2FL2A

Crystal structure of ksp in complex with inhibitor 19
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
345
structure length
330
Chain Sequence
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Kinesin-like protein KIF11
publication title Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 101
structure length 330
sequence length 345
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-01-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2fl2A00
3KENA 4H1GA 1MNEA 2FL2A 2OWMA 2FL6A 3T0QA 4A50A 3LREA 1VFZA 4BBGA 4E7ZA 2Y65A 1D0XA 3H4SA 4HNAK 1D1BA 1FMVA 1D0ZA 2UYMA 1F9WA 3WPNA 2VB6A 1MMGA 2X7DA 2ZFKA 4ZCAA 1F9VA 2IEHA 4BXNA 3CNZA 1D1CA 5LT2A 2UYIA 1X88A 4DBQA 4UBFA 2X7EA 3B6UA 4PJJA 3COBA 4A51A 2G1QA 2ZFJA 1I6IA 1SDMA 2GRYA 1VFWA 2XT3A 1FMWA 2V26A 2ZFLA 4GKRA 3KINA 2PG2A 2X51A 1MMDA 4BN2A 4B7BA 2Q2ZA 5LT0A 2GM1A 1Q0BA 2NCDA 1V8JA 3KARA 3ZCWA 4PFPA 3B6VA 4ANJA 5GSZA 3ZFCA 5HLEA 3K5EA 1LVKA 3CJOA 4DBRA 2FMEA 5LT4A 1MKJA 2VVGA 4ZHIA 4A14A 4PJMA 3U06A 1MMAA 1T5CA 3HQDA 1N6MA 1D0YA 1CZ7A 1BR4A 3PXNA 3ZFDA 1LKXA 2X2RA 2Q2YA 2HEHA 1G8XA 1D1AA 2ZFIA 4AS7A 2ZFMA 1F9UA 3L9HA 4Y05A 2VASA 2FKYA 4FRZA 1VFXA 1BR1A 4ETPA 3X2TA 1II6A 1RY6A 1I5SA 4LNUK 3DC4A 4PJNA 1VFVA 3DCBA 5LT3A 2MYSA 1BG2A 1GOJA 4AP0A 1KK7A 4PJLA 4PK4A 3NWNA 1F9TA 1YRSA 4PFOA 4A5YA 3L1CA 2Y5WA 4E7SA 3WRDA 3GBJA 1BR2A 4A28A 1V8KA 2X7CA 4A1ZA 5LT1A 1VOMA 2WOGA 3K3BA 2KINA 3BFNA 1MMNA 2XAEA
chains in the Genus database with same CATH superfamily
3KENA 4H1GA 1MNEA 2FL2A 2OWMA 2FL6A 3T0QA 4A50A 3LREA 1VFZA 4BBGA 4E7ZA 2Y65A 1D0XA 3H4SA 4ETPB 4HNAK 1D1BA 1FMVA 1D0ZA 2UYMA 1F9WA 3WPNA 2VB6A 1MMGA 2X7DA 2ZFKA 4ZCAA 1F9VA 2IEHA 4BXNA 4GKPA 3CNZA 1D1CA 5LT2A 2UYIA 1X88A 4DBQA 4UBFA 2X7EA 3B6UA 4PJJA 3COBA 4A51A 2G1QA 2ZFJA 1I6IA 1SDMA 2GRYA 1VFWA 2XT3A 1FMWA 2V26A 2ZFLA 4GKRA 3KINA 2PG2A 2X51A 1MMDA 4BN2A 4B7BA 2Q2ZA 5LT0A 2GM1A 1Q0BA 2NCDA 1V8JA 3KARA 3ZCWA 4GKQA 4PFPA 3B6VA 4ANJA 5GSZA 3ZFCA 5HLEA 3K5EA 1LVKA 3CJOA 4DBRA 2FMEA 5LT4A 1MKJA 2VVGA 4ZHIA 4A14A 4PJMA 3U06A 1MMAA 1T5CA 3HQDA 1N6MA 1D0YA 1CZ7A 1BR4A 3PXNA 3ZFDA 1LKXA 2X2RA 2Q2YA 2HEHA 1G8XA 1D1AA 2ZFIA 4AS7A 2ZFMA 1F9UA 3L9HA 4Y05A 2VASA 2FKYA 4FRZA 1VFXA 1BR1A 4ETPA 3X2TA 1II6A 1RY6A 1I5SA 4LNUK 2O0AA 3DC4A 4PJNA 1VFVA 3DCBA 5LT3A 2MYSA 1BG2A 1GOJA 4AP0A 1KK7A 4PJLA 4PK4A 3NWNA 1F9TA 1YRSA 4PFOA 4A5YA 3L1CA 2Y5WA 4E7SA 3WRDA 3GBJA 1BR2A 4A28A 1V8KA 2X7CA 4A1ZA 5LT1A 1VOMA 2WOGA 3K3BA 2KINA 3BFNA 1MMNA 2XAEA
chains in the Genus database with same CATH topology
3KENA 4H1GA 1MNEA 2FL2A 2OWMA 2FL6A 3T0QA 4A50A 3LREA 1VFZA 4BBGA 4E7ZA 2Y65A 1D0XA 3H4SA 4HNAK 1D1BA 1FMVA 1D0ZA 2UYMA 1F9WA 3WPNA 2VB6A 1MMGA 2X7DA 2ZFKA 4ZCAA 1F9VA 2IEHA 4BXNA 3CNZA 1D1CA 5LT2A 2UYIA 1X88A 4DBQA 4UBFA 2X7EA 3B6UA 4PJJA 3COBA 4A51A 2G1QA 2ZFJA 1I6IA 1SDMA 2GRYA 1VFWA 2XT3A 1FMWA 2V26A 2ZFLA 4GKRA 3KINA 2PG2A 2X51A 1MMDA 4BN2A 4B7BA 2Q2ZA 5LT0A 2GM1A 1Q0BA 2NCDA 1V8JA 3KARA 3ZCWA 4PFPA 3B6VA 4ANJA 5GSZA 3ZFCA 5HLEA 3K5EA 1LVKA 3CJOA 4DBRA 2FMEA 5LT4A 1MKJA 2VVGA 4ZHIA 4A14A 4PJMA 3U06A 1MMAA 1T5CA 3HQDA 1N6MA 1D0YA 1CZ7A 1BR4A 3PXNA 3ZFDA 1LKXA 2X2RA 2Q2YA 2HEHA 1G8XA 1D1AA 2ZFIA 4AS7A 2ZFMA 1F9UA 3L9HA 4Y05A 2VASA 2FKYA 4FRZA 1VFXA 1BR1A 4ETPA 3X2TA 1II6A 1RY6A 1I5SA 4LNUK 3DC4A 4PJNA 1VFVA 3DCBA 5LT3A 2MYSA 1BG2A 1GOJA 4AP0A 1KK7A 4PJLA 4PK4A 3NWNA 1F9TA 1YRSA 4PFOA 4A5YA 3L1CA 2Y5WA 4E7SA 3WRDA 3GBJA 1BR2A 4A28A 1V8KA 2X7CA 4A1ZA 5LT1A 1VOMA 2WOGA 3K3BA 2KINA 3BFNA 1MMNA 2XAEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KEN A;  4H1G A;  1MNE A;  2FL2 A;  2OWM A;  2FL6 A;  3T0Q A;  4A50 A;  3LRE A;  1VFZ A;  4BBG A;  4E7Z A;  2Y65 A;  1D0X A;  3H4S A;  4HNA K;  1D1B A;  1FMV A;  1D0Z A;  2UYM A;  1F9W A;  3WPN A;  2VB6 A;  1MMG A;  2X7D A;  2ZFK A;  4ZCA A;  1F9V A;  2IEH A;  4BXN A;  3CNZ A;  1D1C A;  5LT2 A;  2UYI A;  1X88 A;  4DBQ A;  4UBF A;  2X7E A;  3B6U A;  4PJJ A;  3COB A;  4A51 A;  2G1Q A;  2ZFJ A;  1I6I A;  1SDM A;  2GRY A;  1VFW A;  2XT3 A;  1FMW A;  2V26 A;  2ZFL A;  4GKR A;  3KIN A;  2PG2 A;  2X51 A;  1MMD A;  4BN2 A;  4B7B A;  2Q2Z A;  5LT0 A;  2GM1 A;  1Q0B A;  2NCD A;  1V8J A;  3KAR A;  3ZCW A;  4PFP A;  3B6V A;  4ANJ A;  5GSZ A;  3ZFC A;  5HLE A;  3K5E A;  1LVK A;  3CJO A;  4DBR A;  2FME A;  5LT4 A;  1MKJ A;  2VVG A;  4ZHI A;  4A14 A;  4PJM A;  3U06 A;  1MMA A;  1T5C A;  3HQD A;  1N6M A;  1D0Y A;  1CZ7 A;  1BR4 A;  3PXN A;  3ZFD A;  1LKX A;  2X2R A;  2Q2Y A;  2HEH A;  1G8X A;  1D1A A;  2ZFI A;  4AS7 A;  2ZFM A;  1F9U A;  3L9H A;  4Y05 A;  2VAS A;  2FKY A;  4FRZ A;  1VFX A;  1BR1 A;  4ETP A;  3X2T A;  1II6 A;  1RY6 A;  1I5S A;  4LNU K;  3DC4 A;  4PJN A;  1VFV A;  3DCB A;  5LT3 A;  2MYS A;  1BG2 A;  1GOJ A;  4AP0 A;  1KK7 A;  4PJL A;  4PK4 A;  3NWN A;  1F9T A;  1YRS A;  4PFO A;  4A5Y A;  3L1C A;  2Y5W A;  4E7S A;  3WRD A;  3GBJ A;  1BR2 A;  4A28 A;  1V8K A;  2X7C A;  4A1Z A;  5LT1 A;  1VOM A;  2WOG A;  3K3B A;  2KIN A;  3BFN A;  1MMN A;  2XAE A; 
#chains in the Genus database with same CATH topology
 3KEN A;  4H1G A;  1MNE A;  2FL2 A;  2OWM A;  2FL6 A;  3T0Q A;  4A50 A;  3LRE A;  1VFZ A;  4BBG A;  4E7Z A;  2Y65 A;  1D0X A;  3H4S A;  4ETP B;  4HNA K;  1D1B A;  1FMV A;  1D0Z A;  2UYM A;  1F9W A;  3WPN A;  2VB6 A;  1MMG A;  2X7D A;  2ZFK A;  4ZCA A;  1F9V A;  2IEH A;  4BXN A;  4GKP A;  3CNZ A;  1D1C A;  5LT2 A;  2UYI A;  1X88 A;  4DBQ A;  4UBF A;  2X7E A;  3B6U A;  4PJJ A;  3COB A;  4A51 A;  2G1Q A;  2ZFJ A;  1I6I A;  1SDM A;  2GRY A;  1VFW A;  2XT3 A;  1FMW A;  2V26 A;  2ZFL A;  4GKR A;  3KIN A;  2PG2 A;  2X51 A;  1MMD A;  4BN2 A;  4B7B A;  2Q2Z A;  5LT0 A;  2GM1 A;  1Q0B A;  2NCD A;  1V8J A;  3KAR A;  3ZCW A;  4GKQ A;  4PFP A;  3B6V A;  4ANJ A;  5GSZ A;  3ZFC A;  5HLE A;  3K5E A;  1LVK A;  3CJO A;  4DBR A;  2FME A;  5LT4 A;  1MKJ A;  2VVG A;  4ZHI A;  4A14 A;  4PJM A;  3U06 A;  1MMA A;  1T5C A;  3HQD A;  1N6M A;  1D0Y A;  1CZ7 A;  1BR4 A;  3PXN A;  3ZFD A;  1LKX A;  2X2R A;  2Q2Y A;  2HEH A;  1G8X A;  1D1A A;  2ZFI A;  4AS7 A;  2ZFM A;  1F9U A;  3L9H A;  4Y05 A;  2VAS A;  2FKY A;  4FRZ A;  1VFX A;  1BR1 A;  4ETP A;  3X2T A;  1II6 A;  1RY6 A;  1I5S A;  4LNU K;  2O0A A;  3DC4 A;  4PJN A;  1VFV A;  3DCB A;  5LT3 A;  2MYS A;  1BG2 A;  1GOJ A;  4AP0 A;  1KK7 A;  4PJL A;  4PK4 A;  3NWN A;  1F9T A;  1YRS A;  4PFO A;  4A5Y A;  3L1C A;  2Y5W A;  4E7S A;  3WRD A;  3GBJ A;  1BR2 A;  4A28 A;  1V8K A;  2X7C A;  4A1Z A;  5LT1 A;  1VOM A;  2WOG A;  3K3B A;  2KIN A;  3BFN A;  1MMN A;  2XAE A; 
#chains in the Genus database with same CATH homology
 3KEN A;  4H1G A;  1MNE A;  2FL2 A;  2OWM A;  2FL6 A;  3T0Q A;  4A50 A;  3LRE A;  1VFZ A;  4BBG A;  4E7Z A;  2Y65 A;  1D0X A;  3H4S A;  4HNA K;  1D1B A;  1FMV A;  1D0Z A;  2UYM A;  1F9W A;  3WPN A;  2VB6 A;  1MMG A;  2X7D A;  2ZFK A;  4ZCA A;  1F9V A;  2IEH A;  4BXN A;  3CNZ A;  1D1C A;  5LT2 A;  2UYI A;  1X88 A;  4DBQ A;  4UBF A;  2X7E A;  3B6U A;  4PJJ A;  3COB A;  4A51 A;  2G1Q A;  2ZFJ A;  1I6I A;  1SDM A;  2GRY A;  1VFW A;  2XT3 A;  1FMW A;  2V26 A;  2ZFL A;  4GKR A;  3KIN A;  2PG2 A;  2X51 A;  1MMD A;  4BN2 A;  4B7B A;  2Q2Z A;  5LT0 A;  2GM1 A;  1Q0B A;  2NCD A;  1V8J A;  3KAR A;  3ZCW A;  4PFP A;  3B6V A;  4ANJ A;  5GSZ A;  3ZFC A;  5HLE A;  3K5E A;  1LVK A;  3CJO A;  4DBR A;  2FME A;  5LT4 A;  1MKJ A;  2VVG A;  4ZHI A;  4A14 A;  4PJM A;  3U06 A;  1MMA A;  1T5C A;  3HQD A;  1N6M A;  1D0Y A;  1CZ7 A;  1BR4 A;  3PXN A;  3ZFD A;  1LKX A;  2X2R A;  2Q2Y A;  2HEH A;  1G8X A;  1D1A A;  2ZFI A;  4AS7 A;  2ZFM A;  1F9U A;  3L9H A;  4Y05 A;  2VAS A;  2FKY A;  4FRZ A;  1VFX A;  1BR1 A;  4ETP A;  3X2T A;  1II6 A;  1RY6 A;  1I5S A;  4LNU K;  3DC4 A;  4PJN A;  1VFV A;  3DCB A;  5LT3 A;  2MYS A;  1BG2 A;  1GOJ A;  4AP0 A;  1KK7 A;  4PJL A;  4PK4 A;  3NWN A;  1F9T A;  1YRS A;  4PFO A;  4A5Y A;  3L1C A;  2Y5W A;  4E7S A;  3WRD A;  3GBJ A;  1BR2 A;  4A28 A;  1V8K A;  2X7C A;  4A1Z A;  5LT1 A;  1VOM A;  2WOG A;  3K3B A;  2KIN A;  3BFN A;  1MMN A;  2XAE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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