2UYMA

Crystal structure of ksp in complex with adp and thiophene containing inhibitor 37
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
347
structure length
331
Chain Sequence
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Synthesis and Sar of Thiophene Containing Kinesin Spindle Protein (Ksp) Inhibitors.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 102
structure length 331
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-04-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2uymA00
3T0QA 4PFPA 2GRYA 2VASA 1YRSA 2FL2A 2VVGA 1D1BA 3L9HA 2FKYA 3ZFDA 2XAEA 4PJNA 2X51A 3CNZA 1BG2A 4ZHIA 2UYIA 3U06A 4UBFA 5LT0A 2Y65A 3WPNA 3ZFCA 4B7BA 4AS7A 1BR1A 2Q2ZA 4A28A 3CJOA 4FRZA 3BFNA 3K3BA 3GBJA 4LNUK 3COBA 1VOMA 4PJJA 4BXNA 2ZFMA 4PJLA 2KINA 4BN2A 3PXNA 5LT3A 2ZFJA 4A50A 2MYSA 2ZFIA 3L1CA 1F9VA 1F9UA 2FMEA 2VB6A 1N6MA 2Q2YA 4ZCAA 4DBRA 2X2RA 2XT3A 2X7EA 3KINA 1D0ZA 4H1GA 3HQDA 1FMVA 1BR4A 4E7SA 1BR2A 5LT4A 4PK4A 1VFVA 5GSZA 1MKJA 1VFWA 2G1QA 1I5SA 5HLEA 3LREA 1F9TA 1Q0BA 1D1CA 1VFZA 2WOGA 2ZFKA 1II6A 4ETPA 1D1AA 3KENA 2NCDA 4ANJA 4HNAK 3B6UA 4A5YA 1D0XA 4A51A 1MMNA 1V8JA 1V8KA 3ZCWA 1T5CA 2PG2A 4GKRA 1SDMA 1FMWA 1MMGA 2GM1A 1CZ7A 3KARA 2FL6A 2Y5WA 1LKXA 4PFOA 1D0YA 1MMAA 4E7ZA 3DCBA 3WRDA 2X7DA 2UYMA 1F9WA 3X2TA 1VFXA 2OWMA 5LT2A 3NWNA 4BBGA 1X88A 4AP0A 2HEHA 2IEHA 4A14A 5LT1A 3DC4A 4Y05A 1I6IA 1MNEA 3H4SA 1LVKA 4DBQA 4A1ZA 2V26A 3K5EA 3B6VA 1GOJA 1G8XA 1KK7A 1RY6A 2ZFLA 4PJMA 2X7CA 1MMDA
chains in the Genus database with same CATH superfamily
3T0QA 4PFPA 2GRYA 2VASA 1YRSA 2FL2A 2VVGA 1D1BA 3L9HA 2FKYA 4ETPB 3ZFDA 2XAEA 4PJNA 2X51A 3CNZA 1BG2A 4ZHIA 2UYIA 3U06A 4UBFA 5LT0A 2Y65A 3WPNA 3ZFCA 4B7BA 4AS7A 1BR1A 2Q2ZA 4GKPA 4A28A 3CJOA 4FRZA 3BFNA 3K3BA 3GBJA 4LNUK 3COBA 1VOMA 4PJJA 4BXNA 2ZFMA 4PJLA 2KINA 4BN2A 3PXNA 5LT3A 2ZFJA 4A50A 2MYSA 2ZFIA 3L1CA 1F9VA 1F9UA 2FMEA 2VB6A 1N6MA 2Q2YA 4ZCAA 4DBRA 2X2RA 2XT3A 2X7EA 3KINA 1D0ZA 4H1GA 3HQDA 1FMVA 1BR4A 4E7SA 1BR2A 5LT4A 4PK4A 1VFVA 5GSZA 1MKJA 1VFWA 2G1QA 1I5SA 5HLEA 3LREA 1F9TA 1Q0BA 1D1CA 1VFZA 2WOGA 2ZFKA 1II6A 4ETPA 1D1AA 3KENA 2NCDA 4ANJA 4HNAK 3B6UA 2O0AA 4A5YA 1D0XA 4A51A 1MMNA 1V8JA 1V8KA 3ZCWA 1T5CA 2PG2A 4GKRA 1SDMA 1FMWA 1MMGA 2GM1A 1CZ7A 3KARA 4GKQA 2FL6A 2Y5WA 1LKXA 4PFOA 1D0YA 1MMAA 4E7ZA 3DCBA 3WRDA 2X7DA 2UYMA 1F9WA 3X2TA 1VFXA 2OWMA 5LT2A 3NWNA 4BBGA 1X88A 4AP0A 2HEHA 2IEHA 4A14A 5LT1A 3DC4A 4Y05A 1I6IA 1MNEA 3H4SA 1LVKA 4DBQA 4A1ZA 2V26A 3K5EA 3B6VA 1GOJA 1G8XA 1KK7A 1RY6A 2ZFLA 4PJMA 2X7CA 1MMDA
chains in the Genus database with same CATH topology
3T0QA 4PFPA 2GRYA 2VASA 1YRSA 2FL2A 2VVGA 1D1BA 3L9HA 2FKYA 3ZFDA 2XAEA 4PJNA 2X51A 3CNZA 1BG2A 4ZHIA 2UYIA 3U06A 4UBFA 5LT0A 2Y65A 3WPNA 3ZFCA 4B7BA 4AS7A 1BR1A 2Q2ZA 4A28A 3CJOA 4FRZA 3BFNA 3K3BA 3GBJA 4LNUK 3COBA 1VOMA 4PJJA 4BXNA 2ZFMA 4PJLA 2KINA 4BN2A 3PXNA 5LT3A 2ZFJA 4A50A 2MYSA 2ZFIA 3L1CA 1F9VA 1F9UA 2FMEA 2VB6A 1N6MA 2Q2YA 4ZCAA 4DBRA 2X2RA 2XT3A 2X7EA 3KINA 1D0ZA 4H1GA 3HQDA 1FMVA 1BR4A 4E7SA 1BR2A 5LT4A 4PK4A 1VFVA 5GSZA 1MKJA 1VFWA 2G1QA 1I5SA 5HLEA 3LREA 1F9TA 1Q0BA 1D1CA 1VFZA 2WOGA 2ZFKA 1II6A 4ETPA 1D1AA 3KENA 2NCDA 4ANJA 4HNAK 3B6UA 4A5YA 1D0XA 4A51A 1MMNA 1V8JA 1V8KA 3ZCWA 1T5CA 2PG2A 4GKRA 1SDMA 1FMWA 1MMGA 2GM1A 1CZ7A 3KARA 2FL6A 2Y5WA 1LKXA 4PFOA 1D0YA 1MMAA 4E7ZA 3DCBA 3WRDA 2X7DA 2UYMA 1F9WA 3X2TA 1VFXA 2OWMA 5LT2A 3NWNA 4BBGA 1X88A 4AP0A 2HEHA 2IEHA 4A14A 5LT1A 3DC4A 4Y05A 1I6IA 1MNEA 3H4SA 1LVKA 4DBQA 4A1ZA 2V26A 3K5EA 3B6VA 1GOJA 1G8XA 1KK7A 1RY6A 2ZFLA 4PJMA 2X7CA 1MMDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3T0Q A;  4PFP A;  2GRY A;  2VAS A;  1YRS A;  2FL2 A;  2VVG A;  1D1B A;  3L9H A;  2FKY A;  3ZFD A;  2XAE A;  4PJN A;  2X51 A;  3CNZ A;  1BG2 A;  4ZHI A;  2UYI A;  3U06 A;  4UBF A;  5LT0 A;  2Y65 A;  3WPN A;  3ZFC A;  4B7B A;  4AS7 A;  1BR1 A;  2Q2Z A;  4A28 A;  3CJO A;  4FRZ A;  3BFN A;  3K3B A;  3GBJ A;  4LNU K;  3COB A;  1VOM A;  4PJJ A;  4BXN A;  2ZFM A;  4PJL A;  2KIN A;  4BN2 A;  3PXN A;  5LT3 A;  2ZFJ A;  4A50 A;  2MYS A;  2ZFI A;  3L1C A;  1F9V A;  1F9U A;  2FME A;  2VB6 A;  1N6M A;  2Q2Y A;  4ZCA A;  4DBR A;  2X2R A;  2XT3 A;  2X7E A;  3KIN A;  1D0Z A;  4H1G A;  3HQD A;  1FMV A;  1BR4 A;  4E7S A;  1BR2 A;  5LT4 A;  4PK4 A;  1VFV A;  5GSZ A;  1MKJ A;  1VFW A;  2G1Q A;  1I5S A;  5HLE A;  3LRE A;  1F9T A;  1Q0B A;  1D1C A;  1VFZ A;  2WOG A;  2ZFK A;  1II6 A;  4ETP A;  1D1A A;  3KEN A;  2NCD A;  4ANJ A;  4HNA K;  3B6U A;  4A5Y A;  1D0X A;  4A51 A;  1MMN A;  1V8J A;  1V8K A;  3ZCW A;  1T5C A;  2PG2 A;  4GKR A;  1SDM A;  1FMW A;  1MMG A;  2GM1 A;  1CZ7 A;  3KAR A;  2FL6 A;  2Y5W A;  1LKX A;  4PFO A;  1D0Y A;  1MMA A;  4E7Z A;  3DCB A;  3WRD A;  2X7D A;  2UYM A;  1F9W A;  3X2T A;  1VFX A;  2OWM A;  5LT2 A;  3NWN A;  4BBG A;  1X88 A;  4AP0 A;  2HEH A;  2IEH A;  4A14 A;  5LT1 A;  3DC4 A;  4Y05 A;  1I6I A;  1MNE A;  3H4S A;  1LVK A;  4DBQ A;  4A1Z A;  2V26 A;  3K5E A;  3B6V A;  1GOJ A;  1G8X A;  1KK7 A;  1RY6 A;  2ZFL A;  4PJM A;  2X7C A;  1MMD A; 
#chains in the Genus database with same CATH topology
 3T0Q A;  4PFP A;  2GRY A;  2VAS A;  1YRS A;  2FL2 A;  2VVG A;  1D1B A;  3L9H A;  2FKY A;  4ETP B;  3ZFD A;  2XAE A;  4PJN A;  2X51 A;  3CNZ A;  1BG2 A;  4ZHI A;  2UYI A;  3U06 A;  4UBF A;  5LT0 A;  2Y65 A;  3WPN A;  3ZFC A;  4B7B A;  4AS7 A;  1BR1 A;  2Q2Z A;  4GKP A;  4A28 A;  3CJO A;  4FRZ A;  3BFN A;  3K3B A;  3GBJ A;  4LNU K;  3COB A;  1VOM A;  4PJJ A;  4BXN A;  2ZFM A;  4PJL A;  2KIN A;  4BN2 A;  3PXN A;  5LT3 A;  2ZFJ A;  4A50 A;  2MYS A;  2ZFI A;  3L1C A;  1F9V A;  1F9U A;  2FME A;  2VB6 A;  1N6M A;  2Q2Y A;  4ZCA A;  4DBR A;  2X2R A;  2XT3 A;  2X7E A;  3KIN A;  1D0Z A;  4H1G A;  3HQD A;  1FMV A;  1BR4 A;  4E7S A;  1BR2 A;  5LT4 A;  4PK4 A;  1VFV A;  5GSZ A;  1MKJ A;  1VFW A;  2G1Q A;  1I5S A;  5HLE A;  3LRE A;  1F9T A;  1Q0B A;  1D1C A;  1VFZ A;  2WOG A;  2ZFK A;  1II6 A;  4ETP A;  1D1A A;  3KEN A;  2NCD A;  4ANJ A;  4HNA K;  3B6U A;  2O0A A;  4A5Y A;  1D0X A;  4A51 A;  1MMN A;  1V8J A;  1V8K A;  3ZCW A;  1T5C A;  2PG2 A;  4GKR A;  1SDM A;  1FMW A;  1MMG A;  2GM1 A;  1CZ7 A;  3KAR A;  4GKQ A;  2FL6 A;  2Y5W A;  1LKX A;  4PFO A;  1D0Y A;  1MMA A;  4E7Z A;  3DCB A;  3WRD A;  2X7D A;  2UYM A;  1F9W A;  3X2T A;  1VFX A;  2OWM A;  5LT2 A;  3NWN A;  4BBG A;  1X88 A;  4AP0 A;  2HEH A;  2IEH A;  4A14 A;  5LT1 A;  3DC4 A;  4Y05 A;  1I6I A;  1MNE A;  3H4S A;  1LVK A;  4DBQ A;  4A1Z A;  2V26 A;  3K5E A;  3B6V A;  1GOJ A;  1G8X A;  1KK7 A;  1RY6 A;  2ZFL A;  4PJM A;  2X7C A;  1MMD A; 
#chains in the Genus database with same CATH homology
 3T0Q A;  4PFP A;  2GRY A;  2VAS A;  1YRS A;  2FL2 A;  2VVG A;  1D1B A;  3L9H A;  2FKY A;  3ZFD A;  2XAE A;  4PJN A;  2X51 A;  3CNZ A;  1BG2 A;  4ZHI A;  2UYI A;  3U06 A;  4UBF A;  5LT0 A;  2Y65 A;  3WPN A;  3ZFC A;  4B7B A;  4AS7 A;  1BR1 A;  2Q2Z A;  4A28 A;  3CJO A;  4FRZ A;  3BFN A;  3K3B A;  3GBJ A;  4LNU K;  3COB A;  1VOM A;  4PJJ A;  4BXN A;  2ZFM A;  4PJL A;  2KIN A;  4BN2 A;  3PXN A;  5LT3 A;  2ZFJ A;  4A50 A;  2MYS A;  2ZFI A;  3L1C A;  1F9V A;  1F9U A;  2FME A;  2VB6 A;  1N6M A;  2Q2Y A;  4ZCA A;  4DBR A;  2X2R A;  2XT3 A;  2X7E A;  3KIN A;  1D0Z A;  4H1G A;  3HQD A;  1FMV A;  1BR4 A;  4E7S A;  1BR2 A;  5LT4 A;  4PK4 A;  1VFV A;  5GSZ A;  1MKJ A;  1VFW A;  2G1Q A;  1I5S A;  5HLE A;  3LRE A;  1F9T A;  1Q0B A;  1D1C A;  1VFZ A;  2WOG A;  2ZFK A;  1II6 A;  4ETP A;  1D1A A;  3KEN A;  2NCD A;  4ANJ A;  4HNA K;  3B6U A;  4A5Y A;  1D0X A;  4A51 A;  1MMN A;  1V8J A;  1V8K A;  3ZCW A;  1T5C A;  2PG2 A;  4GKR A;  1SDM A;  1FMW A;  1MMG A;  2GM1 A;  1CZ7 A;  3KAR A;  2FL6 A;  2Y5W A;  1LKX A;  4PFO A;  1D0Y A;  1MMA A;  4E7Z A;  3DCB A;  3WRD A;  2X7D A;  2UYM A;  1F9W A;  3X2T A;  1VFX A;  2OWM A;  5LT2 A;  3NWN A;  4BBG A;  1X88 A;  4AP0 A;  2HEH A;  2IEH A;  4A14 A;  5LT1 A;  3DC4 A;  4Y05 A;  1I6I A;  1MNE A;  3H4S A;  1LVK A;  4DBQ A;  4A1Z A;  2V26 A;  3K5E A;  3B6V A;  1GOJ A;  1G8X A;  1KK7 A;  1RY6 A;  2ZFL A;  4PJM A;  2X7C A;  1MMD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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