2UYIA

Crystal structure of ksp in complex with adp and thiophene containing inhibitor 33
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
347
structure length
331
Chain Sequence
b'GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Synthesis and Sar of Thiophene Containing Kinesin Spindle Protein (Ksp) Inhibitors.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 102
structure length 331
sequence length 347
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-04-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2uyiA00
3B6UA 3B6VA 4B7BA 4ETPA 2X7DA 2Q2ZA 4GKRA 1VFWA 1YRSA 1F9VA 5LT2A 4PK4A 1VFXA 2FMEA 3BFNA 3KARA 3LREA 2PG2A 1G8XA 1I5SA 2ZFMA 1II6A 3K5EA 4E7SA 2XAEA 3WRDA 1LVKA 1V8KA 1MMAA 4A51A 3NWNA 4DBQA 3U06A 2FL2A 3K3BA 2IEHA 2ZFLA 4FRZA 2GRYA 2KINA 2XT3A 4A28A 2X7EA 1BG2A 5LT3A 2Y5WA 3WPNA 1X88A 3GBJA 3ZCWA 4PJLA 5LT0A 1BR4A 2NCDA 1F9UA 3L9HA 1T5CA 1F9WA 3T0QA 3COBA 3KINA 4AP0A 1MMDA 1D0YA 1N6MA 1BR1A 4Y05A 4BXNA 4DBRA 1MMNA 4H1GA 4PFOA 2VVGA 2FKYA 1Q0BA 4ZHIA 3DC4A 1KK7A 1VOMA 3DCBA 2OWMA 2FL6A 3KENA 3ZFCA 5LT1A 4PJMA 1CZ7A 1V8JA 2Q2YA 2ZFIA 3PXNA 5GSZA 2X7CA 1VFVA 2VASA 3H4SA 4AS7A 1F9TA 4ZCAA 4ANJA 1I6IA 1LKXA 4LNUK 2UYIA 3X2TA 4A1ZA 1FMVA 2VB6A 4UBFA 4E7ZA 1FMWA 1MNEA 1RY6A 1D1AA 4A50A 2X51A 2GM1A 1D1BA 3HQDA 2UYMA 2X2RA 4HNAK 1D0XA 4PJNA 1MKJA 3ZFDA 1SDMA 1GOJA 1VFZA 2HEHA 2ZFKA 2V26A 4PJJA 5HLEA 2MYSA 2Y65A 5LT4A 1D1CA 2WOGA 1MMGA 4BN2A 1D0ZA 3CNZA 2ZFJA 3L1CA 4BBGA 1BR2A 3CJOA 4A5YA 2G1QA 4A14A 4PFPA
chains in the Genus database with same CATH superfamily
3B6UA 3B6VA 4B7BA 4ETPA 2X7DA 2Q2ZA 4GKRA 1VFWA 1YRSA 1F9VA 5LT2A 4PK4A 1VFXA 2FMEA 3BFNA 3KARA 3LREA 2PG2A 1G8XA 1I5SA 2ZFMA 1II6A 3K5EA 4E7SA 2XAEA 3WRDA 1LVKA 1V8KA 1MMAA 4A51A 3NWNA 4DBQA 3U06A 2FL2A 3K3BA 2IEHA 2ZFLA 4FRZA 2GRYA 2KINA 2XT3A 4A28A 2X7EA 1BG2A 5LT3A 2Y5WA 3WPNA 1X88A 3GBJA 3ZCWA 4PJLA 5LT0A 1BR4A 2NCDA 1F9UA 3L9HA 1T5CA 1F9WA 3T0QA 3COBA 2O0AA 3KINA 1MMDA 4AP0A 1D0YA 1N6MA 1BR1A 4Y05A 4BXNA 4DBRA 1MMNA 4H1GA 4PFOA 2VVGA 2FKYA 1Q0BA 4ZHIA 4ETPB 4GKQA 3DC4A 1KK7A 1VOMA 3DCBA 2OWMA 2FL6A 3KENA 3ZFCA 5LT1A 4PJMA 1CZ7A 1V8JA 2Q2YA 2ZFIA 3PXNA 5GSZA 2X7CA 4GKPA 1VFVA 2VASA 3H4SA 4AS7A 1F9TA 4ZCAA 4ANJA 1I6IA 1LKXA 4LNUK 2UYIA 3X2TA 4A1ZA 1FMVA 2VB6A 4UBFA 4E7ZA 1FMWA 1MNEA 1RY6A 1D1AA 4A50A 2X51A 2GM1A 1D1BA 3HQDA 2UYMA 2X2RA 4HNAK 1D0XA 4PJNA 1MKJA 3ZFDA 1SDMA 1GOJA 1VFZA 2HEHA 2ZFKA 2V26A 4PJJA 5HLEA 2MYSA 2Y65A 5LT4A 1D1CA 2WOGA 1MMGA 4BN2A 1D0ZA 3CNZA 2ZFJA 3L1CA 4BBGA 1BR2A 3CJOA 4A5YA 2G1QA 4A14A 4PFPA
chains in the Genus database with same CATH topology
3B6UA 3B6VA 4B7BA 4ETPA 2X7DA 2Q2ZA 4GKRA 1VFWA 1YRSA 1F9VA 5LT2A 4PK4A 1VFXA 2FMEA 3BFNA 3KARA 3LREA 2PG2A 1G8XA 1I5SA 2ZFMA 1II6A 3K5EA 4E7SA 2XAEA 3WRDA 1LVKA 1V8KA 1MMAA 4A51A 3NWNA 4DBQA 3U06A 2FL2A 3K3BA 2IEHA 2ZFLA 4FRZA 2GRYA 2KINA 2XT3A 4A28A 2X7EA 1BG2A 5LT3A 2Y5WA 3WPNA 1X88A 3GBJA 3ZCWA 4PJLA 5LT0A 1BR4A 2NCDA 1F9UA 3L9HA 1T5CA 1F9WA 3T0QA 3COBA 3KINA 4AP0A 1MMDA 1D0YA 1N6MA 1BR1A 4Y05A 4BXNA 4DBRA 1MMNA 4H1GA 4PFOA 2VVGA 2FKYA 1Q0BA 4ZHIA 3DC4A 1KK7A 1VOMA 3DCBA 2OWMA 2FL6A 3KENA 3ZFCA 5LT1A 4PJMA 1CZ7A 1V8JA 2Q2YA 2ZFIA 3PXNA 5GSZA 2X7CA 1VFVA 2VASA 3H4SA 4AS7A 1F9TA 4ZCAA 4ANJA 1I6IA 1LKXA 4LNUK 2UYIA 3X2TA 4A1ZA 1FMVA 2VB6A 4UBFA 4E7ZA 1FMWA 1MNEA 1RY6A 1D1AA 4A50A 2X51A 2GM1A 1D1BA 3HQDA 2UYMA 2X2RA 4HNAK 1D0XA 4PJNA 1MKJA 3ZFDA 1SDMA 1GOJA 1VFZA 2HEHA 2ZFKA 2V26A 4PJJA 5HLEA 2MYSA 2Y65A 5LT4A 1D1CA 2WOGA 1MMGA 4BN2A 1D0ZA 3CNZA 2ZFJA 3L1CA 4BBGA 1BR2A 3CJOA 4A5YA 2G1QA 4A14A 4PFPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3B6U A;  3B6V A;  4B7B A;  4ETP A;  2X7D A;  2Q2Z A;  4GKR A;  1VFW A;  1YRS A;  1F9V A;  5LT2 A;  4PK4 A;  1VFX A;  2FME A;  3BFN A;  3KAR A;  3LRE A;  2PG2 A;  1G8X A;  1I5S A;  2ZFM A;  1II6 A;  3K5E A;  4E7S A;  2XAE A;  3WRD A;  1LVK A;  1V8K A;  1MMA A;  4A51 A;  3NWN A;  4DBQ A;  3U06 A;  2FL2 A;  3K3B A;  2IEH A;  2ZFL A;  4FRZ A;  2GRY A;  2KIN A;  2XT3 A;  4A28 A;  2X7E A;  1BG2 A;  5LT3 A;  2Y5W A;  3WPN A;  1X88 A;  3GBJ A;  3ZCW A;  4PJL A;  5LT0 A;  1BR4 A;  2NCD A;  1F9U A;  3L9H A;  1T5C A;  1F9W A;  3T0Q A;  3COB A;  3KIN A;  4AP0 A;  1MMD A;  1D0Y A;  1N6M A;  1BR1 A;  4Y05 A;  4BXN A;  4DBR A;  1MMN A;  4H1G A;  4PFO A;  2VVG A;  2FKY A;  1Q0B A;  4ZHI A;  3DC4 A;  1KK7 A;  1VOM A;  3DCB A;  2OWM A;  2FL6 A;  3KEN A;  3ZFC A;  5LT1 A;  4PJM A;  1CZ7 A;  1V8J A;  2Q2Y A;  2ZFI A;  3PXN A;  5GSZ A;  2X7C A;  1VFV A;  2VAS A;  3H4S A;  4AS7 A;  1F9T A;  4ZCA A;  4ANJ A;  1I6I A;  1LKX A;  4LNU K;  2UYI A;  3X2T A;  4A1Z A;  1FMV A;  2VB6 A;  4UBF A;  4E7Z A;  1FMW A;  1MNE A;  1RY6 A;  1D1A A;  4A50 A;  2X51 A;  2GM1 A;  1D1B A;  3HQD A;  2UYM A;  2X2R A;  4HNA K;  1D0X A;  4PJN A;  1MKJ A;  3ZFD A;  1SDM A;  1GOJ A;  1VFZ A;  2HEH A;  2ZFK A;  2V26 A;  4PJJ A;  5HLE A;  2MYS A;  2Y65 A;  5LT4 A;  1D1C A;  2WOG A;  1MMG A;  4BN2 A;  1D0Z A;  3CNZ A;  2ZFJ A;  3L1C A;  4BBG A;  1BR2 A;  3CJO A;  4A5Y A;  2G1Q A;  4A14 A;  4PFP A; 
#chains in the Genus database with same CATH topology
 3B6U A;  3B6V A;  4B7B A;  4ETP A;  2X7D A;  2Q2Z A;  4GKR A;  1VFW A;  1YRS A;  1F9V A;  5LT2 A;  4PK4 A;  1VFX A;  2FME A;  3BFN A;  3KAR A;  3LRE A;  2PG2 A;  1G8X A;  1I5S A;  2ZFM A;  1II6 A;  3K5E A;  4E7S A;  2XAE A;  3WRD A;  1LVK A;  1V8K A;  1MMA A;  4A51 A;  3NWN A;  4DBQ A;  3U06 A;  2FL2 A;  3K3B A;  2IEH A;  2ZFL A;  4FRZ A;  2GRY A;  2KIN A;  2XT3 A;  4A28 A;  2X7E A;  1BG2 A;  5LT3 A;  2Y5W A;  3WPN A;  1X88 A;  3GBJ A;  3ZCW A;  4PJL A;  5LT0 A;  1BR4 A;  2NCD A;  1F9U A;  3L9H A;  1T5C A;  1F9W A;  3T0Q A;  3COB A;  2O0A A;  3KIN A;  1MMD A;  4AP0 A;  1D0Y A;  1N6M A;  1BR1 A;  4Y05 A;  4BXN A;  4DBR A;  1MMN A;  4H1G A;  4PFO A;  2VVG A;  2FKY A;  1Q0B A;  4ZHI A;  4ETP B;  4GKQ A;  3DC4 A;  1KK7 A;  1VOM A;  3DCB A;  2OWM A;  2FL6 A;  3KEN A;  3ZFC A;  5LT1 A;  4PJM A;  1CZ7 A;  1V8J A;  2Q2Y A;  2ZFI A;  3PXN A;  5GSZ A;  2X7C A;  4GKP A;  1VFV A;  2VAS A;  3H4S A;  4AS7 A;  1F9T A;  4ZCA A;  4ANJ A;  1I6I A;  1LKX A;  4LNU K;  2UYI A;  3X2T A;  4A1Z A;  1FMV A;  2VB6 A;  4UBF A;  4E7Z A;  1FMW A;  1MNE A;  1RY6 A;  1D1A A;  4A50 A;  2X51 A;  2GM1 A;  1D1B A;  3HQD A;  2UYM A;  2X2R A;  4HNA K;  1D0X A;  4PJN A;  1MKJ A;  3ZFD A;  1SDM A;  1GOJ A;  1VFZ A;  2HEH A;  2ZFK A;  2V26 A;  4PJJ A;  5HLE A;  2MYS A;  2Y65 A;  5LT4 A;  1D1C A;  2WOG A;  1MMG A;  4BN2 A;  1D0Z A;  3CNZ A;  2ZFJ A;  3L1C A;  4BBG A;  1BR2 A;  3CJO A;  4A5Y A;  2G1Q A;  4A14 A;  4PFP A; 
#chains in the Genus database with same CATH homology
 3B6U A;  3B6V A;  4B7B A;  4ETP A;  2X7D A;  2Q2Z A;  4GKR A;  1VFW A;  1YRS A;  1F9V A;  5LT2 A;  4PK4 A;  1VFX A;  2FME A;  3BFN A;  3KAR A;  3LRE A;  2PG2 A;  1G8X A;  1I5S A;  2ZFM A;  1II6 A;  3K5E A;  4E7S A;  2XAE A;  3WRD A;  1LVK A;  1V8K A;  1MMA A;  4A51 A;  3NWN A;  4DBQ A;  3U06 A;  2FL2 A;  3K3B A;  2IEH A;  2ZFL A;  4FRZ A;  2GRY A;  2KIN A;  2XT3 A;  4A28 A;  2X7E A;  1BG2 A;  5LT3 A;  2Y5W A;  3WPN A;  1X88 A;  3GBJ A;  3ZCW A;  4PJL A;  5LT0 A;  1BR4 A;  2NCD A;  1F9U A;  3L9H A;  1T5C A;  1F9W A;  3T0Q A;  3COB A;  3KIN A;  4AP0 A;  1MMD A;  1D0Y A;  1N6M A;  1BR1 A;  4Y05 A;  4BXN A;  4DBR A;  1MMN A;  4H1G A;  4PFO A;  2VVG A;  2FKY A;  1Q0B A;  4ZHI A;  3DC4 A;  1KK7 A;  1VOM A;  3DCB A;  2OWM A;  2FL6 A;  3KEN A;  3ZFC A;  5LT1 A;  4PJM A;  1CZ7 A;  1V8J A;  2Q2Y A;  2ZFI A;  3PXN A;  5GSZ A;  2X7C A;  1VFV A;  2VAS A;  3H4S A;  4AS7 A;  1F9T A;  4ZCA A;  4ANJ A;  1I6I A;  1LKX A;  4LNU K;  2UYI A;  3X2T A;  4A1Z A;  1FMV A;  2VB6 A;  4UBF A;  4E7Z A;  1FMW A;  1MNE A;  1RY6 A;  1D1A A;  4A50 A;  2X51 A;  2GM1 A;  1D1B A;  3HQD A;  2UYM A;  2X2R A;  4HNA K;  1D0X A;  4PJN A;  1MKJ A;  3ZFD A;  1SDM A;  1GOJ A;  1VFZ A;  2HEH A;  2ZFK A;  2V26 A;  4PJJ A;  5HLE A;  2MYS A;  2Y65 A;  5LT4 A;  1D1C A;  2WOG A;  1MMG A;  4BN2 A;  1D0Z A;  3CNZ A;  2ZFJ A;  3L1C A;  4BBG A;  1BR2 A;  3CJO A;  4A5Y A;  2G1Q A;  4A14 A;  4PFP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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