2GM1A

Crystal structure of the mitotic kinesin eg5 in complex with mg-adp and n-(3-aminopropyl)-n-((3-benzyl-5-chloro-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)(cyclopropyl)methyl)-4-methylbenzamide
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
350
structure length
327
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKEVKIGKLNLVDLAGSENIGRINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-RELATED MOTOR PROTEIN EG5
publication title Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 107
structure length 327
sequence length 350
chains with identical sequence B, D, E
ec nomenclature
pdb deposition date 2006-04-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2gm1A00
2MYSA 1SDMA 4AP0A 1VFZA 2XT3A 2ZFKA 3L9HA 4BXNA 2ZFMA 5LT2A 4Y05A 3H4SA 4A28A 2Q2YA 5LT0A 1MNEA 4E7ZA 1GOJA 2VASA 1RY6A 4AS7A 2VVGA 4PJNA 4DBQA 2Y5WA 1FMVA 4PFPA 3DC4A 2UYIA 3LREA 1I5SA 3BFNA 4A51A 2X7EA 4PJMA 3K3BA 2VB6A 2Y65A 3GBJA 4HNAK 1VFVA 2X7DA 2G1QA 3ZCWA 3COBA 3B6UA 2OWMA 4B7BA 1D1AA 2PG2A 3KARA 1MMDA 2NCDA 2FKYA 1G8XA 4H1GA 1X88A 1Q0BA 1D0XA 1BR1A 5LT1A 4A1ZA 4A50A 3T0QA 4ANJA 4FRZA 2Q2ZA 4GKRA 3HQDA 4ETPA 3U06A 3NWNA 2WOGA 1BR2A 2FMEA 1BG2A 4BN2A 1CZ7A 1F9UA 4UBFA 4ZHIA 3L1CA 3ZFCA 4PK4A 2IEHA 2X51A 3WRDA 1MMGA 3CJOA 2ZFLA 1MKJA 2UYMA 2V26A 5LT4A 4BBGA 1LVKA 4A5YA 1I6IA 1II6A 1D0YA 3B6VA 1BR4A 5GSZA 3K5EA 4PFOA 4A14A 2GRYA 5HLEA 2ZFJA 2GM1A 1LKXA 4PJLA 1VOMA 1KK7A 4PJJA 3WPNA 1T5CA 2X2RA 3CNZA 2ZFIA 3KINA 5LT3A 1F9VA 1D1BA 2XAEA 3KENA 1F9WA 3ZFDA 2KINA 2X7CA 2FL6A 2HEHA 1MMNA 1V8JA 3DCBA 4LNUK 3PXNA 4ZCAA 4DBRA 1MMAA 1VFWA 1FMWA 4E7SA 3X2TA 1D1CA 1D0ZA 1V8KA 1F9TA 1N6MA 1VFXA 1YRSA 2FL2A
chains in the Genus database with same CATH superfamily
2MYSA 1SDMA 4AP0A 1VFZA 2XT3A 2ZFKA 3L9HA 4BXNA 2ZFMA 5LT2A 4Y05A 3H4SA 4A28A 2Q2YA 5LT0A 1MNEA 4E7ZA 1GOJA 2VASA 1RY6A 4AS7A 2VVGA 4GKQA 4PJNA 4DBQA 2Y5WA 1FMVA 4PFPA 3DC4A 2UYIA 3LREA 1I5SA 3BFNA 4GKPA 4A51A 2X7EA 4PJMA 3K3BA 2VB6A 2Y65A 3GBJA 4HNAK 1VFVA 2X7DA 2G1QA 3ZCWA 3COBA 3B6UA 2OWMA 4B7BA 1D1AA 2PG2A 3KARA 1MMDA 2NCDA 2FKYA 1G8XA 4H1GA 1X88A 1Q0BA 1D0XA 1BR1A 5LT1A 4A1ZA 4A50A 3T0QA 4ANJA 4FRZA 2Q2ZA 4GKRA 3HQDA 4ETPA 3U06A 3NWNA 2WOGA 1BR2A 2FMEA 1BG2A 4BN2A 1CZ7A 1F9UA 4UBFA 4ZHIA 3L1CA 3ZFCA 4PK4A 2IEHA 2X51A 3WRDA 1MMGA 2O0AA 3CJOA 2ZFLA 1MKJA 2UYMA 2V26A 5LT4A 4BBGA 1LVKA 4A5YA 1I6IA 1II6A 1D0YA 3B6VA 1BR4A 5GSZA 3K5EA 4PFOA 4A14A 2GRYA 5HLEA 2ZFJA 2GM1A 1LKXA 4PJLA 1VOMA 1KK7A 4PJJA 3WPNA 1T5CA 2X2RA 3CNZA 2ZFIA 3KINA 5LT3A 4ETPB 1F9VA 1D1BA 2XAEA 3KENA 1F9WA 3ZFDA 2KINA 2X7CA 2FL6A 2HEHA 1MMNA 1V8JA 3DCBA 4LNUK 3PXNA 4ZCAA 4DBRA 1MMAA 1VFWA 1FMWA 4E7SA 3X2TA 1D1CA 1D0ZA 1V8KA 1F9TA 1N6MA 1VFXA 1YRSA 2FL2A
chains in the Genus database with same CATH topology
2MYSA 1SDMA 4AP0A 1VFZA 2XT3A 2ZFKA 3L9HA 4BXNA 2ZFMA 5LT2A 4Y05A 3H4SA 4A28A 2Q2YA 5LT0A 1MNEA 4E7ZA 1GOJA 2VASA 1RY6A 4AS7A 2VVGA 4PJNA 4DBQA 2Y5WA 1FMVA 4PFPA 3DC4A 2UYIA 3LREA 1I5SA 3BFNA 4A51A 2X7EA 4PJMA 3K3BA 2VB6A 2Y65A 3GBJA 4HNAK 1VFVA 2X7DA 2G1QA 3ZCWA 3COBA 3B6UA 2OWMA 4B7BA 1D1AA 2PG2A 3KARA 1MMDA 2NCDA 2FKYA 1G8XA 4H1GA 1X88A 1Q0BA 1D0XA 1BR1A 5LT1A 4A1ZA 4A50A 3T0QA 4ANJA 4FRZA 2Q2ZA 4GKRA 3HQDA 4ETPA 3U06A 3NWNA 2WOGA 1BR2A 2FMEA 1BG2A 4BN2A 1CZ7A 1F9UA 4UBFA 4ZHIA 3L1CA 3ZFCA 4PK4A 2IEHA 2X51A 3WRDA 1MMGA 3CJOA 2ZFLA 1MKJA 2UYMA 2V26A 5LT4A 4BBGA 1LVKA 4A5YA 1I6IA 1II6A 1D0YA 3B6VA 1BR4A 5GSZA 3K5EA 4PFOA 4A14A 2GRYA 5HLEA 2ZFJA 2GM1A 1LKXA 4PJLA 1VOMA 1KK7A 4PJJA 3WPNA 1T5CA 2X2RA 3CNZA 2ZFIA 3KINA 5LT3A 1F9VA 1D1BA 2XAEA 3KENA 1F9WA 3ZFDA 2KINA 2X7CA 2FL6A 2HEHA 1MMNA 1V8JA 3DCBA 4LNUK 3PXNA 4ZCAA 4DBRA 1MMAA 1VFWA 1FMWA 4E7SA 3X2TA 1D1CA 1D0ZA 1V8KA 1F9TA 1N6MA 1VFXA 1YRSA 2FL2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2MYS A;  1SDM A;  4AP0 A;  1VFZ A;  2XT3 A;  2ZFK A;  3L9H A;  4BXN A;  2ZFM A;  5LT2 A;  4Y05 A;  3H4S A;  4A28 A;  2Q2Y A;  5LT0 A;  1MNE A;  4E7Z A;  1GOJ A;  2VAS A;  1RY6 A;  4AS7 A;  2VVG A;  4PJN A;  4DBQ A;  2Y5W A;  1FMV A;  4PFP A;  3DC4 A;  2UYI A;  3LRE A;  1I5S A;  3BFN A;  4A51 A;  2X7E A;  4PJM A;  3K3B A;  2VB6 A;  2Y65 A;  3GBJ A;  4HNA K;  1VFV A;  2X7D A;  2G1Q A;  3ZCW A;  3COB A;  3B6U A;  2OWM A;  4B7B A;  1D1A A;  2PG2 A;  3KAR A;  1MMD A;  2NCD A;  2FKY A;  1G8X A;  4H1G A;  1X88 A;  1Q0B A;  1D0X A;  1BR1 A;  5LT1 A;  4A1Z A;  4A50 A;  3T0Q A;  4ANJ A;  4FRZ A;  2Q2Z A;  4GKR A;  3HQD A;  4ETP A;  3U06 A;  3NWN A;  2WOG A;  1BR2 A;  2FME A;  1BG2 A;  4BN2 A;  1CZ7 A;  1F9U A;  4UBF A;  4ZHI A;  3L1C A;  3ZFC A;  4PK4 A;  2IEH A;  2X51 A;  3WRD A;  1MMG A;  3CJO A;  2ZFL A;  1MKJ A;  2UYM A;  2V26 A;  5LT4 A;  4BBG A;  1LVK A;  4A5Y A;  1I6I A;  1II6 A;  1D0Y A;  3B6V A;  1BR4 A;  5GSZ A;  3K5E A;  4PFO A;  4A14 A;  2GRY A;  5HLE A;  2ZFJ A;  2GM1 A;  1LKX A;  4PJL A;  1VOM A;  1KK7 A;  4PJJ A;  3WPN A;  1T5C A;  2X2R A;  3CNZ A;  2ZFI A;  3KIN A;  5LT3 A;  1F9V A;  1D1B A;  2XAE A;  3KEN A;  1F9W A;  3ZFD A;  2KIN A;  2X7C A;  2FL6 A;  2HEH A;  1MMN A;  1V8J A;  3DCB A;  4LNU K;  3PXN A;  4ZCA A;  4DBR A;  1MMA A;  1VFW A;  1FMW A;  4E7S A;  3X2T A;  1D1C A;  1D0Z A;  1V8K A;  1F9T A;  1N6M A;  1VFX A;  1YRS A;  2FL2 A; 
#chains in the Genus database with same CATH topology
 2MYS A;  1SDM A;  4AP0 A;  1VFZ A;  2XT3 A;  2ZFK A;  3L9H A;  4BXN A;  2ZFM A;  5LT2 A;  4Y05 A;  3H4S A;  4A28 A;  2Q2Y A;  5LT0 A;  1MNE A;  4E7Z A;  1GOJ A;  2VAS A;  1RY6 A;  4AS7 A;  2VVG A;  4GKQ A;  4PJN A;  4DBQ A;  2Y5W A;  1FMV A;  4PFP A;  3DC4 A;  2UYI A;  3LRE A;  1I5S A;  3BFN A;  4GKP A;  4A51 A;  2X7E A;  4PJM A;  3K3B A;  2VB6 A;  2Y65 A;  3GBJ A;  4HNA K;  1VFV A;  2X7D A;  2G1Q A;  3ZCW A;  3COB A;  3B6U A;  2OWM A;  4B7B A;  1D1A A;  2PG2 A;  3KAR A;  1MMD A;  2NCD A;  2FKY A;  1G8X A;  4H1G A;  1X88 A;  1Q0B A;  1D0X A;  1BR1 A;  5LT1 A;  4A1Z A;  4A50 A;  3T0Q A;  4ANJ A;  4FRZ A;  2Q2Z A;  4GKR A;  3HQD A;  4ETP A;  3U06 A;  3NWN A;  2WOG A;  1BR2 A;  2FME A;  1BG2 A;  4BN2 A;  1CZ7 A;  1F9U A;  4UBF A;  4ZHI A;  3L1C A;  3ZFC A;  4PK4 A;  2IEH A;  2X51 A;  3WRD A;  1MMG A;  2O0A A;  3CJO A;  2ZFL A;  1MKJ A;  2UYM A;  2V26 A;  5LT4 A;  4BBG A;  1LVK A;  4A5Y A;  1I6I A;  1II6 A;  1D0Y A;  3B6V A;  1BR4 A;  5GSZ A;  3K5E A;  4PFO A;  4A14 A;  2GRY A;  5HLE A;  2ZFJ A;  2GM1 A;  1LKX A;  4PJL A;  1VOM A;  1KK7 A;  4PJJ A;  3WPN A;  1T5C A;  2X2R A;  3CNZ A;  2ZFI A;  3KIN A;  5LT3 A;  4ETP B;  1F9V A;  1D1B A;  2XAE A;  3KEN A;  1F9W A;  3ZFD A;  2KIN A;  2X7C A;  2FL6 A;  2HEH A;  1MMN A;  1V8J A;  3DCB A;  4LNU K;  3PXN A;  4ZCA A;  4DBR A;  1MMA A;  1VFW A;  1FMW A;  4E7S A;  3X2T A;  1D1C A;  1D0Z A;  1V8K A;  1F9T A;  1N6M A;  1VFX A;  1YRS A;  2FL2 A; 
#chains in the Genus database with same CATH homology
 2MYS A;  1SDM A;  4AP0 A;  1VFZ A;  2XT3 A;  2ZFK A;  3L9H A;  4BXN A;  2ZFM A;  5LT2 A;  4Y05 A;  3H4S A;  4A28 A;  2Q2Y A;  5LT0 A;  1MNE A;  4E7Z A;  1GOJ A;  2VAS A;  1RY6 A;  4AS7 A;  2VVG A;  4PJN A;  4DBQ A;  2Y5W A;  1FMV A;  4PFP A;  3DC4 A;  2UYI A;  3LRE A;  1I5S A;  3BFN A;  4A51 A;  2X7E A;  4PJM A;  3K3B A;  2VB6 A;  2Y65 A;  3GBJ A;  4HNA K;  1VFV A;  2X7D A;  2G1Q A;  3ZCW A;  3COB A;  3B6U A;  2OWM A;  4B7B A;  1D1A A;  2PG2 A;  3KAR A;  1MMD A;  2NCD A;  2FKY A;  1G8X A;  4H1G A;  1X88 A;  1Q0B A;  1D0X A;  1BR1 A;  5LT1 A;  4A1Z A;  4A50 A;  3T0Q A;  4ANJ A;  4FRZ A;  2Q2Z A;  4GKR A;  3HQD A;  4ETP A;  3U06 A;  3NWN A;  2WOG A;  1BR2 A;  2FME A;  1BG2 A;  4BN2 A;  1CZ7 A;  1F9U A;  4UBF A;  4ZHI A;  3L1C A;  3ZFC A;  4PK4 A;  2IEH A;  2X51 A;  3WRD A;  1MMG A;  3CJO A;  2ZFL A;  1MKJ A;  2UYM A;  2V26 A;  5LT4 A;  4BBG A;  1LVK A;  4A5Y A;  1I6I A;  1II6 A;  1D0Y A;  3B6V A;  1BR4 A;  5GSZ A;  3K5E A;  4PFO A;  4A14 A;  2GRY A;  5HLE A;  2ZFJ A;  2GM1 A;  1LKX A;  4PJL A;  1VOM A;  1KK7 A;  4PJJ A;  3WPN A;  1T5C A;  2X2R A;  3CNZ A;  2ZFI A;  3KIN A;  5LT3 A;  1F9V A;  1D1B A;  2XAE A;  3KEN A;  1F9W A;  3ZFD A;  2KIN A;  2X7C A;  2FL6 A;  2HEH A;  1MMN A;  1V8J A;  3DCB A;  4LNU K;  3PXN A;  4ZCA A;  4DBR A;  1MMA A;  1VFW A;  1FMW A;  4E7S A;  3X2T A;  1D1C A;  1D0Z A;  1V8K A;  1F9T A;  1N6M A;  1VFX A;  1YRS A;  2FL2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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