4BBGA

Crystal structure of human kinesin eg5 in complex with 3-(((2-aminoethyl)sulfanyl)(3-ethylphenyl) phenylmethyl)phenol
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
350
structure length
336
Chain Sequence
b'KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENININQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVN'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Optimized S-Trityl-L-Cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 109
structure length 336
sequence length 350
ec nomenclature
pdb deposition date 2012-09-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4bbgA00
2X7CA 4DBQA 1LKXA 1BR2A 2Q2ZA 2WOGA 1D0XA 2HEHA 1FMVA 1GOJA 4FRZA 1VFWA 2OWMA 1MKJA 2X7DA 5LT1A 3ZFCA 5GSZA 1FMWA 3DCBA 1VFXA 4BXNA 1BR1A 2G1QA 1X88A 3COBA 4AS7A 4AP0A 1CZ7A 2FL6A 2FKYA 4A51A 2FMEA 2GRYA 2VASA 1F9WA 4B7BA 5LT4A 4A28A 2VB6A 1VFZA 5HLEA 2PG2A 3WPNA 3KENA 1II6A 4A50A 3L9HA 2MYSA 3NWNA 1LVKA 2ZFMA 1T5CA 3B6UA 2IEHA 4BBGA 1MNEA 4PK4A 2FL2A 3LREA 4ZCAA 3CNZA 3L1CA 4UBFA 1BG2A 3ZCWA 1MMAA 3PXNA 3WRDA 5LT2A 1BR4A 3K5EA 3HQDA 4ZHIA 1VFVA 1I6IA 1VOMA 2XT3A 2Y5WA 3ZFDA 1F9TA 1KK7A 4PJNA 2ZFKA 1I5SA 4PJLA 2ZFJA 1MMNA 3DC4A 3X2TA 2Q2YA 3CJOA 3T0QA 5LT0A 1D0YA 1D0ZA 1V8KA 4PFPA 4A1ZA 2V26A 4E7ZA 1SDMA 1MMGA 2UYIA 2XAEA 2X7EA 4DBRA 4HNAK 5LT3A 1D1BA 2ZFLA 4A5YA 1RY6A 3KARA 1N6MA 2GM1A 2ZFIA 4PFOA 2UYMA 3GBJA 3KINA 4PJJA 4ETPA 4H1GA 4BN2A 1D1AA 2Y65A 3U06A 4GKRA 2X51A 3H4SA 2VVGA 1Q0BA 4LNUK 1F9UA 4PJMA 3BFNA 1YRSA 1G8XA 4A14A 2NCDA 2X2RA 3B6VA 1V8JA 1MMDA 4E7SA 1D1CA 2KINA 1F9VA 4ANJA 4Y05A 3K3BA
chains in the Genus database with same CATH superfamily
2X7CA 4DBQA 1LKXA 1BR2A 2Q2ZA 2WOGA 1D0XA 2HEHA 1FMVA 1GOJA 4FRZA 1VFWA 2OWMA 1MKJA 2X7DA 5LT1A 3ZFCA 5GSZA 1FMWA 3DCBA 1VFXA 4BXNA 1BR1A 2G1QA 1X88A 3COBA 4AS7A 4AP0A 1CZ7A 2FL6A 2FKYA 4A51A 2FMEA 2GRYA 2VASA 1F9WA 4B7BA 5LT4A 4A28A 2VB6A 1VFZA 5HLEA 2PG2A 3WPNA 3KENA 1II6A 4A50A 3L9HA 2MYSA 3NWNA 1LVKA 2ZFMA 1T5CA 3B6UA 2IEHA 4BBGA 1MNEA 4PK4A 4GKPA 2FL2A 3LREA 4ZCAA 3CNZA 3L1CA 4UBFA 1BG2A 3ZCWA 1MMAA 3PXNA 3WRDA 5LT2A 1BR4A 3K5EA 3HQDA 4ZHIA 1VFVA 1I6IA 1VOMA 2XT3A 2Y5WA 3ZFDA 4ETPB 1F9TA 1KK7A 4PJNA 2ZFKA 1I5SA 4PJLA 2ZFJA 1MMNA 3DC4A 3X2TA 2Q2YA 3CJOA 3T0QA 5LT0A 1D0YA 1D0ZA 1V8KA 4PFPA 4A1ZA 2V26A 4E7ZA 1SDMA 1MMGA 2UYIA 2XAEA 2X7EA 4DBRA 4HNAK 5LT3A 1D1BA 2ZFLA 4A5YA 1RY6A 3KARA 1N6MA 2GM1A 2ZFIA 4PFOA 2UYMA 3GBJA 3KINA 4PJJA 4ETPA 4H1GA 4BN2A 1D1AA 4GKQA 2Y65A 3U06A 4GKRA 2X51A 3H4SA 2VVGA 2O0AA 1Q0BA 4LNUK 1F9UA 4PJMA 3BFNA 1YRSA 1G8XA 4A14A 2NCDA 2X2RA 3B6VA 1V8JA 1MMDA 4E7SA 1D1CA 2KINA 1F9VA 4ANJA 4Y05A 3K3BA
chains in the Genus database with same CATH topology
2X7CA 4DBQA 1LKXA 1BR2A 2Q2ZA 2WOGA 1D0XA 2HEHA 1FMVA 1GOJA 4FRZA 1VFWA 2OWMA 1MKJA 2X7DA 5LT1A 3ZFCA 5GSZA 1FMWA 3DCBA 1VFXA 4BXNA 1BR1A 2G1QA 1X88A 3COBA 4AS7A 4AP0A 1CZ7A 2FL6A 2FKYA 4A51A 2FMEA 2GRYA 2VASA 1F9WA 4B7BA 5LT4A 4A28A 2VB6A 1VFZA 5HLEA 2PG2A 3WPNA 3KENA 1II6A 4A50A 3L9HA 2MYSA 3NWNA 1LVKA 2ZFMA 1T5CA 3B6UA 2IEHA 4BBGA 1MNEA 4PK4A 2FL2A 3LREA 4ZCAA 3CNZA 3L1CA 4UBFA 1BG2A 3ZCWA 1MMAA 3PXNA 3WRDA 5LT2A 1BR4A 3K5EA 3HQDA 4ZHIA 1VFVA 1I6IA 1VOMA 2XT3A 2Y5WA 3ZFDA 1F9TA 1KK7A 4PJNA 2ZFKA 1I5SA 4PJLA 2ZFJA 1MMNA 3DC4A 3X2TA 2Q2YA 3CJOA 3T0QA 5LT0A 1D0YA 1D0ZA 1V8KA 4PFPA 4A1ZA 2V26A 4E7ZA 1SDMA 1MMGA 2UYIA 2XAEA 2X7EA 4DBRA 4HNAK 5LT3A 1D1BA 2ZFLA 4A5YA 1RY6A 3KARA 1N6MA 2GM1A 2ZFIA 4PFOA 2UYMA 3GBJA 3KINA 4PJJA 4ETPA 4H1GA 4BN2A 1D1AA 2Y65A 3U06A 4GKRA 2X51A 3H4SA 2VVGA 1Q0BA 4LNUK 1F9UA 4PJMA 3BFNA 1YRSA 1G8XA 4A14A 2NCDA 2X2RA 3B6VA 1V8JA 1MMDA 4E7SA 1D1CA 2KINA 1F9VA 4ANJA 4Y05A 3K3BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2X7C A;  4DBQ A;  1LKX A;  1BR2 A;  2Q2Z A;  2WOG A;  1D0X A;  2HEH A;  1FMV A;  1GOJ A;  4FRZ A;  1VFW A;  2OWM A;  1MKJ A;  2X7D A;  5LT1 A;  3ZFC A;  5GSZ A;  1FMW A;  3DCB A;  1VFX A;  4BXN A;  1BR1 A;  2G1Q A;  1X88 A;  3COB A;  4AS7 A;  4AP0 A;  1CZ7 A;  2FL6 A;  2FKY A;  4A51 A;  2FME A;  2GRY A;  2VAS A;  1F9W A;  4B7B A;  5LT4 A;  4A28 A;  2VB6 A;  1VFZ A;  5HLE A;  2PG2 A;  3WPN A;  3KEN A;  1II6 A;  4A50 A;  3L9H A;  2MYS A;  3NWN A;  1LVK A;  2ZFM A;  1T5C A;  3B6U A;  2IEH A;  4BBG A;  1MNE A;  4PK4 A;  2FL2 A;  3LRE A;  4ZCA A;  3CNZ A;  3L1C A;  4UBF A;  1BG2 A;  3ZCW A;  1MMA A;  3PXN A;  3WRD A;  5LT2 A;  1BR4 A;  3K5E A;  3HQD A;  4ZHI A;  1VFV A;  1I6I A;  1VOM A;  2XT3 A;  2Y5W A;  3ZFD A;  1F9T A;  1KK7 A;  4PJN A;  2ZFK A;  1I5S A;  4PJL A;  2ZFJ A;  1MMN A;  3DC4 A;  3X2T A;  2Q2Y A;  3CJO A;  3T0Q A;  5LT0 A;  1D0Y A;  1D0Z A;  1V8K A;  4PFP A;  4A1Z A;  2V26 A;  4E7Z A;  1SDM A;  1MMG A;  2UYI A;  2XAE A;  2X7E A;  4DBR A;  4HNA K;  5LT3 A;  1D1B A;  2ZFL A;  4A5Y A;  1RY6 A;  3KAR A;  1N6M A;  2GM1 A;  2ZFI A;  4PFO A;  2UYM A;  3GBJ A;  3KIN A;  4PJJ A;  4ETP A;  4H1G A;  4BN2 A;  1D1A A;  2Y65 A;  3U06 A;  4GKR A;  2X51 A;  3H4S A;  2VVG A;  1Q0B A;  4LNU K;  1F9U A;  4PJM A;  3BFN A;  1YRS A;  1G8X A;  4A14 A;  2NCD A;  2X2R A;  3B6V A;  1V8J A;  1MMD A;  4E7S A;  1D1C A;  2KIN A;  1F9V A;  4ANJ A;  4Y05 A;  3K3B A; 
#chains in the Genus database with same CATH topology
 2X7C A;  4DBQ A;  1LKX A;  1BR2 A;  2Q2Z A;  2WOG A;  1D0X A;  2HEH A;  1FMV A;  1GOJ A;  4FRZ A;  1VFW A;  2OWM A;  1MKJ A;  2X7D A;  5LT1 A;  3ZFC A;  5GSZ A;  1FMW A;  3DCB A;  1VFX A;  4BXN A;  1BR1 A;  2G1Q A;  1X88 A;  3COB A;  4AS7 A;  4AP0 A;  1CZ7 A;  2FL6 A;  2FKY A;  4A51 A;  2FME A;  2GRY A;  2VAS A;  1F9W A;  4B7B A;  5LT4 A;  4A28 A;  2VB6 A;  1VFZ A;  5HLE A;  2PG2 A;  3WPN A;  3KEN A;  1II6 A;  4A50 A;  3L9H A;  2MYS A;  3NWN A;  1LVK A;  2ZFM A;  1T5C A;  3B6U A;  2IEH A;  4BBG A;  1MNE A;  4PK4 A;  4GKP A;  2FL2 A;  3LRE A;  4ZCA A;  3CNZ A;  3L1C A;  4UBF A;  1BG2 A;  3ZCW A;  1MMA A;  3PXN A;  3WRD A;  5LT2 A;  1BR4 A;  3K5E A;  3HQD A;  4ZHI A;  1VFV A;  1I6I A;  1VOM A;  2XT3 A;  2Y5W A;  3ZFD A;  4ETP B;  1F9T A;  1KK7 A;  4PJN A;  2ZFK A;  1I5S A;  4PJL A;  2ZFJ A;  1MMN A;  3DC4 A;  3X2T A;  2Q2Y A;  3CJO A;  3T0Q A;  5LT0 A;  1D0Y A;  1D0Z A;  1V8K A;  4PFP A;  4A1Z A;  2V26 A;  4E7Z A;  1SDM A;  1MMG A;  2UYI A;  2XAE A;  2X7E A;  4DBR A;  4HNA K;  5LT3 A;  1D1B A;  2ZFL A;  4A5Y A;  1RY6 A;  3KAR A;  1N6M A;  2GM1 A;  2ZFI A;  4PFO A;  2UYM A;  3GBJ A;  3KIN A;  4PJJ A;  4ETP A;  4H1G A;  4BN2 A;  1D1A A;  4GKQ A;  2Y65 A;  3U06 A;  4GKR A;  2X51 A;  3H4S A;  2VVG A;  2O0A A;  1Q0B A;  4LNU K;  1F9U A;  4PJM A;  3BFN A;  1YRS A;  1G8X A;  4A14 A;  2NCD A;  2X2R A;  3B6V A;  1V8J A;  1MMD A;  4E7S A;  1D1C A;  2KIN A;  1F9V A;  4ANJ A;  4Y05 A;  3K3B A; 
#chains in the Genus database with same CATH homology
 2X7C A;  4DBQ A;  1LKX A;  1BR2 A;  2Q2Z A;  2WOG A;  1D0X A;  2HEH A;  1FMV A;  1GOJ A;  4FRZ A;  1VFW A;  2OWM A;  1MKJ A;  2X7D A;  5LT1 A;  3ZFC A;  5GSZ A;  1FMW A;  3DCB A;  1VFX A;  4BXN A;  1BR1 A;  2G1Q A;  1X88 A;  3COB A;  4AS7 A;  4AP0 A;  1CZ7 A;  2FL6 A;  2FKY A;  4A51 A;  2FME A;  2GRY A;  2VAS A;  1F9W A;  4B7B A;  5LT4 A;  4A28 A;  2VB6 A;  1VFZ A;  5HLE A;  2PG2 A;  3WPN A;  3KEN A;  1II6 A;  4A50 A;  3L9H A;  2MYS A;  3NWN A;  1LVK A;  2ZFM A;  1T5C A;  3B6U A;  2IEH A;  4BBG A;  1MNE A;  4PK4 A;  2FL2 A;  3LRE A;  4ZCA A;  3CNZ A;  3L1C A;  4UBF A;  1BG2 A;  3ZCW A;  1MMA A;  3PXN A;  3WRD A;  5LT2 A;  1BR4 A;  3K5E A;  3HQD A;  4ZHI A;  1VFV A;  1I6I A;  1VOM A;  2XT3 A;  2Y5W A;  3ZFD A;  1F9T A;  1KK7 A;  4PJN A;  2ZFK A;  1I5S A;  4PJL A;  2ZFJ A;  1MMN A;  3DC4 A;  3X2T A;  2Q2Y A;  3CJO A;  3T0Q A;  5LT0 A;  1D0Y A;  1D0Z A;  1V8K A;  4PFP A;  4A1Z A;  2V26 A;  4E7Z A;  1SDM A;  1MMG A;  2UYI A;  2XAE A;  2X7E A;  4DBR A;  4HNA K;  5LT3 A;  1D1B A;  2ZFL A;  4A5Y A;  1RY6 A;  3KAR A;  1N6M A;  2GM1 A;  2ZFI A;  4PFO A;  2UYM A;  3GBJ A;  3KIN A;  4PJJ A;  4ETP A;  4H1G A;  4BN2 A;  1D1A A;  2Y65 A;  3U06 A;  4GKR A;  2X51 A;  3H4S A;  2VVG A;  1Q0B A;  4LNU K;  1F9U A;  4PJM A;  3BFN A;  1YRS A;  1G8X A;  4A14 A;  2NCD A;  2X2R A;  3B6V A;  1V8J A;  1MMD A;  4E7S A;  1D1C A;  2KIN A;  1F9V A;  4ANJ A;  4Y05 A;  3K3B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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