2G1QA

Crystal structure of ksp in complex with inhibitor 9h
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
345
structure length
330
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Kinesin-like protein KIF11
publication title Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 99
structure length 330
sequence length 345
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-02-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2g1qA00
1I5SA 4DBRA 1I6IA 3KINA 2UYMA 1VFZA 1F9UA 1LKXA 4PJMA 3CJOA 1MMGA 2FKYA 4PJLA 1FMVA 1GOJA 1F9WA 4AS7A 2FL6A 1N6MA 2GRYA 1D0XA 4A51A 3ZFDA 1BG2A 3B6VA 3WRDA 3PXNA 4BN2A 4H1GA 2Q2ZA 4ZHIA 1BR1A 4PJJA 4A50A 3H4SA 1BR4A 4A28A 3DC4A 2VB6A 2FMEA 3KARA 3LREA 1X88A 1BR2A 1VFVA 3KENA 3L9HA 2X2RA 2ZFMA 4BBGA 2KINA 2ZFJA 1F9TA 2GM1A 5LT1A 1D1AA 1MMNA 3K5EA 3ZCWA 4E7SA 5GSZA 4HNAK 1RY6A 5HLEA 4A14A 5LT2A 4E7ZA 3BFNA 4A5YA 2XAEA 3X2TA 4DBQA 4PFPA 2IEHA 2VVGA 5LT3A 4BXNA 1F9VA 4ZCAA 3T0QA 2X7DA 3GBJA 1SDMA 2UYIA 1VFWA 1Q0BA 3COBA 1MNEA 1LVKA 2NCDA 5LT4A 2ZFKA 3U06A 4UBFA 1D0YA 1CZ7A 1D1CA 2VASA 1KK7A 2HEHA 2X7CA 2Y65A 3HQDA 1V8KA 4AP0A 1YRSA 2ZFIA 3DCBA 4GKRA 3WPNA 1VOMA 3K3BA 4PFOA 4Y05A 1II6A 3CNZA 5LT0A 1D1BA 3NWNA 2V26A 1G8XA 2WOGA 1T5CA 3L1CA 4PJNA 1MMDA 2X7EA 4A1ZA 1FMWA 2X51A 2Q2YA 1V8JA 2OWMA 3B6UA 2Y5WA 1D0ZA 3ZFCA 2PG2A 1MMAA 4ETPA 2ZFLA 1MKJA 2FL2A 4FRZA 2G1QA 4B7BA 2MYSA 4ANJA 1VFXA 2XT3A 4LNUK 4PK4A
chains in the Genus database with same CATH superfamily
1I5SA 4DBRA 1I6IA 3KINA 2UYMA 1VFZA 1F9UA 1LKXA 4PJMA 3CJOA 1MMGA 2FKYA 4PJLA 1FMVA 1GOJA 1F9WA 4AS7A 2FL6A 1N6MA 2GRYA 1D0XA 4A51A 3ZFDA 1BG2A 3B6VA 3WRDA 3PXNA 4BN2A 4H1GA 2Q2ZA 4ZHIA 1BR1A 4PJJA 4A50A 3H4SA 1BR4A 4A28A 3DC4A 2VB6A 2FMEA 3KARA 3LREA 1X88A 1BR2A 1VFVA 3KENA 3L9HA 2X2RA 2ZFMA 4BBGA 2KINA 2ZFJA 1F9TA 2GM1A 5LT1A 1D1AA 1MMNA 3K5EA 3ZCWA 4E7SA 5GSZA 4HNAK 1RY6A 5HLEA 4A14A 5LT2A 4E7ZA 3BFNA 4A5YA 2XAEA 3X2TA 4DBQA 4PFPA 2IEHA 2VVGA 4GKPA 5LT3A 4BXNA 1F9VA 4ZCAA 4GKQA 2X7DA 3GBJA 3T0QA 1SDMA 2UYIA 1VFWA 1Q0BA 3COBA 1MNEA 1LVKA 2NCDA 5LT4A 2ZFKA 3U06A 4UBFA 1D0YA 1CZ7A 1D1CA 2VASA 1KK7A 2HEHA 2X7CA 2Y65A 3HQDA 1V8KA 4AP0A 1YRSA 2ZFIA 3DCBA 4GKRA 3WPNA 1VOMA 3K3BA 4PFOA 4Y05A 1II6A 3CNZA 5LT0A 1D1BA 3NWNA 2V26A 1G8XA 2WOGA 1T5CA 3L1CA 4PJNA 1MMDA 2X7EA 4A1ZA 1FMWA 2X51A 2Q2YA 1V8JA 2OWMA 3B6UA 2Y5WA 1D0ZA 4ETPB 3ZFCA 2PG2A 1MMAA 2O0AA 4ETPA 2ZFLA 1MKJA 2FL2A 4FRZA 2G1QA 4B7BA 2MYSA 4ANJA 1VFXA 2XT3A 4LNUK 4PK4A
chains in the Genus database with same CATH topology
1I5SA 4DBRA 1I6IA 3KINA 2UYMA 1VFZA 1F9UA 1LKXA 4PJMA 3CJOA 1MMGA 2FKYA 4PJLA 1FMVA 1GOJA 1F9WA 4AS7A 2FL6A 1N6MA 2GRYA 1D0XA 4A51A 3ZFDA 1BG2A 3B6VA 3WRDA 3PXNA 4BN2A 4H1GA 2Q2ZA 4ZHIA 1BR1A 4PJJA 4A50A 3H4SA 1BR4A 4A28A 3DC4A 2VB6A 2FMEA 3KARA 3LREA 1X88A 1BR2A 1VFVA 3KENA 3L9HA 2X2RA 2ZFMA 4BBGA 2KINA 2ZFJA 1F9TA 2GM1A 5LT1A 1D1AA 1MMNA 3K5EA 3ZCWA 4E7SA 5GSZA 4HNAK 1RY6A 5HLEA 4A14A 5LT2A 4E7ZA 3BFNA 4A5YA 2XAEA 3X2TA 4DBQA 4PFPA 2IEHA 2VVGA 5LT3A 4BXNA 1F9VA 4ZCAA 3T0QA 2X7DA 3GBJA 1SDMA 2UYIA 1VFWA 1Q0BA 3COBA 1MNEA 1LVKA 2NCDA 5LT4A 2ZFKA 3U06A 4UBFA 1D0YA 1CZ7A 1D1CA 2VASA 1KK7A 2HEHA 2X7CA 2Y65A 3HQDA 1V8KA 4AP0A 1YRSA 2ZFIA 3DCBA 4GKRA 3WPNA 1VOMA 3K3BA 4PFOA 4Y05A 1II6A 3CNZA 5LT0A 1D1BA 3NWNA 2V26A 1G8XA 2WOGA 1T5CA 3L1CA 4PJNA 1MMDA 2X7EA 4A1ZA 1FMWA 2X51A 2Q2YA 1V8JA 2OWMA 3B6UA 2Y5WA 1D0ZA 3ZFCA 2PG2A 1MMAA 4ETPA 2ZFLA 1MKJA 2FL2A 4FRZA 2G1QA 4B7BA 2MYSA 4ANJA 1VFXA 2XT3A 4LNUK 4PK4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I5S A;  4DBR A;  1I6I A;  3KIN A;  2UYM A;  1VFZ A;  1F9U A;  1LKX A;  4PJM A;  3CJO A;  1MMG A;  2FKY A;  4PJL A;  1FMV A;  1GOJ A;  1F9W A;  4AS7 A;  2FL6 A;  1N6M A;  2GRY A;  1D0X A;  4A51 A;  3ZFD A;  1BG2 A;  3B6V A;  3WRD A;  3PXN A;  4BN2 A;  4H1G A;  2Q2Z A;  4ZHI A;  1BR1 A;  4PJJ A;  4A50 A;  3H4S A;  1BR4 A;  4A28 A;  3DC4 A;  2VB6 A;  2FME A;  3KAR A;  3LRE A;  1X88 A;  1BR2 A;  1VFV A;  3KEN A;  3L9H A;  2X2R A;  2ZFM A;  4BBG A;  2KIN A;  2ZFJ A;  1F9T A;  2GM1 A;  5LT1 A;  1D1A A;  1MMN A;  3K5E A;  3ZCW A;  4E7S A;  5GSZ A;  4HNA K;  1RY6 A;  5HLE A;  4A14 A;  5LT2 A;  4E7Z A;  3BFN A;  4A5Y A;  2XAE A;  3X2T A;  4DBQ A;  4PFP A;  2IEH A;  2VVG A;  5LT3 A;  4BXN A;  1F9V A;  4ZCA A;  3T0Q A;  2X7D A;  3GBJ A;  1SDM A;  2UYI A;  1VFW A;  1Q0B A;  3COB A;  1MNE A;  1LVK A;  2NCD A;  5LT4 A;  2ZFK A;  3U06 A;  4UBF A;  1D0Y A;  1CZ7 A;  1D1C A;  2VAS A;  1KK7 A;  2HEH A;  2X7C A;  2Y65 A;  3HQD A;  1V8K A;  4AP0 A;  1YRS A;  2ZFI A;  3DCB A;  4GKR A;  3WPN A;  1VOM A;  3K3B A;  4PFO A;  4Y05 A;  1II6 A;  3CNZ A;  5LT0 A;  1D1B A;  3NWN A;  2V26 A;  1G8X A;  2WOG A;  1T5C A;  3L1C A;  4PJN A;  1MMD A;  2X7E A;  4A1Z A;  1FMW A;  2X51 A;  2Q2Y A;  1V8J A;  2OWM A;  3B6U A;  2Y5W A;  1D0Z A;  3ZFC A;  2PG2 A;  1MMA A;  4ETP A;  2ZFL A;  1MKJ A;  2FL2 A;  4FRZ A;  2G1Q A;  4B7B A;  2MYS A;  4ANJ A;  1VFX A;  2XT3 A;  4LNU K;  4PK4 A; 
#chains in the Genus database with same CATH topology
 1I5S A;  4DBR A;  1I6I A;  3KIN A;  2UYM A;  1VFZ A;  1F9U A;  1LKX A;  4PJM A;  3CJO A;  1MMG A;  2FKY A;  4PJL A;  1FMV A;  1GOJ A;  1F9W A;  4AS7 A;  2FL6 A;  1N6M A;  2GRY A;  1D0X A;  4A51 A;  3ZFD A;  1BG2 A;  3B6V A;  3WRD A;  3PXN A;  4BN2 A;  4H1G A;  2Q2Z A;  4ZHI A;  1BR1 A;  4PJJ A;  4A50 A;  3H4S A;  1BR4 A;  4A28 A;  3DC4 A;  2VB6 A;  2FME A;  3KAR A;  3LRE A;  1X88 A;  1BR2 A;  1VFV A;  3KEN A;  3L9H A;  2X2R A;  2ZFM A;  4BBG A;  2KIN A;  2ZFJ A;  1F9T A;  2GM1 A;  5LT1 A;  1D1A A;  1MMN A;  3K5E A;  3ZCW A;  4E7S A;  5GSZ A;  4HNA K;  1RY6 A;  5HLE A;  4A14 A;  5LT2 A;  4E7Z A;  3BFN A;  4A5Y A;  2XAE A;  3X2T A;  4DBQ A;  4PFP A;  2IEH A;  2VVG A;  4GKP A;  5LT3 A;  4BXN A;  1F9V A;  4ZCA A;  4GKQ A;  2X7D A;  3GBJ A;  3T0Q A;  1SDM A;  2UYI A;  1VFW A;  1Q0B A;  3COB A;  1MNE A;  1LVK A;  2NCD A;  5LT4 A;  2ZFK A;  3U06 A;  4UBF A;  1D0Y A;  1CZ7 A;  1D1C A;  2VAS A;  1KK7 A;  2HEH A;  2X7C A;  2Y65 A;  3HQD A;  1V8K A;  4AP0 A;  1YRS A;  2ZFI A;  3DCB A;  4GKR A;  3WPN A;  1VOM A;  3K3B A;  4PFO A;  4Y05 A;  1II6 A;  3CNZ A;  5LT0 A;  1D1B A;  3NWN A;  2V26 A;  1G8X A;  2WOG A;  1T5C A;  3L1C A;  4PJN A;  1MMD A;  2X7E A;  4A1Z A;  1FMW A;  2X51 A;  2Q2Y A;  1V8J A;  2OWM A;  3B6U A;  2Y5W A;  1D0Z A;  4ETP B;  3ZFC A;  2PG2 A;  1MMA A;  2O0A A;  4ETP A;  2ZFL A;  1MKJ A;  2FL2 A;  4FRZ A;  2G1Q A;  4B7B A;  2MYS A;  4ANJ A;  1VFX A;  2XT3 A;  4LNU K;  4PK4 A; 
#chains in the Genus database with same CATH homology
 1I5S A;  4DBR A;  1I6I A;  3KIN A;  2UYM A;  1VFZ A;  1F9U A;  1LKX A;  4PJM A;  3CJO A;  1MMG A;  2FKY A;  4PJL A;  1FMV A;  1GOJ A;  1F9W A;  4AS7 A;  2FL6 A;  1N6M A;  2GRY A;  1D0X A;  4A51 A;  3ZFD A;  1BG2 A;  3B6V A;  3WRD A;  3PXN A;  4BN2 A;  4H1G A;  2Q2Z A;  4ZHI A;  1BR1 A;  4PJJ A;  4A50 A;  3H4S A;  1BR4 A;  4A28 A;  3DC4 A;  2VB6 A;  2FME A;  3KAR A;  3LRE A;  1X88 A;  1BR2 A;  1VFV A;  3KEN A;  3L9H A;  2X2R A;  2ZFM A;  4BBG A;  2KIN A;  2ZFJ A;  1F9T A;  2GM1 A;  5LT1 A;  1D1A A;  1MMN A;  3K5E A;  3ZCW A;  4E7S A;  5GSZ A;  4HNA K;  1RY6 A;  5HLE A;  4A14 A;  5LT2 A;  4E7Z A;  3BFN A;  4A5Y A;  2XAE A;  3X2T A;  4DBQ A;  4PFP A;  2IEH A;  2VVG A;  5LT3 A;  4BXN A;  1F9V A;  4ZCA A;  3T0Q A;  2X7D A;  3GBJ A;  1SDM A;  2UYI A;  1VFW A;  1Q0B A;  3COB A;  1MNE A;  1LVK A;  2NCD A;  5LT4 A;  2ZFK A;  3U06 A;  4UBF A;  1D0Y A;  1CZ7 A;  1D1C A;  2VAS A;  1KK7 A;  2HEH A;  2X7C A;  2Y65 A;  3HQD A;  1V8K A;  4AP0 A;  1YRS A;  2ZFI A;  3DCB A;  4GKR A;  3WPN A;  1VOM A;  3K3B A;  4PFO A;  4Y05 A;  1II6 A;  3CNZ A;  5LT0 A;  1D1B A;  3NWN A;  2V26 A;  1G8X A;  2WOG A;  1T5C A;  3L1C A;  4PJN A;  1MMD A;  2X7E A;  4A1Z A;  1FMW A;  2X51 A;  2Q2Y A;  1V8J A;  2OWM A;  3B6U A;  2Y5W A;  1D0Z A;  3ZFC A;  2PG2 A;  1MMA A;  4ETP A;  2ZFL A;  1MKJ A;  2FL2 A;  4FRZ A;  2G1Q A;  4B7B A;  2MYS A;  4ANJ A;  1VFX A;  2XT3 A;  4LNU K;  4PK4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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