2UYMA

Crystal structure of ksp in complex with adp and thiophene containing inhibitor 37
Total Genus 102
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
347
structure length
331
Chain Sequence
b'GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Synthesis and Sar of Thiophene Containing Kinesin Spindle Protein (Ksp) Inhibitors.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 102
structure length 331
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-04-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2uymA00
2V26A 2X2RA 3L9HA 1VFWA 3NWNA 4E7ZA 1I5SA 4AS7A 2VB6A 4A1ZA 2XAEA 3U06A 2UYIA 4FRZA 4PFPA 1F9UA 2X7CA 3WRDA 2Y65A 4A28A 4DBQA 2OWMA 4A5YA 4LNUK 3LREA 1D0YA 1F9WA 1VFZA 4ANJA 1N6MA 1MMGA 4BXNA 1D1CA 2ZFJA 5LT3A 3X2TA 2G1QA 5LT2A 2FKYA 2Q2YA 2X7DA 4B7BA 1D0ZA 1FMVA 5GSZA 5LT0A 4A14A 3B6VA 4PJJA 4PJNA 2GM1A 1VFVA 2IEHA 1D1AA 4H1GA 4PFOA 3COBA 4A51A 1II6A 1MMAA 5LT4A 3KENA 2X51A 1D0XA 2UYMA 4BBGA 4PJMA 3K3BA 1VOMA 3L1CA 4BN2A 2MYSA 4A50A 1D1BA 2Y5WA 1V8JA 1T5CA 4PK4A 1LVKA 2VVGA 3T0QA 1YRSA 1BG2A 1BR1A 1F9TA 4GKRA 1LKXA 3H4SA 2ZFIA 2VASA 2XT3A 2Q2ZA 1GOJA 3KINA 3PXNA 2GRYA 5LT1A 4ZHIA 3K5EA 4ZCAA 4HNAK 3DC4A 2WOGA 1BR2A 1G8XA 4AP0A 3CJOA 1MKJA 1V8KA 2ZFMA 3DCBA 5HLEA 1I6IA 2FL6A 2X7EA 2ZFKA 4DBRA 4E7SA 4Y05A 2HEHA 3B6UA 3WPNA 1VFXA 3ZFCA 1MMDA 1MMNA 1SDMA 3GBJA 1FMWA 2PG2A 1BR4A 2FMEA 4ETPA 1F9VA 4PJLA 1RY6A 3ZCWA 1MNEA 2NCDA 3ZFDA 2FL2A 3KARA 4UBFA 3BFNA 1Q0BA 3CNZA 1KK7A 2ZFLA 2KINA 3HQDA 1X88A 1CZ7A
chains in the Genus database with same CATH superfamily
2V26A 2X2RA 3L9HA 1VFWA 3NWNA 4E7ZA 1I5SA 2O0AA 4AS7A 2VB6A 4A1ZA 2XAEA 3U06A 2UYIA 4FRZA 4PFPA 1F9UA 2X7CA 3WRDA 2Y65A 4GKQA 4A28A 4DBQA 2OWMA 4A5YA 4LNUK 3LREA 1D0YA 1F9WA 1VFZA 4ANJA 1N6MA 1MMGA 4BXNA 1D1CA 2ZFJA 5LT3A 3X2TA 2G1QA 5LT2A 2FKYA 2Q2YA 2X7DA 4B7BA 1D0ZA 1FMVA 5GSZA 5LT0A 4A14A 3B6VA 4PJJA 4PJNA 2GM1A 1VFVA 2IEHA 1D1AA 4H1GA 4PFOA 3COBA 4A51A 1II6A 1MMAA 5LT4A 3KENA 2X51A 1D0XA 2UYMA 4BBGA 4PJMA 3K3BA 1VOMA 3L1CA 4BN2A 2MYSA 4A50A 1D1BA 2Y5WA 1V8JA 1T5CA 4PK4A 1LVKA 2VVGA 3T0QA 1YRSA 1BG2A 1BR1A 1F9TA 4GKRA 1LKXA 3H4SA 2ZFIA 2VASA 2XT3A 2Q2ZA 1GOJA 3KINA 3PXNA 2GRYA 5LT1A 4ETPB 4ZHIA 3K5EA 4ZCAA 4HNAK 3DC4A 2WOGA 1BR2A 1G8XA 4AP0A 3CJOA 1MKJA 4GKPA 1V8KA 2ZFMA 3DCBA 5HLEA 1I6IA 2FL6A 2X7EA 2ZFKA 4DBRA 4E7SA 4Y05A 2HEHA 3B6UA 3WPNA 1VFXA 3ZFCA 1MMDA 1MMNA 1SDMA 3GBJA 1FMWA 2PG2A 1BR4A 2FMEA 4ETPA 1F9VA 4PJLA 1RY6A 3ZCWA 1MNEA 2NCDA 3ZFDA 2FL2A 3KARA 4UBFA 3BFNA 1Q0BA 3CNZA 1KK7A 2ZFLA 2KINA 3HQDA 1X88A 1CZ7A
chains in the Genus database with same CATH topology
2V26A 2X2RA 3L9HA 1VFWA 3NWNA 4E7ZA 1I5SA 4AS7A 2VB6A 4A1ZA 2XAEA 3U06A 2UYIA 4FRZA 4PFPA 1F9UA 2X7CA 3WRDA 2Y65A 4A28A 4DBQA 2OWMA 4A5YA 4LNUK 3LREA 1D0YA 1F9WA 1VFZA 4ANJA 1N6MA 1MMGA 4BXNA 1D1CA 2ZFJA 5LT3A 3X2TA 2G1QA 5LT2A 2FKYA 2Q2YA 2X7DA 4B7BA 1D0ZA 1FMVA 5GSZA 5LT0A 4A14A 3B6VA 4PJJA 4PJNA 2GM1A 1VFVA 2IEHA 1D1AA 4H1GA 4PFOA 3COBA 4A51A 1II6A 1MMAA 5LT4A 3KENA 2X51A 1D0XA 2UYMA 4BBGA 4PJMA 3K3BA 1VOMA 3L1CA 4BN2A 2MYSA 4A50A 1D1BA 2Y5WA 1V8JA 1T5CA 4PK4A 1LVKA 2VVGA 3T0QA 1YRSA 1BG2A 1BR1A 1F9TA 4GKRA 1LKXA 3H4SA 2ZFIA 2VASA 2XT3A 2Q2ZA 1GOJA 3KINA 3PXNA 2GRYA 5LT1A 4ZHIA 3K5EA 4ZCAA 4HNAK 3DC4A 2WOGA 1BR2A 1G8XA 4AP0A 3CJOA 1MKJA 1V8KA 2ZFMA 3DCBA 5HLEA 1I6IA 2FL6A 2X7EA 2ZFKA 4DBRA 4E7SA 4Y05A 2HEHA 3B6UA 3WPNA 1VFXA 3ZFCA 1MMDA 1MMNA 1SDMA 3GBJA 1FMWA 2PG2A 1BR4A 2FMEA 4ETPA 1F9VA 4PJLA 1RY6A 3ZCWA 1MNEA 2NCDA 3ZFDA 2FL2A 3KARA 4UBFA 3BFNA 1Q0BA 3CNZA 1KK7A 2ZFLA 2KINA 3HQDA 1X88A 1CZ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2V26 A;  2X2R A;  3L9H A;  1VFW A;  3NWN A;  4E7Z A;  1I5S A;  4AS7 A;  2VB6 A;  4A1Z A;  2XAE A;  3U06 A;  2UYI A;  4FRZ A;  4PFP A;  1F9U A;  2X7C A;  3WRD A;  2Y65 A;  4A28 A;  4DBQ A;  2OWM A;  4A5Y A;  4LNU K;  3LRE A;  1D0Y A;  1F9W A;  1VFZ A;  4ANJ A;  1N6M A;  1MMG A;  4BXN A;  1D1C A;  2ZFJ A;  5LT3 A;  3X2T A;  2G1Q A;  5LT2 A;  2FKY A;  2Q2Y A;  2X7D A;  4B7B A;  1D0Z A;  1FMV A;  5GSZ A;  5LT0 A;  4A14 A;  3B6V A;  4PJJ A;  4PJN A;  2GM1 A;  1VFV A;  2IEH A;  1D1A A;  4H1G A;  4PFO A;  3COB A;  4A51 A;  1II6 A;  1MMA A;  5LT4 A;  3KEN A;  2X51 A;  1D0X A;  2UYM A;  4BBG A;  4PJM A;  3K3B A;  1VOM A;  3L1C A;  4BN2 A;  2MYS A;  4A50 A;  1D1B A;  2Y5W A;  1V8J A;  1T5C A;  4PK4 A;  1LVK A;  2VVG A;  3T0Q A;  1YRS A;  1BG2 A;  1BR1 A;  1F9T A;  4GKR A;  1LKX A;  3H4S A;  2ZFI A;  2VAS A;  2XT3 A;  2Q2Z A;  1GOJ A;  3KIN A;  3PXN A;  2GRY A;  5LT1 A;  4ZHI A;  3K5E A;  4ZCA A;  4HNA K;  3DC4 A;  2WOG A;  1BR2 A;  1G8X A;  4AP0 A;  3CJO A;  1MKJ A;  1V8K A;  2ZFM A;  3DCB A;  5HLE A;  1I6I A;  2FL6 A;  2X7E A;  2ZFK A;  4DBR A;  4E7S A;  4Y05 A;  2HEH A;  3B6U A;  3WPN A;  1VFX A;  3ZFC A;  1MMD A;  1MMN A;  1SDM A;  3GBJ A;  1FMW A;  2PG2 A;  1BR4 A;  2FME A;  4ETP A;  1F9V A;  4PJL A;  1RY6 A;  3ZCW A;  1MNE A;  2NCD A;  3ZFD A;  2FL2 A;  3KAR A;  4UBF A;  3BFN A;  1Q0B A;  3CNZ A;  1KK7 A;  2ZFL A;  2KIN A;  3HQD A;  1X88 A;  1CZ7 A; 
#chains in the Genus database with same CATH topology
 2V26 A;  2X2R A;  3L9H A;  1VFW A;  3NWN A;  4E7Z A;  1I5S A;  2O0A A;  4AS7 A;  2VB6 A;  4A1Z A;  2XAE A;  3U06 A;  2UYI A;  4FRZ A;  4PFP A;  1F9U A;  2X7C A;  3WRD A;  2Y65 A;  4GKQ A;  4A28 A;  4DBQ A;  2OWM A;  4A5Y A;  4LNU K;  3LRE A;  1D0Y A;  1F9W A;  1VFZ A;  4ANJ A;  1N6M A;  1MMG A;  4BXN A;  1D1C A;  2ZFJ A;  5LT3 A;  3X2T A;  2G1Q A;  5LT2 A;  2FKY A;  2Q2Y A;  2X7D A;  4B7B A;  1D0Z A;  1FMV A;  5GSZ A;  5LT0 A;  4A14 A;  3B6V A;  4PJJ A;  4PJN A;  2GM1 A;  1VFV A;  2IEH A;  1D1A A;  4H1G A;  4PFO A;  3COB A;  4A51 A;  1II6 A;  1MMA A;  5LT4 A;  3KEN A;  2X51 A;  1D0X A;  2UYM A;  4BBG A;  4PJM A;  3K3B A;  1VOM A;  3L1C A;  4BN2 A;  2MYS A;  4A50 A;  1D1B A;  2Y5W A;  1V8J A;  1T5C A;  4PK4 A;  1LVK A;  2VVG A;  3T0Q A;  1YRS A;  1BG2 A;  1BR1 A;  1F9T A;  4GKR A;  1LKX A;  3H4S A;  2ZFI A;  2VAS A;  2XT3 A;  2Q2Z A;  1GOJ A;  3KIN A;  3PXN A;  2GRY A;  5LT1 A;  4ETP B;  4ZHI A;  3K5E A;  4ZCA A;  4HNA K;  3DC4 A;  2WOG A;  1BR2 A;  1G8X A;  4AP0 A;  3CJO A;  1MKJ A;  4GKP A;  1V8K A;  2ZFM A;  3DCB A;  5HLE A;  1I6I A;  2FL6 A;  2X7E A;  2ZFK A;  4DBR A;  4E7S A;  4Y05 A;  2HEH A;  3B6U A;  3WPN A;  1VFX A;  3ZFC A;  1MMD A;  1MMN A;  1SDM A;  3GBJ A;  1FMW A;  2PG2 A;  1BR4 A;  2FME A;  4ETP A;  1F9V A;  4PJL A;  1RY6 A;  3ZCW A;  1MNE A;  2NCD A;  3ZFD A;  2FL2 A;  3KAR A;  4UBF A;  3BFN A;  1Q0B A;  3CNZ A;  1KK7 A;  2ZFL A;  2KIN A;  3HQD A;  1X88 A;  1CZ7 A; 
#chains in the Genus database with same CATH homology
 2V26 A;  2X2R A;  3L9H A;  1VFW A;  3NWN A;  4E7Z A;  1I5S A;  4AS7 A;  2VB6 A;  4A1Z A;  2XAE A;  3U06 A;  2UYI A;  4FRZ A;  4PFP A;  1F9U A;  2X7C A;  3WRD A;  2Y65 A;  4A28 A;  4DBQ A;  2OWM A;  4A5Y A;  4LNU K;  3LRE A;  1D0Y A;  1F9W A;  1VFZ A;  4ANJ A;  1N6M A;  1MMG A;  4BXN A;  1D1C A;  2ZFJ A;  5LT3 A;  3X2T A;  2G1Q A;  5LT2 A;  2FKY A;  2Q2Y A;  2X7D A;  4B7B A;  1D0Z A;  1FMV A;  5GSZ A;  5LT0 A;  4A14 A;  3B6V A;  4PJJ A;  4PJN A;  2GM1 A;  1VFV A;  2IEH A;  1D1A A;  4H1G A;  4PFO A;  3COB A;  4A51 A;  1II6 A;  1MMA A;  5LT4 A;  3KEN A;  2X51 A;  1D0X A;  2UYM A;  4BBG A;  4PJM A;  3K3B A;  1VOM A;  3L1C A;  4BN2 A;  2MYS A;  4A50 A;  1D1B A;  2Y5W A;  1V8J A;  1T5C A;  4PK4 A;  1LVK A;  2VVG A;  3T0Q A;  1YRS A;  1BG2 A;  1BR1 A;  1F9T A;  4GKR A;  1LKX A;  3H4S A;  2ZFI A;  2VAS A;  2XT3 A;  2Q2Z A;  1GOJ A;  3KIN A;  3PXN A;  2GRY A;  5LT1 A;  4ZHI A;  3K5E A;  4ZCA A;  4HNA K;  3DC4 A;  2WOG A;  1BR2 A;  1G8X A;  4AP0 A;  3CJO A;  1MKJ A;  1V8K A;  2ZFM A;  3DCB A;  5HLE A;  1I6I A;  2FL6 A;  2X7E A;  2ZFK A;  4DBR A;  4E7S A;  4Y05 A;  2HEH A;  3B6U A;  3WPN A;  1VFX A;  3ZFC A;  1MMD A;  1MMN A;  1SDM A;  3GBJ A;  1FMW A;  2PG2 A;  1BR4 A;  2FME A;  4ETP A;  1F9V A;  4PJL A;  1RY6 A;  3ZCW A;  1MNE A;  2NCD A;  3ZFD A;  2FL2 A;  3KAR A;  4UBF A;  3BFN A;  1Q0B A;  3CNZ A;  1KK7 A;  2ZFL A;  2KIN A;  3HQD A;  1X88 A;  1CZ7 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...