4BBGA

Crystal structure of human kinesin eg5 in complex with 3-(((2-aminoethyl)sulfanyl)(3-ethylphenyl) phenylmethyl)phenol
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
350
structure length
336
Chain Sequence
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENININQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords KINESIN-LIKE PROTEIN KIF11
publication title Optimized S-Trityl-L-Cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle
total genus 109
structure length 336
sequence length 350
ec nomenclature
pdb deposition date 2012-09-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00225 Kinesin Kinesin motor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.850.10 Alpha Beta 3-Layer(aba) Sandwich Kinesin Kinesin motor domain 4bbgA00
5LT1A 5GSZA 2V26A 4DBQA 4A14A 3BFNA 4A51A 4B7BA 2KINA 1F9WA 1F9VA 2ZFLA 3K5EA 1GOJA 4A50A 1SDMA 1FMWA 1VOMA 2FL6A 4BXNA 5HLEA 1V8KA 2XAEA 4PJLA 1Q0BA 4BN2A 2VB6A 1BR2A 4PJJA 3ZFCA 2X7EA 3B6UA 1VFXA 3U06A 3CJOA 3KENA 4Y05A 1II6A 2UYMA 4ANJA 2FKYA 3X2TA 4PFPA 3WRDA 1G8XA 1MMGA 3PXNA 3ZCWA 1V8JA 1YRSA 2Q2ZA 1VFWA 3T0QA 1VFVA 3CNZA 4PK4A 4HNAK 1D0XA 3NWNA 1LKXA 5LT0A 4DBRA 1D1BA 4E7SA 1D0YA 3COBA 2VVGA 4FRZA 1I6IA 2MYSA 4BBGA 3HQDA 2OWMA 2G1QA 3L1CA 3KINA 2HEHA 1RY6A 2ZFMA 4PFOA 4AS7A 1D1AA 1T5CA 4ETPA 3ZFDA 1BG2A 2Y5WA 2Q2YA 1X88A 2FMEA 2UYIA 1N6MA 2X2RA 3B6VA 4ZHIA 1BR4A 1F9TA 2GRYA 5LT4A 2GM1A 2X7DA 2Y65A 2ZFJA 3H4SA 2IEHA 4AP0A 2ZFKA 2FL2A 2PG2A 1FMVA 3KARA 2WOGA 1MMDA 1D0ZA 5LT2A 4PJNA 2X51A 4ZCAA 3LREA 5LT3A 2VASA 1I5SA 4PJMA 4A1ZA 1F9UA 3GBJA 4LNUK 1MMNA 2ZFIA 4E7ZA 1CZ7A 3L9HA 2X7CA 4A28A 3DC4A 3DCBA 1MMAA 2NCDA 4A5YA 1BR1A 2XT3A 3WPNA 1D1CA 1MKJA 4UBFA 4GKRA 4H1GA 1VFZA 1KK7A 1LVKA 1MNEA 3K3BA
chains in the Genus database with same CATH superfamily
5LT1A 5GSZA 2V26A 4DBQA 4A14A 3BFNA 4A51A 4B7BA 2KINA 4GKQA 1F9WA 1F9VA 2O0AA 2ZFLA 3K5EA 1GOJA 4A50A 1SDMA 1FMWA 1VOMA 2FL6A 4BXNA 5HLEA 1V8KA 2XAEA 4PJLA 1Q0BA 4BN2A 2VB6A 1BR2A 4PJJA 3ZFCA 2X7EA 3B6UA 1VFXA 3U06A 3CJOA 3KENA 4Y05A 1II6A 2UYMA 4ANJA 2FKYA 3X2TA 4PFPA 3WRDA 1G8XA 1MMGA 3PXNA 3ZCWA 1V8JA 1YRSA 2Q2ZA 1VFWA 3T0QA 1VFVA 3CNZA 4PK4A 4HNAK 1D0XA 3NWNA 1LKXA 5LT0A 4DBRA 1D1BA 4E7SA 1D0YA 3COBA 2VVGA 4FRZA 1I6IA 2MYSA 4BBGA 3HQDA 4GKPA 2OWMA 2G1QA 3L1CA 3KINA 2HEHA 1RY6A 2ZFMA 4PFOA 4AS7A 1D1AA 1T5CA 4ETPA 3ZFDA 1BG2A 2Y5WA 2Q2YA 1X88A 2FMEA 2UYIA 1N6MA 2X2RA 3B6VA 4ZHIA 1BR4A 1F9TA 2GRYA 5LT4A 2GM1A 2X7DA 2Y65A 2ZFJA 3H4SA 2IEHA 4AP0A 2ZFKA 2FL2A 2PG2A 1FMVA 3KARA 2WOGA 1MMDA 1D0ZA 5LT2A 4PJNA 2X51A 4ZCAA 3LREA 5LT3A 2VASA 1I5SA 4PJMA 4A1ZA 1F9UA 3GBJA 4LNUK 1MMNA 2ZFIA 4E7ZA 1CZ7A 3L9HA 2X7CA 4A28A 3DC4A 3DCBA 1MMAA 2NCDA 4A5YA 1BR1A 2XT3A 3WPNA 1D1CA 1MKJA 4UBFA 4GKRA 4H1GA 1VFZA 1KK7A 4ETPB 1LVKA 1MNEA 3K3BA
chains in the Genus database with same CATH topology
5LT1A 5GSZA 2V26A 4DBQA 4A14A 3BFNA 4A51A 4B7BA 2KINA 1F9WA 1F9VA 2ZFLA 3K5EA 1GOJA 4A50A 1SDMA 1FMWA 1VOMA 2FL6A 4BXNA 5HLEA 1V8KA 2XAEA 4PJLA 1Q0BA 4BN2A 2VB6A 1BR2A 4PJJA 3ZFCA 2X7EA 3B6UA 1VFXA 3U06A 3CJOA 3KENA 4Y05A 1II6A 2UYMA 4ANJA 2FKYA 3X2TA 4PFPA 3WRDA 1G8XA 1MMGA 3PXNA 3ZCWA 1V8JA 1YRSA 2Q2ZA 1VFWA 3T0QA 1VFVA 3CNZA 4PK4A 4HNAK 1D0XA 3NWNA 1LKXA 5LT0A 4DBRA 1D1BA 4E7SA 1D0YA 3COBA 2VVGA 4FRZA 1I6IA 2MYSA 4BBGA 3HQDA 2OWMA 2G1QA 3L1CA 3KINA 2HEHA 1RY6A 2ZFMA 4PFOA 4AS7A 1D1AA 1T5CA 4ETPA 3ZFDA 1BG2A 2Y5WA 2Q2YA 1X88A 2FMEA 2UYIA 1N6MA 2X2RA 3B6VA 4ZHIA 1BR4A 1F9TA 2GRYA 5LT4A 2GM1A 2X7DA 2Y65A 2ZFJA 3H4SA 2IEHA 4AP0A 2ZFKA 2FL2A 2PG2A 1FMVA 3KARA 2WOGA 1MMDA 1D0ZA 5LT2A 4PJNA 2X51A 4ZCAA 3LREA 5LT3A 2VASA 1I5SA 4PJMA 4A1ZA 1F9UA 3GBJA 4LNUK 1MMNA 2ZFIA 4E7ZA 1CZ7A 3L9HA 2X7CA 4A28A 3DC4A 3DCBA 1MMAA 2NCDA 4A5YA 1BR1A 2XT3A 3WPNA 1D1CA 1MKJA 4UBFA 4GKRA 4H1GA 1VFZA 1KK7A 1LVKA 1MNEA 3K3BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LT1 A;  5GSZ A;  2V26 A;  4DBQ A;  4A14 A;  3BFN A;  4A51 A;  4B7B A;  2KIN A;  1F9W A;  1F9V A;  2ZFL A;  3K5E A;  1GOJ A;  4A50 A;  1SDM A;  1FMW A;  1VOM A;  2FL6 A;  4BXN A;  5HLE A;  1V8K A;  2XAE A;  4PJL A;  1Q0B A;  4BN2 A;  2VB6 A;  1BR2 A;  4PJJ A;  3ZFC A;  2X7E A;  3B6U A;  1VFX A;  3U06 A;  3CJO A;  3KEN A;  4Y05 A;  1II6 A;  2UYM A;  4ANJ A;  2FKY A;  3X2T A;  4PFP A;  3WRD A;  1G8X A;  1MMG A;  3PXN A;  3ZCW A;  1V8J A;  1YRS A;  2Q2Z A;  1VFW A;  3T0Q A;  1VFV A;  3CNZ A;  4PK4 A;  4HNA K;  1D0X A;  3NWN A;  1LKX A;  5LT0 A;  4DBR A;  1D1B A;  4E7S A;  1D0Y A;  3COB A;  2VVG A;  4FRZ A;  1I6I A;  2MYS A;  4BBG A;  3HQD A;  2OWM A;  2G1Q A;  3L1C A;  3KIN A;  2HEH A;  1RY6 A;  2ZFM A;  4PFO A;  4AS7 A;  1D1A A;  1T5C A;  4ETP A;  3ZFD A;  1BG2 A;  2Y5W A;  2Q2Y A;  1X88 A;  2FME A;  2UYI A;  1N6M A;  2X2R A;  3B6V A;  4ZHI A;  1BR4 A;  1F9T A;  2GRY A;  5LT4 A;  2GM1 A;  2X7D A;  2Y65 A;  2ZFJ A;  3H4S A;  2IEH A;  4AP0 A;  2ZFK A;  2FL2 A;  2PG2 A;  1FMV A;  3KAR A;  2WOG A;  1MMD A;  1D0Z A;  5LT2 A;  4PJN A;  2X51 A;  4ZCA A;  3LRE A;  5LT3 A;  2VAS A;  1I5S A;  4PJM A;  4A1Z A;  1F9U A;  3GBJ A;  4LNU K;  1MMN A;  2ZFI A;  4E7Z A;  1CZ7 A;  3L9H A;  2X7C A;  4A28 A;  3DC4 A;  3DCB A;  1MMA A;  2NCD A;  4A5Y A;  1BR1 A;  2XT3 A;  3WPN A;  1D1C A;  1MKJ A;  4UBF A;  4GKR A;  4H1G A;  1VFZ A;  1KK7 A;  1LVK A;  1MNE A;  3K3B A; 
#chains in the Genus database with same CATH topology
 5LT1 A;  5GSZ A;  2V26 A;  4DBQ A;  4A14 A;  3BFN A;  4A51 A;  4B7B A;  2KIN A;  4GKQ A;  1F9W A;  1F9V A;  2O0A A;  2ZFL A;  3K5E A;  1GOJ A;  4A50 A;  1SDM A;  1FMW A;  1VOM A;  2FL6 A;  4BXN A;  5HLE A;  1V8K A;  2XAE A;  4PJL A;  1Q0B A;  4BN2 A;  2VB6 A;  1BR2 A;  4PJJ A;  3ZFC A;  2X7E A;  3B6U A;  1VFX A;  3U06 A;  3CJO A;  3KEN A;  4Y05 A;  1II6 A;  2UYM A;  4ANJ A;  2FKY A;  3X2T A;  4PFP A;  3WRD A;  1G8X A;  1MMG A;  3PXN A;  3ZCW A;  1V8J A;  1YRS A;  2Q2Z A;  1VFW A;  3T0Q A;  1VFV A;  3CNZ A;  4PK4 A;  4HNA K;  1D0X A;  3NWN A;  1LKX A;  5LT0 A;  4DBR A;  1D1B A;  4E7S A;  1D0Y A;  3COB A;  2VVG A;  4FRZ A;  1I6I A;  2MYS A;  4BBG A;  3HQD A;  4GKP A;  2OWM A;  2G1Q A;  3L1C A;  3KIN A;  2HEH A;  1RY6 A;  2ZFM A;  4PFO A;  4AS7 A;  1D1A A;  1T5C A;  4ETP A;  3ZFD A;  1BG2 A;  2Y5W A;  2Q2Y A;  1X88 A;  2FME A;  2UYI A;  1N6M A;  2X2R A;  3B6V A;  4ZHI A;  1BR4 A;  1F9T A;  2GRY A;  5LT4 A;  2GM1 A;  2X7D A;  2Y65 A;  2ZFJ A;  3H4S A;  2IEH A;  4AP0 A;  2ZFK A;  2FL2 A;  2PG2 A;  1FMV A;  3KAR A;  2WOG A;  1MMD A;  1D0Z A;  5LT2 A;  4PJN A;  2X51 A;  4ZCA A;  3LRE A;  5LT3 A;  2VAS A;  1I5S A;  4PJM A;  4A1Z A;  1F9U A;  3GBJ A;  4LNU K;  1MMN A;  2ZFI A;  4E7Z A;  1CZ7 A;  3L9H A;  2X7C A;  4A28 A;  3DC4 A;  3DCB A;  1MMA A;  2NCD A;  4A5Y A;  1BR1 A;  2XT3 A;  3WPN A;  1D1C A;  1MKJ A;  4UBF A;  4GKR A;  4H1G A;  1VFZ A;  1KK7 A;  4ETP B;  1LVK A;  1MNE A;  3K3B A; 
#chains in the Genus database with same CATH homology
 5LT1 A;  5GSZ A;  2V26 A;  4DBQ A;  4A14 A;  3BFN A;  4A51 A;  4B7B A;  2KIN A;  1F9W A;  1F9V A;  2ZFL A;  3K5E A;  1GOJ A;  4A50 A;  1SDM A;  1FMW A;  1VOM A;  2FL6 A;  4BXN A;  5HLE A;  1V8K A;  2XAE A;  4PJL A;  1Q0B A;  4BN2 A;  2VB6 A;  1BR2 A;  4PJJ A;  3ZFC A;  2X7E A;  3B6U A;  1VFX A;  3U06 A;  3CJO A;  3KEN A;  4Y05 A;  1II6 A;  2UYM A;  4ANJ A;  2FKY A;  3X2T A;  4PFP A;  3WRD A;  1G8X A;  1MMG A;  3PXN A;  3ZCW A;  1V8J A;  1YRS A;  2Q2Z A;  1VFW A;  3T0Q A;  1VFV A;  3CNZ A;  4PK4 A;  4HNA K;  1D0X A;  3NWN A;  1LKX A;  5LT0 A;  4DBR A;  1D1B A;  4E7S A;  1D0Y A;  3COB A;  2VVG A;  4FRZ A;  1I6I A;  2MYS A;  4BBG A;  3HQD A;  2OWM A;  2G1Q A;  3L1C A;  3KIN A;  2HEH A;  1RY6 A;  2ZFM A;  4PFO A;  4AS7 A;  1D1A A;  1T5C A;  4ETP A;  3ZFD A;  1BG2 A;  2Y5W A;  2Q2Y A;  1X88 A;  2FME A;  2UYI A;  1N6M A;  2X2R A;  3B6V A;  4ZHI A;  1BR4 A;  1F9T A;  2GRY A;  5LT4 A;  2GM1 A;  2X7D A;  2Y65 A;  2ZFJ A;  3H4S A;  2IEH A;  4AP0 A;  2ZFK A;  2FL2 A;  2PG2 A;  1FMV A;  3KAR A;  2WOG A;  1MMD A;  1D0Z A;  5LT2 A;  4PJN A;  2X51 A;  4ZCA A;  3LRE A;  5LT3 A;  2VAS A;  1I5S A;  4PJM A;  4A1Z A;  1F9U A;  3GBJ A;  4LNU K;  1MMN A;  2ZFI A;  4E7Z A;  1CZ7 A;  3L9H A;  2X7C A;  4A28 A;  3DC4 A;  3DCB A;  1MMA A;  2NCD A;  4A5Y A;  1BR1 A;  2XT3 A;  3WPN A;  1D1C A;  1MKJ A;  4UBF A;  4GKR A;  4H1G A;  1VFZ A;  1KK7 A;  1LVK A;  1MNE A;  3K3B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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