2X7EA

Crystal structure of human kinesin eg5 in complex with (r)-fluorastrol
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
348
structure length
333
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 104
structure length 333
sequence length 348
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 2x7eA00
2X2RA 1MNEA 2IEHA 3COBA 2FL2A 2X7CA 1SDMA 1II6A 1F9VA 1MMAA 3CJOA 3PXNA 4A50A 5LT0A 1MMGA 1D0ZA 1MMDA 4Y05A 4AP0A 2MYSA 4ZCAA 1VOMA 5LT1A 2HEHA 1YRSA 4BBGA 2PG2A 1BR4A 1V8KA 2NCDA 4UBFA 2ZFKA 2ZFMA 1KK7A 5LT4A 1VFVA 2ZFIA 2FKYA 4AS7A 1F9UA 2Y5WA 2VVGA 2ZFJA 3H4SA 3HQDA 5HLEA 2XT3A 1FMVA 2GM1A 4E7ZA 3LREA 1Q0BA 4DBRA 1BR1A 3B6VA 2G1QA 3BFNA 1D1BA 3KARA 1T5CA 2KINA 1I5SA 3GBJA 3K3BA 5GSZA 1MKJA 2VASA 1F9WA 2V26A 4PJMA 1FMWA 5LT2A 1F9TA 1VFWA 1RY6A 1G8XA 1CZ7A 4B7BA 2UYMA 3B6UA 2XAEA 4LNUK 1I6IA 2UYIA 1GOJA 4A51A 3U06A 1D1AA 4A14A 4PFPA 3DCBA 4ANJA 1D0XA 3L1CA 4A28A 3ZCWA 3X2TA 2ZFLA 2X51A 4BN2A 2WOGA 3KENA 3NWNA 4PJNA 2X7DA 1X88A 4ETPA 1V8JA 3ZFDA 5LT3A 4DBQA 1D0YA 4ZHIA 1VFZA 2X7EA 2Q2ZA 3ZFCA 3L9HA 3WRDA 1BG2A 2Q2YA 1N6MA 4PJJA 1LVKA 4PK4A 2FMEA 2OWMA 2GRYA 4H1GA 3K5EA 2Y65A 1LKXA 3WPNA 3DC4A 2VB6A 1BR2A 3T0QA 1MMNA 4FRZA 1VFXA 4HNAK 4A1ZA 4E7SA 1D1CA 3KINA 4A5YA 4BXNA 4PJLA 3CNZA 4GKRA 4PFOA 2FL6A
chains in the Genus database with same CATH superfamily
2X2RA 4GKQA 1MNEA 2IEHA 3COBA 2FL2A 2X7CA 1SDMA 1II6A 1F9VA 1MMAA 3CJOA 3PXNA 4A50A 5LT0A 1MMGA 1D0ZA 1MMDA 4Y05A 4AP0A 2MYSA 4ZCAA 1VOMA 5LT1A 2HEHA 1YRSA 4BBGA 2PG2A 1BR4A 1V8KA 2NCDA 2O0AA 4UBFA 2ZFKA 2ZFMA 1KK7A 5LT4A 1VFVA 2ZFIA 2FKYA 4AS7A 1F9UA 2Y5WA 2VVGA 2ZFJA 3H4SA 3HQDA 5HLEA 2XT3A 1FMVA 2GM1A 4E7ZA 3LREA 1Q0BA 4DBRA 1BR1A 3B6VA 2G1QA 3BFNA 1D1BA 3KARA 1T5CA 2KINA 4GKPA 1I5SA 3GBJA 3K3BA 5GSZA 1MKJA 2VASA 1F9WA 2V26A 4PJMA 1FMWA 5LT2A 1F9TA 1VFWA 1RY6A 1G8XA 1CZ7A 4B7BA 2UYMA 3B6UA 2XAEA 4LNUK 1I6IA 2UYIA 1GOJA 4A51A 3U06A 1D1AA 4A14A 4PFPA 3DCBA 4ANJA 1D0XA 3L1CA 4A28A 3ZCWA 3X2TA 2ZFLA 2X51A 4BN2A 2WOGA 3KENA 3NWNA 4PJNA 4ETPB 2X7DA 1X88A 4ETPA 1V8JA 3ZFDA 5LT3A 4DBQA 1D0YA 4ZHIA 1VFZA 2X7EA 2Q2ZA 3ZFCA 3L9HA 3WRDA 1BG2A 2Q2YA 1N6MA 4PJJA 1LVKA 4PK4A 2FMEA 2OWMA 2GRYA 4H1GA 3K5EA 2Y65A 1LKXA 3WPNA 3DC4A 2VB6A 1BR2A 3T0QA 1MMNA 4FRZA 1VFXA 4HNAK 4A1ZA 4E7SA 1D1CA 3KINA 4A5YA 4BXNA 4PJLA 3CNZA 4GKRA 4PFOA 2FL6A
chains in the Genus database with same CATH topology
2X2RA 1MNEA 2IEHA 3COBA 2FL2A 2X7CA 1SDMA 1II6A 1F9VA 1MMAA 3CJOA 3PXNA 4A50A 5LT0A 1MMGA 1D0ZA 1MMDA 4Y05A 4AP0A 2MYSA 4ZCAA 1VOMA 5LT1A 2HEHA 1YRSA 4BBGA 2PG2A 1BR4A 1V8KA 2NCDA 4UBFA 2ZFKA 2ZFMA 1KK7A 5LT4A 1VFVA 2ZFIA 2FKYA 4AS7A 1F9UA 2Y5WA 2VVGA 2ZFJA 3H4SA 3HQDA 5HLEA 2XT3A 1FMVA 2GM1A 4E7ZA 3LREA 1Q0BA 4DBRA 1BR1A 3B6VA 2G1QA 3BFNA 1D1BA 3KARA 1T5CA 2KINA 1I5SA 3GBJA 3K3BA 5GSZA 1MKJA 2VASA 1F9WA 2V26A 4PJMA 1FMWA 5LT2A 1F9TA 1VFWA 1RY6A 1G8XA 1CZ7A 4B7BA 2UYMA 3B6UA 2XAEA 4LNUK 1I6IA 2UYIA 1GOJA 4A51A 3U06A 1D1AA 4A14A 4PFPA 3DCBA 4ANJA 1D0XA 3L1CA 4A28A 3ZCWA 3X2TA 2ZFLA 2X51A 4BN2A 2WOGA 3KENA 3NWNA 4PJNA 2X7DA 1X88A 4ETPA 1V8JA 3ZFDA 5LT3A 4DBQA 1D0YA 4ZHIA 1VFZA 2X7EA 2Q2ZA 3ZFCA 3L9HA 3WRDA 1BG2A 2Q2YA 1N6MA 4PJJA 1LVKA 4PK4A 2FMEA 2OWMA 2GRYA 4H1GA 3K5EA 2Y65A 1LKXA 3WPNA 3DC4A 2VB6A 1BR2A 3T0QA 1MMNA 4FRZA 1VFXA 4HNAK 4A1ZA 4E7SA 1D1CA 3KINA 4A5YA 4BXNA 4PJLA 3CNZA 4GKRA 4PFOA 2FL6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2X2R A;  1MNE A;  2IEH A;  3COB A;  2FL2 A;  2X7C A;  1SDM A;  1II6 A;  1F9V A;  1MMA A;  3CJO A;  3PXN A;  4A50 A;  5LT0 A;  1MMG A;  1D0Z A;  1MMD A;  4Y05 A;  4AP0 A;  2MYS A;  4ZCA A;  1VOM A;  5LT1 A;  2HEH A;  1YRS A;  4BBG A;  2PG2 A;  1BR4 A;  1V8K A;  2NCD A;  4UBF A;  2ZFK A;  2ZFM A;  1KK7 A;  5LT4 A;  1VFV A;  2ZFI A;  2FKY A;  4AS7 A;  1F9U A;  2Y5W A;  2VVG A;  2ZFJ A;  3H4S A;  3HQD A;  5HLE A;  2XT3 A;  1FMV A;  2GM1 A;  4E7Z A;  3LRE A;  1Q0B A;  4DBR A;  1BR1 A;  3B6V A;  2G1Q A;  3BFN A;  1D1B A;  3KAR A;  1T5C A;  2KIN A;  1I5S A;  3GBJ A;  3K3B A;  5GSZ A;  1MKJ A;  2VAS A;  1F9W A;  2V26 A;  4PJM A;  1FMW A;  5LT2 A;  1F9T A;  1VFW A;  1RY6 A;  1G8X A;  1CZ7 A;  4B7B A;  2UYM A;  3B6U A;  2XAE A;  4LNU K;  1I6I A;  2UYI A;  1GOJ A;  4A51 A;  3U06 A;  1D1A A;  4A14 A;  4PFP A;  3DCB A;  4ANJ A;  1D0X A;  3L1C A;  4A28 A;  3ZCW A;  3X2T A;  2ZFL A;  2X51 A;  4BN2 A;  2WOG A;  3KEN A;  3NWN A;  4PJN A;  2X7D A;  1X88 A;  4ETP A;  1V8J A;  3ZFD A;  5LT3 A;  4DBQ A;  1D0Y A;  4ZHI A;  1VFZ A;  2X7E A;  2Q2Z A;  3ZFC A;  3L9H A;  3WRD A;  1BG2 A;  2Q2Y A;  1N6M A;  4PJJ A;  1LVK A;  4PK4 A;  2FME A;  2OWM A;  2GRY A;  4H1G A;  3K5E A;  2Y65 A;  1LKX A;  3WPN A;  3DC4 A;  2VB6 A;  1BR2 A;  3T0Q A;  1MMN A;  4FRZ A;  1VFX A;  4HNA K;  4A1Z A;  4E7S A;  1D1C A;  3KIN A;  4A5Y A;  4BXN A;  4PJL A;  3CNZ A;  4GKR A;  4PFO A;  2FL6 A; 
#chains in the Genus database with same CATH topology
 2X2R A;  4GKQ A;  1MNE A;  2IEH A;  3COB A;  2FL2 A;  2X7C A;  1SDM A;  1II6 A;  1F9V A;  1MMA A;  3CJO A;  3PXN A;  4A50 A;  5LT0 A;  1MMG A;  1D0Z A;  1MMD A;  4Y05 A;  4AP0 A;  2MYS A;  4ZCA A;  1VOM A;  5LT1 A;  2HEH A;  1YRS A;  4BBG A;  2PG2 A;  1BR4 A;  1V8K A;  2NCD A;  2O0A A;  4UBF A;  2ZFK A;  2ZFM A;  1KK7 A;  5LT4 A;  1VFV A;  2ZFI A;  2FKY A;  4AS7 A;  1F9U A;  2Y5W A;  2VVG A;  2ZFJ A;  3H4S A;  3HQD A;  5HLE A;  2XT3 A;  1FMV A;  2GM1 A;  4E7Z A;  3LRE A;  1Q0B A;  4DBR A;  1BR1 A;  3B6V A;  2G1Q A;  3BFN A;  1D1B A;  3KAR A;  1T5C A;  2KIN A;  4GKP A;  1I5S A;  3GBJ A;  3K3B A;  5GSZ A;  1MKJ A;  2VAS A;  1F9W A;  2V26 A;  4PJM A;  1FMW A;  5LT2 A;  1F9T A;  1VFW A;  1RY6 A;  1G8X A;  1CZ7 A;  4B7B A;  2UYM A;  3B6U A;  2XAE A;  4LNU K;  1I6I A;  2UYI A;  1GOJ A;  4A51 A;  3U06 A;  1D1A A;  4A14 A;  4PFP A;  3DCB A;  4ANJ A;  1D0X A;  3L1C A;  4A28 A;  3ZCW A;  3X2T A;  2ZFL A;  2X51 A;  4BN2 A;  2WOG A;  3KEN A;  3NWN A;  4PJN A;  4ETP B;  2X7D A;  1X88 A;  4ETP A;  1V8J A;  3ZFD A;  5LT3 A;  4DBQ A;  1D0Y A;  4ZHI A;  1VFZ A;  2X7E A;  2Q2Z A;  3ZFC A;  3L9H A;  3WRD A;  1BG2 A;  2Q2Y A;  1N6M A;  4PJJ A;  1LVK A;  4PK4 A;  2FME A;  2OWM A;  2GRY A;  4H1G A;  3K5E A;  2Y65 A;  1LKX A;  3WPN A;  3DC4 A;  2VB6 A;  1BR2 A;  3T0Q A;  1MMN A;  4FRZ A;  1VFX A;  4HNA K;  4A1Z A;  4E7S A;  1D1C A;  3KIN A;  4A5Y A;  4BXN A;  4PJL A;  3CNZ A;  4GKR A;  4PFO A;  2FL6 A; 
#chains in the Genus database with same CATH homology
 2X2R A;  1MNE A;  2IEH A;  3COB A;  2FL2 A;  2X7C A;  1SDM A;  1II6 A;  1F9V A;  1MMA A;  3CJO A;  3PXN A;  4A50 A;  5LT0 A;  1MMG A;  1D0Z A;  1MMD A;  4Y05 A;  4AP0 A;  2MYS A;  4ZCA A;  1VOM A;  5LT1 A;  2HEH A;  1YRS A;  4BBG A;  2PG2 A;  1BR4 A;  1V8K A;  2NCD A;  4UBF A;  2ZFK A;  2ZFM A;  1KK7 A;  5LT4 A;  1VFV A;  2ZFI A;  2FKY A;  4AS7 A;  1F9U A;  2Y5W A;  2VVG A;  2ZFJ A;  3H4S A;  3HQD A;  5HLE A;  2XT3 A;  1FMV A;  2GM1 A;  4E7Z A;  3LRE A;  1Q0B A;  4DBR A;  1BR1 A;  3B6V A;  2G1Q A;  3BFN A;  1D1B A;  3KAR A;  1T5C A;  2KIN A;  1I5S A;  3GBJ A;  3K3B A;  5GSZ A;  1MKJ A;  2VAS A;  1F9W A;  2V26 A;  4PJM A;  1FMW A;  5LT2 A;  1F9T A;  1VFW A;  1RY6 A;  1G8X A;  1CZ7 A;  4B7B A;  2UYM A;  3B6U A;  2XAE A;  4LNU K;  1I6I A;  2UYI A;  1GOJ A;  4A51 A;  3U06 A;  1D1A A;  4A14 A;  4PFP A;  3DCB A;  4ANJ A;  1D0X A;  3L1C A;  4A28 A;  3ZCW A;  3X2T A;  2ZFL A;  2X51 A;  4BN2 A;  2WOG A;  3KEN A;  3NWN A;  4PJN A;  2X7D A;  1X88 A;  4ETP A;  1V8J A;  3ZFD A;  5LT3 A;  4DBQ A;  1D0Y A;  4ZHI A;  1VFZ A;  2X7E A;  2Q2Z A;  3ZFC A;  3L9H A;  3WRD A;  1BG2 A;  2Q2Y A;  1N6M A;  4PJJ A;  1LVK A;  4PK4 A;  2FME A;  2OWM A;  2GRY A;  4H1G A;  3K5E A;  2Y65 A;  1LKX A;  3WPN A;  3DC4 A;  2VB6 A;  1BR2 A;  3T0Q A;  1MMN A;  4FRZ A;  1VFX A;  4HNA K;  4A1Z A;  4E7S A;  1D1C A;  3KIN A;  4A5Y A;  4BXN A;  4PJL A;  3CNZ A;  4GKR A;  4PFO A;  2FL6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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