2FL2A

Crystal structure of ksp in complex with inhibitor 19
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
345
structure length
330
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cell cycle
molecule keywords Kinesin-like protein KIF11
publication title Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.
pubmed doi rcsb
source organism Homo sapiens
total genus 101
structure length 330
sequence length 345
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-01-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2fl2A00
4BBGA 3B6VA 4PK4A 3K5EA 1FMWA 2Q2ZA 3KARA 4B7BA 1F9VA 5LT1A 3WPNA 1MNEA 1D0YA 1VFVA 2MYSA 1G8XA 4A28A 2FL2A 2VVGA 3ZFDA 4A5YA 1D1BA 1RY6A 4PJJA 4A1ZA 2UYIA 1D0ZA 3HQDA 5HLEA 2KINA 1MKJA 2ZFMA 2VASA 3K3BA 1II6A 3B6UA 3DCBA 4ETPA 3L1CA 4FRZA 1F9WA 1VOMA 4A50A 3L9HA 5LT3A 1D1AA 3X2TA 1BG2A 4AS7A 4E7SA 1MMNA 2X2RA 3CNZA 1V8JA 4PJNA 1GOJA 4PFPA 4PFOA 5LT0A 1MMGA 3ZCWA 2Q2YA 4ZHIA 4ZCAA 4UBFA 3WRDA 2XAEA 3COBA 3LREA 2XT3A 3GBJA 3U06A 2PG2A 1X88A 2FL6A 2OWMA 3PXNA 2X7DA 2ZFJA 1V8KA 1VFWA 1D0XA 1VFXA 1LKXA 2ZFLA 1F9TA 3T0QA 1CZ7A 1VFZA 1I6IA 3ZFCA 2FKYA 4PJLA 4A14A 3KENA 3CJOA 2WOGA 2X51A 3KINA 1N6MA 2Y65A 2X7CA 2IEHA 4A51A 2FMEA 2UYMA 2X7EA 1BR2A 1KK7A 2GRYA 5LT2A 4ANJA 1MMAA 5GSZA 2VB6A 4PJMA 5LT4A 4DBQA 4BXNA 2GM1A 2ZFKA 1YRSA 1F9UA 3DC4A 4E7ZA 4HNAK 1T5CA 1I5SA 1BR4A 1Q0BA 1SDMA 1BR1A 3BFNA 4Y05A 4LNUK 2G1QA 2HEHA 2NCDA 1LVKA 4GKRA 2Y5WA 4H1GA 2V26A 2ZFIA 3NWNA 4DBRA 3H4SA 1MMDA 1D1CA 1FMVA 4BN2A 4AP0A
chains in the Genus database with same CATH superfamily
4BBGA 3B6VA 4PK4A 3K5EA 1FMWA 2Q2ZA 3KARA 4B7BA 1F9VA 5LT1A 3WPNA 1MNEA 1D0YA 1VFVA 2MYSA 1G8XA 4A28A 2FL2A 2VVGA 3ZFDA 4A5YA 1D1BA 1RY6A 4PJJA 4A1ZA 2UYIA 1D0ZA 3HQDA 5HLEA 2KINA 1MKJA 2ZFMA 2VASA 3K3BA 1II6A 3B6UA 3DCBA 4ETPA 3L1CA 4FRZA 1F9WA 1VOMA 4A50A 3L9HA 5LT3A 1D1AA 3X2TA 1BG2A 4AS7A 4E7SA 1MMNA 2X2RA 3CNZA 1V8JA 4PJNA 1GOJA 4PFPA 4PFOA 5LT0A 1MMGA 3ZCWA 2Q2YA 4ZHIA 4ZCAA 4UBFA 3WRDA 2XAEA 3COBA 3LREA 2XT3A 3GBJA 3U06A 2PG2A 1X88A 2FL6A 2OWMA 3PXNA 2X7DA 2ZFJA 1V8KA 1VFWA 1D0XA 1VFXA 1LKXA 2ZFLA 1F9TA 3T0QA 1CZ7A 1VFZA 1I6IA 3ZFCA 2FKYA 4PJLA 4A14A 3KENA 3CJOA 2WOGA 2X51A 3KINA 1N6MA 2Y65A 2X7CA 2IEHA 4A51A 2FMEA 2UYMA 2X7EA 1BR2A 1KK7A 2GRYA 5LT2A 4ANJA 1MMAA 5GSZA 2VB6A 4GKPA 4PJMA 4GKQA 5LT4A 4DBQA 4BXNA 2GM1A 2ZFKA 1YRSA 1F9UA 3DC4A 4E7ZA 4HNAK 1T5CA 1I5SA 1BR4A 1Q0BA 2O0AA 1SDMA 1BR1A 3BFNA 4Y05A 4ETPB 4LNUK 2G1QA 2HEHA 2NCDA 1LVKA 4GKRA 2Y5WA 4H1GA 2V26A 2ZFIA 3NWNA 4DBRA 3H4SA 1MMDA 1D1CA 1FMVA 4BN2A 4AP0A
chains in the Genus database with same CATH topology
4BBGA 3B6VA 4PK4A 3K5EA 1FMWA 2Q2ZA 3KARA 4B7BA 1F9VA 5LT1A 3WPNA 1MNEA 1D0YA 1VFVA 2MYSA 1G8XA 4A28A 2FL2A 2VVGA 3ZFDA 4A5YA 1D1BA 1RY6A 4PJJA 4A1ZA 2UYIA 1D0ZA 3HQDA 5HLEA 2KINA 1MKJA 2ZFMA 2VASA 3K3BA 1II6A 3B6UA 3DCBA 4ETPA 3L1CA 4FRZA 1F9WA 1VOMA 4A50A 3L9HA 5LT3A 1D1AA 3X2TA 1BG2A 4AS7A 4E7SA 1MMNA 2X2RA 3CNZA 1V8JA 4PJNA 1GOJA 4PFPA 4PFOA 5LT0A 1MMGA 3ZCWA 2Q2YA 4ZHIA 4ZCAA 4UBFA 3WRDA 2XAEA 3COBA 3LREA 2XT3A 3GBJA 3U06A 2PG2A 1X88A 2FL6A 2OWMA 3PXNA 2X7DA 2ZFJA 1V8KA 1VFWA 1D0XA 1VFXA 1LKXA 2ZFLA 1F9TA 3T0QA 1CZ7A 1VFZA 1I6IA 3ZFCA 2FKYA 4PJLA 4A14A 3KENA 3CJOA 2WOGA 2X51A 3KINA 1N6MA 2Y65A 2X7CA 2IEHA 4A51A 2FMEA 2UYMA 2X7EA 1BR2A 1KK7A 2GRYA 5LT2A 4ANJA 1MMAA 5GSZA 2VB6A 4PJMA 5LT4A 4DBQA 4BXNA 2GM1A 2ZFKA 1YRSA 1F9UA 3DC4A 4E7ZA 4HNAK 1T5CA 1I5SA 1BR4A 1Q0BA 1SDMA 1BR1A 3BFNA 4Y05A 4LNUK 2G1QA 2HEHA 2NCDA 1LVKA 4GKRA 2Y5WA 4H1GA 2V26A 2ZFIA 3NWNA 4DBRA 3H4SA 1MMDA 1D1CA 1FMVA 4BN2A 4AP0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BBG A;  3B6V A;  4PK4 A;  3K5E A;  1FMW A;  2Q2Z A;  3KAR A;  4B7B A;  1F9V A;  5LT1 A;  3WPN A;  1MNE A;  1D0Y A;  1VFV A;  2MYS A;  1G8X A;  4A28 A;  2FL2 A;  2VVG A;  3ZFD A;  4A5Y A;  1D1B A;  1RY6 A;  4PJJ A;  4A1Z A;  2UYI A;  1D0Z A;  3HQD A;  5HLE A;  2KIN A;  1MKJ A;  2ZFM A;  2VAS A;  3K3B A;  1II6 A;  3B6U A;  3DCB A;  4ETP A;  3L1C A;  4FRZ A;  1F9W A;  1VOM A;  4A50 A;  3L9H A;  5LT3 A;  1D1A A;  3X2T A;  1BG2 A;  4AS7 A;  4E7S A;  1MMN A;  2X2R A;  3CNZ A;  1V8J A;  4PJN A;  1GOJ A;  4PFP A;  4PFO A;  5LT0 A;  1MMG A;  3ZCW A;  2Q2Y A;  4ZHI A;  4ZCA A;  4UBF A;  3WRD A;  2XAE A;  3COB A;  3LRE A;  2XT3 A;  3GBJ A;  3U06 A;  2PG2 A;  1X88 A;  2FL6 A;  2OWM A;  3PXN A;  2X7D A;  2ZFJ A;  1V8K A;  1VFW A;  1D0X A;  1VFX A;  1LKX A;  2ZFL A;  1F9T A;  3T0Q A;  1CZ7 A;  1VFZ A;  1I6I A;  3ZFC A;  2FKY A;  4PJL A;  4A14 A;  3KEN A;  3CJO A;  2WOG A;  2X51 A;  3KIN A;  1N6M A;  2Y65 A;  2X7C A;  2IEH A;  4A51 A;  2FME A;  2UYM A;  2X7E A;  1BR2 A;  1KK7 A;  2GRY A;  5LT2 A;  4ANJ A;  1MMA A;  5GSZ A;  2VB6 A;  4PJM A;  5LT4 A;  4DBQ A;  4BXN A;  2GM1 A;  2ZFK A;  1YRS A;  1F9U A;  3DC4 A;  4E7Z A;  4HNA K;  1T5C A;  1I5S A;  1BR4 A;  1Q0B A;  1SDM A;  1BR1 A;  3BFN A;  4Y05 A;  4LNU K;  2G1Q A;  2HEH A;  2NCD A;  1LVK A;  4GKR A;  2Y5W A;  4H1G A;  2V26 A;  2ZFI A;  3NWN A;  4DBR A;  3H4S A;  1MMD A;  1D1C A;  1FMV A;  4BN2 A;  4AP0 A; 
#chains in the Genus database with same CATH topology
 4BBG A;  3B6V A;  4PK4 A;  3K5E A;  1FMW A;  2Q2Z A;  3KAR A;  4B7B A;  1F9V A;  5LT1 A;  3WPN A;  1MNE A;  1D0Y A;  1VFV A;  2MYS A;  1G8X A;  4A28 A;  2FL2 A;  2VVG A;  3ZFD A;  4A5Y A;  1D1B A;  1RY6 A;  4PJJ A;  4A1Z A;  2UYI A;  1D0Z A;  3HQD A;  5HLE A;  2KIN A;  1MKJ A;  2ZFM A;  2VAS A;  3K3B A;  1II6 A;  3B6U A;  3DCB A;  4ETP A;  3L1C A;  4FRZ A;  1F9W A;  1VOM A;  4A50 A;  3L9H A;  5LT3 A;  1D1A A;  3X2T A;  1BG2 A;  4AS7 A;  4E7S A;  1MMN A;  2X2R A;  3CNZ A;  1V8J A;  4PJN A;  1GOJ A;  4PFP A;  4PFO A;  5LT0 A;  1MMG A;  3ZCW A;  2Q2Y A;  4ZHI A;  4ZCA A;  4UBF A;  3WRD A;  2XAE A;  3COB A;  3LRE A;  2XT3 A;  3GBJ A;  3U06 A;  2PG2 A;  1X88 A;  2FL6 A;  2OWM A;  3PXN A;  2X7D A;  2ZFJ A;  1V8K A;  1VFW A;  1D0X A;  1VFX A;  1LKX A;  2ZFL A;  1F9T A;  3T0Q A;  1CZ7 A;  1VFZ A;  1I6I A;  3ZFC A;  2FKY A;  4PJL A;  4A14 A;  3KEN A;  3CJO A;  2WOG A;  2X51 A;  3KIN A;  1N6M A;  2Y65 A;  2X7C A;  2IEH A;  4A51 A;  2FME A;  2UYM A;  2X7E A;  1BR2 A;  1KK7 A;  2GRY A;  5LT2 A;  4ANJ A;  1MMA A;  5GSZ A;  2VB6 A;  4GKP A;  4PJM A;  4GKQ A;  5LT4 A;  4DBQ A;  4BXN A;  2GM1 A;  2ZFK A;  1YRS A;  1F9U A;  3DC4 A;  4E7Z A;  4HNA K;  1T5C A;  1I5S A;  1BR4 A;  1Q0B A;  2O0A A;  1SDM A;  1BR1 A;  3BFN A;  4Y05 A;  4ETP B;  4LNU K;  2G1Q A;  2HEH A;  2NCD A;  1LVK A;  4GKR A;  2Y5W A;  4H1G A;  2V26 A;  2ZFI A;  3NWN A;  4DBR A;  3H4S A;  1MMD A;  1D1C A;  1FMV A;  4BN2 A;  4AP0 A; 
#chains in the Genus database with same CATH homology
 4BBG A;  3B6V A;  4PK4 A;  3K5E A;  1FMW A;  2Q2Z A;  3KAR A;  4B7B A;  1F9V A;  5LT1 A;  3WPN A;  1MNE A;  1D0Y A;  1VFV A;  2MYS A;  1G8X A;  4A28 A;  2FL2 A;  2VVG A;  3ZFD A;  4A5Y A;  1D1B A;  1RY6 A;  4PJJ A;  4A1Z A;  2UYI A;  1D0Z A;  3HQD A;  5HLE A;  2KIN A;  1MKJ A;  2ZFM A;  2VAS A;  3K3B A;  1II6 A;  3B6U A;  3DCB A;  4ETP A;  3L1C A;  4FRZ A;  1F9W A;  1VOM A;  4A50 A;  3L9H A;  5LT3 A;  1D1A A;  3X2T A;  1BG2 A;  4AS7 A;  4E7S A;  1MMN A;  2X2R A;  3CNZ A;  1V8J A;  4PJN A;  1GOJ A;  4PFP A;  4PFO A;  5LT0 A;  1MMG A;  3ZCW A;  2Q2Y A;  4ZHI A;  4ZCA A;  4UBF A;  3WRD A;  2XAE A;  3COB A;  3LRE A;  2XT3 A;  3GBJ A;  3U06 A;  2PG2 A;  1X88 A;  2FL6 A;  2OWM A;  3PXN A;  2X7D A;  2ZFJ A;  1V8K A;  1VFW A;  1D0X A;  1VFX A;  1LKX A;  2ZFL A;  1F9T A;  3T0Q A;  1CZ7 A;  1VFZ A;  1I6I A;  3ZFC A;  2FKY A;  4PJL A;  4A14 A;  3KEN A;  3CJO A;  2WOG A;  2X51 A;  3KIN A;  1N6M A;  2Y65 A;  2X7C A;  2IEH A;  4A51 A;  2FME A;  2UYM A;  2X7E A;  1BR2 A;  1KK7 A;  2GRY A;  5LT2 A;  4ANJ A;  1MMA A;  5GSZ A;  2VB6 A;  4PJM A;  5LT4 A;  4DBQ A;  4BXN A;  2GM1 A;  2ZFK A;  1YRS A;  1F9U A;  3DC4 A;  4E7Z A;  4HNA K;  1T5C A;  1I5S A;  1BR4 A;  1Q0B A;  1SDM A;  1BR1 A;  3BFN A;  4Y05 A;  4LNU K;  2G1Q A;  2HEH A;  2NCD A;  1LVK A;  4GKR A;  2Y5W A;  4H1G A;  2V26 A;  2ZFI A;  3NWN A;  4DBR A;  3H4S A;  1MMD A;  1D1C A;  1FMV A;  4BN2 A;  4AP0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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