2UYMA

Crystal structure of ksp in complex with adp and thiophene containing inhibitor 37
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
347
structure length
331
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Synthesis and Sar of Thiophene Containing Kinesin Spindle Protein (Ksp) Inhibitors.
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords KINESIN-LIKE PROTEIN KIF11
total genus 102
structure length 331
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-04-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2uymA00
5LT0A 1LVKA 4A5YA 2FMEA 4DBQA 4FRZA 5LT1A 2V26A 3DCBA 1I5SA 2X7DA 3CJOA 1FMWA 4ETPA 4B7BA 2OWMA 2X7EA 1VOMA 3NWNA 4DBRA 4E7ZA 4BN2A 1MKJA 2X2RA 4A28A 4ANJA 1N6MA 2FL2A 3KARA 4A14A 1YRSA 3KINA 4A50A 3B6UA 1MMGA 2G1QA 2VVGA 4UBFA 2X51A 2UYMA 2ZFJA 2ZFKA 2ZFMA 2PG2A 2Q2ZA 2HEHA 2XAEA 1SDMA 1V8JA 3L1CA 2GM1A 4ZCAA 4LNUK 3LREA 3WPNA 2FL6A 1FMVA 2Y65A 3HQDA 3ZFCA 1CZ7A 3X2TA 1F9UA 4AS7A 2VB6A 3COBA 1D1AA 4BXNA 1MMAA 1D0YA 3WRDA 1RY6A 1I6IA 1V8KA 4H1GA 1D1BA 1MNEA 4PJNA 1VFXA 1II6A 3H4SA 3K5EA 3ZCWA 1KK7A 1T5CA 1BR1A 2X7CA 4PJMA 4E7SA 1VFWA 2IEHA 1F9WA 2Q2YA 2VASA 2KINA 4HNAK 4PFPA 4PFOA 4PJJA 2WOGA 1F9TA 1G8XA 4Y05A 4A1ZA 1D0XA 1VFVA 4PJLA 1GOJA 3KENA 4PK4A 5HLEA 2Y5WA 2UYIA 2XT3A 3CNZA 2ZFLA 5LT2A 3T0QA 1Q0BA 3L9HA 3K3BA 4ZHIA 1BG2A 3B6VA 4BBGA 2MYSA 1MMNA 1D1CA 3DC4A 4GKRA 3U06A 5LT3A 5GSZA 3GBJA 1VFZA 4A51A 1D0ZA 1BR4A 1BR2A 3PXNA 3BFNA 5LT4A 1F9VA 1LKXA 2GRYA 1MMDA 1X88A 2FKYA 2ZFIA 4AP0A 2NCDA 3ZFDA
chains in the Genus database with same CATH superfamily
5LT0A 1LVKA 4A5YA 2FMEA 4DBQA 4FRZA 5LT1A 2V26A 3DCBA 1I5SA 2X7DA 3CJOA 1FMWA 4ETPA 4B7BA 2OWMA 2X7EA 1VOMA 3NWNA 4DBRA 4E7ZA 4BN2A 1MKJA 2X2RA 4A28A 4ANJA 1N6MA 2FL2A 3KARA 4A14A 1YRSA 3KINA 4A50A 3B6UA 1MMGA 2G1QA 2VVGA 4UBFA 2X51A 2UYMA 2ZFJA 2ZFKA 2ZFMA 2PG2A 2Q2ZA 2HEHA 2XAEA 1SDMA 1V8JA 3L1CA 2GM1A 4ZCAA 4LNUK 3LREA 3WPNA 2FL6A 1FMVA 2Y65A 3HQDA 3ZFCA 1CZ7A 3X2TA 1F9UA 4AS7A 2VB6A 3COBA 1D1AA 4BXNA 1MMAA 1D0YA 3WRDA 4GKPA 1RY6A 1I6IA 1V8KA 4H1GA 1D1BA 1MNEA 4PJNA 1VFXA 4GKQA 1II6A 3H4SA 3K5EA 3ZCWA 1KK7A 1T5CA 1BR1A 2X7CA 4PJMA 4E7SA 1VFWA 2IEHA 1F9WA 2Q2YA 2VASA 2KINA 4HNAK 4PFPA 4PFOA 4PJJA 2WOGA 1F9TA 1G8XA 4Y05A 4A1ZA 1D0XA 1VFVA 4PJLA 1GOJA 3KENA 4PK4A 5HLEA 2Y5WA 2UYIA 2XT3A 3CNZA 2ZFLA 5LT2A 3T0QA 1Q0BA 3L9HA 4ETPB 3K3BA 4ZHIA 1BG2A 3B6VA 4BBGA 2MYSA 1MMNA 1D1CA 3DC4A 4GKRA 3U06A 5LT3A 2O0AA 5GSZA 3GBJA 1VFZA 4A51A 1D0ZA 1BR4A 1BR2A 3PXNA 3BFNA 5LT4A 1F9VA 1LKXA 2GRYA 1MMDA 1X88A 2FKYA 2ZFIA 4AP0A 2NCDA 3ZFDA
chains in the Genus database with same CATH topology
5LT0A 1LVKA 4A5YA 2FMEA 4DBQA 4FRZA 5LT1A 2V26A 3DCBA 1I5SA 2X7DA 3CJOA 1FMWA 4ETPA 4B7BA 2OWMA 2X7EA 1VOMA 3NWNA 4DBRA 4E7ZA 4BN2A 1MKJA 2X2RA 4A28A 4ANJA 1N6MA 2FL2A 3KARA 4A14A 1YRSA 3KINA 4A50A 3B6UA 1MMGA 2G1QA 2VVGA 4UBFA 2X51A 2UYMA 2ZFJA 2ZFKA 2ZFMA 2PG2A 2Q2ZA 2HEHA 2XAEA 1SDMA 1V8JA 3L1CA 2GM1A 4ZCAA 4LNUK 3LREA 3WPNA 2FL6A 1FMVA 2Y65A 3HQDA 3ZFCA 1CZ7A 3X2TA 1F9UA 4AS7A 2VB6A 3COBA 1D1AA 4BXNA 1MMAA 1D0YA 3WRDA 1RY6A 1I6IA 1V8KA 4H1GA 1D1BA 1MNEA 4PJNA 1VFXA 1II6A 3H4SA 3K5EA 3ZCWA 1KK7A 1T5CA 1BR1A 2X7CA 4PJMA 4E7SA 1VFWA 2IEHA 1F9WA 2Q2YA 2VASA 2KINA 4HNAK 4PFPA 4PFOA 4PJJA 2WOGA 1F9TA 1G8XA 4Y05A 4A1ZA 1D0XA 1VFVA 4PJLA 1GOJA 3KENA 4PK4A 5HLEA 2Y5WA 2UYIA 2XT3A 3CNZA 2ZFLA 5LT2A 3T0QA 1Q0BA 3L9HA 3K3BA 4ZHIA 1BG2A 3B6VA 4BBGA 2MYSA 1MMNA 1D1CA 3DC4A 4GKRA 3U06A 5LT3A 5GSZA 3GBJA 1VFZA 4A51A 1D0ZA 1BR4A 1BR2A 3PXNA 3BFNA 5LT4A 1F9VA 1LKXA 2GRYA 1MMDA 1X88A 2FKYA 2ZFIA 4AP0A 2NCDA 3ZFDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LT0 A;  1LVK A;  4A5Y A;  2FME A;  4DBQ A;  4FRZ A;  5LT1 A;  2V26 A;  3DCB A;  1I5S A;  2X7D A;  3CJO A;  1FMW A;  4ETP A;  4B7B A;  2OWM A;  2X7E A;  1VOM A;  3NWN A;  4DBR A;  4E7Z A;  4BN2 A;  1MKJ A;  2X2R A;  4A28 A;  4ANJ A;  1N6M A;  2FL2 A;  3KAR A;  4A14 A;  1YRS A;  3KIN A;  4A50 A;  3B6U A;  1MMG A;  2G1Q A;  2VVG A;  4UBF A;  2X51 A;  2UYM A;  2ZFJ A;  2ZFK A;  2ZFM A;  2PG2 A;  2Q2Z A;  2HEH A;  2XAE A;  1SDM A;  1V8J A;  3L1C A;  2GM1 A;  4ZCA A;  4LNU K;  3LRE A;  3WPN A;  2FL6 A;  1FMV A;  2Y65 A;  3HQD A;  3ZFC A;  1CZ7 A;  3X2T A;  1F9U A;  4AS7 A;  2VB6 A;  3COB A;  1D1A A;  4BXN A;  1MMA A;  1D0Y A;  3WRD A;  1RY6 A;  1I6I A;  1V8K A;  4H1G A;  1D1B A;  1MNE A;  4PJN A;  1VFX A;  1II6 A;  3H4S A;  3K5E A;  3ZCW A;  1KK7 A;  1T5C A;  1BR1 A;  2X7C A;  4PJM A;  4E7S A;  1VFW A;  2IEH A;  1F9W A;  2Q2Y A;  2VAS A;  2KIN A;  4HNA K;  4PFP A;  4PFO A;  4PJJ A;  2WOG A;  1F9T A;  1G8X A;  4Y05 A;  4A1Z A;  1D0X A;  1VFV A;  4PJL A;  1GOJ A;  3KEN A;  4PK4 A;  5HLE A;  2Y5W A;  2UYI A;  2XT3 A;  3CNZ A;  2ZFL A;  5LT2 A;  3T0Q A;  1Q0B A;  3L9H A;  3K3B A;  4ZHI A;  1BG2 A;  3B6V A;  4BBG A;  2MYS A;  1MMN A;  1D1C A;  3DC4 A;  4GKR A;  3U06 A;  5LT3 A;  5GSZ A;  3GBJ A;  1VFZ A;  4A51 A;  1D0Z A;  1BR4 A;  1BR2 A;  3PXN A;  3BFN A;  5LT4 A;  1F9V A;  1LKX A;  2GRY A;  1MMD A;  1X88 A;  2FKY A;  2ZFI A;  4AP0 A;  2NCD A;  3ZFD A; 
#chains in the Genus database with same CATH topology
 5LT0 A;  1LVK A;  4A5Y A;  2FME A;  4DBQ A;  4FRZ A;  5LT1 A;  2V26 A;  3DCB A;  1I5S A;  2X7D A;  3CJO A;  1FMW A;  4ETP A;  4B7B A;  2OWM A;  2X7E A;  1VOM A;  3NWN A;  4DBR A;  4E7Z A;  4BN2 A;  1MKJ A;  2X2R A;  4A28 A;  4ANJ A;  1N6M A;  2FL2 A;  3KAR A;  4A14 A;  1YRS A;  3KIN A;  4A50 A;  3B6U A;  1MMG A;  2G1Q A;  2VVG A;  4UBF A;  2X51 A;  2UYM A;  2ZFJ A;  2ZFK A;  2ZFM A;  2PG2 A;  2Q2Z A;  2HEH A;  2XAE A;  1SDM A;  1V8J A;  3L1C A;  2GM1 A;  4ZCA A;  4LNU K;  3LRE A;  3WPN A;  2FL6 A;  1FMV A;  2Y65 A;  3HQD A;  3ZFC A;  1CZ7 A;  3X2T A;  1F9U A;  4AS7 A;  2VB6 A;  3COB A;  1D1A A;  4BXN A;  1MMA A;  1D0Y A;  3WRD A;  4GKP A;  1RY6 A;  1I6I A;  1V8K A;  4H1G A;  1D1B A;  1MNE A;  4PJN A;  1VFX A;  4GKQ A;  1II6 A;  3H4S A;  3K5E A;  3ZCW A;  1KK7 A;  1T5C A;  1BR1 A;  2X7C A;  4PJM A;  4E7S A;  1VFW A;  2IEH A;  1F9W A;  2Q2Y A;  2VAS A;  2KIN A;  4HNA K;  4PFP A;  4PFO A;  4PJJ A;  2WOG A;  1F9T A;  1G8X A;  4Y05 A;  4A1Z A;  1D0X A;  1VFV A;  4PJL A;  1GOJ A;  3KEN A;  4PK4 A;  5HLE A;  2Y5W A;  2UYI A;  2XT3 A;  3CNZ A;  2ZFL A;  5LT2 A;  3T0Q A;  1Q0B A;  3L9H A;  4ETP B;  3K3B A;  4ZHI A;  1BG2 A;  3B6V A;  4BBG A;  2MYS A;  1MMN A;  1D1C A;  3DC4 A;  4GKR A;  3U06 A;  5LT3 A;  2O0A A;  5GSZ A;  3GBJ A;  1VFZ A;  4A51 A;  1D0Z A;  1BR4 A;  1BR2 A;  3PXN A;  3BFN A;  5LT4 A;  1F9V A;  1LKX A;  2GRY A;  1MMD A;  1X88 A;  2FKY A;  2ZFI A;  4AP0 A;  2NCD A;  3ZFD A; 
#chains in the Genus database with same CATH homology
 5LT0 A;  1LVK A;  4A5Y A;  2FME A;  4DBQ A;  4FRZ A;  5LT1 A;  2V26 A;  3DCB A;  1I5S A;  2X7D A;  3CJO A;  1FMW A;  4ETP A;  4B7B A;  2OWM A;  2X7E A;  1VOM A;  3NWN A;  4DBR A;  4E7Z A;  4BN2 A;  1MKJ A;  2X2R A;  4A28 A;  4ANJ A;  1N6M A;  2FL2 A;  3KAR A;  4A14 A;  1YRS A;  3KIN A;  4A50 A;  3B6U A;  1MMG A;  2G1Q A;  2VVG A;  4UBF A;  2X51 A;  2UYM A;  2ZFJ A;  2ZFK A;  2ZFM A;  2PG2 A;  2Q2Z A;  2HEH A;  2XAE A;  1SDM A;  1V8J A;  3L1C A;  2GM1 A;  4ZCA A;  4LNU K;  3LRE A;  3WPN A;  2FL6 A;  1FMV A;  2Y65 A;  3HQD A;  3ZFC A;  1CZ7 A;  3X2T A;  1F9U A;  4AS7 A;  2VB6 A;  3COB A;  1D1A A;  4BXN A;  1MMA A;  1D0Y A;  3WRD A;  1RY6 A;  1I6I A;  1V8K A;  4H1G A;  1D1B A;  1MNE A;  4PJN A;  1VFX A;  1II6 A;  3H4S A;  3K5E A;  3ZCW A;  1KK7 A;  1T5C A;  1BR1 A;  2X7C A;  4PJM A;  4E7S A;  1VFW A;  2IEH A;  1F9W A;  2Q2Y A;  2VAS A;  2KIN A;  4HNA K;  4PFP A;  4PFO A;  4PJJ A;  2WOG A;  1F9T A;  1G8X A;  4Y05 A;  4A1Z A;  1D0X A;  1VFV A;  4PJL A;  1GOJ A;  3KEN A;  4PK4 A;  5HLE A;  2Y5W A;  2UYI A;  2XT3 A;  3CNZ A;  2ZFL A;  5LT2 A;  3T0Q A;  1Q0B A;  3L9H A;  3K3B A;  4ZHI A;  1BG2 A;  3B6V A;  4BBG A;  2MYS A;  1MMN A;  1D1C A;  3DC4 A;  4GKR A;  3U06 A;  5LT3 A;  5GSZ A;  3GBJ A;  1VFZ A;  4A51 A;  1D0Z A;  1BR4 A;  1BR2 A;  3PXN A;  3BFN A;  5LT4 A;  1F9V A;  1LKX A;  2GRY A;  1MMD A;  1X88 A;  2FKY A;  2ZFI A;  4AP0 A;  2NCD A;  3ZFD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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