9T A;  3L1C A;  4UBF A;  1YRS A;  3B6U A;  4BBG A;  1X88 A;  1BR4 A;  4A50 A;  1CZ7 A;  1BG2 A;  4LNU K;  1D0Z A;  5LT3 A;  2KIN A;  2X51 A;  1MMG A;  3B6V A;  4ZCA A;  4A1Z A;  2Y65 A;  4BXN A;  5LT4 A;  3T0Q A;  3X2T A;  2FL6 A;  2UYI A;  1I5S A;  1MMD A;  2IEH A;  2X2R A;  4BN2 A;  3KIN A;  2FKY A;  5HLE A;  3CNZ A;  4DBR A; 
#chains in the Genus database with same CATH homology
 2ZFJ A;  4PK4 A;  4Y05 A;  2GM1 A;  4DBQ A;  3PXN A;  2ZFK A;  3DC4 A;  4PFO A;  2UYM A;  1MMA A;  4HNA K;  1KK7 A;  2Q2Z A;  3GBJ A;  2FL2 A;  3K3B A;  2VVG A;  2Y5W A;  1II6 A;  2X7E A;  4AS7 A;  3L9H A;  3LRE A;  2FME A;  3U06 A;  3COB A;  1F9U A;  4PJL A;  3K5E A;  1FMW A;  1MMN A;  1VFX A;  4E7S A;  1D1A A;  3ZCW A;  1F9V A;  4H1G A;  1SDM A;  4A28 A;  2X7C A;  4PFP A;  2XT3 A;  1Q0B A;  2G1Q A;  3KAR A;  3H4S A;  4ZHI A;  4PJM A;  3ZFD A;  1VFV A;  4A5Y A;  2PG2 A;  1F9W A;  2ZFM A;  4E7Z A;  2ZFL A;  1MKJ A;  4A51 A;  2ZFI A;  1RY6 A;  3CJO A;  1I6I A;  2VAS A;  2WOG A;  3BFN A;  4PJN A;  1BR1 A;  1MNE A;  4ETP A;  1D1B A;  1LVK A;  2X7D A;  2HEH A;  4AP0 A;  1D1C A;  1VFW A;  1GOJ A;  2XAE A;  3WPN A;  4FRZ A;  3ZFC A;  1D0Y A;  1FMV A;  3NWN A;  1LKX A;  5GSZ A;  1T5C A;  2MYS A;  1VFZ A;  3WRD A;  1BR2 A;  2NCD A;  4PJJ A;  1VOM A;  5LT0 A;  2VB6 A;  1N6M A;  2V26 A;  4A14 A;  4ANJ A;  1G8X A;  1V8J A;  3DCB A;  4GKR A;  2Q2Y A;  3HQD A;  1V8K A;  5LT1 A;  2GRY A;  2OWM A;  5LT2 A;  1D0X A;  4B7B A;  3KEN A;  1F9T A;  3L1C A;  4UBF A;  1YRS A;  3B6U A;  4BBG A;  1X88 A;  1BR4 A;  4A50 A;  1CZ7 A;  1BG2 A;  4LNU K;  1D0Z A;  5LT3 A;  2KIN A;  2X51 A;  1MMG A;  3B6V A;  4ZCA A;  4A1Z A;  2Y65 A;  4BXN A;  5LT4 A;  3T0Q A;  3X2T A;  2FL6 A;  2UYI A;  1I5S A;  1MMD A;  2IEH A;  2X2R A;  4BN2 A;  3KIN A;  2FKY A;  5HLE A;  3CNZ A;  4DBR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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